Teriflunomide

Qanacsan

• Kahor qaadashada teriflunomide,
• Teriflunomide waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, jooji qaadashada teriflunomide isla markaana wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo degdeg ah:

Teriflunomide waxay sababi kartaa dhaawac halis ah ama naf-gooyn ah oo beerka ah, taas oo u baahan karta beerka beeris. Khatarta waxyeelada beerka waxaa lagu kordhin karaa dadka qaata daawooyinka kale ee loo yaqaan inay sababaan dhaawaca beerka, iyo dadka horeyba u lahaa cudurka beerka. U sheeg dhakhtarkaaga haddii aad qabto cudurka beerka. Dhakhtarkaagu wuxuu kuu sheegi karaa inaadan qaadan teriflunomide. U sheeg dhakhtarkaaga iyo farmashiistaha dhammaan daawooyinka aad qaadanaysid si ay u hubiyaan in mid ka mid ah daawooyinkaagu ay kordhin karaan halista aad ku yeelan karto dhaawaca beerka inta lagu jiro daaweyntaada teriflunomide. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga: lallabbo, matag, daal aad u daran, dhiig-bax aan caadi ahayn ama nabarro, tamar la'aan, cunno xumo, xanuunka qaybta sare ee midig ee caloosha, maqaarka ama indhaha oo hurdi noqda , kaadida midabbada madow, ama calaamadaha hargabka oo kale ah. Haddii laga shakisan yahay waxyeelada beerka, dhakhtarkaagu wuxuu joojin karaa teriflunomide wuxuuna ku siin karaa daaweyn kaa caawin doonta sidii dhaqso looga saari lahaa teriflunomide jirkaaga.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa baaritaano gaar ah ka hor intaadan bilaabin daaweyntaada iyo si joogto ah inta lagu jiro daaweyntaada si loo hubiyo jawaabta jirkaaga ee teriflunomide.

Ha qaadan teriflunomide haddii aad uur leedahay ama aad qorsheyneyso inaad uur yeelato. Teriflunomide waxay waxyeelayn kartaa uurjiifka. Waa inaadan bilaabin qaadashada teriflunomide ilaa aad ka qaadatid baaritaanka uurka natiijooyin taban oo dhakhtarkaagu kuu sheego inaadan uur lahayn. Waa inaad isticmaashaa qaab wax ku ool ah oo xakameynta dhalmada ka hor intaadan bilaabin qaadashada teriflunomide, inta lagu guda jiro daaweyntaada teriflunomide, iyo ilaa 2 sano daaweynta ka dib, illaa baaritaanka dhiigga ay muujiso inaad leedahay heerar ku filan oo ah teriflunomide ee dhiigaaga. Haddii caadadaadu soo daahdo, waad tabaysaa muddo, ama waxaad u maleyneysaa inaad uur leedahay inta lagaa daweynayo teriflunomide ama 2 sano daaweyntaada kadib, isla markiiba wac dhakhtarkaaga. Haddii aad tahay lab oo lammaanahaagu uuraysan karo, adiga iyo lammaanahaagu waa inaad isticmaashaan xakameynta uurka ee waxtarka leh inta lagu jiro daaweyntaada. Haddii adiga ama lammaanahaagu aad qorsheyneysaan inaad uur yeelatid ama aad uur qaadi kartid, kala hadal dhakhtarkaaga daaweyn kaa caawin doonta in dhakhso looga saaro teriflunomide jirkaaga ka dib markaad joojiso qaadashada daawada.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo-saaraha (Tilmaamaha Daawada) markaad bilowdo daaweynta teriflunomide iyo mar kasta oo aad dib u buuxiso dawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Kala hadal dhakhtarkaaga khataraha qaadashada teriflunomide.

Teriflunomide waxaa loo isticmaalaa in lagu daaweeyo dadka qaangaarka ah ee leh noocyo kala duwan oo cudurka sclerosis (MS; cudur ah oo neerfayaashu aysan si sax ah u shaqeynin dadkuna ay la kulmi karaan daciifnimo, kabuubyo, luminta isuduwidda murqaha, iyo dhibaatooyinka aragga, hadalka, iyo kaadiheysta) :

• cillad caafimaad oo ku go'doonsan (CIS, astaamaha neerfaha ee dhacda ugu yaraan 24 saacadood),
• foomamka soo noqoshada-dib-u-noqoshada (habka cudurka ee astaamuhu marba marka ka dambeysa u soo baxaan), ama
• foomamka horusocodka labaad (habka cudurka ee soo noqnoqoshada badanaa ku dhaca).

Teriflunomide waxay ku jirtaa nooc daawooyin ah oo loo yaqaan wakiilada difaaca jirka. Waxaa loo maleynayaa inay ku shaqeyso iyadoo la yareeyo bararka iyo hoos u dhigista ficilka unugyada difaaca ee keeni kara dhaawaca dareemayaasha.

Teriflunomide waxay u timaadaa sidii kiniin afka laga qaato. Caadi ahaan waxaa la qaataa maalintii hal mar iyadoo la cuno ama aan la cunin. Qaado teriflunomide qiyaastii isla waqtigaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado teriflunomide sida saxda ah ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Teriflunomide ayaa laga yaabaa inay gacan ka geysato sidii loo xakameyn lahaa astaamaha cudurka loo yaqaan 'sclerosis multiple', laakiin ma daaweynayo. Sii wad inaad qaadato teriflunomide xitaa haddii aad dareento fiicnaan. Ha u joojin qaadashada teriflunomide adigoon la hadlin dhakhtarkaaga.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada teriflunomide,

• u sheeg dhakhtarkaaga iyo farmashiistaha haddii aad xasaasiyad ku leedahay teriflunomide (finan, finan, neefta oo kugu qabata, barar wejiga, indhaha, afka, cunaha, carrabka, bushimaha, gacmaha, cagaha, anqawyada, ama lugaha hoose), leflunomide (Arava) , daawooyin kale, ama walxaha ku jira kiniiniyada teriflunomide. Weydii farmashiistahaaga ama ka hubi Hagaha Daawada liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanayso leflunomide (Arava). Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan teriflunomide haddii aad qaadanaysid dawadan.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto daawooyinka ku qoran qaybta DIGNIIN MUHIIM AH iyo mid ka mid ah kuwan soo socda: alosetron (Lotronex); daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida warfarin (Coumadin, Jantoven); atorvastatin (Lipitor, Caduet); cefaclor; cimetidine (Tagamet); ciprofloxacin (Cipro); duloxetine (Cymbalta); eltrombopag (Promacta); furosemide (Lasix); gefitinib (Iressa); ketoprofen; daawooyinka sababi kara dhaawaca dareemayaasha sida daawooyinka kansarka, HIV, ama AIDS; daawooyinka kale ee xakameynaya habka difaaca jirka sida azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), iyo tacrolimus (Astagraf, Envarsus XR, Prograf); methotrexate (Otrexup, Rasuvo, Trexall); mitoxantrone; nateglinide (Starlix); p-pillerka (kaniiniyada xakameynta dhalmada); paclitaxel (Abraxane, Taxol); penicillin G; pioglitazone (Actos, ee Actoplus Met, Duetact); pravastatin (Pravachol); repaglinide (Prandin, gudaha Prandimet); rifampin (Rifadin, Rimactane, gudaha Rifamate, Rifater); rosiglitazone (Avandia); rosuvastatin (Crestor); simvastatin (Zocor, oo ku yaal Vytorin); theophylline (Elixophyllin, Theo-24, Uniphyl, kuwa kale); tizanidine (Zanaflex); iyo zidovudine (Retrovir, Combivir, Trizivir). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara teriflunomide, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• u sheeg dhakhtarkaaga haddii aad infekshan hadda qabtid, oo ay kujirto infekshan socda oo aan dhammaanayn, ama haddii aad yeelatay ama aad waligaa dareen-celin daran ku yeelatay maqaarka ka dib markii aad qaadatay daawo kale; sonkorowga; dhibaatooyinka neefsashada; kansar ama xaalado kale oo saameeya dhuuxa lafta ama nidaamka difaaca jirka; dhiig kar; neuropathy durugsan (kabuubyo, gubasho ama xoqitaan gacmaha ama cagaha oo dareemaya inay ka duwan yihiin astaamahaaga MS); ama cudurka kalyaha.
• u sheeg dhakhtarkaaga haddii aad naas nuujinayso. Ha nuujin naaska inta aad qaadaneysid teriflunomide.
• haddii lammaanahaagu qorsheynayo inuu uur yeesho, waa inaad kala hadashaa dhakhtarkaaga sidii loo joojin lahaa teriflunomide loona heli lahaa daaweyn ka caawisa sidii looga saari lahaa daawadan jirkaaga si dhakhso leh. Haddii lammaanahaagu uusan qorsheyneynin inuu uur yeesho, adiga iyo lammaanahaagu waa inaad isticmaashaan hab wax ku ool ah oo xakameynta dhalmada ah inta lagu guda jiro daaweyntaada teriflunomide iyo illaa 2 sano daaweynta ka dib, illaa baaritaanka dhiigga ay muujiso inaad ku filan tahay heerarka teriflunomide ee dhiig.
• haddii aad qalliin tahay, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarka ama dhakhtarka ilkaha inaad qaadanayso teriflunomide.
• waxa laga yaabaa inaad hore u qaadday cudurka qaaxada (TB; infekshan daran oo sambabaha ah) laakiin aadan lahayn wax calaamado ah oo cudurka ah. U sheeg dhakhtarkaaga haddii aad qabtid ama aad waligaa qaaxo qabtid, haddii aad ku nooleyd ama aad booqatay waddan ay qaaxadu ku badan tahay, ama haddii aad ag joogtay qof qaba ama weligaa qaaday qaaxada. Kahor intaadan bilaabin daaweyntaada teriflunomide, dhakhtarkaagu wuxuu sameyn doonaa baaritaanka maqaarka si loo arko inaad qabto TB. Haddii aad qabtid TB, dhakhtarkaaga ayaa daweyn doona infekshankan ka hor intaadan bilaabin qaadashada teriflunomide.
• Ma lihid wax talaal ah adigoon lahadlin dhaqtarkaaga inta aad qaadaneyso teriflunomide iyo 6 bilood kadib markaad joojiso qaadashada.
• waa inaad ogaataa in teriflunomide ay sababi karto dhiig kar. Waa inaad iska hubisaa cadaadiska dhiiggaaga kahor intaadan bilaabin daaweynta iyo si joogto ah inta aad qaadanaysid dawadan.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Qaado qiyaasta la seegay isla marka aad xasuusatoba. Si kastaba ha noqotee, haddii ay ku dhowdahay waqtiga qiyaasta xigta, ka bood qiyaasta la seegay oo sii wad jadwalka daawadaada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Teriflunomide waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• timo lumis
• shuban
• aragti cakiran
• ilko xanuun
• finanka
• kalagoys ama muruq xanuun
• walaac
• miisaanka oo yaraada

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, jooji qaadashada teriflunomide isla markaana wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo degdeg ah:

• dhakhso, aan caadi ahayn, ama garaaca wadnaha oo gaabis ah
• madax xanuun
• dawakhaad
• maqaarka cirro leh
• jahwareer
• qandho, qufac, cuna xanuun, dhaxan, iyo calaamadaha kale ee infekshanka
• kabuubyo, gubasho, ama xoqid gacmaha, gacmaha, cagaha, ama lugaha
• luminta muruqyada
• daciifnimo ama culeys lugaha ah
• hargab, maqaar cawlan
• casaan, fiiqan, ama maqaarka nabarro leh
• finan
• finan
• cuncun
• dhib liqidda
• barar wejiga, indhaha, afka, cunaha, carrabka, ama bushimaha
• neefta oo ku qabata
• finan yaryar oo laga yaabo inay ku dhacaan qandho, qanjirro barar, ama barar wejiga ah
• caloosha, dhinac, ama dhabar xanuun

Teriflunomide waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Aubagio^®