Daaweynta hormoonka ee kansarka naasaha

Daaweynta hoormoonka ee lagu daaweeyo kansarka naasaha waxay u isticmaashaa daawooyin ama daaweyn heerar hoose ama xannibaya ficilka hormoonnada galmada dumarka (estrogen iyo progesterone) ee jirka dumarka. Tani waxay caawineysaa inay gaabiso koritaanka kansarrada badan ee naasaha.

Daaweynta hormoonka ayaa ka dhigaysa kansarka inay u dhowdahay inuu soo noqdo qalliinka kansarka naasaha ka dib. Waxa kale oo ay hoos u dhigtaa koritaanka kansarka naasaha ee ku faafay qaybaha kale ee jidhka.

Daaweynta hoormoonka ayaa sidoo kale loo isticmaali karaa si looga caawiyo kahortagga kansarka haweenka halista sare ugu jira kansarka naasaha.

Way ka duwan tahay daaweynta hoormoonka daaweynta calaamadaha menopause.

Hormoonnada estrogen iyo progesterone ayaa kansarka naasaha qaarkood ku kora. Waxaa loogu yeeraa kansarka naasaha ee u nugul hormoonka. Inta badan kansarka naasaha ayaa u nugul hormoonnada.

Estrogen iyo progesterone waxaa lagu soo saaraa ugxan sidaha iyo unugyada kale sida dufanka iyo maqaarka. Caadada ka dib, ugxan sidayaashu waxay joojiyaan soosaarka hormoonadan. Laakiin jidhku wuxuu sii wadaa inuu sameeyo qadar yar.

Daaweynta hormoonka waxay kaliya ka shaqeysaa kansarka xasaasiga u ah hoormoonka. Si loo hubiyo in daaweynta hoormoonka ay shaqeyn karto, dhakhaatiirtu waxay baaraan muunad ka mid ah burooyinka la soo saaray intii lagu jiray qalliinka si loo arko haddii kansarku u nugul yahay hoormoonka.

Daaweynta hoormoonka waxay ku shaqeyn kartaa laba siyaabood:

• Adoo ka joojinaya estrogen inuu ku dhaqmo unugyada kansarka
• Adoo hoos u dhigaya heerarka estrogen ee jirka dumarka

Daawooyinka qaar waxay ku shaqeeyaan iyaga oo ka horjoogsada estrogen inay sababaan unugyada kansarku inay koraan.

Tamoxifen (Nolvadex) waa dawo ka hortageysa estrogen inuu u sheego unugyada kansarka inay koraan. Waxay leedahay faa'iidooyin dhowr ah:

• Qaadashada Tamoxifen muddo 5 sano ah ka dib qalliinka kansarka naasaha waxay jareysaa fursadda kansarka inuu ku soo laabto kala bar. Daraasadaha qaarkood waxay muujinayaan in qaadashada 10 sano laga yaabo inay xitaa ka sii fiicnaato.
• Waxay yareysaa halista ah in kansarku ku koro naaska kale.
• Waxay hoos u dhigtaa koritaanka waxayna yaraysaa kansarka ku faafay.
• Waxay yareysaa halista in kansarku ku dhaco dumarka halista sare leh.

Daawooyinka kale ee u shaqeeya si la mid ah waxaa loo isticmaalaa in lagu daaweeyo kansarka horumarsan ee faafay:

• Toremifene (Fareston)
• Fulvestrant (Faslodex)

Daawooyinka qaar, oo loo yaqaan aromatase inhibitors (AIs), ayaa jirka ka joojiya sameynta estrogen ee unugyada sida dufanka iyo maqaarka. Laakiin, daroogadani uma shaqeeyaan inay ugxan-yartu joojiso samaynta estrogen. Sababtaas awgeed, waxaa badanaa loo isticmaalaa in lagu yareeyo heerarka estrogen ee haweenka soo maray caadada (postmenopausal). Ugxansideyaashoodu mar dambe ma sameeyaan estrogen.

Haweenka premenopausal waxay qaadan karaan AIs haddii ay waliba qaataan daawooyin ka joojiya ugxansidayaashooda inay sameeyaan estrogen.

Kahortaga Aromatase waxaa ka mid ah:

• Anastrozole (Arimidex)
• Letrozole (Femara)
• Exemestane (Aromasin)

Daaweynta noocan ah waxay ka shaqeysaa oo keliya haweenka uurka ku jira ee uurka ku jira ugxan sideedana shaqeeya. Waxay kaa caawin kartaa noocyada qaarkood ee daaweynta hoormoonka inay si fiican u shaqeeyaan. Waxaa sidoo kale loo isticmaalaa in lagu daaweeyo kansarka faafay.

Waxaa jira seddex qaab oo hoos loogu dhigo heerarka estrogen ee ugxan sidaha:

• Qalliin si looga saaro ugxan sidaha
• Shucaac waxyeeleeya ugxan sidaha si aysan u sii shaqeyn, kaasoo ah mid joogto ah
• Daawooyinka sida goserelin (Zoladex) iyo leuprolide (Lupron) kuwaas oo si ku meelgaar ah u joojiya ugxan sidaha inay sameystaan ​​estrogen

Mid kasta oo ka mid ah qaababkani waxay haweeney gelin doontaa caadada. Tani waxay keentaa astaamaha menopause:

• Ololayaal kulul
• Dhidid habeenkii
• Qalitaanka siilka
• Niyad jabka
• Niyad jab
• Danta xiisaha galmada

Dhibaatooyinka soo raaca ee daaweynta hoormoonka waxay ku xiran tahay daroogada. Waxyeellooyinka caadiga ah waxaa ka mid ah shidmo kulul, dhidid habeenkii ah, iyo qallajin siilka ah.

Daawooyinka qaar waxay sababi karaan waxyeelo aan badnayn laakiin aad u daran, sida:

• Tamoxifen. Xinjirowga dhiigga, istaroogga, cataract, endometrial iyo kansarka makaanka, isbedelka niyadda, niyadjabka, iyo luminta xiisaha galmada.
• Kahortaga Aromatase. Kalastarool badan, wadne qabad, lafo beelid, kalagoys xanuun, isbadalka niyadda, iyo diiqadda.
• Fulvestrant. Cunto xumo, lallabbo, matag, calool istaag, shuban, calool xanuun, daciifnimo, iyo xanuun.

Go'aansiga daaweynta hoormoonka kansarka naasaha wuxuu noqon karaa go'aan adag oo xitaa adag. Nooca daaweynta ee aad heleyso waxay ku xirnaan kartaa haddii aad caadada ka gudubtay ka hor daaweynta kansarka naasaha. Waxay kaloo kuxirantahay inaad caruur dhaleyso iyo inkale. Inaad kala hadasho daryeel caafimaad bixiyahaaga waxyaabaha ku saabsan xulashooyinkaaga iyo faa'iidooyinka iyo halista ay leedahay daaweyn kasta waxay kaa caawin kartaa inaad adiga go’aanka ugu fiican adiga gaarto.

Daaweynta Hormonal - kansarka naasaha; Daaweynta hoormoonka - kansarka naasaha; Daaweynta endocrine; Kansarka xasaasiga u ah hormoonka - daaweynta; ER-daweynta; Kahortaga Aromatase - kansarka naasaha

Websaydhka Bulshada Kansarka ee Maraykanka. Daaweynta hormoonka ee kansarka naasaha. www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-breast-cancer.html. La cusbooneysiiyay Sebtember 18, 2019. La helay Noofambar 11, 2019.

Henry NL, Shah PD, Haider I, Freer PE, Jagsi R, Sabel MS. Kansarka naasaha. Gudaha: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6aad ed. Philadelphia, PA: Elsevier; 2020: cutubka 88.

Websaydhka Machadka Kansarka Qaranka. Daaweynta hormoonka ee kansarka naasaha. www.cancer.gov/types/breast/breast-hormone-therapy-fact-sheet. La cusbooneysiiyay Febraayo 14, 2017. La helay Noofambar 11, 2019.

Rugo HS, Rumble RB, Macrae E, iyo al. Endocrine therapy for hormone receptor-positive metastatic cancer cancer: Bulshada Mareykanka ee Tilmaamaha Caafimaadka Oncology Clinical. J Clin Oncol. 2016; 34 (25): 3069-3103. PMID: 27217461 www.ncbi.nlm.nih.gov/pubmed/27217461.

• Kansarka Naasaha