Cudurka 'granulomatous' ee joogtada ah

Cudurka daba-dheer ee loo yaqaan 'granulomatous disease' (CGD) waa cillad la iska dhaxlo oo unugyada habka difaaca jirka qaarkood aysan si sax ah u shaqeyn. Tani waxay keenaysaa infekshanno soo noqnoqda oo daran.

CGD, unugyada difaaca jirka ee loo yaqaan 'phagocytes' ma awoodaan inay dilaan noocyada qaar ee bakteeriyada iyo fungi. Cilladaan waxay keentaa infekshan muddo dheer ah (dabadheeraad ah) iyo soo noqnoqosho (soo noqnoqon). Xaaladda badanaa waxaa la ogaadaa xilli hore carruurnimada. Foomamka khafiifka ah ayaa laga yaabaa in lagu ogaado inta lagu jiro sannadaha qaan-gaarka, ama xitaa qaan-gaarnimada.

Waxyaabaha halista keena waxaa ka mid ah taariikhda qoyska ee infekshannada soo noqnoqda ama joogtada ah.

Qiyaastii kalabar kiisaska CGD waxaa loo gudbiyaa qoysaska iyada oo ah astaamo xagga galmada oo xiriir la leh. Tani waxay ka dhigan tahay in wiilasha ay u badan tahay inay ku dhacaan cudurka marka loo eego gabdhaha. Hidda-wadaha cilladaysan waxaa lagu qaadaa X koromosoomka. Wiilasha waxay leeyihiin 1 koromosoom X iyo 1 Y koromosoom. Haddii wiilku leeyahay koromosoomka X oo leh hiddo-wade cilladaysan, wuu dhaxli karaa xaaladdan. Gabdhaha waxay leeyihiin 2 koromosoomyada X. Haddii gabadhu leedahay 1 X kromosoom leh hiddo-wade cilladaysan, X-koromosoomka kale ayaa laga yaabaa inuu leeyahay hiddo-wadaha shaqada si uu ugu kabo. Gabadhu waa inay ka dhaxashaa hiddo-wade X cilladaysan waalid kasta si ay cudurka ugu dhacdo.

CGD wuxuu sababi karaa noocyo badan oo infekshannada maqaarka ah oo ay adag tahay in la daweeyo, oo ay ka mid yihiin:

• Nabarro ama nabarro wejiga ka soo baxa (impetigo)
• Canbaar
• Kobaca ay ka buuxsanto malax (barar)
• Kuuskuus finanka ka buuxsamay oo maqaarka ku yaal (karkaraya)

CGD sidoo kale wuxuu sababi karaa:

• Shuban joogto ah
• Qanjirrada qanjidhada oo barara qoorta
• Infekshannada sambabaha, sida oof wareenka ama sambabka oo barara

Bixiyaha xanaanada caafimaadka ayaa sameyn doona baaritaan waxaana laga yaabaa inuu ogaado:

• Bararka beerka
• Spleen barar
• Qanjidhada oo barara

Waxaa jiri kara calaamado infekshinka lafaha, oo saameyn ku yeelan kara lafo badan.

Tijaabooyinka la qaadi karo waxaa ka mid ah:

• Baadhitaanka lafaha
• Raajo xabadka ah
• Tirinta dhiigga oo dhameystiran (CBC)
• Qulqulka tijaabooyinka cytometry si ay uga caawiyaan xaqiijinta cudurka
• Tijaabada hida sidaha si loo xaqiijiyo cudurka
• Tijaabinta shaqada unugyada dhiigga cad
• Cad ka-qaadista unugyada

Antibiyootikada ayaa loo isticmaalaa in lagu daaweeyo cudurka, sidoo kale waxaa loo isticmaali karaa in looga hortago infekshannada. Daawada loo yaqaan 'interferon-gamma' ayaa sidoo kale kaa caawin karta yareynta tirada infekshannada daran. Qalliin ayaa loo baahan karaa si loo daaweeyo qaar ka mid ah maqaarka.

Daawada kaliya ee CGD waa dhuuxa lafta ama xubinta taranka unugyada.

Daaweynta antibiyootigga ee muddada-dheer ayaa laga yaabaa inay gacan ka geysato yareynta infekshannada, laakiin geerida hore waxay ka dhici kartaa infekshannada sambabaha ee soo noqnoqda

CGD waxay sababi kartaa dhibaatooyinkan:

• Burburka lafaha iyo infekshannada
• Infekshannada joogtada ah ee sanka
• Oof-wareenka oo soo noqnoqonaya oo ay adag tahay in la daweeyo
• Burburka sambabka
• Dhaawaca maqaarka
• Qanjidhada bararsan ee barara, siiba badanaa, ama sameeya murqo u baahan qalliin si looga soo saaro

Haddii adiga ama ilmahaagu aad xaaladdan leedahay oo aad ka shakisan tahay oof-wareen ama infekshan kale, wac dhakhtarkaaga isla markiiba.

U sheeg daryeel bixiyahaaga haddii sanbabka, maqaarka, ama infekshan kale uusan ka jawaabin daaweynta.

La-talinta hidaha ayaa lagula taliyaa haddii aad qorsheyneyso inaad carruur dhasho oo aad taariikh qoys ku leedahay cudurkan. Horumarka baaritaanka hidda-socodka iyo kordhinta isticmaalka chorionic villus sampling (tijaabo laga yaabo in lagu sameeyo inta lagu jiro haweeneyda toddobaadkeeda 10aad illaa 12aad ee uurka) ayaa ka dhigtay ogaanshaha hore ee CGD suurtagal. Si kastaba ha noqotee, dhaqamadaasi wali ma baahsana ama si buuxda looma aqbalo.

CGD; Cudurka 'granulomatosis' ee carruurnimada; Cudurka 'granulomatous' ee carruurnimada; Granulomatosis-ka dhiiga ku sii kordha; Yaraanta Phagocyte - cudurka daba-dheer ee granulomatous

Glogauer M. Cilladaha fagocyte function. Gudaha: Goldman L, Schafer AI, eds. Daawada Goldman-Cecil. 25aad. Philadelphia, PA: Elsevier Saunders; 2016: cutubka 169.

Holland SM, Uzel G. Phagocyte yaraanta. Gudaha: Rich RR, Fleisher TA, Shearer WT, Schroeder JR. HW, Frew AJ, Weyand CM, eds. Immunology Clinical: Mabaadi'da iyo Tababarka. 5aad. Philadelphia, PA: Elsevier; 2019: cutubka 22.