Cushing syndrome sababo la xiriira burooyinka adrenal

Cushing syndrome sababo la xiriira burooyinka adrenal waa nooc ka mid ah Cushing syndrome. Waxay dhacdaa markii buro ka mid ah qanjidhada 'adrenal gland' ay sii deyso xaddi xad-dhaaf ah hormoonka cortisol.

Cudurka 'Cushing syndrome' waa cillad dhacda marka jirkaagu leeyahay heer ka sarreeya heerka caadiga ah ee hormoonka cortisol. Hormoonkan waxaa lagu sameeyay qanjidhada adrenal. Cortisol badan ayaa sababi kara dhibaatooyin kala duwan. Mid ka mid ah dhibaatooyinka noocan oo kale ah waa buro ku taal mid ka mid ah qanjidhada adrenal. Burooyinka Adrenal waxay sii daayaan cortisol.

Burooyinka adrenal waa dhif. Waxay noqon karaan non-cancer (benign) ama kansar (malignant).

Burooyinka aan caadiga aheyn ee sababi kara cudurka 'Cushing syndrome' waxaa ka mid ah:

• Adrenal adenomas, oo ah buro caadi ah oo si dhif ah u sameysa cortisol xad dhaaf ah
• Macronodular hyperplasia, oo sababa qanjidhada adrenal inay weynaadaan oo sameeyaan cortisol xad dhaaf ah

Burooyinka kansarka ee sababi kara cudurka 'Cushing syndrome' waxaa ka mid ah kansarka 'adrenal carcinoma'. Kani waa buro naadir ah, laakiin badanaa waxay sameysaa cortisol xad dhaaf ah.

Inta badan dadka qaba xanuunka 'Cushing syndrome' waxay leeyihiin:

• Wareeg, casaan, waji buuxa (wajiga dayaxa)
• Heerka koritaanka ilmaha oo gaabis ah
• Kordhinta culeyska dufanka ku urursan jirridda, laakiin dufanka oo ka lumiya gacmaha, lugaha, iyo badhida (buurnida dhexe)

Isbedelada maqaarka ee badanaa la arko:

• Caabuqyada maqaarka
• Calaamadaha fidinta (guduudka ah) (1/2 inji ama 1 sentimitir ama ka ballaaran), oo loo yaqaan 'striae', maqaarka caloosha, bowdyaha, gacmaha kore, iyo naasaha
• Maqaar khafiif ah oo nabar fudud leh

Isbedelada murqaha iyo lafaha waxaa ka mid ah:

• Dhabar xanuun, oo ku dhaca waxqabadyada caadiga ah
• Lafa xanuun ama danqasho
• Uruurinta dufanka inta udhaxeysa garbaha iyo lafta qoorta
• Feeraha iyo jabka lafdhabarta ee ay keento khafiifinta lafaha
• Murqaha daciifka ah, gaar ahaan miskaha iyo garbaha

Isbedelada jirka oo dhan (nidaamsan) waxaa ka mid ah:

• Nooca 2aad ee sonkorowga mellitus
• Dhiig kar
• Kalastaroolka iyo triglycerides oo kordhay

Haweenka badanaa waxay leeyihiin:

• Kordhinta timaha xad dhaafka ah ee wejiga, qoorta, laabta, caloosha, iyo bowdyaha (aad ayey uga badan tahay noocyada kale ee Cushing syndrome)
• Muddooyinka oo noqda kuwo aan caadi ahayn ama joogsada

Ragga waxaa laga yaabaa inay leeyihiin:

• Hoos udhaca ama rabitaanka galmada (libido hoose)
• Dhibaatooyinka kacsiga

Calaamadaha kale ee dhici kara waxaa ka mid ah:

• Isbeddelada maskaxda, sida niyadjabka, walwalka, ama isbeddelada dabeecadda
• Daal
• Madax xanuun
• Haraad iyo kaadi badan

Bixiyaha xanaanada caafimaadka ayaa sameyn doona baaritaan jireed wuxuuna weydiin doonaa astaamahaaga.

Tijaabooyinka lagu xaqiijinayo xanuunka 'Cushing syndrome'

• 24-saac tijaabo kaadi ah si loo cabiro heerarka cortisol iyo creatinine
• Tijaabooyinka dhiigga si loo hubiyo ACTH, cortisol, iyo heerarka potassium
• Imtixaanka xakamaynta Dexamethasone
• Heerarka cortisol ee dhiigga
• Heerka dhiigga DHEA
• Saliva cortisol

Tijaabooyinka lagu ogaanayo waxa sababay ama dhibaatooyinka waxaa ka mid ah:

• Caloosha CT
• ACTH
• Cufnaanta macdanta lafaha
• Kalastarool
• Gulukooska soonka

Qalliin ayaa loo sameeyaa si looga soo saaro burada adrenal. Badanaa, qanjirka 'adrenal gland' oo dhan ayaa laga saaraa.

Daaweynta beddelka Glucocorticoid badanaa waa loo baahan yahay illaa qanjirka kale ee 'adrenal gland' uu ka soo kabsado qalliinka. Waxaad u baahan kartaa daaweyntan 3 ilaa 12 bilood.

Haddii qalliin aysan suurtagal ahayn, sida xaaladaha kansarka adrenal ee faafay (metastasis), daawooyinka ayaa loo isticmaali karaa in lagu joojiyo sii deynta cortisol.

Dadka qaba burooyinka adrenal ee qalliinka leh waxay leeyihiin aragti wanaagsan. Cudurka kansarka 'adrenal cancer', qalliin mararka qaarkood suurtagal maaha. Markii qalliin la sameeyo, had iyo jeer ma daaweyso kansarka.

Burooyinka kansarka maskaxda ku dhaca ayaa ku faafi kara beerka ama sambabaha.

Wac adeeg bixiyahaaga haddii aad isku aragto astaamo kasta oo ah 'Cushing syndrome'.

Daaweynta habboon ee burooyinka adrenal waxay yareyn kartaa halista dhibaatooyinka dadka qaarkood ee qaba burooyinka la xiriira burooyinka la xiriira Cushing syndrome.

Burada Adrenal - Cushing syndrome

• Qanjirada 'Endocrine'
• Adrenal metastases - CT scan
• Buro Adrenal - CT

Asban A, Patel AJ, Reddy S, Wang T, Balentine CJ, Chen H. Kansarka nidaamka endocrine. Gudaha: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6aad ed. Philadelphia, PA: Elsevier; 2020: cutubka 68.

Nieman LK, Biller BM, Findling JW, iyo al. Daaweynta Cudurka 'Cushing's syndrome': tilmaamaha ku-takhasuska bulshada ee Endocrine Society. J Clin Endocrinol Metab. 2015; 100 (8): 2807-2831. PMID: 26222757 www.ncbi.nlm.nih.gov/pubmed/26222757.

Stewart PM, Newell-Price JDC. Kiliyaha adrenal. Gudaha: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Buugga Buugga Endocrinology. 13aad. Philadelphia, PA: Elsevier; 2016: cutubka 15.