Cudurka leukoencephalopathy ee horumarka badan leh

Cudurka 'Lukoencephalopathy' ee hormarka badan leh (PML) waa infekshan dhif ah oo waxyeeleeya maadada (myelin) oo daboosha oo ilaalisa neerfaha arrimaha cad ee maskaxda.

Fayraska John Cunningham, ama JC virus (JCV) wuxuu sababa PML. Fayraska JC waxaa sidoo kale loo yaqaan bini-aadanka polyomavirus-ka 2. Marka ay gaaraan da'da 10, dadka badankood wuxuu ku dhacay viruskan wallow uusan waligiis calaamado keenin. Laakiin dadka nidaamka difaaca jirka daciifka ahi waxay halis ugu jiraan inuu ku dhaco PML. Waxyaabaha keena difaaca jirka oo daciifa waxaa ka mid ah:

• HIV / AIDS (sababta ugu yar ee PML hadda sababta oo ah maaraynta wanaagsan ee HIV / AIDS).
• Daawooyinka qaarkood ee xakameynaya habka difaaca jirka ee loo yaqaan monoclonal antibodies. Daawooyinka noocan oo kale ah ayaa loo isticmaali karaa si looga hortago diidmada xubinta xubnaha ama lagu daaweeyo cudurka 'sclerosis', 'rheumatoid arthritis' iyo cuduro kale oo iswada, iyo xaaladaha la xiriira.
• Kansarrada, sida leukemia iyo Hodgkin lymphoma.

Calaamadaha waxaa ka mid noqon kara mid ka mid ah kuwan soo socda:

• Luminta isuduwidda, isku-buuqsanaanta
• Lumida awooda luuqada (aphasia)
• Xusuusta oo lunta
• Dhibaatooyinka aragga
• Tabar darrida lugaha iyo gacmaha oo ka sii daraya
• Shakhsiyadda ayaa is beddelay

Bixiyaha xanaanada caafimaadka ayaa sameyn doona baaritaan jireed wuxuuna weydiin doonaa astaamaha.

Tijaabooyinka waxaa ka mid noqon kara:

• Qalitaanka maskaxda (xaaladaha dhifka ah)
• Tijaabada dareeraha maskaxda ee JCV
• CT iskaanka maskaxda
• Electroencephalogram (EEG)
• MRI maskaxda

Dadka qaba HIV / AIDS, daaweynta lagu xoojinayo habka difaaca jirka waxay u horseedi kartaa ka soo kabashada astaamaha PML. Ma jiraan daaweyn kale oo waxtar u noqotay PML.

PML waa xaalad nafta halis gelisa. Waxay kuxirantahay sida uu infekshanku u daran yahay, ilaa kala bar dadka laga helo PML waxay u dhintaan bilaha ugu horeeya. Kala hadal daryeel bixiyahaaga wixii ku saabsan go'aamada daryeelka.

PML; John Cunningham virus; JCV; Human polyomavirus 2; Fayraska JC

• Cawl iyo arrin cad oo maskaxda ah
• Leukoencephalopathy

Berger JR, Nath A. Cytomegalovirus, Epstein-Barr virus, iyo infekshannada viruska ee gaabiska ee nidaamka neerfaha. Gudaha: Goldman L, Schafer AI, eds. Daawada Goldman-Cecil. 26aad. Philadelphia, PA: Elsevier; 2020: baab 346.

Tan CS, Koralnik IJ. JC, BK, iyo polyomaviruses kale: horumarka leukoencephalopathy multifocal (PML). Gudaha: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, iyo Bennett Mabaadi'da iyo Ku Dhaqanka Cudurada faafa. 9aad. Philadelphia, PA: Elsevier; 2020: cutubka 144.