Safinamide

Qanacsan

• Kahor qaadashada safinamide,
• Safinamide waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

Safinamide waxaa loo isticmaalaa iskudhafka levodopa iyo carbidopa (Duopa, Rytary, Sinemet, kuwa kale) si loogu daaweeyo dhacdooyinka '' off '' (waqtiyada dhibka dhaqdhaqaaqa, socodka, iyo hadalka oo dhici kara markay daawadu xirmato ama si kadis ah) dadka qaba cudurka Parkinson (PD; khalkhal ku dhaca habdhiska neerfaha oo sababa dhibaatooyin xagga dhaqdhaqaaqa, xakameynta murqaha, iyo dheelitirka ah). Safinamide waxay ku jirtaa koox daawooyin ah oo loo yaqaan 'monoamine oxidase type B (MAO-B) inhibitors'. Waxay ku shaqeysaa iyadoo la kordhinayo qadarka dopamine (walax dabiici ah oo loo baahan yahay si loo xakameeyo dhaqdhaqaaqa) maskaxda.

Safinamide waxay u timaadaa sidii kiniin afka laga qaato. Caadi ahaan waxaa la qaataa ama cunno la'aan maalintii hal mar. Qaado safinamide qiyaastii isla waqtigaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado safinamide sida saxda ah ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Dhakhtarkaagu wuxuu kuugu bilaabi doonaa qadar yar oo safinamide ah waxaana laga yaabaa inuu kordhiyo qiyaastaada hal mar ka dib ugu yaraan 2 toddobaad daaweynta.

Ha u joojin qaadashada safinamide adigoon la hadlin dhakhtarkaaga. Dhakhtarkaaga ayaa laga yaabaa inuu yareeyo qiyaastaada ka hor intaadan joojin. Haddii aad si lama filaan ah u joojiso qaadashada safinamide, waxaad la kulmi kartaa calaamadaha ka-noqoshada sida qandhada; murqaha oo adkaada; jahwareer; ama isbeddelada miyirka. U sheeg dhakhtarkaaga haddii aad isku aragto mid ka mid ah astaamahan marka qiyaastaada safinamide ay hoos u dhacdo.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada safinamide,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay safinamide (barar afka ama carrabka ah, neefta oo ku qabata), dawooyin kale oo kasta, ama wax ka mid ah maaddooyinka ku jira kiniiniyada safinamide. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanaysid mid ka mid ah kuwan soo socda: amphetamines (kiciyayaal, 'uppers') sida amphetamine (Adderall, Adzenys, Dyanavel XR, in Adderall), dextroamphetamine (Dexedrine, in Adderall), iyo methamphetamine (Desoxyn); dawooyinka murugada qaarkood sida amitriptyline (Elavil), amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), mirtazapine (Remeron) iyo trazodone; buspirone; cyclobenzaprine (Amrix); methylphenidate (Aptensio, Metadate, Ritalin, kuwa kale); opioids sida meperidine (Demerol), methadone (Dolophine, Methadose), propoxyphene (oo aan hadda laga helin Mareykanka; Darvon), ama tramadol (Conzip, Ultram, Ultracet); xulashada serotonin iyo norepinephrine reuptake inhibitors (SSNRIs) sida duloxetine (Cymbalta) iyo venlafaxine (Effexor); iyo johannesört wort; Sidoo kale u sheeg dhakhtarkaaga haddii aad qaadanayso dawada MAO sida isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), ama tranylcypromine (Parnate) iyaga labadii toddobaad ee la soo dhaafay. Dhakhtarkaaga ayaa laga yaabaa inuu kuu sheego inaadan qaadan safinamide oo ay la socdaan mid ka mid ah daawooyinkan. Haddii aad joojiso qaadashada safinamide, waa inaad sugtaa ugu yaraan 14 maalmood ka hor intaadan bilaabin inaad qaadato mid ka mid ah daawooyinkan. Sidoo kale, ha u qaadan dextromethorphan (Robitussin DM; waxaa laga helaa qufac badan iyo daawooyinka qabow) oo ay weheliyaan safinamide.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: antipsychotics sida clozapine (Clozaril, Fazaclo, Versacloz) iyo olanzapine (Zyprexa); benzodiazepines sida alprazolam (Xanax), diazepam (Diastat, Valium), lorazepam (Ativan), temazepam (Restoril), iyo triazolam (Halcion); daawooyinka hargabka iyo xasaasiyadda (suuxdiyayaal) oo ay ku jiraan kuwa isha ama sanka la galiyay; imatinib (Gleevec); irinotecan (Camptosar, Onivyde); isoniazid (Laniazid, Rifamate, Rifater); lapatinib (Tykerb); methotrexate (Otrexup, Rasuvo); metoclopramide (Reglan); mitoxantrone; rosuvastatin (Crestor); xakamaynta serotonin reuptake inhibitors sida citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax, kuwa kale), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), iyo sertraline (Zoloft); sulfasalazine (Azulfidine); iyo Topotecan (Hycamtin). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• u sheeg dhakhtarkaaga haddii aad qabto cudur beerka ah. Dhakhtarkaaga ayaa laga yaabaa inuu kuu sheego inaadan qaadan safinamide.
• u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa qabtid cudur maskaxeed sida shisoofrani (cudur maskaxeed oo sababa fekerka khalkhalka, xiisaha nolosha oo lumiya, iyo shucuur xoog leh ama aan caadi ahayn), laba-cirifoodka (niyadda oo isu beddeleysa niyad jab iyo farxad aan caadi ahayn) , ama cilmu-nafsiyeed; ama haddii aad qabtid cadaadis dhiig oo sarreeya ama hooseeya; dyskinesia (dhaqdhaqaaq aan caadi ahayn); ama dhibaatooyinka hurdada. Sidoo kale u sheeg dhakhtarkaaga haddii adiga ama xubin qoyskaaga ka mid ah ama aad dhibaatooyin ku qabeen qaybta dambe ee indhahaaga ama albinism (xaalad la iska dhaxlo oo sababa midab yaraan maqaarka, timaha iyo indhaha).
• u sheeg dhakhtarkaaga haddii aad uur leedahay ama aad qorsheyneyso inaad uur yeelato. Haddii aad uur yeelato inta aad qaadanaysid safinamide, wac dhakhtarkaaga.
• u sheeg dhakhtarkaaga haddii aad naas nuujinayso ama aad qorshaynayso inaad naas nuujiso.
• waa inaad ogaataa in safinamide laga yaabo inuu kaa dhigo mid lulmo leh ama waxay kuu sababi kartaa inaad si lama filaan ah ugu seexato inta lagu jiro howlahaaga caadiga ah ee maalinlaha ah. Waxaa laga yaabaa inaadan dareemin lulmo ama aad yeelato wax calaamado digniin ah ka hor intaadan si lama filaan ah u seexan.Baabuur ha wadin, ha ku shaqeynin mashiinno, ha ka shaqeyn meelaha dhaadheer, hana ka qeybgalin nashaadaadyo qatar ah bilowga daaweyntaada illaa aad ka ogaato sida daawadu kuu saameyneyso. Haddii aad si lama filaan ah u seexato intaad wax qabanayso sida daawashada telefishanka, hadalka, cunista, ama raacitaanka baabuurka, ama haddii aad noqoto qof hurdo badan, gaar ahaan xilliga maalinta, wac dhakhtarkaaga. Gaari ha wadin, ha ka shaqeyn meelaha sare, ama ha ku shaqeyn mashiin ilaa aad dhakhtarkaaga kala hadlayso.
• Xusuusnow in aalkoladu ku dari karto dawada ay keento dawada. Ha cabin aalkolo inta aad qaadanaysid safinamide.
• waa inaad ogaataa in dadka qaata daawooyinka sida safinamide ay kudhaceen dhibaatooyin khamaar ama dhiirigelin kale ama dabeecado qasab ku ah ama aan caadi aheyn iyaga, sida kacsi galmo iyo dabeecado badan. Wac dhakhtarkaaga haddii aad leedahay rabitaan khamaaris ah oo ay adag tahay in la xakameeyo, aad leedahay kacsanaan daran, ama aadan awoodin inaad xakamayso dhaqankaaga. U sheeg xubnaha qoyskaaga halistaan ​​si ay ugu yeeraan dhakhtarka xitaa haddii aadan ogeyn in khamaarkaaga ama waxyaabo kale oo xoog leh ama dabeecado aan caadi aheyn ay noqdeen dhibaato.

Waxaad la kulmi kartaa falcelin daran haddii aad cuntid cuntooyin ay ku badan tahay maadada 'tyramine' inta lagu guda jiro daaweyntaada safinamide. Tyramine waxaa laga helaa cunnooyin iyo cabitaanno badan, oo ay ku jiraan hilib, digaag, kalluun, ama farmaajo la cabo, da ', si khaldan loo kaydiyo, ama la kharibo; miraha qaarkood, khudaarta, iyo digirta; cabitaanka khamriga; iyo alaabada khamiirka ee khamiirisay. Dhakhtarkaaga ama dhakhtarka cuntada ayaa kuu sheegi doona cuntooyinka ay tahay inaad gebi ahaanba iska ilaaliso, iyo cuntooyinka aad ku cuni karto qaddar yar. Haddii aad cuntid cunno ku badan tyramine intaad qaadanaysid safinamide, la xiriir dhakhtarkaaga.

Ka gudub xaddiga aad seegtay oo qaado qiyaastaada xigta waqtiga caadiga ah maalinta ku xigta. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Safinamide waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• lallabbo
• dhibaato xagga hurdada ama hurdada ah

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

• dhaqdhaqaaqa jidhka oo ka sii daraya ama ka badan oo aanad xakamayn karin
• aragtida isbeddelay
• dhalanteed (aragtida wax ama maqalka codad aan jirin)
• caqiidooyin khiyaali ah (rumaynta waxyaalo aan run ahayn)
• kacsan, mala-awaal, qandho, dhidid, jahwareer, garaaca wadnaha oo dhaqso ah, gariir, muruq adag ama qallooc, luminta iskuxirnaanta, lallabbo, matag, ama shuban

Safinamide waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Dhammaan ballamaha la dhig dhakhtarkaaga.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

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