Plasma amino acids

Plasma amino acids waa baaritaan tijaabo ah oo lagu sameeyo dhallaanka taasoo eegaysa xaddiga amino acids-ka ee dhiigga ku jira. Amino acids-ka ayaa ah dhismooyinka borotiinada ku jira jirka.

Inta badan, dhiig ayaa laga soo qaataa xididka ku yaal gudaha xusulka ama dhabarka gacanta.

Dhallaanka ama carruurta yaryar, qalab fiiqan oo loo yaqaan 'lancet' ayaa loo isticmaali karaa in lagu mudo maqaarka.

• Dhiiggu wuxuu ku ururiyaa tuubbo yar oo dhalo ah oo loo yaqaanno 'pipe', ama ku soo duub ama aaladda wax lagu baaro.
• Faashad ayaa la dul dhigayaa meesha si loo joojiyo wax dhiig bax ah.

Tijaabada dhiigga waxaa loo diraa shaybaarka. Waxaa jira dhowr nooc oo habab ah oo loo isticmaalo go'aaminta heerarka shakhsiga amino acid ee dhiiga ku jira.

Qofka baaritaanka la samaynayo waa inuusan cunin 4 saac baaritaanka ka hor.

Waxaa jiri kara xanuun yar ama xaniin markii irbadda la geliyo. Waxa kale oo laga yaabaa inaad dareento xoogaa jug ah goobta ka dib markii dhiigga lagaa qaado. Cirbadda cirbaddu waxay u badan tahay inay ilmaha ama cunugga u ooyaan.

Tijaabadan waxaa loo sameeyaa si loo cabiro heerka amino acids-ka ku jira dhiiga.

Heerka sii kordhaya ee amino acid gaar ah waa calaamad adag. Tani waxay muujineysaa inay dhibaato ka jirto awoodda jirku u leeyahay inuu burburiyo (metabolize) amino acid.

Baadhitaanka waxaa sidoo kale loo isticmaali karaa in lagu raadiyo hoos u dhaca heerarka amino acids ee dhiiga ku jira.

Kordhinta ama hoos udhaca heerarka amino acids ee dhiiga kujira waxaa lagayaabaa qandho, nafaqo daro, iyo xaaladaha caafimaad qaarkood.

Dhammaan cabbiradu waxay ku jiraan micromoles halkii litir (µmol / L). Qiimaha caadiga ahi wuu ku kala duwanaan karaa shaybaarrada kala duwan. Kala hadal daryeel caafimaad bixiyahaaga natiijooyinka baaritaankaaga gaarka ah.

Alanine:

• Carruurta: 200 illaa 450
• Dadka waaweyn: 230 ilaa 510

Alfa-aminoadipic acid:

• Carruurta: lama oga
• Dadka waaweyn: lama oga

Alfa-amino-N-butyric acid:

• Carruurta: 8 illaa 37
• Dadka waaweyn: 15 illaa 41

Arginine:

• Carruurta: 44 illaa 120
• Dadka waaweyn: 13 illaa 64

Asparagine:

• Carruurta: 15 illaa 40
• Dadka waaweyn: 45 illaa 130

Aspartic acid:

• Carruurta: 0 illaa 26
• Dadka waaweyn: 0 ilaa 6

Beta-alanine:

• Carruurta: 0 illaa 49
• Dadka waaweyn: 0 illaa 29

Beta-amino-isobutyric acid:

• Carruurta: lama oga
• Dadka waaweyn: lama oga

Carnosine:

• Carruurta: lama oga
• Dadka waaweyn: lama oga

Citrulline:

• Carruurta: 16 illaa 32
• Dadka waaweyn: 16 illaa 55

Cystine:

• Carruurta: 19 illaa 47
• Dadka waaweyn: 30 ilaa 65

Glutamic acid:

• Carruurta: 32 illaa 140
• Dadka waaweyn: 18 ilaa 98

Glutamine:

• Carruurta: 420 ilaa 730
• Dadka waaweyn: 390 ilaa 650

Glycine:

• Carruurta: 110 illaa 240
• Dadka waaweyn: 170 illaa 330

Histidine:

• Carruurta: 68 illaa 120
• Dadka waaweyn: 26 illaa 120

Hydroxyproline:

• Caruurta: 0 ilaa 5
• Dadka waaweyn: lama oga

Isoleucine:

• Carruurta: 37 illaa 140
• Dadka waaweyn: 42 ilaa 100

Leucine:

• Carruurta: 70 illaa 170
• Dadka waaweyn: 66 ilaa 170

Lysine:

• Carruurta: 120 illaa 290
• Dadka waaweyn: 150 illaa 220

Methionine:

• Carruurta: 13 illaa 30
• Dadka waaweyn: 16 illaa 30

1-methylhistidine:

• Carruurta: lama oga
• Dadka waaweyn: lama oga

3-methylhistidine:

• Carruurta: 0 illaa 52
• Dadka waaweyn: 0 ilaa 64

Ornithine:

• Carruurta: 44 illaa 90
• Dadka waaweyn: 27 illaa 80

Phenylalanine:

• Carruurta: 26 illaa 86
• Dadka waaweyn: 41 illaa 68

Phosphoserine:

• Carruurta: 0 illaa 12
• Dadka waaweyn: 0 illaa 12

Phosphoethanolamine:

• Carruurta: 0 illaa 12
• Dadka waaweyn: 0 ilaa 55

Jadwalka:

• Carruurta: 130 illaa 290
• Dadka waaweyn: 110 illaa 360

Serine:

• Carruurta: 93 illaa 150
• Dadka waaweyn: 56 ilaa 140

Taurine:

• Carruurta: 11 illaa 120
• Dadka waaweyn: 45 illaa 130

Threonine:

• Carruurta: 67 illaa 150
• Dadka waaweyn: 92 illaa 240

Tyrosine:

• Carruurta: 26 illaa 110
• Dadka waaweyn: 45 illaa 74

Valine:

• Carruurta: 160 illaa 350
• Dadka waaweyn: 150 ilaa 310

Tusaalooyinka kor ku xusan waxay muujinayaan cabirka guud ee natiijooyinka imtixaanadan. Shaybaarada qaarkood waxay isticmaalaan cabbiro kala duwan ama waxay tijaabin karaan tijaabooyin kala duwan.

Kordhinta wadarta heerka amino acids ee dhiiga waxaa sababi kara:

• Eclampsia
• Baadi ku dhasha dheef-shiid kiimikaadka
• Dulqaad la'aanta Fructose
• Ketoacidosis (laga bilaabo sonkorowga)
• Kelyaha oo hawl gab
• Reye syndrome
• Cilad shaybaar

Hoos u dhac ku yimaada heerka guud ee amino acids-ka dhiiga waxaa sababi kara:

• Qalitaanka 'adrenal kortikal hyperfunction'
• Qandho
• Cudurka Hartnup
• Baadi ku dhasha dheef-shiid kiimikaadka
• Huntington chorea
• Nafaqo darrada
• Cudurka 'Nephrotic syndrome'
• Qandhada 'Phlebotomus fever'
• Rheumatoid arthritis
• Cilad shaybaar

Xaddiga sare ama hooseeya ee shakhsiyaadka amino acids-ka ah waa in lagu tixgeliyaa macluumaad kale. Natiijooyinka aan caadiga ahayn waxaa laga yaabaa inay ugu wacan tahay cuntada, dhibaatooyinka la iska dhaxlo, ama saameynta daawada.

Baadhitaanka dhallaanka ee heerarka sii kordhaya ee amino acids-ka ayaa kaa caawin kara ogaanshaha dhibaatooyinka dheef-shiid kiimikaadka. Daaweynta hore ee xaaladahaan waxay ka hortagi kartaa dhibaatooyinka mustaqbalka.

Baadhitaanka dhiigga ee amino acids

• Acids amino

Dietzen DJ. Amino acids, peptides, iyo borotiinada. Gudaha: Rifai N, ed. Tietz Textbook ee Kiimikada Caafimaadka iyo Cilad-baarista Molecular. 6aad ed. St Louis, MO: Elsevier; 2018: cutubka 28.

Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM. Cilladaha dheef-shiid kiimikaad ee amino acids. Gudaha: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Buugga Buugga Caafimaadka Caruurta. 21aad ed. Philadelphia, PA: Elsevier; 2020: baab 103.

Riley RS, McPherson RA. Baadhitaanka aasaasiga ah ee kaadida. Gudaha: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis iyo Maareynta Hababka Shaybaarka. 23aad ed. St Louis, MO: Elsevier; 2017: cutubka 28.