Felty syndrome

Felty syndrome waa cilad ay ka mid yihiin rheumatoid arthritis, murqo barar, hoos u dhaca tirada unugyada dhiigga cad, iyo infekshannada soo noqnoqda. Waa dhif iyo naadir.

Sababta Felty syndrome lama yaqaan. Wuxuu ku badan yahay dadka uu ku dhacay rheumatoid arthritis (RA) waqti dheer. Dadka qaba cilladani waxay halis ugu jiraan infekshin sababtoo ah waxay leeyihiin tiro unug unugyada dhiigga cad oo hooseeya.

Calaamadaha waxaa ka mid ah:

• Dareen guud oo raaxo la'aan ah
• Daal
• Tabar-darrida lugta ama gacanta
• Cunto xumo
• Miisaan lumis aan ula kac ahayn
• Boogaha maqaarka
• Bararka wadajirka ah, qallafsanaanta, xanuunka, iyo naafanimada
• Infekshannada soo noqnoqda
• Isha cas oo gubasho ama dheecaan leh

Baadhitaanka jirka ayaa muujin doona:

• Cawrada oo barara
• Kala-goysyada muujinaya calaamadaha RA
• Waxaa macquul ah beerka iyo qanjidhada oo barara

Tirinta dhiigga oo dhammeystiran (CBC) oo leh kala duwanaansho ayaa muujin doona tiro yar oo unugyada dhiigga cad oo loo yaqaanno neutrophils. Ku dhowaad dhammaan dadka qaba cudurka 'Felty syndrome' waxay leeyihiin baaritaan wanaagsan oo ku saabsan cunsuriyadda 'rheumatoid factor'.

Ultrasound-ka caloosha ayaa laga yaabaa inuu xaqiijiyo muruq bararsan.

Xaaladaha badankood, dadka qaba cilladani ma helaan daaweyn lagula taliyo RA. Waxaa laga yaabaa inay u baahdaan daawooyin kale si loo xakameeyo nidaamka jirkooda loona yareeyo howlaha RA.

Methotrexate waxay hagaajin kartaa tirinta nafaqada yar. Daawada rituximab ayaa ku guuleysatay dadka aan ka jawaabin daawada methotrexate.

Cunsurka kiciya Granulocyte-colony (G-CSF) wuxuu kordhin karaa tirada nafaqada.

Dadka qaarkiis waxay ka faa'iideystaan ​​ka-soo-baxa muruqa (splenectomy).

Daaweyn la'aan, infekshannada ayaa sii wadi kara inay dhacaan.

RA waxay u egtahay inay kasii darayso.

Daaweynta RA, si kastaba ha noqotee, waa inay hagaajiso cilladda Felty syndrome.

Waxaa laga yaabaa inaad qabtid infakshanno soo noqnoqonaya.

Dadka qaarkood ee qaba Felty syndrome waxay kordhiyeen tirooyinka waaweyn ee 'lymphocytes', oo sidoo kale loo yaqaan 'LGL leukemia'. Tan waxaa lagu daaweyn doonaa daawada methotrexate xaalado badan.

Wac daryeel caafimaad bixiyahaaga haddii aad isku aragto astaamaha cilladan.

Daaweynta degdegga ah ee RA ee hadda lagula taliyay daawooyinka waxay si muuqata hoos ugu dhigeysaa halista ah inuu ku dhaco cudurka Felty syndrome.

Seropositive rheumatoid arthritis (RA); Felty’s syndrome

• Antibodies

Bellistri JP, Muscarella P. Splenectomy ee cudurada hematologic. Gudaha: Cameron JL, Cameron AM, eds. Daaweynta Qalliinka ee Hadda. 12aad ed. Philadelphia, PA: Elsevier; 2017: 603-610.

Erickson AR, Cannella AC, Mikuls TR. Tilmaamaha caafimaad ee rheumatoid arthritis. Gudaha: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley iyo Firestein's Buugga Buugga Rheumatology. 10aad ed. Philadelphia, PA: Elsevier; 2017: cutubka 70.

Gazitt T, Loughran TP Jr. Nutropenia dabadheeraad ah oo ku dhaca LGL leukemia iyo rheumatoid arthritis. Barnaamijka Barashada Hematology Am Soc Hematol. 2017; 2017 (1): 181-186. PMID: 29222254 www.ncbi.nlm.nih.gov/pubmed/29222254.

Myasoedova E, Turesson C, Matteson EL. Tilmaamaha gaarka ah ee rheumatoid arthritis. Gudaha: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. 7aad ed. Philadelphia, PA: Elsevier; 2019: cutubka 95.

Savola P, Brück O, Olson T, iyo al. Somatic STAT3 isbeddellada ku dhaca cilladda 'Felty Syndrome': oo ah saameyn ku yeelanaysa cudur-sidaha guud ee cudurka kansarka leh 'lempmia lymphocyte leukemia'. Haematologica. 2018; 103 (2): 304-312. PMID: 29217783 www.ncbi.nlm.nih.gov/pubmed/29217783.

Wang CR, Chiu YC, Chen YC. Daaweynta guusha leh ee neutropenia diidan ee Felty's syndrome ee leh rituximab. Scand J Rheumatol. 2018; 47 (4): 340-341. PMID: 28753121 www.ncbi.nlm.nih.gov/pubmed/28753121.