Tilmaamaha Fudud ee Nidaamka Endocannabinoid

Qanacsan

• Sidee u shaqaysaa?
• Endocannabinoids
• Soo-saareyaasha Endocannabinoid
• Enzymes
• Maxay yihiin shaqooyinkooda?
• Sidee THC ula falgalaan ECS?
• Sidee CBD ula falgashaa ECS?
• Ka waran yaraanta endocannabinoid?
• Qeybta hoose

Nidaamka endocannabinoid (ECS) waa nidaam unugyo calaamadeysan oo adag oo lagu aqoonsaday horaantii 1990-meeyadii cilmi-baarayaashu sahaminta THC, oo caan ku ah cannabinoid. Cannabinoids waa iskudhisyo laga helo xashiishka.

Khubarada ayaa wali isku dayaya inay si buuxda u fahmaan ECS. Laakiin illaa iyo hadda, waxaan ognahay inay door ka ciyaareyso nidaaminta howlo iyo habab kala duwan, oo ay ka mid yihiin:

• seexo
• niyadda
• rabitaanka cuntada
• xusuusta
• taranka iyo bacriminta

ECS way jirtaa wayna ka shaqeysaa jirkaaga xitaa haddii aadan isticmaalin xashiishad.

Akhriso si aad waxbadan uga barato ECS oo ay kujirto sida ay ushaqeyso iyo ula macaamilka xashiishadda.

Sidee u shaqaysaa?

ECS waxay ku lug leedahay seddex qaybood oo asaasi ah: endocannabinoids, receptors, iyo enzymes.

Endocannabinoids

Endocannabinoids, oo sidoo kale loo yaqaan 'cannabinoids endogenous', waa molecules uu sameeyo jirkaaga. Waxay la mid yihiin cannabinoids, laakiin waxay soo saaraan jirkaaga.

Khubarada ayaa aqoonsaday laba muhiim ah endocannabinoids ilaa hadda:

• anandamide (AEA)
• 2-arachidonoylglyerol (2-AG)

Kuwani waxay kaa caawinayaan inay howlaha gudaha si habsami leh u socdaan. Jirkaaga ayaa u soo saara iyaga sidii loogu baahdo, taasoo adkeyneysa in la ogaado heerarka caadiga ah ee mid kasta.

Soo-saareyaasha Endocannabinoid

Raawiyeyaashan waxaa laga helaa jirkaaga oo dhan. Endocannabinoids iyaga ayaa isku xira si ay u muujiyaan in ECS ay u baahan tahay inay tallaabo qaado.

Waxaa jira laba qaatayaasha waaweyn ee endocannabinoid:

• Daawooyinka CB1, kuwaas oo inta badan laga helo nidaamka neerfaha ee dhexe
• Daaweeyeyaasha CB2, kuwaas oo inta badan laga helo nidaamka neerfaha ee durugsan, gaar ahaan unugyada difaaca jirka

Endocannabinoids waxay ku xirnaan kartaa midkood qaataha. Saameynaha ka dhasha waxay kuxiran yihiin halka uu kujiro soo-dhoweynta iyo endocannabinoid ay ku xirto.

Tusaale ahaan, endocannabinoids waxay bartilmaameedsan kartaa soo-dhoweeyeyaasha CB1 ee dareemaha laf-dhabarka si loo yareeyo xanuunka. Kuwa kale waxay ku xirnaan karaan daaweeyaha CB2 ee unugyada difaaca jirka si ay u muujiyaan in jirkaaga uu dareemayo barar, calaamad guud oo ku saabsan jirrooyinka jirka.

Enzymes

Enzymes-ka ayaa mas'uul ka ah jabinta endocannabinoids markay fuliyaan shaqadooda.

Waxaa jira laba enzymes oo muhiim ah tan:

• fatty acid amide hydrolase, oo jabinaysa AEA
• monoacylglycerol acid lipase, oo sida caadiga ah burburisa 2-AG

Maxay yihiin shaqooyinkooda?

ECS waa mid dhib badan, khubaraduna wali ma aysan go’aamin sida saxda ah ee ay u shaqeyso ama dhammaan shaqooyinka suurtagalka ah.

wuxuu ku xiray ECS howlaha socda:

• rabitaanka cuntada iyo dheefshiidka
• dheef-shiid kiimikaad
• xanuun joogto ah
• caabuq iyo jawaabaha kale ee habka difaaca jirka
• niyadda
• barashada iyo xusuusta
• xakamaynta mootada
• seexo
• shaqada nidaamka wadnaha
• sameynta murqaha
• dib u habeynta iyo koritaanka
• shaqada beerka
• shaqada nidaamka taranka
• cadaadis
• shaqada maqaarka iyo neerfaha

Hawlahaani dhammaantood waxay gacan ka geystaan ​​homeostasis, oo loola jeedo xasiloonida deegaankaaga gudaha. Tusaale ahaan, haddii xoog dibedda ah, sida xanuun ka soo gaaray dhaawac ama qandho, ay iska tuurto homeostasis-ka jirkaaga, ECS-gaaga ayaa bilaabaya si ay uga caawiso jirkaaga inuu ku laabto hawlgalkiisii ​​ugu habboonaa.

Maanta, khubaradu waxay aaminsan yihiin dayactirka homeostasis haddii doorka koowaad ee ECS.

Sidee THC ula falgalaan ECS?

Tetrahydrocannabinol (THC) waa mid ka mid ah cannabinoids-ka ugu waaweyn ee laga helo xashiishka. Waa isku dhafka kaa dhigaya "sare."

Mar uun jirkaaga, THC wuxuu la falgalaa ECS-kaaga adoo ku xiraya qaboojiyeyaasha, sida endocannabinoids. Waa awood qayb ahaan maxaa yeelay waxay ku xidhan kartaa labadaba CB1 iyo CB2 reseptors.

Tani waxay u oggolaaneysaa inay ku yeelato waxyeelo kala duwan jirkaaga iyo maskaxdaada, qaarna aad looga jecel yahay kuwa kale. Tusaale ahaan, THC waxay kaa caawin kartaa yareynta xanuunka iyo kicinta rabitaankaaga cuntada. Laakiin sidoo kale waxay sababi kartaa jahwareer iyo walwal mararka qaarkood.

Khubarada ayaa hadda raadinaya qaabab loo soo saaro synthetic THC cannabinoids oo la falgala ECS siyaabo faa'iido leh oo keliya.

Sidee CBD ula falgashaa ECS?

Kan kale ee weyn ee cannabinoid ee laga helo cannabis waa cannabidiol (CBD). Si ka duwan THC, CBD kaama dhigayso "mid sarreeya" oo caadi ahaan ma keento wax saameyn ah oo xun.

Khubarada ayaan si buuxda u hubin sida CBD ay ula falgasho ECS. Laakiin way ogyihiin inaysan ku xirneyn CB1 ama CB2 soo dhaweeyeyaasha sida THC ay u sameyso.

Taabadalkeed, inbadan waxay rumeysan yihiin inay ku shaqeyso iyadoo laga hortagayo endocannabinoids in la jajabiyo. Tani waxay u oggolaaneysaa inay saameyn badan ku yeeshaan jirkaaga. Qaar kale waxay aaminsan yihiin in CBD ay ku xidhan tahay soo-dhowre aan weli la ogaan.

In kasta oo faahfaahinta sida ay u shaqeyso ay weli dood ka taagan tahay, cilmi baarista ayaa soo jeedinaysa in CBD ay ka caawin karto xanuunka, lallabbada, iyo astaamaha kale ee la xiriira xaalado badan.

Ka waran yaraanta endocannabinoid?

Khubarada qaar waxay aaminsan yihiin aragti loo yaqaan cillad yaraanta endocannabinoid (CECD). Aragtidan ayaa soo jeedinaysa in heerarka hoose ee endocannabinoid ee jirkaaga ama cillad la'aanta ECS ay gacan ka geysan karto horumarinta xaaladaha qaarkood.

Dib-u-eegis lagu sameeyay 10 sano oo cilmi-baaris ah oo ku saabsan mawduuca ayaa soo jeedinaysa in aragtida ay sharrax ka bixin karto sababta dadka qaar ay ugu dhacaan madax-xanuunka dhanjafka, fibromyalgia, iyo cilladda mindhicirka xanaaqa.

Xaaladahaas midkoodna malaha sababo cad oo sababa. Waxay sidoo kale badanaa iska caabbiyaan daaweynta mararka qaarkoodna way isku dhacaan.

Haddii CECD ay ka ciyaarto nooc kasta oo door ah xaaladahaas, bartilmaameedka ECS ama soo saarista endocannabinoid waxay noqon kartaa furaha maqnaanshaha daaweynta, laakiin cilmi baaris dheeraad ah ayaa loo baahan yahay.

Qeybta hoose

ECS ayaa door weyn ka ciyaareysa sidii howlahaaga gudaha ay u xasili lahaayeen. Laakiin weli wax badan oo aynaan ka ogayn ayaa jira. Maaddaama khubaradu ay horumariyaan faham wanaagsan oo ku saabsan ECS, waxay aakhirka hayn kartaa fure u daaweynta dhowr xaaladood.