IgA nephropathy

Cudurka 'IgA nephropathy' waa cillad kelyo ah oo unugyada unugyada kilyaha loo yaqaan 'IgA' ay ku soo baxaan. Nefropathy waa dhaawac, cudur, ama dhibaatooyin kale oo kelyaha ku dhaca.

IgA nephropathy waxaa sidoo kale loo yaqaannaa cudurka Berger.

IgA waa borotiin, loo yaqaanno antibody, oo jirka ka caawisa la dagaallanka infekshinnada. IgA nephropathy wuxuu dhacaa marka in badan oo borotiinkan ah lagu shubo kilyaha. IgA wuxuu ku dhismaa gudaha xididdada dhiigga ee yaryar ee kilyaha. Qaabdhismeedyada kilyaha ee loo yaqaan glomeruli way bararaan oo dhaawacmaan.

Cilladdu waxay u muuqan kartaa si lama filaan ah (daran), ama si tartiib tartiib ah ayey uga sii xumaan kartaa sanado badan (chronic glomerulonephritis).

Waxyaabaha halista keena waxaa ka mid ah:

• Taariikh shaqsiyadeed ama qoys oo ah IgA nephropathy ama Henoch-Schönlein purpura, waa nooc ka mid ah vaskulitis-ka oo ku dhaca qaybo badan oo jirka ah.
• Cadaan ama Aasiyaan asal ahaan

Cudurka 'IgA nephropathy' wuxuu ku dhici karaa dadka da 'kasta leh, laakiin badanaa waxay ku dhacdaa ragga ragga ah ee ku jira da' yarta illaa dhammaadka 30s.

Malaha calaamado malahan sanado badan.

Markay jiraan astaamo, waxaa ka mid noqon kara:

• Kaadi dhiig leh oo bilaabma inta lagu jiro ama waxyar kadib infakshanka neef-mareenka
• Qaybaha soo noqnoqda ee kaadi madow ama dhiig leh
• Barar gacmaha iyo cagaha
• Calaamadaha cudurka kelyaha ee joogtada ah

Cudurka 'IgA nephropathy' waxaa badanaa la ogaadaa marka qof aan lahayn calaamado kale oo dhibaatooyinka kelyaha ah uu leeyahay hal ama in kabadan oo ah dhacdooyin kaadi madow ama dhiig leh.

Ma jiraan wax isbeddello gaar ah oo la arko inta lagu jiro baaritaanka jirka. Mararka qaarkood, cadaadiska dhiigga ayaa laga yaabaa inuu sarreeyo ama waxaa jiri kara barar jidhka ah.

Tijaabooyinka waxaa ka mid ah:

• Tijaabada dhiigga urea nitrogen (BUN) si loo cabbiro shaqada kelyaha
• Baadhitaanka dhiigga ee Creatinine si loo cabbiro shaqada kelyaha
• Soo-saarista kilyaha si loo xaqiijiyo cudurka
• Kaadida
• Kaadida immunoelectrophoresis

Ujeedada daaweyntu waa in la yareeyo astaamaha lagana hortago ama dib loo dhigo hawl gabka kelyaha ee joogtada ah.

Daaweynta waxaa ka mid noqon kara:

• Angiotensin-converting enzyme (ACE) inhibitors iyo angiotensin receptor blockers (ARBs) si loo xakameeyo dhiig karka iyo bararka (edema)
• Corticosteroids, daawooyin kale oo xakameynaya nidaamka difaaca jirka
• Saliida kaluunka
• Daawooyinka si loo yareeyo kolestaroolka

Cusbada iyo dareerayaasha waa la xadidi karaa si loo xakameeyo bararka. Cunto-borotiin dhexdhexaad-dhexdhexaad ah ayaa lagula talin karaa xaaladaha qaarkood.

Ugu dambeyntiina, dad badan waa in laga daaweeyaa cudurka kelyaha ee joogtada ah waxayna u baahan karaan sifeyn.

IgA nephropathy si tartiib tartiib ah ayuu uga sii darayaa. Xaalado badan, kama sii xumaanayso haba yaraatee. Xaaladdaadu waxay u badan tahay inay ka sii darto haddii aad leedahay:

• Dhiig kar
• Qadar badan oo borotiin ah oo ku jira kaadida
• Kordhinta BUN ama heerarka creatinine

Wac daryeel caafimaad bixiyahaaga haddii aad leedahay kaadi dhiig leh ama haddii aad soo saareyso kaadi ka yar sidii caadiga ahayd.

Nefropathy - IgA; Cudurka Berger

• Anatomy kilyaha

Feehally J, Floege J. Immunoglobulin A nephropathy iyo IgA vasculitis (Henoch-Schönlein purpura). Gudaha: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Neefroloji Caafimaad oo dhameystiran. 6aad ed. Philadelphia, PA: Elsevier; 2019: cutubka 23.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ. Cudurka glomerular ee aasaasiga ah. Gudaha: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner iyo Raktarka kilyaha. 11aad. Philadelphia, PA: Elsevier; 2020: cutubka 31.