Dawooyinka Coronavirus (COVID-19): waa la oggolaaday oo daraasad ayaa lagu jiraa

Qanacsan

• Daawooyinka la ansixiyay ee coronavirus
• Daawooyinka la baranayo
• 1. Ivermectin
• 2. Plitidepsin
• 3. Dib-u-habeyn
• 4. Dexamethasone
• 5. Hydroxychloroquine iyo chloroquine
• 6. Colchicine
• 7. Mefloquine
• 8. Tocilizumab
• 9. Plasma-ka qanjirka 'Convalescent'
• 10. Avifavir
• 11. Baricitinib
• 12. EXO-CD24
• Fursadaha daaweynta dabiiciga ee coronavirus

Waqtigan xaadirka ah, ma jiraan dawooyin la yaqaan oo awood u leh inay jirka ka baabi'iyaan coronavirus-ka cusub, sababtaas awgeed, xaaladaha badankood, daaweynta waxaa lagu sameeyaa oo keliya dhowr tallaabo iyo daawooyin awood u leh yareynta calaamadaha COVID-19.

Kiisaska fudud, oo leh astaamo la mid ah hargabka caadiga ah, waxaa guriga loogu daaweyn karaa nasasho, fuuq-celin iyo isticmaalka daawooyinka qandhada iyo xanuun joojiyaha. Xaaladaha ugu halista badan, ee ay ka muuqdaan astaamaha iyo dhibaatooyinka daran sida oof wareenka, ayaa loo baahan yahay in lagu daaweeyo markii isbitaalka la dhigo, inta badanna Qaybaha Daryeelka Degdegga ah (ICU), si loo hubiyo, gaar ahaan, maamulka ku filan ee oksijiinta iyo kormeerka calaamadaha muhiimka ah.

Eeg faahfaahin dheeraad ah oo ku saabsan daaweynta COVID-19.

Daroogooyinka ka sokow, qaar ka mid ah tallaallada ka dhanka ah COVID-19 ayaa sidoo kale la darsaa, la soo saaraa lana qaybiyaa. Tallaalladaani waxay ballan qaadayaan inay ka hortagaan infekshinka COVID-19, laakiin waxay sidoo kale u muuqdaan inay yareynayaan xoojinta calaamadaha markii uu infekshanku dhaco. Si fiican ayaa loo fahmayaa tallaallada ka dhanka ah COVID-19 ee jira, sida ay u shaqeeyaan iyo dhibaatooyinka ka imaan kara.

Daawooyinka la ansixiyay ee coronavirus

Daawooyinka loo oggol yahay daaweynta coronavirus, ee Anvisa iyo Wasaaradda Caafimaadka, ay yihiin kuwa karti u leh yareynta astaamaha cudurka, sida:

• Antipyretics: si loo yareeyo heerkulka oo loola dagaallamo qandhada;
• Xanuun joojiyeyaasha: si loo yareeyo murqaha xanuunka jirka oo dhan;
• Antibiyootikada: in lagu daaweeyo infekshannada bakteeriyada ee suurtogalka ah ee ka soo bixi kara COVID-19.

Daawooyinkan waa in loo adeegsadaa kaliya hagista dhaqtarka, inkasta oo loo ogolaaday daaweynta coronavirus-ka cusub, ma awoodaan inay ka tirtiraan fayraska jirka, laakiin waxaa kaliya loo isticmaalaa in lagu yareeyo astaamaha laguna hagaajiyo raaxada qofka cudurka qaba.

Daawooyinka la baranayo

Daawooyinka ka caawiya yareynta astaamaha ka sokow, dhowr waddan ayaa horumarinaya daraasado ku saabsan xayawaanka shaybaarka iyo bukaannada cudurka qaba si ay isugu dayaan inay aqoonsadaan dawo jirka ka tirtiri karta.

Daawooyinka la darsayo waa in aan loo isticmaalin hagitaan dhakhtar, ama hab looga hortago infekshinka, maadaama ay sababi karaan waxyeelo kala duwan oo nolosha halis gelin kara.

Liiska soo socda ayaa ah dawooyinka ugu waaweyn ee loo baranayo coronavirus-ka cusub:

1. Ivermectin

Ivermectin waa vermifuge loogu talagalay daaweynta cayayaanka dulinka, taas oo keenta dhibaatooyin sida onchocerciasis, elephantiasis, pediculosis (injirta), ascariasis (wareega wareega), isnadaamiska ama mindhicirka xoog lehyloidiasis oo, dhawaanahan, ay muujisay natiijooyin aad u wanaagsan oo ku saabsan ciribtirka ciribtirka fayruus cusub Corona, ku jira fitamiin.

Daraasad lagu sameeyay Australia, ayaa lagu baaray ivermectin shaybaarka, dhaqamada unugyada ku jira fitamiin, waxaana la ogaaday in maaddadani ay awood u leedahay inay ku baabiiso fayraska SARS-CoV-2 48 saacadood gudahood ^[7]. Si kastaba ha noqotee, tijaabooyinka caafimaad ee aadanaha ayaa loo baahan yahay si loo xaqiijiyo waxtarkeeda in vivo, iyo sidoo kale qiyaasta daaweynta iyo badbaadada daawada, taas oo la filayo inay dhacdo muddo u dhexeysa 6 ilaa 9 bilood.

Intaa waxaa dheer, daraasad kale ayaa muujisay in isticmaalka ivermectin ee bukaanada laga helay COVID-19 ay ka dhigan tahay halista hoos u dhaca dhibaatooyinka iyo horumarka cudurka, taasoo muujineysa in ivermectin uu horumarin karo saadaasha cudurka. ^[33]. Isla mar ahaantaana, daraasad laga sameeyay Bangladesh ayaa muujisay in isticmaalka ivermectin (12 mg) muddo 5 maalmood ah ay waxtar iyo ammaan ku tahay daaweynta COVID-19 ^[34].

Bishii Nofeembar 2020 ^[35] mala-awaalka cilmi-baarayaasha Hindida ee ah in ivermectin uu awood u yeelan doono inuu fara-gelin ku sameeyo u-qaadista fayraska unugga unugyada, ka-hortagga horumarka cudurka, waxaa lagu daabacay joornaal saynis ah, hase yeeshe saameyntan waxay ku suurta geli doontaa oo keliya qaddarrada sare ee ivermectin, oo sun ku noqon kara noolaha aadanaha.

Daraasad kale oo la sii daayay Diisambar 2020 ^[36] waxay kaloo muujisay in adeegsiga nanoparticles-ka ay ku jirto ivermectin ay hoos u dhigi karto muujinta unugyada 'AcE2 receptors', taasoo hoos u dhigaysa suurtagalnimada in fayrasku ku xirnaado qabtayaashan oo uu keeno infekshan. Si kastaba ha noqotee, daraasaddan waxaa lagu sameeyay kaliya fitamiinada, suurtagalna maaha in la sheego in natiijadu ay isku mid noqon doonto vivo. Intaa waxaa dheer, maadaama tani ay tahay qaab daaweyn cusub, daraasadaha sunta ayaa lagama maarmaan ah.

In kasta oo natiijooyinkani jiraan, daraasado dheeraad ah ayaa loo baahan yahay si loo muujiyo waxtarka ivermectin ee daaweynta COVID-19, iyo sidoo kale saameynta ay ku leedahay ka-hortagga infekshinka. Arag wax badan oo ku saabsan isticmaalka ivermectin ee ka dhanka ah COVID-19.

Julaay 2, 2020 Cusboonaysiinta:

Golaha Farmashiyaha Gobolka São Paulo (CRF-SP) ayaa sii daayay qoraal farsamo ^[20] taas oo ay ku qoran tahay in daawada ivermectin ay muujineyso ficil ka hortagga fayraska qaar ka mid ah daraasadaha in-vitro, laakiin baaritaanno dheeri ah ayaa loo baahan yahay si loo tixgeliyo in ivermectin si badbaado leh loogu adeegsan karo aadanaha ka hortagga COVID-19.

Sidaa darteed, wuxuu kula talinayaa in iibinta ivermectin ay tahay in lagu sameeyo oo keliya soo bandhigida rijeeto caafimaad iyo inta lagu guda jiro qiyaasaha iyo waqtiyada uu dhakhtarku faray.

Luulyo 10, 2020 Cusboonaysiinta:

Sida ku cad qoraal cadeyn ah oo ay sii deysay ANVISA ^[22], Ma jiraan daraasado gunaanad ah oo cadeynaya isticmaalka ivermectin ee daaweynta COVID-19, iyo isticmaalka daroogada si loogu daaweeyo infekshinka cusub ee coronavirus waa inay masuuliyadeeda leedahay dhakhtarka hagaya daaweynta.

Intaa waxaa dheer, natiijooyinkii ugu horreeyay ee ay soo saartay daraasad uu sameeyay machadka USP ee Sayniska Biyomediga (ICB) ^[23], Muuji in ivermectin, in kasta oo uu awood u leeyahay inuu fayraska ka baabi’iyo unugyada cudurka ku haya shaybaarka, sidoo kale wuxuu sababaa dhimashada unugyadan, taas oo tilmaamaysa in daawadani aysan noqon karin xalka daaweynta ugu fiican.

Cusboonaysii Diseembar 9, 2020:

Dukumiinti ay soo saartay bulshada reer Brazil ee cudurada faafa (SBI) ^[37] waxaa la tilmaamay in aysan jirin talo bixin hore oo daawo iyo daawo daaweyn ah oo loogu talagalay COVID-19 oo leh daawo kasta, oo ay ku jirto ivermectin, maadaama daraasadihii caafimaad ee la kala soocay ee ilaa hadda la sameeyay aysan tilmaamaynin waxtarrada iyo, iyadoo ku xiran xaddiga, ee la isticmaalay, laga yaabo lala xiriiriyo waxyeelo saameyn ku yeelan karta caafimaadka guud ee qofka.

Cusboonaysii Febraayo 4, 2021:

Merck, oo ah shirkadda dawooyinka ee mas'uulka ka ah soo saarista daawada Ivermectin, ayaa tilmaamtay in daraasadaha la sameeyay aysan aqoonsan wax caddeyn cilmi ah oo tilmaamaya awoodda daaweynta ee daawadan ee ka dhanka ah COVID-19, sidoo kale ma aysan cadeynin saameynta bukaanka. hore looga helay cudurka.

2. Plitidepsin

Plitidepsin waa daawo kahortaga burooyinka oo ay soo saarto sheybaar Isbaanish ah oo loogu talagalay daaweynta xaaladaha qaarkood ee myeloma badan, laakiin sidoo kale saameyn xoog leh oo anti-virus ah ku leh coronavirus-ka cusub.

Sida laga soo xigtay daraasad lagu sameeyay Maraykanka ^[39], plitidepsin wuxuu awooday inuu yareeyo culeyska fayraska ee coronavirus ilaa 99% sanbabada jiirka sheybaarka qaba COVID-19. Baarayaasha ayaa qiil ka bixinaya guusha daroogada ay u leedahay inay xakameyso borotiinka ku jira unugyada taas oo muhiim u ah fayrasku inuu ku tarmo kuna faafo jirka oo dhan.

Natiijooyinkan, oo ay weheliso xaqiiqda ah in daroogada mar horeba loo isticmaalay aadanaha si loogu daaweeyo myeloma badan, waxay soo jeedinayaan in daroogadu ay suurtagal tahay in lagu baaro bukaanada aadanaha ee qaba COVID-19. Sidaa darteed, waa lagama maarmaan in la sugo natiijada baaritaanadan caafimaad si loo fahmo qiyaasta iyo sunta suurtagalka ah ee daroogada.

3. Dib-u-habeyn

Kani waa daawada fayraska looga hortago ee loo yaqaan 'virus-virus' oo loo sameeyay in lagu daaweeyo cudurka faafa ee Ebola, laakiin ma uusan helin natiijooyin wax ku ool ah sida walxaha kale. Si kastaba ha noqotee, ficilkeeda ballaaran ee ka dhanka ah fayrasyada, waxaa loo baranayaa si loo fahmo haddii ay soo bandhigi karto natiijooyin wanaagsan oo ku saabsan ciribtirka fayraska cusub ee coronavirus.

Daraasadihii ugu horreeyay ee lagu sameeyo shaybaarka dawadan, labadaba Maraykanka ^{[1] [2]}, sida Shiinaha oo kale ^[3], waxay muujisay saameyn wax ku ool ah, maaddaama maadadu awood u yeelatay inay ka hortagto taranka iyo isku dhufashada cusub ee coronavirus, iyo sidoo kale fayrasyada kale ee qoyska coronavirus.

Si kastaba ha noqotee, ka hor intaan lagula talin karin qaab daaweyn ah, daawadani waxay u baahan tahay in la maro daraasado dhowr ah oo lala yeesho bini-aadamka, si loo fahmo waxtarkeeda iyo nabadgelyadeeda dhabta ah. Sidaa darteed, waxaa jira, waqtigan, illaa 6 daraasadood oo lagu fulinayo tiro aad u tiro badan oo bukaan ah oo uu ku dhacay COVID-19, labadaba Mareykanka, Yurub iyo Japan, laakiin natiijooyinka waa in la sii daayaa oo keliya Abriil , xilligan la joogo, ma jirto wax caddayn ah in Remdesivir, dhab ahaantii, si ammaan ah loogu isticmaali karo si looga takhaluso coronavirus-ka cusub ee aadanaha.

Abriil 29, 2020 Cusboonaysiinta:

Sida laga soo xigtay baadhitaan ay sameeyeen sayniska Gilead ^[8], Maraykanka gudihiisa, isticmaalka Remdesivir ee bukaanada qaba COVID-19 waxay umuuqdaan inay soo bandhigayaan isla natiijooyinka muddada daaweynta 5 ama 10 maalmood, labada xaaladoodna bukaanada waxaa laga saaray isbitaalka qiyaastii 14 maalmood iyo dhinaca dhacdooyinka saameyntu sidoo kale way hooseysaa. Daraasadani ma muujineyso heerka waxtarka daroogada si looga takhaluso coronavirus-ka cusub sidaas darteedna, daraasado kale ayaa wali la sameynayaa.

Laga yaabaa 16, 2020 Cusboonaysiinta:

Daraasad lagu sameeyay Shiinaha oo ku saabsan 237 bukaan ah oo saameyn daran ku yeeshay cudurka COVID-19 ^[15] ayaa soo wariyay in bukaanada lagu daweeyay dawadan ay muujiyeen soo kabasho wax yar ka dhaqso badan marka loo eego bukaanada gacanta ku haya, celcelis ahaan 10 maalmood marka la barbar dhigo 14 maalmood ee ay soo bandhigeen kooxdii lagu daaweeyay placebo.

Cusboonaysii May 22, 2020:

Warbixinta hordhaca ah ee baaritaanka kale ee lagu sameeyay Mareykanka ee Remdesivir ^[16] sidoo kale wuxuu tilmaamay in adeegsiga dawadan ay umuuqato inay yareyneyso waqtiga soo kabashada dadka qaangaarka ah ee isbitaalada jiifa, iyo sidoo kale inay yareyso halista infekshinka mareenka hoose.

Cusboonaysii July 26, 2020:

Sida lagu sheegay daraasad ay samaysay Dugsiga Caafimaadka Bulshada ee Jaamacadda Boston ^[26], Remdesivir wuxuu yareeyaa waqtiga daaweynta bukaanka la dhigey ICU.

Nofeembar 5, 2020 Cusboonaysiinta:

Warbixinta ugu dambeysa ee daraasadda lagu sameynayo Mareykanka ee Remdesivir waxay muujineysaa in isticmaalka daawadani ay, dhab ahaantii, yareyneyso celceliska waqtiga soo kabashada ee dadka waaweyn ee isbitaalka la dhigay, laga bilaabo 15 illaa 10 maalmood. ^[31].

Nofeembar 19, 2020 Cusboonaysiinta:

Hay'adda FDA ee dalka Mareykanka ayaa soo saartay rukhsad deg-deg ah ^[32] kaas oo u oggolaanaya isku darka isticmaalka Remdesivir daawada Baricitinib, ee daaweynta bukaannada qaba infekshinka daran ee coronavirus iyo u baahan oksijiin ama hawo.

Nofeembar 20, 2020 Cusboonaysiinta:

WHO ayaa kula talisay isticmaalka Remdesivir daaweynta bukaan jiifka COVID-19 sababo la xiriira la'aanta xog dhameystiran oo muujineysa in Remdesivir ay hoos u dhigeyso heerka dhimashada.

4. Dexamethasone

Dexamethasone waa nooc ka mid ah daawada loo yaqaan 'corticosteroid' oo si weyn loogu isticmaalo bukaanada qaba dhibaatooyinka neef mareenka ee joogtada ah, sida neefta, laakiin sidoo kale waxaa loo isticmaali karaa dhibaatooyinka kale ee caabuqa, sida arthritis ama maqaarka oo barara. Daawadan waxaa loo tijaabiyay hab lagu yareeyo astaamaha COVID-19, maadaama ay kaa caawin karto yareynta caabuqa jirka.

Sida ku cad daraasad laga sameeyo dalka Ingiriiska ^[18], dexamethasone waxay umuuqataa inay tahay daroogada uguhoreysa ee la baaray si aad hoos ugu dhigto heerka dhimashada bukaanada aadka u xanuunsan ee qaba COVID-19. Marka la eego natiijooyinka daraasadda, dexamethasone waxay ku guuleysatay inay yareyso heerka dhimashada illaa 28 maalmood ka dib markii uu ku soo booday cudurka cusub ee loo yaqaan 'coronavirus', gaar ahaan dadka u baahan in laga caawiyo hawo-haye ama ay maamulaan oksijiinta.

Waa muhiim in la xasuusnaado in dexamethasone uusan ka baabi'inaynin jirka coronavirus, kaliya wuxuu caawiyaa inuu yareeyo astaamaha iyo inuu ka fogaado dhibaatooyinka ka sii daran.

Juun 19, 2020 Cusboonaysiinta:

Bulshada reer Brazil ee cudurada faafa waxay ku taliyeen in la isticmaalo dexamethasone mudo 10 maalmood ah si loogu daaweeyo dhamaan bukaanada qaba COVID-19 ee la dhigey ICU iyadoo leh hawo farsamo ama kuwa u baahan inay helaan oksijiin. Si kastaba ha noqotee, corticosteroids looma isticmaali karo kiisaska khafiifka ah ama qaab looga hortago infekshinka ^[19].

Cusboonaysii Luulyo 17, 2020:

Sida lagu sheegay cilmi baaris cilmiyeed oo laga sameeyay Boqortooyada Ingiriiska ^[24], daaweynta dexamethasone 10 maalmood oo isku xigta waxay umuuqataa inay yareyneyso heerka dhimashada bukaannada qaba infekshin aad u daran oo ay qaadaan coronavirus-ka cusub, oo ubaahan hawo-mareenka. Xaaladahaas, heerka dhimashada waxay umuuqataa inay hoos uga dhacayso 41.4% ilaa 29.3%. Bukaanada kale, saameynta daaweynta dexamethasone ma muujin natiijooyin calaamadeysan.

Cusboonaysii Sebtember 2, 2020:

Falanqeyn meta ah oo ku saleysan 7 tijaabooyin caafimaad ^[29] waxay ku soo gabagabeeyeen isticmaalka dexamethasone iyo corticosteroids kale, runti, waxay yareyn karaan dhimashada bukaanka halista ah ee qaba COVID-19.

Cusboonaysii Sebtember 18, 2020:

Wakaaladda dawooyinka Yurub (EMA) ^[30] ansixiyay isticmaalka dexamethasone ee daaweynta dhalinyarada iyo dadka waaweyn ee uu ku dhacay coronavirus-ka cusub, ee u baahan taageerada oksijiinta ama hawo farsamaynta.

5. Hydroxychloroquine iyo chloroquine

Hydroxychloroquine, iyo sidoo kale chloroquine, waa laba walxood oo loo isticmaalo daaweynta bukaanka qaba duumada, lupus iyo dhibaatooyin caafimaad oo kale oo gaar ah, laakiin aan weli loo arkin inay badbaado u yihiin dhammaan kiisaska COVID-19.

Daraasad lagu sameeyay Faransiiska ^[4] iyo Shiinaha ^[5], wuxuu muujiyey saamayn rajo leh oo ka mid ah chloroquine iyo hydroxychloroquine si loo yareeyo culeyska fayraska loona yareeyo u gudbinta fayraska unugyada, iyadoo la yareynayo awoodda fayrasku ku tarmi karo, iyadoo la siinayo, sidaas darteed, soo kabasho dhakhso leh. Si kastaba ha noqotee, daraasadahaan waxaa lagu sameeyay shaybaarro yar yar oo imtixaannada oo dhami ma ahayn kuwo wanaagsan.

Hadda, sida laga soo xigtay Wasaaradda Caafimaadka ee Brazil, kiniinka loo yaqaan 'chloroquine' waxaa loo isticmaali karaa oo keliya dadka la dhigo cisbitaalka, muddo 5 maalmood ah, kormeer joogto ah, si loo qiimeeyo muuqaalka waxyeellooyinka halista ah ee suurtagalka ah, sida dhibaatooyinka wadnaha ama isbeddellada aragga .

Abriil 4, 2020 Cusboonaysiinta:

Mid ka mid ah daraasadaha socda, iyadoo la isku daray isticmaalka hydroxychloroquine iyo antibiyootikada azithromycin ^[9], Faransiiska, waxay soo bandhigeen natiijooyin rajo leh oo ka kooban koox ka kooban 80 bukaan ah oo leh calaamado dhexdhexaad ah oo ah COVID-19. Kooxdan, hoos u dhac ku yimid culeyska fayraska ee coronavirus-ka cusub ee jirka ayaa la ogaaday, ka dib qiyaastii 8 maalmood oo daaweyn ah, taas oo ka yar celcelis ahaan 3 toddobaad oo ay soo bandhigeen dad aan qaadan daaweyn gaar ah.

Baadhitaankan, 80ka bukaan ee waxbartay, kaliya 1 qof ayaa kudhamaaday inuu dhinto, maxaa yeelay waxaa lageyn lahaa isbitaalka heer aad u heer sareeya oo cudurka ah, oo laga yaabo inuu carqaladeeyo daaweynta.

Natiijooyinkani waxay sii wadaan inay taageeraan aragtida ah in isticmaalka hydroxychloroquine uu noqon karo hab badbaado leh oo lagu daaweyn karo infekshanka COVID-19, gaar ahaan xaaladaha astaamaha khafiifka ama dhexdhexaadka ah, marka lagu daro yareynta halista gudbinta cudurka. Sidaas oo ay tahay, waa lagama maarmaan in la sugo natiijooyinka daraasado kale oo lagu fulinayo daroogada, si loo helo natiijooyinka shaybaar tiro badan.

Abriil 23, 2020 Cusboonaysiinta:

Golaha Caafimaadka ee Dowlada Baraasiil waxay ansixiyeen isticmaalka Hydroxychloroquine oo ay weheliso Azithromycin hadba sida uu takhtarka u go'aansado, bukaanka qaba astaamo fudud ama dhexdhexaad ah, laakiin aan u baahneyn gelitaanka ICU, oo ay ku dhacaan infekshanada kale ee fayraska, sida Hargabka ama H1N1 , iyo ogaanshaha cudurka COVID-19 waa la xaqiijiyay ^[12].

Sidaa darteed, la'aanta natiijooyin cilmiyaysan oo adag, isku-darka daawooyinka waa in loo adeegsadaa oo keliya oggolaanshaha bukaanka iyo talo-bixinta dhakhtarka, ka dib marka la qiimeeyo halista suurtagalka ah.

Laga yaabaa 22, 2020 Cusboonaysiinta:

Sida laga soo xigtay daraasad laga sameeyay Maraykanka oo ay la socdaan 811 bukaan ah ^[13], isticmaalka Chloroquine iyo Hydroxychloroquine, oo xiriir la leh ama aan ku jirin azithromycin, uma muuqato inay saameyn waxtar leh ku leedahay daaweynta COVID-19, xitaa waxay umuuqataa inay sii laba jibaareyso heerka dhimashada bukaannada, maadaama daawooyinkani ay kordhiyaan halista dhibaatooyinka cudurada wadnaha, gaar ahaan arrhythmia iyo fibrillation atrial.

Illaa iyo hadda, tani waa daraasadda ugu ballaaran ee lagu sameeyo hydroxychloroquine iyo chloroquine. Maaddaama natiijooyinka la soo bandhigay ay ka soo horjeedaan waxa laga sheegay daroogadan, daraasado dheeraad ah ayaa wali loo baahan yahay.

Laga yaabaa 25, 2020 Cusboonaysiinta:

Hay'adda Caafimaadka Adduunka (WHO) waxay si ku-meel-gaar ah u joojisay cilmi-baaris ku saabsan hydroxychloroquine oo ay isku dubariday dhowr dal. Ka joojinta waa in la ilaaliyaa illaa inta daweynta dawada dib loo qiimeynayo.

Laga yaabaa 30, 2020 Cusboonaysiinta:

Gobolka Espírito Santo, oo ku yaal Brazil, ayaa ka laabtay calaamadda isticmaalka chloroquine ee bukaannada qaba COVID-19 xaalad halis ah.

Intaa waxaa dheer, dacwad oogayaasha ka socda Wasaaradda Dadweynaha ee São Paulo, Rio de Janeiro, Sergipe iyo Pernambuco waxay codsanayaan in la laalo xeerarka tilmaamaya isticmaalka hydroxychloroquine iyo chloroquine ee daaweynta bukaannada qaba COVID-19.

Juun 4, 2020 Cusboonaysiinta:

Majaladda Lancet ayaa ka noqotay daabacaadda daraasadda bukaanada 811 ee muujiyey in isticmaalka hydroxychloroquine iyo chloroquine aysan wax saameyn ah ku yeelan daaweynta COVID-19, iyadoo ay ugu wacan tahay dhibaatada helitaanka xogta aasaasiga ah ee lagu soo bandhigay daraasadda.

Juun 15, 2020 Cusboonaysiinta:

FDA, oo ah hay'adda ugu weyn ee maareynta daroogada Mareykanka, ayaa la noqotay rukhsad deg-deg ah oo loogu talagalay isticmaalka chloroquine iyo hydroxychloroquine ee daaweynta COVID-19 ^[17], qiil u sameynta heerka sare ee halista daroogada iyo awooda muuqata ee hoose ee daaweynta coronavirus-ka cusub.

Cusboonaysii Luulyo 17, 2020:

Bulshada reer Brazil ee cudurada faafa ^[25] waxay ku talineysaa in isticmaalka hydroxychloroquine ee daaweynta COVID-19 la iska daayo, marxalad kasta oo cudurka laga qaado.

July 23, 2020 Cusboonaysiinta:

Sida laga soo xigtay daraasad reer Brazil ah ^[27], oo ay si wada jir ah u wada qabteen Albert Einstein, HCor, Sírio-Libanês, Moinhos de Vento, Oswaldo Cruz iyo Beneficência Portuguesa Hospitals, isticmaalka hydroxychloroquine, ee laxiriira ama aan kujirin azithromycin, uma muuqato inay wax saameyn ah kuyeelaneyso daaweynta dadka qaba cudurka dhexdhexaad ilaa dhexdhexaad ah. bukaanka qaba coronavirus-ka cusub.

6. Colchicine

Sida lagu sheegay daraasad laga sameeyay Kanada ^[38], colchicine, daawo si ballaaran loogu isticmaalo daaweynta dhibaatooyinka rheumatological, sida gout, ayaa kaa caawin kara daaweynta bukaanka qaba COVID-19.

Sida laga soo xigtay cilmi-baarayaasha, kooxda bukaanada lagu daweeyay dawadan tan iyo markii la ogaaday infekshanka, markii la barbardhigo kooxdii isticmaashay placebo, waxay muujisay hoos u dhac muuqda oo ah halista ah inuu ku dhaco qaabka daran ee cudurka. Intaas waxaa sii dheer, hoos u dhigista isbitaalada iyo heerarka dhimashada ayaa sidoo kale la soo sheegay.

7. Mefloquine

Mefloquine waa daawo loogu talagalay ka hortagga iyo daaweynta cudurka duumada, dadka doonaya inay u safraan aagagga cudurada. Iyada oo ku saleysan daraasado lagu sameeyay Shiinaha iyo Talyaaniga^[6], Nidaam daaweyneed oo mefloquine lagu daro daawooyin kale ayaa lagu baranayaa Ruushka si loo xaqiijiyo waxtarkeeda xakameynta cudurka COVID-19, laakiin ma jiraan natiijooyin wax ku ool ah weli.

Sidaa darteed, isticmaalka mefloquine si loogu daaweeyo infekshinka cusub ee coronavirus weli laguma talin maxaa yeelay daraasado dheeraad ah ayaa loo baahan yahay si loo caddeeyo waxtarkeeda iyo nabadgelyadeeda.

8. Tocilizumab

Tocilizumab waa daawo yareyneysa ficilka nidaamka difaaca jirka, sidaas darteed, waxaa caadi ahaan loo adeegsadaa daaweynta bukaannada qaba cudurka 'rheumatoid arthritis', si loo yareeyo jawaabta difaaca jirka oo sii xumaatay, yareynta caabuqa iyo yareynta astaamaha.

Daawadan waxaa la baranayaa si ay gacan uga geysato daaweynta COVID-19, gaar ahaan heerarka ugu horumarsan ee infekshanka, marka ay jiraan maaddooyin fara badan oo caabuq leh oo ay soo saaraan nidaamka difaaca jirka, taas oo ka sii dari karta xaaladda caafimaad.

Sida lagu sheegay daraasad ka dhacday Shiinaha ^[10] 15 bukaan ah oo uu ku dhacay COVID-19, isticmaalka tocilizumab wuxuu cadeeyay inuu ka waxtar badan yahay uuna sababo waxyeelo yar, marka la barbardhigo corticosteroids, oo ah daawooyinka guud ahaan loo isticmaalo in lagu xakameeyo bararka ay keento jawaab celinta difaaca jirka.

Weli, daraasado dheeraad ah ayaa loo baahan yahay in la sameeyo, si loo fahmo waxa ugu fiican ee qiyaasta, loo go'aamiyo nidaamka daaweynta loona ogaado waxa ka dhalan kara dhibaatooyinkaas.

Abriil 29, 2020 Cusboonaysiinta:

Sida laga soo xigtay daraasad cusub oo lagu sameeyay Shiinaha 21 bukaan ah oo uu ku dhacay COVID-19^[14], daaweynta tocilizumab waxay umuuqataa inay yareyn karto astaamaha infekshanka waxyar kadib maamulka dawada, yareynta qandhada, yareynta dareenka cidhiidhiga xabadka iyo hagaajinta heerarka oksijiinta.

Daraasadani waxaa lagu sameeyay bukaanada qaba calaamadaha daran ee infekshanka waxayna soo jeedineysaa in daaweynta tocilizumab ay tahay in sida ugu dhaqsiyaha badan loo bilaabo marka bukaanku uu ka gudbo xaalad dhexdhexaad ah una gudbo xaalad halis ah oo infekshan ah ee coronavirus-ka cusub.

Cusboonaysii July 11, 2020:

Cilmi baaris cusub oo ay sameysay Jaamacadda Michigan ee dalka Mareykanka ^[28], ayaa lagu soo gabagabeeyay in isticmaalka tocilizumab ee bukaanada qaba COVID-19 ay u muuqato inay yareynayso heerka dhimashada bukaannada hawo laga qabo, in kasta oo ay kordhisay halista infekshannada kale.

9. Plasma-ka qanjirka 'Convalescent'

Plasma-ka loo yaqaan 'Convalescent plasma' waa nooc ka mid ah daaweynta nafleyda ee sambal dhiig laga qaado, oo laga qaado dadka horey ugu dhacay cudurka loo yaqaan 'coronavirus' iyo kuwa laga bogsaday, kuwaas oo markaa qaata qaar ka mid ah wax ka qabashada wax ka qabashada dhiigga si ay u kala soocaan dhiigga unugyada cas. Ugu dambeyntiina, plasma-kan ayaa lagu duraa qofka jiran si ay uga caawiso nidaamka difaaca jirka inuu la dagaallamo fayraska.

Aragtida ka dambeysa daaweynta noocan ahi waxay tahay in unugyada difaaca jirka ee ay soo saartay jirka qofka cudurka qabay, ee ku haray plasma, loo gudbin karo dhiigga qof kale oo weli cudurka la jira, oo gacan ka geysanaya xoojinta difaaca jirka iyo fududeynta tirtirka fayraska.

Sida ku xusan qoraalka Farsamada ee tirsigiisu yahay 21 ee ay sii deysay Anvisa, gudaha Brazil, plasma convalescent waxaa loo isticmaali karaa daaweyn tijaabo ah oo loogu talagalay bukaanada qaba cudurka cusub ee coronavirus, ilaa iyo inta la raacayo dhammaan sharciyada Ilaalinta Caafimaadka. Intaa waxaa sii dheer, dhammaan kiisaska u adeegsada 'plavama convalescent' daaweynta daaweynta COVID-19 waa in loo gudbiyaa Isuduwaha Guud ee Dhiigga iyo Dhiigga ee Wasaaradda Caafimaadka.

10. Avifavir

Avifavir waa daawo laga soo saaray Ruushka oo qaybteeda firfircoon ay tahay walaxda favipiravir, taasoo sida ku xusan Sanduuqa Maalgashiga Tooska ah ee Ruushka (RDIF) ^[21] awood u leh daaweynta cudurka coronavirus, iyadoo lagu soo daray baratakoolka daaweynta iyo ka hortagga ee COVID-19 ee Ruushka.

Marka loo eego daraasadaha la sameynayay, 10 maalmood gudahood, Avifavir ma uusan laheyn wax saameyn ah oo cusub iyo, 4 maalmood gudahood, 65% bukaannada la daweeyay ayaa baaritaan aan fiicneyn ku sameeyay COVID-19.

11. Baricitinib

FDA waxay fasaxday isticmaalka degdega ah ee daroogada Baricitinib ee daaweynta cudurada halista ah ee COVID-19 ^[32]lagu daro Remdesivir. Baricitinib waa walax yareyneysa jawaabta nidaamka difaaca jirka, iyadoo hoos u dhigeysa ficillada enzymes-ka ee dhiirrigeliya caabuqa waxaana horey loogu adeegsaday kiisaska xanuunka loo yaqaan 'rheumatoid arthritis'.

Sida laga soo xigtay FDA, isku dhafkan waxaa loo isticmaali karaa bukaanka qaangaarka ah iyo carruurta ka weyn 2 sano, isbitaal la dhigay oo u baahan in lagu daaweeyo oksijiin ama hawo farsamo.

12. EXO-CD24

EXO-CD24 waa daawo loo tilmaamay in lagu daweeyo kansarka ugxansidaha ugxansidaha waxayna awood u yeelatay inay bogsato 29 ka mid ah 30 bukaan ah oo qaba COVID-19. Si kastaba ha noqotee, daraasado dheeraad ah ayaa wali la fulinayaa, iyada oo dad aad u tiro badan, iyada oo ujeedadu tahay in la hubiyo in daawadani ay waxtar u yeelanayso daaweynta cudurka iyo qiyaasta loo arko inay badbaado u tahay isticmaalka.

Fursadaha daaweynta dabiiciga ee coronavirus

Illaa iyo hadda ma jiraan wax daaweyn dabiici ah oo la xaqiijiyay oo lagu tirtirayo coronavirus isla markaana lagu caawiyo daaweynta COVID-19, si kastaba ha noqotee, WHO waxay aqoonsan tahay in geedka Artemisia annua kaa caawin kara daaweynta ^[11], gaar ahaan meelaha ay ka adag tahay helitaanka daawooyinka oo dhirta loo isticmaalo daawo dhaqameedka, sida ka dhacda gobollada kala duwan ee Afrika.

Caleemaha geedka Artemisia annua dhaqan ahaan waxaa loo adeegsadaa Afrika si looga caawiyo daaweynta duumada sidaa darteedna, WHO waxay aqoonsan tahay in loo baahan yahay daraasado si loo fahmo in geedka sidoo kale loo isticmaali karo daaweynta COVID-19, maaddaama qaar ka mid ah daawooyinka synthetic ee ka dhanka ah duumada ay iyaguna muujiyeen natiijooyin rajo leh. .

Weli, waxaa muhiim ah in la xasuusto in isticmaalka geedka aan la xaqiijin ka dhanka ah COVID-19 loona baahan yahay baaritaanno dheeri ah.