Cobicistat

Qanacsan

• Kahor qaadashada cobicistat,
• Cobicistat waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii astaamahani ay daran yihiin ama aysan tagi doonin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac dhakhtarkaaga isla markiiba:

Cobicistat waxaa loo isticmaalaa in lagu kordhiyo qadarka atazanavir (Reyataz, ee Evotaz) dadka waaweyn iyo caruurta culeyskoodu yahay ugu yaraan 77 rodol (35 kg) ama darunavir (Prezista, Prezcobix) dadka waaweyn iyo caruurta culeyskoodu yahay ugu yaraan 88 rodol (40 kg) gudaha dhiigga marka daawooyinkan loo isticmaalo in lagu daaweeyo fayraska difaaca jirka ee aadanaha (HIV). Cobicistat waxay ku jirtaa nooc daawooyin ah oo loo yaqaan 'cytochrome P450 3A (CYP3A) inhibitors'. Waxay ku shaqeysaa iyadoo la kordhinayo qadarka atazanavir ama darunavir ee jirka si ay u yeeshaan saameyn weyn.

Cobicistat waxay u timaadaa sidii kiniin afka laga qaato. Caadi ahaan waxaa lagu qaataa cuntada hal mar maalintii oo ay weheliyaan atazanavir ama darunavir. Ku qaado cobicistat atazanavir ama darunavir isla waqtigaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado cobicistat sida saxda ah ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Waa muhiim inaad marwalba qaadato cobicistat isla waqtigaas atazanavir ama darunavir.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada cobicistat,

• u sheeg dhakhtarkaaga iyo farmashiistaha haddii aad xasaasiyad ku leedahay cobicistat, daawooyin kale, ama wax kasta oo ka mid ah kiniiniyada ku jira kiniiniyada cobicistat. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanayso mid ka mid ah daawooyinka soo socda: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid) (aan laga heli karin Mareykanka); colchicine (Colcrys, Mitigare, oo ku yaal Col-Probenecid); dronedarone (Multaq); dawooyinka ergot sida dihydroergotamine (DHH 45, Migranal), ergotamine (Ergomar, Cafergot, Migergot), iyo methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (Loogu talagalay) afka; phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rimactane, Rifadin, gudaha Rifamate, Rifater); sildenafil (kaliya magaca Revatio ee loo isticmaalo cudurka sanbabada); simvastatin (Flolipid, Zocor); Johannesört wort; ama triazolam (Halcion). Haddii aad qaadanayso atazanavir oo ay weheliso cobicistat, u sheeg dhakhtarkaaga haddii aad qaadanayso dawada loo yaqaan 'drospirenone' iyo 'ethinyl estradiol' (ka hortagga uurka qaarkood ee afka laga qaato sida Beyaz, Safyral, Yasmin, Yaz, kuwa kale); indinavir (Crixivan), irinotecan (Camptosar), ama nevirapine (Viramune). Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan cobicistat haddii aad qaadanaysid mid ka mid ah daawooyinkan.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida apixaban (Eliquis), betrixaban (Bevyxxa), dabigatran (Pradaxa), edoxaban (Savaysa), rivaroxaban (Xarelto), iyo warfarin (Coumadin, Jantoven) ; dawooyinka ka hortagga sida 'clopidogrel (Plavix) iyo ticagrelor (Brilinta); atorvastatin (Lipitor, Caduet); benzodiazepines sida diazepam (Valium), estazolam, midazolam oo la siinayo xidid (xidid), iyo zolpidem (Ambien, Edluar, Intermezzo); beta blockers sida carvedilol (Coreg), metoprolol (Lopressor), iyo timolol; boceprevir (Victrelis) (oo aan laga heli karin Mareykanka); bosentan (Tracleer); buprenorphine (Belbuca, Butrans, Probuphine); buprenorphine iyo naloxone (Suboxone, Zubsolv); buspirone; kaalsiyamka xanibaada sida amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, kuwa kale), felodipine, nifedipine (Adalat, Afeditab, Procardia), iyo verapamil (Calan, Verelan, kuwa kale); clarithromycin (Biaxin, gudaha PrevPac); corticosteroids sida beclomethasone (Beconase AQ), budesonide (Rhinocort Aqua), ciclesonide (Omnaris), dexamethasone (Decadron), fluticasone (Flonase, Flovent), methylprednisolone (Medrol), momentasone (Flonaselone), iyo triamino dasatinib (Sprycel); efavirenz (Sustiva, oo ku taal Atripla); erythromycin (EE.S, Erytab, kuwa kale); etravirine (Intelence); fentanyl (Abstral, Actiq, Fentora, kuwa kale); itraconazole (Onmel, Sporanox); ketoconazole; daawooyinka niyadjabka sida amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), iyo trazodone; daawooyinka loogu talagalay garaaca wadnaha aan caadiga ahayn sida amiodarone (Cordarone, Nexterone, Pacerone), digoxin (Lanoxin), benebramram (Norpace), flecainide, mexiletine, propafenone (Rythmol), iyo quinidine (Nuedexta); daawooyinka suuxdinta sida clonazepam (Klonopin), eslicarbazepine (Aptiom), iyo oxcarbazepine (Trileptal); daawooyinka xakameynaya habka difaaca jirka sida cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), iyo tacrolimus (Astagraf, Envarsus XR, Prograf); lopinavir (Kaletra); maraviroc (Selzentry); methadone (Dolophine, Methadose); nilotinib (Tasigna); p-pillerka (kaniiniyada xakameynta dhalmada); perphenazine; qaar ka mid ah xannibaadayaasha fosfodiesterase (PDE5) sida avanafil (Stendra), sildenafil (Viagra), tadalafil (Adcirca, Cialis), iyo vardenafil (Levitra); quetiapine (Seroquel); rifabutin (Mycobutin); risperidone (Risperdal); ritonavir (Norvir, Kaletra); rivaroxaban (Xarelto); rosuvastatin; salmeterol (Serevent, Advair); simeprevir (Olysio); telaprevir (Incivek) (oo aan laga heli karin Mareykanka); telithromycin (Ketek); tenofovir (Viread, gudaha Atripla, Complera, Truvada, kuwa kale), thioridazine; tramadol (Conzip, Ultram, oo ku taal Ultracet); vinblastine; vincristine (Qalabka Marqibo); iyo voriconazole (Vfend). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara cobicistat markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• haddii aad qaadaneysid cobicistat leh atazanavir oo aad sidoo kale qaadaneyso antiacids (Maalox, Mylanta, Tums, kuwa kale), u qaado 2 saacadood ka hor ama 2 saacadood ka dib cobicistat iyo atazanavir.
• haddii aad qaadaneysid cobicistat leh atazanavir oo aad sidoo kale daawo u qaadanaysid barar, laab xanuun, ama boogo (H₂ xannibaadaha) sida cimetidine, famotidine (Pepcid, in Duexis), nizatidine (Axid), ama ranitidine (Zantac), ku qaado isla waqtigaas ama ugu yaraan 10 saacadood ka dib qaadashada H₂ xiraha
• haddii aad qaadato cobicistat leh atazanavir oo aad sidoo kale daawo u qaadanaysid calool xanuun, laab xanuun, ama boogo (proton pump inhibitors) sida esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, in Zegerid), pantoprazole (Protonix), ama rabeprazole (AcipHex) waxay qaataan ugu yaraan 12 saacadood kadib markay qaataan proton pump inhibitor.
• u sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabto cudurka kalyaha ama beerka.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelato inta aad qaadanaysid cobicistat, wac dhakhtarkaaga. Waa inaadan naas nuujin haddii aad qabtid HIV ama haddii aad qaadaneysid cobicistat.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Haddii qiyaastaada xigta ay ku eg tahay 12 saacadood ama ka badan, qaado qiyaasta la seegay isla marka aad xusuusatoba. Si kastaba ha noqotee, haddii qiyaasta xigta lagu qaadan doono wax ka yar 12 saacadood, ka bood qiyaasta la seegay oo sii wad jadwalkaaga qiyaasta daawada ee caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Cobicistat waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii astaamahani ay daran yihiin ama aysan tagi doonin:

• lallabbo

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac dhakhtarkaaga isla markiiba:

• hurdi maqaarka ama indhaha
• finan
• kaadida oo yaraatay

Cobicistat waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa tijaabooyinka shaybaarka qaarkood kahor iyo inta daaweyntaadu socoto si loo hubiyo jawaabta jirkaaga ee cobicistat.

Dawada ku hay gacantaada. Ha sugin illaa ay kaa dhammaato daawada si aad ugu buuxiso dawada laguu qoray.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Tybost^®

• Evotaz^® (oo ay ku jiraan Atazanavir, Cobicistat)
• Prezcobix^® (ay ku jiraan Cobicistat, Darunavir)