Buro unugyada yar-yar ee qanjirka 'Pancreatic islet'

Buro unugyada qanjidhada isleedahay waa buro naadir ah oo ku dhacda ganaca oo ka bilaabma nooc ka mid ah unugyada loo yaqaanno unugga islet.

Xammeetida caafimaadka qabta, unugyada loo yaqaan unugyada isirku waxay soo saaraan hormoonno nidaamiya shaqooyinka kala duwan ee jirka. Kuwaas waxaa ka mid ah heerka sonkorta dhiigga iyo soo saarista aashitada caloosha.

Burooyinka ka soo baxa unugyada jasiiraddu waxay kaloo soo saari karaan hormoonno kala duwan, taasoo u horseedi karta calaamado gaar ah.

Burooyinka unugyada yar yar ee kansarku waxay noqon karaan kuwa aan kansar lahayn (aan fiicnayn) ama kansar (malignant).

Burooyinka unugyada soo baxa waxaa ka mid ah:

• Gastrinoma (Zollinger-Ellison syndrome)
• Glucagonoma
• Insulinoma
• Somatostatinoma
  
• VIPoma (Verner-Morrison syndrome)

Taariikh qoys oo ku saabsan endoprine neoplasia badan, nooca I (MEN I) waa halista ugu weyn ee horumarinta burooyinka unugyada unugyada.

Astaamuhu waxay kuxiranyihiin hoormoonka uu sameeyo burada.

Tusaale ahaan, insulinomasku waxay soo saaraan insulin, taas oo hoos u dhigta heerka sonkorta dhiigga. Calaamadaha waxaa ka mid noqon kara:

• Dareemid ama daciifnimo
• Ruxitaan ama dhidid
• Madax xanuun
• Gaajo
• Dareen, walaac, ama dareemid xanaaq
• Feker aan caddayn ama dareemid degganaan la'aan
• Aragti laba-laab ama indho-sarcaad ah
• Wadne garaac ama garaacis

Haddii heerka sonkorta dhiiggu aad hoos ugu dhacdo, waad suuxi kartaa, suuxdin baa kugu dhici karta, ama xitaa miyir beelid.

Gastrinomas waxay sameysaa hormoonka gastrin, kaasoo u sheega jirka inuu sameeyo aashitada caloosha. Calaamadaha waxaa ka mid noqon kara:

• Calool xanuun
• Shuban
• Boogaha caloosha iyo mindhicirka yar
• Matag dhiig (mar mar)

Glucagonomas waxay sameysaa hormoonka glucagon, kaasoo jirka ka caawiya inuu sare u qaado heerka sonkorta dhiigga. Calaamadaha waxaa ka mid noqon kara:

• Sonkorowga
• Guduudasho, finanka finanka leh ee gumaarka ama badhida
• Miisaanka oo yaraada
• Kaadi joogta ah iyo harraad

Somatostatinomas waxay sameysaa hormoonka somatostatin. Calaamadaha waxaa ka mid noqon kara:

• Sonkor dhiig oo sareeya
• Dhagxaanta
• Muuqaal huruud ah maqaarka, iyo indhaha
• Miisaanka oo yaraada
• Shuban saxaro ur xun leh

VIPomas waxay sameeyaan hormoonka vasoactive mindhicirka peptide (VIP) kaas oo ku lug leh ilaalinta dheelitirka cusbada, sodium, potassium iyo macdanaha kale ee ku jira mareenka GI. VIPomas waxay sababi karaan:

• Shuban daran oo u horseedi kara fuuqbax
• Heerarka dhiigga ee dhiigga oo hooseeya, iyo heerarka kaalshiyamka oo sarreeya
• Calool xanuun
• Miisaanka oo yaraada

Bixiyahaaga daryeelka caafimaadka ayaa qaadan doona taariikhdaada caafimaad wuxuuna sameyn doonaa baaritaan jireed.

Tijaabooyinka dhiiggu way kala duwanaan karaan, iyadoo ku xidhan hadba calaamadaha, laakiin waxaa ka mid noqon kara:

• Heerka gulukooska soonka
• Heerka Gastrin
• Tijaabada dulqaadka gulukooska
• Imtixaanka kicinta sirta ee xammeetida
• Heerka glucagon dhiigga
• Insulin-ta dhiigga ee C-peptide
• Heerka insulin-ta dhiigga
• Heerka soomka ee somatostatin
• Heerka Serum vasoactive mindhicirka peptide (VIP)

Tijaabinta sawirka waa la sameyn karaa:

• Sawirka CT-ga ee caloosha
• Ultrasound caloosha
• Ultrasound-ka Endoscopic
• MRI caloosha

Muunad dhiig ayaa sidoo kale laga qaadi karaa xididka xammeetida si loo baaro.

Mararka qaarkood, qalliin ayaa loo baahan yahay si loo ogaado loona daweeyo xaaladdan. Inta lagu guda jiro howshan, dhakhtarka qalliinka wuxuu ku baaraa xammeetida gacanta iyo ultrasound.

Daaweyntu waxay kuxirantahay nooca burooyinka iyo haduu kansar yahay.

Burooyinka kansarku si dhakhso leh ayey u kori karaan oo ugu fidi karaan xubnaha kale. Laga yaabee inaysan noqon kuwo la daaweyn karo. Burooyinka waxaa badanaa lagu qaadaa qalliin, haddii ay suurtagal tahay.

Haddii unugyada kansarku ku faafaan beerka, qayb ka mid ah beerka ayaa sidoo kale laga saari karaa, haddii ay suurogal tahay. Haddii kansarku faafo, kiimoteraabiga ayaa loo isticmaali karaa in lagu tijaabiyo laguna yareeyo burooyinka.

Haddii soosaarka aan caadiga ahayn ee hormoonnada uu sababayo astaamo, waxaa laga yaabaa inaad hesho daawooyin si aad uga hortagto saameyntooda. Tusaale ahaan, gastrinomas, soosaarka badan ee gastrin wuxuu keenaa aashito badan caloosha. Daawooyinka xannibaya sii deynta aashitada caloosha ayaa yareyn kara astaamaha.

Waad yareyn kartaa diiqada jirrada adoo ku biiraya kooxda taageerta kansarka. La wadaagida dadka kale ee leh khibradaha guud iyo dhibaatooyinka ayaa kaa caawin kara inaadan kali dareemin.

Waad bogsan kartaa haddii burooyinka qalliin looga saaro ka hor intaysan ku faafin xubnaha kale. Haddii burooyinka ay yihiin kansar, kiimiko ku daaweyn ayaa la isticmaali karaa, laakiin badanaa ma daaweyn karto dadka.

Dhibaatooyinka nolosha halista ku ah (sida sonkorta dhiiga oo aad u hooseysa) waxay ku dhici kartaa soo saarida hoormoon saaid ah, ama haddii kansarku ku faafo jirka oo dhan.

Dhibaatooyinka burooyinkan waxaa ka mid ah:

• Sonkorowga
• Dhibaatooyinka hormoonka (haddii burooyinka ay sii daayaan noocyo hoormoonno ah)
• Sonkor dhiig oo aad u hooseysa (insulinomas)
• Nabaro daran oo caloosha ku jira iyo xiidmaha yar (oo ka yimaad gastrinomas)
• Ku faafidda burada beerka

Wac daryeel bixiyahaaga haddii aad isku aragto astaamaha burooyinkaan, gaar ahaan haddii aad taariikh qoys ku leedahay RAGGA I.

Ma jiro ka hortag la yaqaan oo ku saabsan burooyinkan.

Kansarka - xammeetida; Kansarka - beeryarada; Kansarka qanjirada; Burooyinka unugyada Islet; Islet of buro Langerhans; Burooyinka Neuroendocrine; Boog boogta - burooyinka unugyada soo baxa; Hypoglycemia - buro unugyada soo baxa; Xanuunka Zollinger-Ellison; Cudurka Verner-Morrison; Gastrinoma; Insulinoma; VIPoma; Somatostatinoma; Glucagonoma

• Qanjirada 'Endocrine'
• Xammeetida

Foster DS, Norton JA. Maareynta burooyinka unugyada unugyada beeryarada oo laga reebo gastrinoma. Gudaha: Cameron AM, Cameron JL, eds. Daaweynta Qalliinka ee Hadda. 13aad. Philadelphia, PA: Elsevier; 2020: 581-584.

Websaydhka Machadka Kansarka Qaranka. Daaweynta kansarka Pancreatic (PDQ) - nooca caafimaadka xirfadleyda. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. La cusbooneysiiyay Janaayo 2, 2020. Waxaa la helay Febraayo 25, 2020.

Shabakada Shabakada Shabakada Kansarka oo dhameystiran. Tilmaamaha tababarka caafimaadka ee NCCN ee kansarka (tilmaamaha NCCN). Neuroendocrine iyo burooyinka adrenal. Nooca 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. La cusbooneysiiyay Maarso 5, 2019. Waxaa la helay Febraayo 25, 2020.

Shabakada Shabakada Shabakada Kansarka oo dhameystiran. Tilmaamaha NCCN ee bukaanka. Burooyinka Neuroendocrine. 2018. www.nccn.org/patients/guidelines/content/PDF/neuroendocrine-patient.pdf.