Dasabuvir, Ombitasvir, Paritaprevir, iyo Ritonavir

Qanacsan

• Kahor qaadashada dasabuvir, ombitasvir, paritaprevir, iyo ritonavir,
• Dasabuvir, ombitasvir, paritaprevir, iyo ritonavir waxay sababi karaan waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga

Dasabuvir, ombitasvir, paritaprevir, iyo ritonavir hada lagama heli karo Mareykanka.

Waxaa laga yaabaa inaad horeyba u qaadsiisay cagaarshowga B (fayras ku dhaca beerka oo sababi kara waxyeelo daran oo beerka ah) laakiin aadan lahayn wax calaamado ah oo cudurka ah. Xaaladdan oo kale, qaadashada iskudhafka dasabuvir, ombitasvir, paritaprevir, iyo ritonavir waxay kordhin kartaa halista in infekshankaagu noqdo mid aad u daran ama naf-gooya oo aad yeelato calaamado U sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabtid infekshinka fayraska hepatitis B. Dhakhtarkaagu wuxuu amri doonaa baaritaanka dhiigga si loo arko haddii aad qabto ama aad waligaa qabtid cudurka cagaarshowga B. Dhakhtarkaaga ayaa waliba kaa ilaalin doona calaamadaha cudurka cagaarshowga B inta lagu jiro iyo dhowr bilood daaweyntaada ka dib. Haddii loo baahdo, dhakhtarkaagu wuxuu ku siin karaa daawo aad ku daaweyso infekshankan kahor iyo inta lagu guda jiro daaweyntaada oo la isku daro dasabuvir, ombitasvir, paritaprevir, iyo ritonavir. Haddii aad isku aragto mid ka mid ah astaamaha soo socda inta lagu jiro ama ka dib daaweyntaada, isla markiiba wac dhakhtarkaaga: daal fara badan, maqaarka ama indhaha oo jaale noqda, cunto xumo, lallabbo ama matag, saxaro cirro leh, calool xanuun, ama kaadi madow.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu dalban karaa baaritaano gaar ah kahor, inta lagu jiro, iyo kadib daaweyntaada si loo hubiyo jawaabta jirkaaga ee isku dhafka dasabuvir, ombitasvir, paritaprevir, iyo ritonavir.

Kala hadal dhakhtarkaaga khatarta (yada) ah qaadashada isku darka dasabuvir, ombitasvir, paritaprevir, iyo ritonavir.

Dasabuvir, ombitasvir, paritaprevir, iyo ritonavir waxaa loo isticmaalaa kaligood ama lagu daraa ribavirin (Copegus, Rebetol, Ribasphere) si loogu daaweeyo infekshinka cagaarshowga C (ee muddada dheer) (bararka beerka ee uu keeno virus). Dasabuvir waa non-nucleoside NS5B polymerase inhibitor. Waxay ku shaqeysaa iyadoo la dhimayo qaddarka HCV ee jirka ku jira. Ombitasvir waa fayraska cagaarshowga C (HCV) NS5A. Waxay ku shaqeysaa joojinta fayraska keena cagaarshowga C inuu ku faafo jirka. Paritaprevir waa kahortaga difaaca jirka. Waxay ku shaqeysaa iyadoo la dhimayo qaddarka HCV ee jirka ku jira. Ritonavir waa kahortaga difaaca jirka. Waxay ka caawineysaa kordhinta xaddiga daawada 'paritaprevir' ee jirka si daawadu u yeelato saameyn weyn.

Isku darka dasabuvir, ombitasvir, paritaprevir, iyo ritonavir ayaa imanaya sidii loo sii daayay (muddo dheer) kiniinno lagu qaato afka. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado dasabuvir, ombitasvir, paritaprevir, iyo ritonavir isla waqti isku mid ah maalin kasta. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Kiniiniyada sii-deynta-dheer waxay la timid xirmo 28 maalmood oo dawo ah. Xirmo kasta oo qaadasho maalinle ah waxay ka kooban tahay 3 kiniin oo mid walba ay ku jiraan isku-dar ah dasabuvir, ombitasvir, paritaprevir, iyo ritonavir. Qaado dasabuvir, ombitasvir, paritaprevir, iyo ritonavir (3 kiniin) subax kasta cunno. Raac tilmaamaha ku jira xirmo kasta oo qiyaas qaadasho ah maalin walba oo ku saabsan sida looga saaro kiniinnada.

Kiniiniyada sii-daynta sii wada liq; ha kala qaybin, calalin, ama burburin.

Sii wad inaad qaadato dasabuvir, ombitasvir, paritaprevir, iyo ritonavir xitaa haddii aad fiicantahay. Dhererka daaweyntaada (12 illaa 24 toddobaad) waxay kuxirantahay xaaladaada, sida ugu wanaagsan ee aad uga jawaabeyso daawada, iyo inaad la kulanto waxyeelo daran. Ha joojin qaadashada dasabuvir, ombitasvir, paritaprevir, iyo ritonavir adigoon dhaqtarkaaga lahadlin.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada dasabuvir, ombitasvir, paritaprevir, iyo ritonavir,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay dasabuvir, ombitasvir, paritaprevir, iyo ritonavir, dawooyin kale oo kasta, ama mid ka mid ah maaddooyinka ku jira dasabuvir, ombitasvir, paritaprevir, iyo ritonavir kiniinka la sii-daayay. Haddii aad ku yeelatay falcelin halis ah ama nafta halis gelinaysa ritonavir (firiiric, finka ama xoqidda maqaarka), dhakhtarkaaga ayaa u badan inuu kuu sheego inaadan qaadan dasabuvir, ombitasvir, paritaprevir, iyo ritonavir. Weydii farmashiistahaaga ama ka hubi Hagaha Daawada liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanaysid alfuzosin (Uroxatral); apalutamide (Erleada); atorvastatin (Lipitor, Caduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid; mar dambe lagama heli karo Mareykanka); dronedarone (Multaq); efavirenz (Sustiva, oo ku taal Atripla); daawooyinka ergot-ku jira sida dihydroergotamine mesylate (DHEE 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), iyo methylergonovine (Methergine); ka hortagga uurka ee loo yaqaan 'ethinyl estradiol' sida qaar ('kaniiniyada xakamaynta dhalmada'), balastarro, faraantiinka xubinta taranka hoormoonka, iyo waxyaabaha kale ee ethinyl estradiol; everolimus (Afinitor, Zortress); gemfibrozil (Lopid); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (afka); phenytoin (Dilantin, Phenytek); phenobarbital; pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, gudaha Rifamate, Rifater); sildenafil (Revatio) oo loogu talagalay daaweynta dhiig karka sambabaha; simvastatin (Flolipid, Zocor, oo ku yaal Vytorin); sirolimus (Rapamune); Johannesört wort; tacrolimus (Astagraf XL, Envarsus XR, Prograf); ama triazolam (Halcion). Sidoo kale, u sheeg dhakhtarkaaga haddii aad qaadanayso colchicine (Colcrys, Mitigare) oo aad qabto cudur beerka ama kelyo ah. Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan dasabuvir, ombitasvir, paritaprevir, iyo ritonavir haddii aad qaadanaysid mid ama kabadan dawooyinkan.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: acetaminophen iyo hydrocodone (Anexsia, Zyfrel); alprazolam (Xanax); xannibaadaha loo yaqaan 'angiotensin receptor blockers' (ARBs) sida candesartan (Atacand, in Atacand HCT), losartan (Cozaar, in Hyzaar), ama valsartan (Diovan, Diovan HCT, Exforge); daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida warfarin (Coumadin, Jantoven); buprenorphine iyo naloxone (Suboxone, Zubsolv); kaalsiyamka xayirayaasha sida amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, kuwa kale), nifedipine (Adalat, Procardia), ama verapamil (Calan, Verelan, kuwa kale); carisoprodol (Soma); cyclobenzaprine (Amrix); cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); elagolix (Orilissa); umerafenib (Braftovi); fostamatinib (Tavalisse); fluticasone (Flonase, Flovent, Advair); furosemide (Lasix); ibrutinib (Imbruvica); ivosidenib (Tibsovo); ketoconazole; daawooyinka loogu talagalay garaaca wadnaha aan caadiga ahayn sida amiodarone (Nexterone, Pacerone), bepridil (oo aan hadda laga helin Mareykanka), sibibramram (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), ama quinidine (Nuedexta); metformin (Glucophage, Riomet, kuwa kale); omeprazole (Prilosec); pravastatin (Pravachol); quetiapine (Seroquel); rilpivirine (Edurant; oo dhammeystiran, Odefsey); ritonavir (Norvir, oo ku taal Kaletra) oo loo isticmaalay iskudhafka kahortagayaasha kale ee HIV sida atazanavir (Reyataz), darunavir (Prezista), iyo lopinavir (Kaletra); rosuvastatin (Crestor); salmeterol (Serevent, Advair); iyo voriconazole (Vfend). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• u sheeg dhakhtarkaaga haddii aad qabtid nooc cudur beer ah oo aan ahayn cagaarshowga C. Takhtarkaaga ayaa kuu sheegi kara inaadan qaadan dasabuvir, ombitasvir, paritaprevir, iyo ritonavir.
• u sheeg dhakhtarkaaga haddii aad waligaa ku tallaashay beerka, sonkorow, ama fayraska difaaca jirka ee dadka (HIV).
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelato inta aad qaadanaysid dasabuvir, ombitasvir, paritaprevir, iyo ritonavir, wac dhakhtarkaaga.
• waa inaad ogaataa in dasabuvir, ombitasvir, paritaprevir, iyo ritonavir ay yareyn karaan waxtarka ka hortagga uurka ee hormoonada (kaniiniyada xakameynta dhalmada, balastarrada, faraantiyo, maqaar-galaha, irbado, iyo aaladda intrauterine). Isticmaal nooc kale oo ah xakameynta dhalmada inta aad qaadaneyso dasabuvir, ombitasvir, paritaprevir, iyo ritonavir iyo 2 toddobaad kadib qiyaastaada ugu dambeysa. Kala hadal dhakhtarkaaga noocyada ka hortagga uurka ee kuu shaqeyn doona inta lagu jiro iyo kadib daaweyntaada dasabuvir, ombitasvir, paritaprevir, iyo ritonavir.
• Xusuusnow inaadan khamri ku cabin 4 saacadood gudahood markaad qaadatay dasabuvir, ombitasvir, paritaprevir, iyo ritonavir kiniiniyada la sii daayay.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Waa muhiim inaadan seegin ama ka boodin wax qiyaas ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Dasabuvir, ombitasvir, paritaprevir, iyo ritonavir waxay sababi karaan waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• dhibaato xagga hurdada ama hurdada ah
• qufac
• xanaaq
• madax xanuun
• shuban
• murqo xanuun

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga

• finan
• casaan maqaarka
• cuncun
• finan
• daal ama tamar la’aan
• daciifnimo
• jahwareer

Dasabuvir, ombitasvir, paritaprevir, iyo ritonavir waxay sababi karaan waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hayso kartoonka ay soo gashay, si adag u xir, oo ka fog carruurta. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha). Ha ka saarin kiniiniyada xirmada qiyaasta maalinlaha ah ee ay soo saarto soo saaraha ilaa aad diyaar u tahay inaad qaadato.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Viekira XR^® (sida shey isku dhafan oo ka kooban Dasabuvir, Ombitasvir, Paritaprevir, iyo Ritonavir)