Simeprevir

Qanacsan

• Kahor qaadashada simeprevir,
• Simeprevir wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybaha digniinta muhiimka ah iyo taxaddarrada gaarka ah, wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

Simeprevir hadda lagama heli karo Mareykanka. Haddii aad hadda qaadanayso simeprevir, waa inaad wacdaa dhakhtarkaaga si aad ugala hadasho u beddelashada daaweyn kale.

Waxaa laga yaabaa inaad horeyba u qaadsiisay cagaarshowga B (fayras ku dhaca beerka oo sababi kara waxyeelo daran oo beerka ah) laakiin aadan lahayn wax calaamado ah oo cudurka ah. Xaaladdan oo kale, qaadashada simeprevir waxay kordhin kartaa halista in infekshinkaagu uu noqdo mid aad u daran ama nafta halis geliya waxaadna yeelan doontaa calaamado. U sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabtid infekshinka fayraska cagaarshow B. Dhakhtarkaagu wuxuu amri doonaa baaritaanka dhiigga si loo arko haddii aad qabto ama aad waligaa qabto cudurka cagaarshowga B. Dhakhtarkaaga ayaa waliba kaa ilaalin doona calaamadaha cudurka cagaarshowga B inta lagu jiro iyo dhowr bilood daaweyntaada ka dib. Haddii loo baahdo, dhakhtarkaagu wuxuu ku siin karaa daawo aad ku daaweyso cudurkaan kahor iyo inta lagugu daaweynayo simeprevir. Haddii aad isku aragto mid ka mid ah astaamaha soo socda inta lagu jiro ama ka dib daaweyntaada, isla markiiba wac dhakhtarkaaga: daal fara badan, maqaarka ama indhaha oo jaale noqda, cunto xumo, lallabbo ama matag, saxaro cirro leh, calool xanuun, ama kaadi madow.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu dalban karaa baaritaano gaar ah kahor, inta lagu jiro, iyo kadib daaweyntaada si loo hubiyo jawaabta jirkaaga ee simeprevir.

Takhtarkaaga kala hadal halista (halyeeyada) qaadashada simeprevir.

Simeprevir waxaa loo isticmaalaa ribavirin (Copegus, Rebetol) iyo peginterferon alfa (Pegasys) si loo daaweeyo cagaarshowga C ee joogtada ah (infekshin joogto ah oo fayras ah oo waxyeeleeya beerka). Simeprevir wuxuu ku jiraa nooc daawooyin ah oo loo yaqaan 'protease inhibitors'. Waxay ku shaqeysaa iyadoo la yareeyo xaddiga fayraska cagaarshowga C (HCV) ee jirka ku jira. Simeprevir lagama yaabo inuu ka hortago faafitaanka cagaarshowga C dadka kale.

Simeprevir wuxuu u yimaadaa sidii kaabsul afka laga qaato. Badanaa waxaa lagu qaataa cuntada hal mar maalintii. Qaado simeprevir waqti isku mid ah maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado simeprevir sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Kaabsoosha wada liq; ha kala qaybin, calalin, ama burburin.

Waxaad ku qaadan doontaa simeprevir peginterferon alfa iyo ribavirin muddo 12 toddobaad ah. Markaa waad joojin doontaa qaadashada simeprevir waxaadna qaadan doontaa peginterferon iyo ribavirin 12 ama 36 toddobaad oo dheeri ah. Dhererka daaweyntaadu waxay kuxirantahay haddii aad horey uheshay daaweynta cagaarshowga C, sida aad ugajawaabtay daaweynta kahor, sida aad ugajawaabto daawooyinka, iyo inaad lakulmayso waxyeelo daran. Sii wad inaad qaadato simeprevir, peginterferon alfa, iyo ribavirin ilaa iyo inta ay kuu qorayaan dhakhtarkaagu. Ha u joojin qaadashada mid ka mid ah daawooyinkan adiga oo aan la hadlin dhakhtarkaaga xitaa haddii aad caafimaad qabto.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada simeprevir,

• u sheeg dhakhtarkaaga iyo farmashiistaha haddii aad xasaasiyad ku leedahay simeprevir, dawooyinka sulfa, dawooyin kale, ama wax kasta oo ka kooban kaabsoosha simeprevir. Weydii farmashiistahaaga ama ka hubi macluumaadka bukaanka soo saaraha liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: dawooyinka qaarkood ee antifungal dawooyinka sida fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), ama voriconazole (Vfend); kaalsiyamka xanibaada sida amlodipine (Norvasc), diltiazem (Cardizem, Dilacor XR, Tiazac), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), ama verapamil (Calan, Verelan, kuwa kale) dawooyinka qaarkood ee loogu talagalay kolestaroolka sare sida atorvastatin (Lipitor, in Caduet), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), ama simvastatin (Flolipid, Zocor, in Vytorin); cisapride (Propulsid) (aan laga heli karin Mareykanka); clarithromycin (Biaxin, gudaha Prevpac); daawooyinka ay kujiraan cobicistat (Stribild); erythromycin, (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), saquinavir (Invirase), ama tipranavir (Aptivus); daawooyinka qaarkood ee garaaca wadnaha aan caadiga ahayn sida amiodarone (Nexterone, Pacerone), sibibramram (Norpace), flecainide (Tambocor), mexiletine, propafenone (Rythmol SR), ama quinidine (Nuedexta); cyclosporine (Gengraf, Neoral, Sandimmune); dexamethasone; digoxin (Lanoxin); ledipasvir (Harvoni); midazolam oo afka laga qaato; rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, gudaha Rifamate, Rifater); rifapentine (Priftin); dawooyinka qaarkood ee suuxdinta sida carbamazepine (Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, ama phenytoin (Dilantin, Phenytek); sildenafil (kaliya magaca Revatio ee loo isticmaalo cudurka sanbabada); sirolimus (Rapamune); tacrolimus (Prograf); tadalafil (kaliya magaca Adcirca ee loo isticmaalo cudurka sanbabada); telithromycin (Ketek); triazolam (Halcion) oo afka laga qaato; vardenafil (Levitra, Staxyn), ama warfarin (Coumadin, Jantoven). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara simeprevir, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• u sheeg dhakhtarkaaga waxa ka soo baxa dhirta aad qaadanaysid, gaar ahaan yamaarugga caanaha ama johannesört St. Waa inaadan qaadan yamaarug caano ah ama johannesört St. John inta lagu guda jiro daaweyntaada simeprevir.
• u sheeg dhakhtarkaaga haddii aad ku bedeshay beerka, haddii aad qaadanaysid sawir qaadasho, haddii aad ka soo jeedo Bariga Aasiya, iyo haddii aad qabto ama aad waligaa qabto nooc beer xanuun ah oo aan ahayn cagaarshowga C.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad uur yeelan karto. Haddii aad tahay lab, u sheeg dhakhtarkaaga haddii lammaanahaagu uur leeyahay, qorsheynayo inuu uur qaado, ama suuragal tahay inuu uur qaado. Simeprevir waa in lagu qaataa ribavirin kaas oo dhaawici kara ilmaha caloosha ku jira. Waa inaad isticmaashaa laba hab oo xakameynta dhalmada ah si looga hortago uur qaadista adiga ama lammaanahaaga inta lagu guda jiro daaweynta daawooyinkan iyo 6 bilood daaweyntaada ka dib. Kala hadal dhakhtarkaaga hababka ay tahay inaad isticmaasho; Uur ka hortagga uurka (kaniiniyada ka hortagga uurka, balastarro, implants, giraan, ama irbado) si fiican ugama shaqeyn karaan haweenka qaadanaya daawooyinkan. Adiga ama lammaanahaaga waa in lagaa baaro uurka daaweynta kahor, bil kasta inta daaweyntaada socoto, iyo 6 bilood daaweyntaada kadib. Haddii adiga ama lammaanahaagu aad uur yeelataan inta aad qaadanaysaan daawooyinkan, isla markiiba wac dhakhtarkaaga.
• u sheeg dhakhtarkaaga haddii aad naas nuujinayso.
• qorsheyso inaad iska ilaaliso soo-gaadhista qorraxda oo aan loo baahnayn ama daba dheeraatay iyo inaad xidhato dhar ilaaliya, muraayadaha indhaha, koofiyad, iyo shaashadda qorraxda inta lagu daweynayo simeprevir. Sidoo kale iska ilaali isticmaalka sariiraha maqaarka, qorraxda, ama noocyada kale ee daaweynta iftiinka inta lagu jiro daaweyntaada. Simeprevir ayaa laga yaabaa inuu maqaarkaaga u nugleeyo iftiinka qoraxda. Wac dhakhtarkaaga isla markiiba haddii aad isku aragto qorax daran ama gubasho, casaan, barar, finanka maqaarkaaga, ama indhaha casaanka ama bararsan.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Qaado qiyaasta la seegay ee cuntada isla marka aad xusuusato. Si kastaba ha noqotee, haddii ay ka yar tahay 12 saacadood kahor waqtiga loo qorsheeyay qiyaastaada xigta, ka bood qiyaasta la seegay oo sii wad jadwalkaaga qaadashada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Simeprevir wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• cuncun
• lallabbo
• murqo xanuun

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybaha digniinta muhiimka ah iyo taxaddarrada gaarka ah, wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

• neefsashada oo adkaata
• finan
• nabarrada afka ama nabarrada
• indhaha casaanka ama bararsan ("indhaha casaanka")

Simeprevir wuxuu sababi karaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog iftiinka, kuleylka badan iyo qoyaanka (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Olysio^®