HER2 (Kansarka Naasaha) Tijaabada

Qanacsan

• Waa maxay HER2 baaritaanka kansarka naasaha?
• Maxaa loo adeegsadaa?
• Maxaan ugu baahanahay HER2 baaritaanka kansarka naasaha?
• Maxaa dhacaya inta lagu jiro baaritaanka kansarka naasaha ee HER2?
• Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?
• Ma jiraan wax khatar ah oo imtaxaanku leeyahay?
• Maxay natiijooyinka ka dhigan yihiin?
• Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka kansarka naasaha ee HER2?
• Tixraacyo

Waa maxay HER2 baaritaanka kansarka naasaha?

HER2 waxay u taagan tahay soo-dhoweynta epidermal factor factor receptor 2. Waa hiddo sameeya borotiin laga helo dusha sare ee dhammaan unugyada naaska. Waxay ku lug leedahay koritaanka unugyada caadiga ah.

Hiddo-wadaha waa cutubyada aasaasiga ah ee dhaxalka, ee laga soo gudbiyay hooyadaa iyo aabbahaa. Kansarrada qaarkood, gaar ahaan kansarka naasaha, hiddo-wadaha HER2 wuu isbeddelaa (wuuna isbeddelaa) wuxuuna sameeyaa nuqulo dheeri ah oo ku saabsan hidda-wadaha. Markay taasi dhacdo, hiddo-wadaha HER2 wuxuu sameeyaa borotiin aad u tiro badan oo HER2 ah, taasoo keenta in unugyadu kala-baxaan oo ay dhaqso u koraan.

Kansarrada leh heerar sare ee borotiinka HER2 waxaa loo yaqaan HER2-positive. Kansarrada leh heerarka hoose ee borotiinka waxaa loo yaqaan HER2-negative. Qiyaastii boqolkiiba 20 kansarka naasaha waa HER2-positive.

Baaritaanka HER2 wuxuu eegaa muunad ka mid ah unugyada burooyinka. Siyaabaha ugu badan ee lagu baaro unugyada burooyinka ayaa ah:

• Immunohistochemistry (IHC) baaritaanka wuxuu cabiraa borotiinka HER2 dusha sare ee unugyada
• Fluorescence in situation hybridization (FISH) baaritaanka wuxuu raadinayaa nuqulo dheeri ah oo ku saabsan hidda-wadaha HER2

Labada nooc ee baadhitaano ah ayaa kuu sheegi kara inaad qabtid cudurka kansarka ee HER2. Daawooyinka si gaar ah u bartilmaameedsada kansarka naasaha ee HER2 oo leh waxtar badan.

Magacyada kale: Cunsurka epidermal koritaanka cunsuriyaha 2, Kordhinta ERBB2, HER2 si xad dhaaf ah, HER2 / neu tests

Maxaa loo adeegsadaa?

Baaritaanka HER2 waxaa badanaa loo isticmaalaa in lagu ogaado in kansarku yahay HER2-positive. Waxaa sidoo kale mararka qaarkood loo isticmaalaa in lagu arko haddii kansarku uu ka jawaabayo daaweynta ama haddii kansarku soo laabtay daaweynta ka dib.

Maxaan ugu baahanahay HER2 baaritaanka kansarka naasaha?

Haddii lagaa helay kansarka naasaha, waxaad u baahan kartaa baaritaankaan si loo ogaado haddii kansarkaagu yahay HER2-positive ama HER2-diidmo. Haddii lagaa daaweynayo kansarka naasaha ee HER2-positive, waxaad u baahan kartaa baadhitaankan si aad:

• Ogow haddii daaweyntaadu shaqeyneyso. Heerarka caadiga ah ee HER2 ayaa laga yaabaa inay macnaheedu tahay inaad ka jawaabeyso daaweynta. Heerarka sare ayaa laga yaabaa inay macnaheedu tahay in daaweyntu aysan shaqeyneyn.
• Ogow haddii kansarku soo noqday daaweynta ka dib.

Maxaa dhacaya inta lagu jiro baaritaanka kansarka naasaha ee HER2?

Badi baaritaanka HER2 wuxuu ku lug leeyahay qaadista muunad ka mid ah unugyada burooyinka hab loo yaqaan 'biopsy'. Waxaa jira saddex nooc oo hababka dheecaanka cad ka soo baxa ah:

• Cad ka-qaadista cirbadda wanaagsan, kaas oo isticmaala cirbad aad u khafiif ah si looga qaado saamiga unugyada naaska ama dareeraha
• Cad ka-qaadista irbadda kaas oo isticmaala irbad ka weyn si looga qaado muunad
• Cad ka-qaadista qalliinka, kaas oo ka qaadaya muunad hawl yar oo bukaan socod socod ah

Himilada cirbadda wanaagsan iyo ka-qaadista cirbadda laf-dhabarka badanaa ku dar talaabooyinka soo socda:

• Waxaad u jiifsan doontaa dhinacaaga ama waxaad ku fariisan doontaa miiska imtixaanka.
• Bixiye daryeel caafimaad ayaa nadiifin doona goobta ka-soo-qaadista lagaa qaadayo oo lagu duray suuxdinta si aanad u dareemin wax xanuun ah inta lagu jiro hawsha.
• Marka aaggu kabuubyo, bixiyaha ayaa galin doona irbad himilo wanaagsan ama irbadda xinjirowga lafdhabarta ah ee goobta baaritaanka lagana qaadayo qayb unug ama dheecaan ah.
• Waxaad dareemi kartaa xoogaa cadaadis ah markii tijaabada lagaa qaadayo.
• Cadaadis ayaa lagu dhejin doonaa goobta cad ka-qaadista illaa dhiiggu joogsanayo.
• Bixiyahaaga ayaa ku dhajin doona faashad aan nadiif aheyn goobta baaritaanka.

Biyobsiga qalliinka, dhakhtar qalliin ayaa maqaarkaaga ka jari doona xoogaa yar si looga saaro dhammaan ama qayb ka mid ah buruqda naaska. Cad ka-qaadista qalliinka waxaa mararka qaarkood la sameeyaa haddii buruqda aan lagu gaari karin ka-qaadista cirbadda. Cad ka-qaadista qalliinka badanaa waxaa ku jira tallaabooyinka soo socda.

• Waxaad ku seexan doontaa miiska qalliinka. IV (xarig xidid ah) ayaa lagaa saari karaa gacantaada ama gacantaada.
• Waxaa laga yaabaa in lagu siiyo daawo, oo loo yaqaan dajin, si ay kaaga caawiso inaad isdejiso.
• Waxaa lagu siin doonaa suuxdinta maxalliga ah ama guud ahaan si aadan u dareemin xanuun inta howshu socoto.
  • Suuxdinta maxalliga ah, bixiye daryeel caafimaad ayaa ku duraya goobta biopsiga daawo si loo kabuubiyo aagga.
  • Suuxdinta guud, takhasusle loo yaqaan takhtarka suuxinta ayaa ku siin doona daawo si aad u miyir beesho inta hawshu socoto.
• Marka aagga cad ka-qaadista la kabuubyo ama aad suuxdo, dhakhtarka qalliinka ayaa xoogaa naasaha ka goyn doona oo ka saari doona qayb ama dhammaan buro. Cadka qaar ku wareegsan buruqda ayaa waliba la soo saari karaa.
• Joogitaanka maqaarkaaga waxaa lagu xiri doonaa tolmo ama xarigyo dhejis ah.

Nooca biopsy ee lagaa qaadayo wuxuu ku xirnaan doonaa arrimo kala duwan, oo ay ku jiraan cabirka iyo meesha buroku ku taal. HER2 sidoo kale waa lagu cabiri karaa dhiig baaris, laakiin baaritaanka dhiiga ee HER2 lama cadeyn inuu waxtar u leeyahay bukaanada badankood. Markaa badanaa laguma talin.

Ka dib marka lagaa qaado saamiga unuggaaga, waxaa lagu tijaabin doonaa laba hab midkood:

• Heerarka borotiinka HER2 waa la cabirayaa.
• Muunada waxaa la eegi doonaa nuqulo dheeri ah oo ku saabsan hidda-wadaha HER2.

Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?

Uma baahnid wax diyaargarow ah oo gaar ah haddii aad ku suuxinaysid maxalliga ah (kabuubinta goobta qalliinka). Haddii aad qaadanayso suuxdinta guud, waxaad u baahan tahay inaad soonto (ha cunin ama cabin) dhowr saacadood qalliinka ka hor. Dhakhtarkaaga qalliinka ayaa ku siin doona tilmaamo gaar ah oo dheeraad ah. Sidoo kale, haddii aad qaadanayso suuxdin ama suuxdin guud, hubi inaad diyaarsato qof guriga kuugu kaxeeya. Waxaa laga yaabaa inaad tahay qof culeys badan oo wareersan ka dib markaad ka soo kacdo hawsha.

Ma jiraan wax khatar ah oo imtaxaanku leeyahay?

Waxaa laga yaabaa inaad waxoogaa nabar ama dhiig ah ku yeelatid goobta lagaa qaadayo. Mararka qaarkood goobta ayaa qaadsiisa. Haddii taasi dhacdo, waxaa lagugu daaweyn doonaa antibiyootiko. Cad ka-qaadista qalliinka waxay sababi kartaa xoogaa xanuun iyo raaxo-darro ah. Bixiyaha xanaanada caafimaadkaaga ayaa kugula talin kara ama kuu qori kara daawo kaa caawineysa inaad fiicnaato.

Khatar aad u yar baa jirta in dhiig lagaa qaado. Waxaa laga yaabaa inaad xanuun yar ama nabar ku yeelato barta irbadda lagu muday, laakiin astaamaha badankood si dhakhso leh ayey u baxaan.

Maxay natiijooyinka ka dhigan yihiin?

Haddii heerarka borotiinka HER2 ay ka sarreeyaan caadiga ama nuqullo dheeri ah oo hiddo-wadaha HER2 la helo, waxay u badan tahay inay ka dhigan tahay inaad qabtid kansarka HER2-positive. Haddii natiijooyinkaagu muujiyaan xaddiga caadiga ah ee borotiinka HER2 ama hidde-sideyaasha caadiga ah ee HER2, waxaad u badan tahay inaad qabto kansarka HER2-taban.

Haddii natiijooyinkaagu aysan si cad u fiicnayn ama aan fiicnayn, waxaa suuragal ah in dib lagugu tijaabiyo, adigoo isticmaalaya muunad buro kala duwan ama qaab tijaabo ah oo ka duwan. Badanaa, IHC (baaritaanka borotiinka HER2) waa la sameeyaa marka hore, waxaana ku xiga FISH (baaritaanka nuqulada dheeraadka ah ee hidda-wadaha). Imtixaanka IHC wuu ka qaalisan yahay wuxuuna bixiyaa natiijooyin ka dhakhso badan kalluunka. Laakiin inta badan khubarada naaska waxay u maleynayaan baaritaanka FISH inuu ka saxsan yahay.

Daaweynta kansarka naasaha ee HER2-positive waxay si weyn u yareyn kartaa burooyinka kansarka, oo leh waxyeelo aad u yar. Daawooyinkani waxtar uma leh kansarka HER2-taban.

Haddii lagaa daweynayo kansarka HER2-positive, natiijooyinka caadiga ah waxay noqon karaan inay ka jawaabayaan daaweynta. Natiijooyinka muujiya qaddar ka badan inta caadiga ah waxay macnaheedu noqon karaan in daaweyntaadu shaqeynaynin, ama in kansarku soo noqday daaweyn ka dib.

Wax badan ka baro baaritaanka shaybaarka, kala duwanaanshaha tixraaca, iyo fahamka natiijooyinka.

Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka kansarka naasaha ee HER2?

In kasta oo ay aad ugu badan tahay dumarka, haddana kansarka naasaha, oo ay ku jiraan kansarka naasaha ee HER2-positive, sidoo kale wuu ku dhici karaa ragga. Haddii nin laga helay kansarka naasaha, baaritaanka HER2 ayaa lagula talin karaa.

Intaas waxaa sii dheer, ragga iyo dumarkuba waxay u baahan karaan baaritaanka HER2 haddii laga helay kansarrada qaarkood ee caloosha iyo hunguriga. Kansarradan mararka qaarkood waxay leeyihiin heerar sare oo ah borotiinka HER2 waxaana laga yaabaa inay si fiican uga jawaabaan daaweynta kansarka HER2-ee wanaagsan.

Tixraacyo

1. Bulshada Kansarka Mareykanka [Internet]. Atlanta: American Cancer Society Inc.; c2018. Cad ka-qaadista naasaha [cusbooneysiiyay 2017 Oct 9; daliishaday 2018 Aug 11]; [ilaa 4 shaashadood]. Waxaa laga heli karaa: https://www.cancer.org/cancer/breast-cancer/screening-tests-and-early-detection/breast-biopsy.html
2. Bulshada Kansarka Mareykanka [Internet]. Atlanta: American Cancer Society Inc.; c2018. Xaaladda Kansarka Naasaha HER2 [cusbooneysiiyay 2017 Sep 25; daliishaday 2018 Aug 11]; [ilaa 4 shaashadood]. Waxaa laga heli karaa: https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancer-diagnosis/breast-cancer-her2-status.html
3. Naas-nuujinta.org [Internet]. Ardmore (PA): Naas-nuujinta.org; c2018. Xaaladda HER2 [la cusboonaysiiyay 2018 Feb 19; daliishaday 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.breastcancer.org/symptoms/diagnosis/her2
4. Cancer.net [Internet]. Alexandria (VA): Bulshada Mareykanka ee Clinical Oncology; c2005–2018. Kansarka Naasaha: Cilad-sheegista; 2017 Apr [daliishaday 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.cancer.net/cancer-types/breast-cancer/diagnosis
5. Cancer.net [Internet]. Alexandria (VA): Bulshada Mareykanka ee Clinical Oncology; c2005–2018. Kansarka Naasaha: Hordhac; 2017 Apr [daliishaday 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.cancer.net/cancer-types/breast-cancer/introduction
6. Johns Hopkins Medicine [Internetka]. Jaamacadda Johns Hopkins; Maktabadda Caafimaadka: Kansarka Naasaha: Darajooyinka iyo Marxaladaha [la soo xigtay 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/breast_health/breast_cancer_grades_and_stages_34,8535-1
7. Tijaabooyinka Shaybaarka ee Internetka [Internetka] Washington D.C; Ururka Mareykanka ee Kiimikada Caafimaadka; c2001–2018. HER2 [cusbooneysiiyay 2018 Jul 27; daliishaday 2018 Aug 11]; [ilaa 2 shaashad]. Waxaa laga heli karaa: https://labtestsonline.org/tests/her2
8. Mayo Clinic [Internet]. Aasaaska Mayo ee Caafimaadka Caafimaadka iyo Cilmi-baarista; c1998–2018. Cad ka-qaadista naasaha: Ku saabsan 2018 Mar 22 [la xusay 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.mayoclinic.org/tests-procedures/breast-biopsy/about/pac-20384812
9. Mayo Clinic [Internet]. Aasaaska Mayo ee Caafimaadka Caafimaadka iyo Cilmi-baarista; c1998–2018. Suuxdinta Guud: Ku saabsan; 2017 Dec 29 [daliishaday 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.mayoclinic.org/tests-procedures/anesthesia/about/pac-20384568
10. Mayo Clinic [Internet]. Aasaaska Mayo ee Caafimaadka Caafimaadka iyo Cilmi-baarista; c1998–2018. HER2-kansarka naasaha oo wanaagsan: waa maxay ?; 2018 Mar 29 [daliishaday 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.mayoclinic.org/breast-cancer/expert-answers/faq-20058066
11. Mayo Clinic: Mayo Laboratories [Internet]. Aasaaska Mayo ee Caafimaadka Caafimaadka iyo Cilmi-baarista; c1995–2018. Aqoonsiga Tijaabada: HERDN: HER2, Naaska, DCIS, Tiro-koob Immunohistochemistry, Buug No Reflex: Rug Caafimaad iyo Tarjumaad [la sheegay 2018 Aug 11]; [ilaa 4 shaashadood]. Waxaa laga heli karaa: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/71498
12. Xarunta Kansarka MD Anderson [Internet]. Jaamacadda Texas ee Xarunta Kansarka ee Anderson; c2018. Kansarka Naasaha [daliishaday 2018 Aug 11]; [ilaa 4 shaashadood]. Waxaa laga heli karaa: https://www.mdanderson.org/cancer-types/breast-cancer.html
13. Memorial Sloan Kettering Xarunta Kansarka [Internet]. New York: Xarunta Kansarka ee Memorial Sloan Kettering; c2018. Maxaad Ka Baahan Tahay Inaad Ka Ogaato Kansarka Naasaha ee Metastatic; 2016 Oktoobar 27 [daliishaday 2018 Ogos 11]; [ilaa 4 shaashadood]. Waxaa laga heli karaa: https://www.mskcc.org/blog/what-you-should-know-about-metastatic-breast
14. Nooca Merck Manual Consumer Version [Internet]. Kenilworth (NJ): Merck & Co., Inc.; c2018. Kansarka Naasaha [daliishaday 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.merckmanuals.com/home/women-s-health-issues/breast-disorders/breast-cancer
15. Aasaaska Kansarka Naasaha ee Qaranka [Internet]. Frisco (TX): Hay'adda National Cancer Foundation Inc.; c2016. Tijaabooyinka Shaybaarka [xigasho 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.nationalbreastcancer.org/breast-cancer-lab-tests
16. Machadka Wadnaha, Sambabka, iyo Machadka Dhiiga [Internet]. Bethesda (MD): Waaxda Caafimaadka iyo Adeegyada Aadanaha ee Mareykanka; Tijaabooyinka Dhiigga [la sheegay 2018 Aug 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.nhlbi.nih.gov/health-topics/blood-tests
17. Machadka Kansarka Qaranka [Internet]. Bethesda (MD): Waaxda Caafimaadka iyo Adeegyada Aadanaha ee Mareykanka; Qaamuuska NCI ee Shuruudaha Kansarka: hiddo-wade [xigasho 2018 Agoosto 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
18. Machadka Kansarka Qaranka [Internet]. Bethesda (MD): Waaxda Caafimaadka iyo Adeegyada Aadanaha ee Mareykanka; Qaamuuska NCI ee Shuruudaha Shuruudaha Kansarka: Imtixaanka HER2 [xigasho 2018 Agoosto 11]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=HER2
19. Jaamacadda Rochester Medical Center [Internet]. Rochester (NY): Jaamacadda Rochester Medical Center; c2018. Encyclopedia Caafimaadka: HER2 / neu [oo lagu xusay 2018 Aug 11]; [ilaa 2 shaashad].Waxaa laga heli karaa: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=her2neu

Macluumaadka ku yaal boggan waa in aan loo isticmaalin beddel daryeel caafimaad oo xirfad leh ama talo. La xiriir bixiye daryeel caafimaad haddii aad su'aalo ka qabtid caafimaadkaaga.