Daaweynta hormoonka ee kansarka qanjirka 'prostate'

Daaweynta hormoonka ee kansarka qanjirka 'prostate' wuxuu adeegsadaa qalliin ama daawooyin si loo yareeyo heerarka hormoonnada galmada lab ee jirka nin. Tani waxay caawineysaa inay gaabiso koritaanka kansarka qanjirka 'prostate'

Androgens waa hormoonnada galmada ragga. Testosterone waa nooc ka mid ah androgen. Inta badan testosterone waxaa sameeya xiniinyaha. Qanjirrada adrenal sidoo kale waxay soo saaraan qadar yar.

Androgens waxay sababaan unugyada kansarka qanjirka 'prostate' inay koraan. Daaweynta hormoonka ee kansarka qanjirka 'prostate' wuxuu hoos u dhigaa heerka saameynta androgens ee jirka. Waxay ku samayn kartaa sidan:

• Ka joojinta xiniinyaha sameynta androgens iyadoo la isticmaalayo qalliin ama daawooyin
• Joojinta ficil-celinta asrogens-ka jirka
• Jirka oo laga joojiyo sameynta androgens

Daaweynta hormoonka badanaa looma isticmaalin dadka qaba Stage I ama Stage II kansarka qanjirka 'prostate'.

Waxaa badanaa loo isticmaalaa:

• Kansarka horumarsan ee ku faafay meel ka baxsan qanjirka 'prostate'
• Kansarka ku guuldareystay inuu ka jawaabo qalliinka ama shucaaca
• Kansarka soo noqnoqday

Waxaa sidoo kale loo isticmaali karaa:

• Shucaaca ama qalliinka ka hor si loo yareeyo burooyinka
• Waxa weheliya daaweynta shucaaca ee kansarka oo ay u badan tahay inuu soo noqnoqdo

Daaweynta ugu caansan waa in la qaato daawooyin hoos u dhiga xaddiga androgens ee ay sameeyeen xiniinyaha. Waxaa loo yaqaan 'luteinizing hormone-releasing hormone (LH-RH) analogs (irbado) iyo anti-androgens (kiniinno afka ah). Daawooyinkani waxay hoos u dhigaan heerarka quudinta iyo qalliinka. Daaweynta noocan ah waxaa mararka qaarkood loo yaqaan "tuurista kiimikada."

Ragga qaata daaweynta quudinta quudinta iyo quudinta waa inay lahaadaan baaritaano dabagal ah dhakhtarka kuu qoraya daawooyinka:

• 3 illaa 6 bilood gudahood ka dib bilaabista daaweynta
• Ugu yaraan hal mar sanadkii, si loola socdo cadaadiska dhiigga loona sameeyo sokorta dhiigga (gulukoos) iyo baaritaanka kalastaroolka
• Si loo helo baaritaanka dhiigga PSA si loola socdo sida ugu wanaagsan ee ay daaweyntu u shaqeyneyso

Analogyada LH-RH waxaa loo bixiyaa sidii tallaal ama sidii qalab yar oo la geliyo maqaarka hoostiisa. Waxaa la siiyaa meel kasta laga bilaabo bishiiba mar illaa sanadkiiba hal mar. Daawooyinkaas waxaa ka mid ah:

• Leuprolide (Lupron, Eligard)
• Goserelin (Zoladex)
• Triptorelin (Trelstar)
• Histrelin (Vantas)

Daawo kale, degarelix (Firmagon), waa LH-RH antagonist. Waxay yareysaa heerarka androgen-ka si dhakhso leh waxayna leedahay waxyeellooyin yar. Waxaa loo adeegsadaa ragga qaba kansarka horumarsan.

Dhakhaatiirta qaarkood waxay ku talinayaan in la joojiyo oo dib loo bilaabo daaweynta (is-dhexgalka daaweynta). Habkani wuxuu umuuqdaa inuu gacan ka geysanayo yareynta waxyeelooyinka daaweynta ee hormoonka. Si kastaba ha noqotee, ma cadda haddii daaweyn goos goos ah ay u shaqeyso sidoo kale daaweyn joogto ah. Daraasadaha qaarkood waxay muujinayaan in daaweynta joogtada ah ay waxtar badan leedahay ama in daaweyn goos goos ah loo isticmaalo kaliya noocyada xulashada kansarka qanjirka 'prostate'

Qalliin looga saarayo xiniinyaha (castration) wuxuu joojiyaa soo-saarka inta badan androgens-ka jirka. Tani waxay sidoo kale yareysaa ama joojisaa kansarka qanjirka 'prostate' inuu koro. In kasta oo ay waxtar leeyihiin, ragga badankood ma doortaan xulashadan.

Daawooyinka qaarkood ee ku shaqeeya iyaga oo xayiraya saameynta androgen ku yeelato unugyada kansarka qanjirka 'prostate'. Waxaa loo yaqaan anti-androgens. Daawooyinkan waxaa loo qaataa kiniin ahaan. Waxaa badanaa la isticmaalaa marka daawooyinka si loo yareeyo heerarka androgen aysan sidoo kale u shaqeynin sidoo kale.

Anti-androgens waxaa ka mid ah:

• Flutamide (Eulexin)
• Enzalutamide (Xtandi)
• Abirateron (Zytiga)
• Bicalutamide (Casodex)
• Nilutamide (Nilandron)

Androgens waxaa lagu soo saari karaa meelaha kale ee jirka, sida qanjidhada adrenal. Qaar ka mid ah unugyada kansarka qanjirka 'prostate' sidoo kale waxay sameyn karaan androgens. Saddex daroogo ayaa ka caawiya joojinta jirka inuu sameeyo androgens ka unugyo aan ahayn xiniinyaha.

Laba daawo, ketoconazole (Nizoral) iyo aminoglutethimide (Cytradren), ayaa daweeya cuduro kale laakiin mararka qaar waxaa loo isticmaalaa in lagu daaweeyo kansarka qanjirka 'prostate'. Midka saddexaad, abiraterone (Zytiga) wuxuu daaweeyaa kansarka qanjirka 'prostate' ee ku faafay meelaha kale ee jirka.

Waqti ka dib, kansarka qanjirka 'prostate' wuxuu noqdaa mid u adkaysta daaweynta hoormoonka. Tani waxay ka dhigan tahay in kansarku u baahan yahay oo keliya heerar hoose oo androgen ah si uu u koro. Marka tani dhacdo, daawooyin dheeri ah ama daaweyn kale ayaa lagu dari karaa.

Androgens waxay saameyn ku leeyihiin jirka oo dhan. Marka, daaweynta hoos u dhigta hormoonnadaas waxay sababi karaan waxyeelo badan oo kala duwan. Muddada aad qaadaneysid dawooyinkaan, ayay u badan tahay inaad waxyeellooyin soo gaarto.

Waxaa ka mid ah:

• Dhibaato kacsiga iyo xiisaha galmada
• Xiniinyaha iyo guska oo yaraada
• Ololayaal kulul
• Lafaha daciifa ama jaban
• Muruqyada oo yar, daciifna ah
• Isbedelada dufanka dhiigga, sida kolestaroolka
• Isbedelada sonkorta dhiiga
• Miisaanka oo kordha
• Niyad jabka
• Daal
• Kobaca nudaha naaska, jilicsanaanta naaska

Daaweynta yaraanta androgen waxay kordhin kartaa halista cudurka macaanka iyo cudurada wadnaha.

Go'aan ka gaarista daaweynta hoormoonka kansarka qanjirka 'prostate' wuxuu noqon karaa go'aan adag oo xitaa adag. Nooca daaweyntu wuxuu ku xirnaan karaa:

• Khatarta aad u leedahay in kansarku kugu soo laabto
• Sida kansarkaagu u horumarsan yahay
• Inay daaweyntii kale shaqadii joojisay
• Haddii kansarku faafay

Inaad kala hadasho takhtarkaaga waxyaabaha ku saabsan xulashooyinkaaga iyo faa'iidooyinka iyo halista ay leedahay daaweyn kasta waxay kaa caawin kartaa inaad adiga go’aanka ugu fiican adiga gaarto.

Daaweynta yaraanta Androgen; Xayeysiis; Daaweynta xakamaynta Androgen; Isugeynta xannibaadda androgen; Orchiectomy - kansarka qanjirka 'prostate'; Kabka - kansarka qanjirka 'prostate'

• Jirka anatomy taranka

Websaydhka Bulshada Kansarka ee Maraykanka. Daaweynta hormoonka ee kansarka qanjirka 'prostate'. www.cancer.org/cancer/prostate-cancer/treating/hormone-therapy.html. La cusbooneysiiyay Diseembar 18, 2019. Waxaa la helay 24-kii Maarso, 2020.

Websaydhka Machadka Kansarka Qaranka. Daaweynta hormoonka ee kansarka qanjirka 'prostate'. www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet. La cusbooneysiiyay Febraayo 28, 2019. La helay Diseembar 17, 2019.

Websaydhka Machadka Kansarka Qaranka. Daaweynta kansarka qanjirka 'Prostate cancer' (PDQ) - nooca xirfad-yaqaan caafimaad. www.cancer.gov/types/prostate/hp/prostate-treatment-pdq. La cusbooneysiiyay Janaayo 29, 2020. Waxaa la helay 24-kii Maarso, 2020.

Shabakada Shabakada Shabakada Kansarka oo dhameystiran. Tilmaamaha tababarka caafimaadka ee NCCN ee kansarka (tilmaamaha NCCN): kansarka qanjirka 'prostate'. Nooca 1.2020. www.nccn.org/professionals/physician_gls/pdf/prostate.pdf. La cusbooneysiiyay Maarso 16, 2020. Waxaa la helay Maarso 24, 2020.

Eggener S. Daaweynta Hormonal ee kansarka qanjirka 'prostate'. Gudaha: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. Campbell-Walsh Urolojiga. 12aad ed. Philadelphia, PA: Elsevier; 2021: cutubka 161.

• Kansarka Prostate