Imtixaanka CPK: maxaa loogu talagalay maxaase loogu beddelay
Qanacsan
Creatinophosphokinase, oo loo yaqaan 'acronym' CPK ama CK, waa enzyme ku shaqeysa inta badan unugyada muruqyada, maskaxda iyo wadnaha, waxaana qaddarkiisa laga codsanayaa in la baaro dhaawacyada ka imaan kara xubnahan.
Dhakhtarku wuxuu amri karaa baaritaankaan marka uu qofku yimaado isbitaalka asagoo ka cabanaya xanuunka xabadka ama inuu hubiyo calaamadaha istaroogga ama cudur kasta oo muruqyada ku dhaca, tusaale ahaan.
Qiimaha tixraaca
Qiimaha tixraaca ee creatine phosphokinase (CPK) waa 32 iyo 294 U / L ragga iyo 33 illaa 211 U / L ee haweenka laakiin way kala duwanaan karaan waxayna kuxirantahay sheybaarka halka baaritaanka lagu sameeyo.
Maxaa loogu talagalay
Tijaabada loo yaqaan 'creatinophosphokinase (CPK)' waa mid waxtar leh si looga caawiyo baaritaanka cudurada sida wadno qabadka, kilyaha ama sambabka oo aan shaqeyn, iyo kuwa kale. Enzyme-kan waxaa loo qaybiyaa saddex nooc iyadoo loo eegayo halka uu ku yaal:
- CPK 1 ama BB: Waxaa laga heli karaa sambabaha iyo maskaxda, badanaa;
- CPK 2 ama MB: Waxaa laga helaa muruqa wadnaha sidaas darteedna waxaa loo isticmaali karaa calaamadee infarction, tusaale ahaan;
- CPK 3 ama MM: Waxay ku jirtaa unugyada muruqyada waxayna u taagan tahay 95% dhammaan fosfokinases-ka creatine (BB iyo MB).
Qiyaasta nooc kasta oo CK ah waxaa lagu sameeyaa habab shaybaarro kala duwan sida ay u kala yihiin iyo sida ku cad tilmaanta caafimaadka. Marka qiyaasta CPK la codsado si loo qiimeeyo infarction, tusaale ahaan, CK MB waxaa lagu cabiraa marka lagu daro astaamaha kale ee wadnaha, sida myoglobin iyo troponin, badanaa.
Qiime CK MB ah oo u dhigma ama ka yar 5 ng / mL ayaa loo arkaa inuu yahay mid caadi ah isku urursigiisuna badanaa wuu sarreeyaa haddii uu dhaco wadne qabad. Heerarka CK MB badiyaa waxay kordhiyaan 3 ilaa 5 saacadood kadib infarction-ka, waxay gaarayaan heerka ugu sareeya ilaa 24 saacadood qiimuhuna wuxuu kusoo noqonayaa caadi inta udhaxeysa 48 ilaa 72 saacadood infarction kadib. In kasta oo loo arko calaamadeeyaha wadnaha oo wanaagsan, cabbirka CK MB ee lagu ogaanayo cudurka infarction waa in si wadajir ah loogu sameeyaa troonin, badanaa sababta oo ah qiimaha troponin wuxuu caadi ku soo noqdaa 10 maalmood ka dib infarction, isagoo, sidaas darteed, ka sii gaar ah. Eeg waxa loo yaqaan 'troonin test'.
Waa maxay macnaha sare iyo hoose ee CPK
Kordhinta feejignaanta ee loo yaqaan 'creatinophosphokinase enzyme' ayaa tilmaami karta:
CPK sare | CPK hooseeya | |
CPK BB | Kala-soocid, istaroog, buro maskaxda ah, qalal, sambabka oo shaqeynaya | -- |
CPK MB | Caabuq wadnaha, dhaawaca laabta, shoogga korantada, haddii ay dhacdo kala-goynta wadnaha, qalliinka wadnaha | -- |
MM CPK | Dhaawaca burburka, jimicsiga jirka oo xoog leh, dhaqdhaqaaq dheer, isticmaalka daroogooyinka sharci darrada ah, caabuqa jirka, murqaha dystrophy, electromyography kadib | Lumida murqaha, cachexia iyo nafaqo daro |
WADARTA CPK | Qaadashada xad dhaafka ah ee cabitaanka aalkolada, iyadoo ay ugu wacan tahay isticmaalka daawooyinka sida amphotericin B, clofibrate, ethanol, carbenoxolone, halothane iyo succinylcholine oo si wada jir ah loo wada maamulo, laguna sumoobo barbiturates | -- |
Si loo sameeyo qiyaasta CPK, soonku qasab maahan, waxaana laga yaabaa ama laga yaabaa inuu takhtarku kugula taliyo, si kastaba ha noqotee waxaa muhiim ah in laga fogaado sameynta jimicsi culus jimicsiga ugu yaraan 2 maalmood kahor baaritaanka, maaddaama enzyme-kan laga yaabo inuu sare u kaco jimicsiga ka dib soo saarista muruqyada, marka lagu daro joojinta daawooyinka, sida Amphotericin B iyo Clofibrate, tusaale ahaan, maadaama ay faragelin ku sameyn karaan natiijada baaritaanka.
Haddii baaritaanka la codsado ujeedada ka dambeysa baaritaanka wadnaha, waxaa lagu talinayaa in xiriirka ka dhexeeya CPK MB iyo CPK la qiimeeyo iyadoo la adeegsanayo qaaciddada soo socota: 100% x (CK MB / CK total). Haddii natiijada xiriirkani ka badan yahay 6%, waxay tilmaam u tahay dhaawacyada muruqa wadnaha, laakiin haddii ay ka yar tahay 6%, waxay calaamad u tahay dhaawacyada muruqa lafaha, takhtarkuna waa inuu baaraa sababta.