Tijaabada dhiigga ee TBG

Tijaabada dhiigga ee TBG waxay cabireysaa heerka borotiinka dhaqaajiya hormoonka tayroodhka ee jirkaaga oo dhan. Borotiinkan waxaa loo yaqaan 'thyroxine binding globulin' (TBG).

Muunad dhiig ah ayaa la qaadayaa ka dibna loo dirayaa shaybaarka si loo baaro.

Daawooyinka qaarkood iyo daawooyinka ayaa saameyn ku yeelan kara natiijooyinka baaritaanka. Bixiyaha xanaanada caafimaadkaaga ayaa laga yaabaa inuu kuu sheego inaad joojiso qaadashada daawo gaar ah mudo gaaban baaritaanka ka hor. Weligaa ha joojin qaadashada wax daawo ah adiga oo aan marka hore lahadlin takhtarkaaga.

Daawooyinkan iyo daawooyinkani waxay kordhin karaan heerka TBG:

• Estrogens, oo laga helay kaniiniyada xakameynta dhalmada iyo daaweynta beddelka estrogen
• Heroin
• Methadone
• Phenothiazines (dawooyinka dhimirka qaarkood)

Daawooyinka soo socda ayaa yareyn kara heerarka TBG:

• Depakote ama depakene (sidoo kale loo yaqaan 'valproic acid')
• Dilantin (sidoo kale loo yaqaan phenytoin)
• Qiyaaso badan oo saliid ah, oo ay ku jiraan asbiriin
• Hormoonka ragga, oo ay ku jiraan androgens iyo testosterone
• Prednisone

Marka irbadda la geliyo si dhiig loo qaado, dadka qaar waxay dareemaan xanuun dhexdhexaad ah. Qaar kale waxay dareemaan oo keliya dharbaaxo ama xaniin. Intaas ka dib, waxaa laga yaabaa in xoogaa wax garaaco ama nabarro yar yeeshaan. Tani dhawaan way tagi doontaa.

Tijaabadan waxaa loo samayn karaa si loo ogaado dhibaatooyinka ka jira qanjirkaaga tayroodhka.

Heerka caadiga ah waa 13 illaa 39 microgram halkii deciliter (mcg / dL), ama 150 ilaa 360 nanomoles halkii litir (nmol / L).

Heerarka qiimaha caadiga ahi way ku kala duwanaan karaan shaybaarada kala duwan. Shaybaarada qaarkood waxay isticmaalaan cabbiro kala duwan ama waxay tijaabin karaan shaybaarro kala duwan. Kala hadal adeeg bixiyahaaga macnaha natiijooyinka baaritaankaaga gaarka ah.

Heerka qaaxada ee sii kordheysa waxaa sababi kara:

• Cudurka ba'an ee loo yaqaan 'porphyria' (cillad dheef-shiid kiimikaad naadir ah)
• Hypothyroidism (qanjirka 'thyroid')
• Cudurka beerka
• Uurka (heerarka TBG caadi ahaan way kordheen xilliga uurka)

Ogsoonow: Heerarka TBG caadi ahaan waxay ku badan yihiin carruurta dhasha.

Hoos udhaca heerarka TBG waxaa sababi kara:

• Xanuun daran
• Acromegaly (cillad ay keento hoormoon koritaan aad u badan)
• Hyperthyroidism (qanjirka 'thyroid')
• Nafaqo darrada
• Cudurka 'Nephrotic syndrome' (astaamo muujinaya in dhaawac kelyaha jiro)
• Cadaadiska qalitaanka

Heerarka TBG sare ama hooseeya waxay saameeyaan xiriirka ka dhexeeya wadarta T4 iyo baaritaanka dhiigga ee T4 oo bilaash ah. Isbeddel ku yimaada heerarka dhiigga ee TBG ayaa wax ka beddeli kara qiyaasta habboon ee beddelka levothyroxine ee loogu talagalay dadka qaba cudurka hypothyroidism.

Khatar yar ayaa ku jirta in dhiigga lagaa qaado. Xididdada iyo halbowlayaasha waxay ku kala duwan yihiin cabirka qof ilaa qof kale iyo dhinac jirka ah ilaa dhinac kale. Helitaanka tijaabada dhiigga ee dadka qaarkiis way ka dhib badan tahay kuwa kale.

Khataraha kale ee ah in dhiig lagaa qaado way yar yihiin, laakiin waxaa ka mid noqon kara:

• Dhiigbax xad dhaaf ah
• Miyir beelid ama dareemid madax-wareer
• Daloollo badan si loo helo xididdada
• Hematoma (dhiigbax maqaarka hoostiisa)
• Infekshan (halis yar mar kasta oo maqaarku jabo)

Serum thyroxine ku xiraya globulin; Heerka TBG; Serum TBG heerka; Hypothyroidism - TBG; Hyperthyroidism - TBG; Thyroid aan firfircooneyn - TBG; Qanjirka 'Thyroid' - TBG

• Baaritaanka dhiigga

Guber HA, Farag AF. Qiimeynta shaqada endocrine. Gudaha: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis iyo Maareynta Hababka Shaybaarka. 23aad ed. St Louis, MO: Elsevier; 2017: cutubka 24.

Kruse JA. Ciladaha qanjirka 'thyroid'. Gudaha: Parrillo JE, Dellinger RP, eds. Daaweynta Daryeelka Khatarta ah: Mabaadi'da Ciladda iyo Maareynta ee Dadka Waaweyn. 5aad. Philadelphia, PA: Elsevier; 2019: cutubka 57.

Salvatore D, Cohen R, Kopp PA, Larsen PR. Cudurka qanjirka 'thyroid' iyo qiimeynta ogaanshaha cudurka. Gudaha: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Buugga Buugga Endocrinology. 14aad. Philadelphia, PA: Elsevier; 2020: cutubka 11.