Polyarteritis nodosa

Polyarteritis nodosa waa cudur halisa xididada dhiiga. Halbowlayaasha yaryar iyo kuwa dhexdhexaadka ah ayaa barara oo dhaawacma.

Halbowlayaasha waa xididdada dhiigga ee u qaada dhiigga oksijiinta leh xubnaha iyo unugyada. Sababta cudurka loo yaqaan 'polyarteritis nodosa' lama garanayo. Xaaladdu waxay dhacdaa marka unugyada difaaca qaarkood ay weeraraan xididdada dhiigga qaba. Unugyada ay quudiyaan xididdada dhiban ma helaan oksijiinta iyo nafaqada ay u baahan yihiin. Burburku wuxuu dhacaa natiijada.

Dad aad uga tiro badan ayaa ku dhaca cudurkan.

Dadka qaba hepatitis B firfircoon ama cagaarshowga C ayaa laga yaabaa inay ku dhacaan cudurkan

Calaamadaha waxaa sababa dhaawac soo gaara xubnaha jirka. Maqaarka, kala-goysyada, muruqyada, mareenka caloosha iyo mindhicirka, wadnaha, kilyaha, iyo habdhiska dareenka inta badan waa la saameeyaa.

Calaamadaha waxaa ka mid ah:

• Calool xanuun
• Cunto yaraanta
• Daal
• Qandho
• Wadajir xanuun
• Murqo xanuun
• Miisaan lumis aan ula kac ahayn
• Tabar darrida

Haddii neerfaha waxyeelleeyaan, waxaad yeelan kartaa kabuubyo, xanuun, gubasho, iyo daciifnimo. Waxyeellada nidaamka neerfaha waxay sababi kartaa istaroog ama qalal.

Ma jiro baaritaano shaybaar oo gaar ah oo la heli karo si loo ogaado polyarteritis nodosa. Waxaa jira tiro cilado ah oo leh astaamo la mid ah polyarthritis nodosa. Kuwaas waxaa loo yaqaan "mimics".

Waxaad mari doontaa baaritaanka jirka oo dhameystiran.

Tijaabooyinka shaybaarka ee kaa caawin kara sameynta cudurka iyo ka hortagga jilitaanka waxaa ka mid ah:

• Tirinta dhiigga oo dhammeystiran (CBC) oo leh kala duwanaansho, creatinine, baaritaannada cagaarshowga B iyo C, iyo baaritaanka kaadida
• Qiyaasta Erythrocyte sedimentation (ESR) ama protein C-reactive (CRP)
• Serum protein electrophoresis, cryoglobulins
• Heerarka dhammaystirka serum
• Arteriogram
• Cad ka-qaadista unugyada
• Baadhitaano kale oo dhiig ah ayaa la samayn doonaa si meesha looga saaro xaaladaha la midka ah, sida nidaamka lupus erythematosus (ANA) ama granulomatosis oo leh polyangiitis (ANCA)
• Baaritaanka HIV
• Cryoglobulins
• Unugyada difaaca jirka ee 'phospholipid'
• Dhaqamada dhiigga

Daaweyntu waxay ku lug leedahay daawooyinka lagu xakameynayo caabuqa iyo habka difaaca jirka. Kuwaas waxaa ka mid noqon kara steroids, sida prednisone. Daawooyinka la midka ah, sida azathioprine, methotrexate ama mycophenolate oo u oggolaanaya yaraynta qiyaasta daawada steroids inta badan sidoo kale waa la isticmaalaa. Cyclophosphamide waxaa loo isticmaalaa xaaladaha daran.

Cudurka 'polyarteritis nodosa' ee la xiriira cagaarshowga, daaweynta waxaa ku jiri kara plasmapheresis iyo dawooyinka fayraska looga hortago.

Daawooyinka hadda lagu daaweeyo steroids iyo dawooyinka kale ee xakameynaya nidaamka difaaca jirka (sida azathioprine ama cyclophosphamide) waxay hagaajin karaan astaamaha iyo fursadda noolaanshaha muddada-dheer.

Dhibaatooyinka ugu halista badan badanaa waxay ku lug leeyihiin kelyaha iyo marinka caloosha.

Daaweyn la'aan, aragtida ayaa liidata.

Dhibaatooyinka waxaa ka mid noqon kara:

• Wadne qabad
• Necrosis xiidmaha iyo daloolin
• Kelyaha oo hawl gab
• Faalig

Wac daryeel caafimaad bixiyahaaga haddii aad isku aragto astaamaha cilladan. Cilad-baarista hore iyo daaweynta waxay hagaajin kartaa fursadda natiijada wanaagsan.

Ma jiro ka hortag la yaqaan. Si kastaba ha noqotee, daaweynta hore waxay ka hortagi kartaa waxyeelada iyo astaamaha.

Periarteritis nodosa; DHAQANKA; Nidaamka necrotizing vasculitis

• Cudurka yar-yar ee 'polyyarteritis'
• Nidaamka wareegga dhiigga

Luqmani R, Awisat A. Polyarteritis nodosa iyo cilado la xiriira. Gudaha: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Buugga Cilmiga Rheumatology. 11aad. Philadelphia, PA: Elsevier; 2021: cutubka 95.

Puéchal X, Pagnoux C, Baron G, iyo al. Ku darista azathioprine si loo yareeyo 'glucocorticoids' oo loo yaqaan 'eosinophilic granulomatosis' oo leh polyangiitis (Churg-Strauss), polyyangiitis microscopic, ama polyarteritis nodosa iyada oo aan la helin sababaha saadaalinta liidata: tijaabo la kala sooco, la xakameeyo. Arthritis Rheumatol. 2017; 69 (11): 2175-2186. PMID: 28678392 www.pubmed.ncbi.nlm.nih.gov/28678392/.

Shanmugam VK. Vasculitis iyo arteriopathies kale oo aan caadi ahayn. Gudaha: Sidawy AN, Perler BA, eds. Qalliinka Rutherford ee Vascular and Endovascular Therapy. 9aad. Philadelphia, PA: Elsevier; 2019: cutubka 137.

Dhagax JH. Vasculitides-ka nidaamka. Gudaha: Goldman L, Schafer AI, eds. Daawada Goldman-Cecil. 26aad. Philadelphia, PA: Elsevier; 2020: cutubka 254.