Qoraa: Marcus Baldwin
Taariikhda Abuurista: 20 Juun 2021
Taariikhda Cusboonaysiinta: 16 Noofeembar 2024
Anonim
Self‐nanoemulsifying Drug Delivery Systems of Artemether and Lumefantrine
Dareemoleyad: Self‐nanoemulsifying Drug Delivery Systems of Artemether and Lumefantrine

Qanacsan

Isku-darka artemether iyo lumefantrine waxaa loo isticmaalaa in lagu daaweeyo noocyo ka mid ah infekshannada duumada (infekshan daran oo ay kaneecadu ku faafto qaybo ka mid ah adduunka oo sababi kara dhimasho). Artemether iyo lumefantrine looma isticmaali karo in looga hortago duumada. Artemether iyo lumefantrine waxay ku jiraan fasal dawooyin ah oo loo yaqaan antimalarials. Waxay ku shaqeysaa iyada oo la dilayo noolaha keena duumada.

Isku darka artemether iyo lumefantrine waxay u yimaadaan sidii kiniin afka lagu qaato. Badanaa waxaa la qaataa laba jeer maalintii 3 maalmood sida dhakhtarkaagu ku faro. Markasta cunto ku qaad artemether iyo lumefantrine. Haddii aadan awoodin inaad wax cunto, la xiriir dhakhtarkaaga. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado artemether iyo lumefantrine sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Haddii aad dhib ku qabtid liqidda kiniinnada, waa la jajabin karaa oo lagu qasi karaa 1 ama 2 qaado oo biyo ah weel nadiif ah. Cab isku darka isla markiiba. Ku mayr galaaska biyo badan oo liq waxa ku jira oo dhan.


Waad matagi kartaa isla marka aad daawada qaadato. Haddii aad hunqaacdo 1 illaa 2 saacadood gudahood ka dib markaad qaadato artemether iyo lumefantrine, waa inaad qaadataa qadar kale oo buuxa oo ah artemether iyo lumefantrine. Haddii aad mar kale matagto ka dib qaadashada daawada dheeriga ah, wac dhakhtarkaaga.

Waa inaad bilowdaa inaad fiicnaato inta lagu jiro maalmaha ugu horreeya ee daaweynta artemether iyo lumefantrine. Haddii calaamadahaagu aysan fiicnayn ama ka sii darayn, wac dhakhtarkaaga. Sidoo kale wac dhakhtarkaaga haddii aad leedahay qandho, qarqaryo, murqo xanuun, ama madax xanuun isla marka aad dhammayso daaweyntaada. Tani waxay noqon kartaa calaamad muujinaysa inaad wali kujirto cudurka duumada.

Qaado artemether iyo lumefantrine illaa aad ka dhammeysid rijeetada laguu qoray, xitaa haddii aad fiicnaan dareento. Haddii aad joojiso qaadashada artemether iyo lumefantrine si dhakhso leh ama aad ka boodo qiyaasaha, infekshinkaaga gebi ahaanba lama daaweyn karo oo noolaha ayaa iska caabin kara antimalarials.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.


Kahor qaadashada artemether iyo lumefantrine,

  • u sheeg dhakhtarkaaga iyo farmashiistaha haddii aad xasaasiyad ku leedahay farshaxanka iyo lumefantrine, daawooyinka kale, ama wax ka mid ah maaddooyinka ku jira farshaxanka iyo kiniiniyada lumefantrine. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
  • u sheeg dhakhtarkaaga haddii aad qaadanaysid carbamazepine (Carbatrol, Epitol, Tegretol); phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rifamate, Rifater, Rimactane); ama johannesört johannesört. Dhakhtarkaaga ayaa u badan inuu kuu sheego inaadan qaadan artemether iyo lumefantrine haddii aad qaadanaysid mid ama in kabadan oo daawooyinkan ah.
  • u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: antidepressants oo ay ku jiraan amitriptyline (Elavil), clomipramine (Anafranil), iyo imipramine (Tofranil); antifungals qaarkood sida fluconazole (Diflucan); itraconazole (Sporanox) iyo ketoconazole (Nizoral); antimalarials sida mefloquine (Lariam) iyo quinine (Qualaquin); cisapride (Propulsid) (aan laga heli karin Mareykanka); antibiyootigga fluoroquinolone sida ciprofloxacin (Cipro), gatifloxacin (Tequin) (oo aan laga heli karin Mareykanka), gemifloxacin (Factive), levofloxacin (Levaquin), lomefloxacin (Maxaquin) (oo aan laga heli karin Mareykanka), moxifloxacin (Avelox), acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), iyo sparfloxacin (Zagam) (oo aan laga heli karin Mareykanka); antibayootiga macrolide sida clarithromycin (Biaxin, in PrevPac), erythromycin (E.E.S., Ery-tab, Eryc), iyo telithromycin (Ketek); dawooyinka qaarkood ee fayraska difaaca jirka ee dadka (HIV) ama cillad la'aanta cillad la'aanta (AIDS) sida atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), etravirine (Intelence), fosamprenavir (Lexiva) , indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), nevirapine (Viramune), rilpivirine (Edurant, in Complera), ritonavir (Norvir, Kaletra), saquinavir (Invirase), iyo tipranavir; daawooyinka loogu talagalay garaaca wadnaha aan caadiga ahayn oo ay ku jiraan amiodarone (Cordarone), sibibramram (Norpace), flecainide (Tambocor), procainamide (Procanbid), quinidine, iyo sotalol (Betapace, Betapace AF, Sorine); iyo dawooyinka qaarkood ee cudurada maskaxda sida pimozide (Orap) iyo ziprasidone (Geodon). Sidoo kale u sheeg dhakhtarkaaga ama farmashiistaha haddii aad qaadanaysid ama aad joojisay qaadashada halofantrine (Halfan) (oo aan laga heli karin Maraykanka) bishii la soo dhaafay. Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara farshaxanka iyo lumefantrine, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
  • u sheeg dhakhtarkaaga haddii adiga ama qof kale oo qoyskaaga ka mid ah uu soo maray qadar dheeri ah oo QT ah (dhibaato wadnaha oo dhif ah oo u horseedi karta garaaca wadnaha oo aan joogto ahayn, suuxdin, ama dhimasho lama filaan ah); ama haddii aad yeelatay ama aad waligaa wadno garaac, soon, ama aan caadi ahayn wadno garaac; wadno xanuun dhowaan; heer hoose oo magnesium ama potassium ah dhiigaaga; kilyaha, wadnaha, ama cudurka beerka.
  • u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelato inta aad qaadanaysid artemether iyo lumefantrine, wac dhakhtarkaaga.
  • waa inaad ogaataa in farshaxanka iyo lumefantrine ay yareyn karaan waxtarka uur-qaadidda ee hormoonnada (kaniiniyada ka hortagga uurka, balastarro, faraantiyo, qalabka la isku duro, iyo irbado). Kala hadal dhakhtarkaaga hababka xakameynta dhalmada ee adiga kuu shaqeyn doona inta aad qaadanaysid artemether iyo lumefantrine.

Ha cabbin casiir canab ah markaad qaadanayso dawadan.


Qaado qiyaasta la seegay isla marka aad xasuusatoba. Si kastaba ha noqotee, haddii ay ku dhowdahay waqtiga qiyaasta xigta, ka bood qiyaasta la seegay oo sii wad jadwalka daawadaada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Artemether iyo lumefantrine waxay sababi karaan waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

  • madax xanuun
  • dawakhaad
  • daciifnimo
  • murqaha ama kalagoysyada oo xanuuna
  • daallan
  • dhibaato xagga hurdada ama hurdada ah
  • matagid
  • cunto xumo
  • qandho
  • qarqaryo

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah.Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

  • garaaca wadnaha oo aan caadi ahayn ama dhakhso ah
  • miyir beelid
  • finan
  • finan
  • neefsashada ama wax liqidda oo ku adkaata
  • bararka bushimaha, carrabka, wejiga, ama cunaha
  • xabeeb
  • hadalka oo adkaada

Artemether iyo lumefantrine waxay sababi karaan waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Dhammaan ballamaha la dhig dhakhtarkaaga.

Ha u ogolaan qof kale inuu qaato daawadaada. Takhtarka laguu qoray ayaa laga yaabaa inaan dib loo buuxin karin. Haddii aad wali leedahay calaamadaha cudurka kadib markaad dhameysid farshaxanka iyo lumefantrine, wac dhakhtarkaaga.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

  • Coartem® (ay ku jiraan Artemether, Lumefantrine)
Markii ugu dambeysay ee dib loo eegay - 10/15/2016

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