Qoraa: Clyde Lopez
Taariikhda Abuurista: 24 Julay 2021
Taariikhda Cusboonaysiinta: 1 Abriil 2025
Anonim
How does Niacin (B3) Work? (+ Pharmacology)
Dareemoleyad: How does Niacin (B3) Work? (+ Pharmacology)

Qanacsan

Niacin waa nooc ka mid ah fiitamiin B3. Waxaa laga helaa cuntooyinka ay ka midka yihiin khamiirka, hilibka, kalluunka, caanaha, ukunta, khudradda cagaaran, iyo badarka. Niacin sidoo kale waxaa laga soo saaraa jirka oo laga sameeyaa tryptophan, oo laga helo cuntada ay ku jirto borotiinka. Markii loo qaato kaabis ahaan, niacin waxaa badanaa laga helaa iyadoo lagu darayo fiitamiinnada kale ee B.

Ha ku khaldin niacin NADH, niacinamide, inositol nicotinate, IP-6, ama tryptophan. Eeg liisaska kaladuwan ee mawduucyadan.

Noocyada daawada ee niacin waxaa ansixiyay Maamulka Cuntada iyo Dawooyinka ee Mareykanka (FDA) ee loogu talagalay kolestaroolka sare iyo in la kordhiyo heerarka nooc gaar ah oo kolestarool wanaagsan ah, oo loo yaqaan HDL. Daawada Niacin iyo waxyaabaha laguu qoro sidoo kale afka ayaa loo qaataa si looga hortago yaraanshaha fitamiin B3 iyo xaaladaha la xariira sida pellagra.

Daawooyinka Dabiiciga ah ee Xogta Dhamaystiran waxay qiimeysaa waxtarka ku saleysan caddeynta sayniska iyadoo loo eegayo cabirka soo socda: Wax ku ool ah, Suurta gal ah inuu wax ku ool yahay, suurtagal tahay wax ku ool ah, macquul ahaan waxtar la'aan, suurtagal ahaan waxtar la'aan, waxtar la'aan, iyo caddayn ku filan oo lagu qiimeeyo.

Qiimeynta waxtarka ee NIACIN waa sida soo socota:


Waxtar u leh ...

  • Heerarka aan caadiga ahayn ee kolestaroolka ama dufanka dhiigga (dyslipidemia). Qaar ka mid ah alaabta niacin waxaa ansixiyay Maamulka Cuntada iyo Dawooyinka ee Mareykanka (FDA) oo ah alaabooyinka loo qoro ee lagu daaweynayo heerarka aan caadiga ahayn ee dufanka dhiigga. Waxyaabahan daawada niacin lagu qoro waxay caadi ahaan ku yimaadaan xoog sare oo ah 500 mg ama ka sareeya. Noocyada kaabista cuntada ee niacin badanaa waxay ku yimaadaan xoogag dhan 250 mg ama ka yar. Maaddaama qiyaasta aad u sarreeya ee niacin looga baahan yahay hagaajinta heerarka kolestaroolka, nafaqada dheeraadka ah ee loo yaqaan 'niacin' caadi ahaan ma habboon. Niacin waxaa lagu dari karaa dawooyinka kale ee hoos u dhiga kolestaroolka marka cuntada iyo daaweynta hal-daroogada aysan ku filneyn. Niacin wuxuu hagaajiyaa heerarka kolestaroolka, laakiin ma hagaajiyo natiijooyinka wadnaha iyo wadnaha iyo istaroogga.
  • Cudur uu sababo niacin yaraanta (pellagra). Niacin waxaa ansixiyay Maamulka Cuntada iyo Dawooyinka ee Mareykanka (FDA) adeegsigaan. Si kastaba ha noqotee, niacin wuxuu sababi karaa "dheecaan" (casaan, cuncun, iyo xoqid). Markaa badeecad kale, oo la yiraahdo niacinamide, ayaa mararka qaarkood la door bidaa maxaa yeelay ma keento saameyntan dhinaca ah

Suurtagal inay wax ku ool u tahay ...

  • Heerarka aan caadiga ahayn ee dufanka dhiigga ee dadka qaba HIV / AIDS. Qaadashada niacin waxay umuuqataa inay wanaajineyso heerarka kalastarolka iyo dufanka dhiiga ee looyaqaan triglycerides ee bukaanada xaaladan qaba.
  • Isugeynta astaamaha kor u qaada halista cudurka sokorowga, cudurka wadnaha, iyo istaroogga (cillad dheef-shiid kiimikaad). Qaadashada niacin waxay umuuqataa inay kordhineyso heerarka lipoprotein-ka cufnaanta badan (HDL ama "wanaagsan") kolestaroolka waxayna yareyneysaa heerarka dufanka dhiigga ee loo yaqaan triglycerides ee dadka qaba cilladda dheef-shiid kiimikaadka. Qaadashada niacin oo ay weheliso warqad dhakhtareed oo ah omega-3 dufan ayaa u muuqata inay si fiican ushaqeyso.

Waxtar uma leh ...

  • Wadne xanuun. Cilmi baaris tayo sare leh ayaa muujineysa in niacin uusan ka hortagin wadno istaagga ama istaroogga dadka qaata niacin si looga hortago ama loo daaweeyo cudurka wadnaha. Niacin sidoo kale looma muujin inay yareyso halista dhimashada. Niacin looma qaadan karo in lagu daaweeyo ama laga hortago cudurka wadnaha.

Cadeymo aan ku filneyn in lagu qiimeeyo wax ku oolnimada ...

  • Adkaanshaha xididdada dhiigga (atherosclerosis). Qaadashada niacin afka oo ay weheliyaan daawooyinka loo yaqaan 'bile acid sequestrants' waxay yareyn kartaa adkaanshaha halbowlayaasha ragga ee xaaladdan leh. Waxay umuuqataa inay sida ugufiican ugu shaqeyso ragga leh heerar sare oo dufan dhiig ah oo looyaqaan triglycerides. Laakiin qaadashada niacin uma muuqato inay yareynayso adkaanshaha halbowlayaasha bukaannada qaba xaalad loo yaqaan 'peripheral arterial disease' (PAD). Sidoo kale, niacin ma ka hortago dhacdooyinka wadnaha iyo wadnaha ama istaroogga.
  • Cudurka Alzheimer. Dadka qaata xaddi badan oo niacin ah oo ka yimaada cuntada iyo fitamiinada badan ayaa umuuqda inay ka halis yartahay inuu ku dhaco cudurka Alzheimer marka loo eego dadka isticmaala naasiin yar. Laakiin ma jiraan wax caddayn ah in qaadashada kaabis niacin ah ay ka caawinayso kahortagga cudurka Alzheimer.
  • Indho-beelka indhaha. Dadka cuna cunnada ay ku badan tahay niacin waxaa laga yaabaa inay yaraato fursadda ah inay yeeshaan indha-beel nukliyeer. Indho-beelka nukliyeerka waa nooca ugu badan ee indha-beelka. Saamaynta qaadashada kaabista niacin lama yaqaan.
  • Infekshan ku dhaca xiidmaha oo sababa shuban (daacuun). Qaadashada niacin afka ayaa umuuqata inay yareynayso shubanka ku dhaca dadka qaba daacuunka.
  • Cilad xumo (ED). Qaadashada niacin-sii-dheereynta waqtiga jiifka ee toddobaadyada 12 waxay umuuqataa inay ka caawineyso ragga qaba ED iyo heerarka sare ee baruurta inay sii wadaan kacsiga xilliga galmada.
  • Heerarka sare ee fosfateetka dhiiga ku jira (hyperphosphatemia). Dadka qaba shaqada kelyaha waxay yeelan karaan heerar dhiig oo sareeya oo ah fosfoos. Qaar ka mid ah cilmibaarista hore waxay muujinayaan in qaadashada niacin ay yareyn karto heerarka dhiigga ee fosfateerka dadka qaba cudurka kelyaha ee heerka dhammaadka iyo heerarka sare ee fosfateetka dhiigga. Laakiin cilmi baaris kale ayaa muujineysa in qaadashada niacin aysan hoos u dhigeynin heerarka fosfateetka dhiigga ee dadka sidoo kale qaata daawooyinka loo isticmaalo in lagu yareeyo heerarka fosfateerka dhiigga.
  • Xannibaadda xididka isha (xiidmaha xididdada isha): Cilmi baaris hore waxay muujisay in qaadashada niacin ay wanaajiso aragga dadka qaba xaaladan.
  • Cudurka Sickle cell: Cilmibaaris hore waxay muujisay in qaadashada niacin aysan hagaajinaynin heerarka dufanka dhiigga ee dadka qaba cudurka sickle cell.
  • Finanka.
  • Ciladda isticmaalka aalkolada.
  • Waxqabadka Ciyaaraha.
  • Feejignaanta maqnaanshaha-jahwareerka (ADHD).
  • Niyad jab.
  • Dawakhaad.
  • Daawooyinka dhalanteed ee daroogada keena.
  • Dhanjaf.
  • Cudurka dhaqdhaqaaqa.
  • Schizophrenia.
  • Xaaladaha kale.
Cadeymo dheeraad ah ayaa loo baahan yahay si loogu qiimeeyo niacin adeegyadan.

Niacin wuxuu nuugaa jirka markuu biyo ku milmo afka ayaa laga qaadaa. Waxaa loo beddelaa niacinamide haddii lagu qaato qaddar ka badan inta jidhku u baahan yahay.

Niacin waxaa looga baahan yahay shaqada saxda ah ee dufanka iyo sonkorta jidhka ku jirta iyo inuu ilaaliyo unugyada caafimaadka qaba. Qiyaasta sare, niacin ayaa laga yaabaa inay ka caawiso dadka qaba cudurka wadnaha sababtoo ah saameynta ay ku leedahay xinjirowga. Waxa kale oo laga yaabaa inay hagaajiso heerarka nooc dufan ah oo loo yaqaan triglycerides oo ku jirta dhiigga.

Yaraanta Niacin waxay sababi kartaa xaalad loo yaqaan pellagra, oo keenta cuncun maqaarka, shuban, iyo waallida. Pellagra wuxuu caan ku ahaa horraantii qarnigii labaatanaad, laakiin hadda waa ku yar yahay, maadaama cuntooyinka qaarkood oo bur ku jiro hadda lagu xoojiyay niacin. Pellagra waxaa gebi ahaanba laga tirtiray dhaqanka reer galbeedka.

Dadka qaba cunno xumo, aalkolo, iyo noocyada qaar ee burooyinka tartiib tartiib ah ee loo yaqaan burooyinka kansarka ayaa laga yaabaa inay halis ugu jiraan yaraanta niacin. Markii afka lagaa qaado: Niacin waa KU SOO DHAWEYN SAFE dadka badankood marka si haboon loo qaato. Wax soo saarka dawada ee ay ku jirto niacin waa badbaado marka loo qaado sida lagu faray. Cuntooyinka ay ku jiraan Niacin ama nafaqada dheeraadka ah ee niacin ayaa badbaado leh marka la qaato qiyaaso ka yar 35 mcg maalin kasta.

Saameyn-wadareed caadi ah ee niacin waa fal-dilis Tani waxay sababi kartaa gubasho, cuncun, cuncun, iyo guduudasho wajiga, gacmaha, iyo xabadka, iyo madax xanuun. Laga bilaabo qaadasho yar oo niacin ah iyo qaadashada 325 mg oo asbiriin ah ka hor qiyaas kasta oo niacin ah ayaa kaa caawin doonta yareynta fal-celinta dheecaanka. Caadi ahaan, fal-celintani waxay tagtaa markii jidhku ula qabsado daawada. Aalkoladu waxay sii xumeyn kartaa fal-celinta dheecaanka Iska ilaali qaddarka badan ee khamriga intaad qaadanayso niacin.

Dhibaatooyinka kale ee yar ee niacin waa calool xanuun, gaaska xiidmaha, dawakhaad, xanuun ku dhaca afka, iyo dhibaatooyin kale.

Marka qaadashada in ka badan 3 garaam maalintii ee niacin la qaato, waxyeelo ka sii daran ayaa dhici karta. Kuwaas waxaa ka mid ah dhibaatooyinka beerka, gout, boogaha marinka dheefshiidka, aragga oo luma, sonkorta dhiigga oo sarreysa, garaaca wadnaha oo aan joogto ahayn, iyo dhibaatooyin kale oo daran.

Taxaddarrada gaarka ah & digniinta:

Uurka iyo nuujinta: Niacin waa KU SOO DHAWEYN SAFE loogu talagalay haweenka uurka leh iyo kuwa naas nuujinaya marka afka laga qaato qaddarka lagu taliyay. Qiyaasta ugu badan ee lagu taliyo ee niacin ee haweenka uurka leh ama naas nuujinaya waa 30 mg maalintii dumarka ka yar 18 sano, iyo 35 mg dumarka ka weyn 18.

Caruurta: Niacin waa KU SOO DHAWEYN SAFE marka afka lagaga qaado qaddarka lagula taliyay da 'kasta oo da' ah. Laakiin carruurtu waa inay ka fogaadaan qaadashada qiyaasta niacin ee ka sarreysa xadka sare ee maalin kasta, kuwaas oo ah 10 mg oo loogu talagalay carruurta 1-3 sano jir ah, 15 mg loogu talagalay carruurta 4-8 sano jir ah, 20 mg loogu talagalay carruurta 9-13 sano jir ah, iyo 30 mg carruurta da'doodu tahay 14-18 sano.

Xasaasiyadda: Niacin waxaa laga yaabaa inuu ka sii daro xasaasiyada isagoo keenaya histamine, kiimikada mas'uulka ka ah calaamadaha xasaasiyadda, in la sii daayo.

Wadne xanuun / angina aan xasillooneyn: Niacin aad u tiro badan waxay kordhin kartaa halista wadno garaac aan caadi ahayn. Si taxaddar leh u isticmaal.

Cudurka 'Crohn': Dadka qaba cudurka Crohn waxaa laga yaabaa inay yeeshaan heerar niacin oo hooseeya waxayna u baahan yihiin kaabis inta lagu jiro kacsanaanta.

Sonkorowga: Niacin wuxuu kordhin karaa sonkorta dhiiga. Dadka qaba sonkorowga ee qaata niacin waa inay si taxadar leh u hubiyaan sonkorta dhiigooda.

Xameetida: Niacin waxaa laga yaabaa inuu ka sii daro cudurka xameetida.

Turqo: Qiyaas badan oo niacin ah ayaa laga yaabaa inay keento gout.

Cudurka kilyaha: Niacin waxaa laga yaabaa inuu ku ururo dadka qaba cudurka kalyaha. Tani waxay sababi kartaa waxyeelo.

Cudurka beerka: Niacin wuxuu kordhin karaa dhaawaca beerka. Ha isticmaalin xaddi badan haddii aad qabtid cudurka beerka.

Caloosha ama boogaha mindhicirka: Niacin waxaa laga yaabaa inuu ka sii daro boogaha. Ha isticmaalin xaddi badan haddii aad nabaro leedahay.

Cadaadis dhiig oo aad u hooseeya: Niacin waxaa laga yaabaa inuu hoos u dhigo cadaadiska dhiigga isla markaana uu uga sii daro xaaladan.

Qalliinka: Niacin waxaa laga yaabaa inuu farageliyo xakameynta sonkorta dhiiga inta lagu jiro iyo qalliinka kadib. Jooji qaadashada niacin ugu yaraan 2 toddobaad kahor qalliinka jadwalka ku jira.

Kaydinta dufanka ah ee ku wareegsan jilicsanaanta (tendon xanthomas): Niacin wuxuu kordhin karaa halista cudurada ku dhaca xanthomas.

Ciladaha qanjirka 'thyroid': Thyroxine waa hormoon uu soo saaro qanjirka 'thyroid'. Niacin wuxuu yareyn karaa heerarka dhiigga ee tiroxine. Tani waxay ka sii dari kartaa calaamadaha jirrooyinka qaarkood.

Dhexdhexaad
Ka taxaddar isku-dhafkan.
Khamriga (Ethanol)
Niacin wuxuu sababi karaa dheecaan iyo cuncun. Isticmaalka aalkolo iyo niacin waxay ka sii dari kartaa fuuq baxa iyo cuncunka. Waxaa sidoo kale jira xoogaa walaac ah in khamriga lagu cabo niacin inuu kordhiyo fursadda inuu beerku ku xumaado.
Allopurinol (Zyloprim)
Allopurinol (Zyloprim) waxaa loo isticmaalaa in lagu daaweeyo turqo. Qaadashada qiyaaso badan oo niacin ah ayaa laga yaabaa inay ka sii darto gout isla markaana hoos u dhigto waxtarka allopurinol (Zyloprim).
Clonidine (Catapres)
Clonidine iyo niacin labaduba waxay hooseeyaan cadaadiska dhiigga. Qaadashada niacin ee loo yaqaan 'clonidine' waxay sababi kartaa cadaadiska dhiiggaagu inuu aad u hooseeyo.
Gemfibrozil (Lopid)
Qaadashada niacin oo ay weheliso gemfibrozil waxay dadka qaarkood u keeni kartaa dhaawac muruqa ah. Si taxaddar leh u isticmaal.
Daawooyinka sonkorowga (Daawooyinka sonkorowga)
Isticmaalka qiyaaso badan oo niacin ah (qiyaastii 3-4 garaam maalin kasta) waxay kordhin kartaa sonkorta dhiiga. Markaad kordhiso sonkorta dhiiga, niacin waxay yareyn kartaa waxtarka daawooyinka sonkorowga. Si dhaw ula soco sonkorta dhiigaaga. Qiyaasta daawadaada sonkorowga ah waxay u baahan kartaa in la beddelo.

Daawooyinka qaarkood ee loo isticmaalo sonkorowga waxaa ka mid ah glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), metformin (Glucophage), nateglinide (Starlix), repaglinide (Prandin), chlor Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), iyo kuwo kale.
Daawooyinka dhiig karka (Daawooyinka dhiig karka)
Isticmaalka niacin ee daawooyinka hoos u dhigaya cadaadiska dhiigga waxay kordhin karaan saameynta daawooyinkan waxayna yareyn karaan cadaadiska dhiigga si aad ah.

Daawooyinka qaar ee dhiig karka waxaa ka mid ah captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), iyo kuwa kale oo badan. .
Daawooyinka waxyeelo u geysan kara beerka (Hepatotoxic drugs)
Niacin waxaa laga yaabaa inuu waxyeeleeyo beerka. Diyaargarowga sii-deynta joogtada ah ee niacin waxay umuuqataa inay leedahay halista ugu badan. Qaadashada niacin oo ay weheliso daawo sidoo kale waxyeelayn karta beerka waxay kordhin kartaa halista waxyeellada beerka. Ha u qaadan niacin haddii aad qaadanaysid daawo waxyeelayn karta beerka.

Daawooyinka qaar ee waxyeeli kara beerka waxaa kamid ah acetaminophen (Tylenol iyo kuwa kale), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporan) erythromycin (Erythrocin, Ilosone, kuwa kale), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), iyo kuwa kale oo badan.
Daawooyinka yareeya xinjirowga dhiigga (Daawooyinka Anticoagulant / Antiplatelet)
Niacin wuxuu yareyn karaa xinjirowga dhiigga. Qaadashada niacin iyo daawooyinka sidoo kale gaabiya xinjirowga ayaa kordhin kara fursadaha nabarrada iyo dhiig baxa.

Daawooyinka qaar ee gaabiya xinjirowga dhiigga waxaa kamid ah aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), iyo kuwa kale.
Daawooyinka loo isticmaalo hoos u dhigga kolestaroolka (isku xigxigayaasha Bile acid)
Daawooyinka qaar ee hoos u dhigga kolestaroolka ee loo yaqaan 'bile acid sequestrants' ayaa yareyn kara inta niacin ee jirka nuugo. Tani waxay yareyn kartaa waxtarka niacin. Qaado niacin iyo daawooyinka ugu yaraan 4-6 saacadood.

Daawooyinkaan qaarkood ee loo isticmaalo yareynta kolestaroolka waxaa ka mid ah cholestyramine (Questran) iyo colestipol (Colestid).
Daawooyinka loo isticmaalo yareynta kolestaroolka (Statins)
Niacin wuxuu saameyn xun ku yeelan karaa muruqyada. Daawooyinka qaar ee loo isticmaalo hoos u dhigga kolestaroolka loo yaqaan 'statins' ayaa sidoo kale saameyn ku yeelan kara murqaha. Qaadashada niacin iyo daawooyinkan waxay kordhin kartaa halista dhibaatooyinka muruqyada.

Qaar ka mid ah daawooyinka loo isticmaalo kolestaroolka sare waxaa ka mid ah rosuvastatin (Crestor), atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), fluvastatin (Lescol), iyo simvastatin (Zocor).
Probenecid (Benemid)
Probenecid waxaa loo isticmaalaa in lagu daaweeyo turqo. Qaadashada qiyaaso badan oo niacin ah ayaa laga yaabaa inay ka sii darto gout isla markaana hoos u dhigto waxtarka probenecid.
Sulfinpyrazone (Anturane)
Sulfinpyrazone (Anturane) waxaa loo isticmaalaa in lagu daaweeyo turqo. Qaadashada qiyaaso badan oo niacin ah ayaa laga yaabaa inay ka sii darto gout isla markaana hoos u dhigto waxtarka sulfinpyrazone (Anturane).
Hormoonka tayroodhka
Jidhku si dabiici ah ayuu u soo saaraa hormoonnada tayroodhka. Niacin wuxuu yareyn karaa heerarka hoormoonka tayroodhka. Qaadashada niacin ee kaniiniga hoormoonka tayroodhku waxay yareyn kartaa saameynta iyo dhibaatooyinka soo raaca hormoonka tayroodhka
Yar
Ka taxaddar iskudhafkan.
Aspirin
Aspirin waxaa badanaa loo isticmaalaa niacin si loo yareeyo dheecaanka ay keento niacin. Qaadashada qiyaaso badan oo asbiriin ah ayaa yareyn karta sida ugu dhakhsaha badan ee jirka uga takhaluso niacin. Tani waxay sababi kartaa inay jirka ku jirto niasiin aad u tiro badan waxayna u horseedi kartaa waxyeelo. Si kastaba ha noqotee, qiyaasta hoose ee asbiriin badanaa loo isticmaalo daweynta niacin la xiriirta uma muuqato inay dhibaato tahay.
Balastar nikotiinka (Nicoderm)
Niacin wuxuu mararka qaarkood sababi karaa dheecaan iyo wareer. Faashadda nikotiinka waxay kaloo sababi kartaa dheecaan iyo wareer. Qaadashada niacin ama niacinamide iyo isticmaalka balastarka nikotiinka ayaa kordhin kara suurtagalnimada noqoshada jirka iyo wareerka.
Beta-carotene
Isku darka niacin iyo daawada loo qoro simvastatin (Zocor) ayaa kor u qaadaya HDL (cufnaanta sare ee lipoprotein) kolestaroolka ("kolestarool wanaagsan") ee dadka qaba cudurada wadnaha iyo heerarka HDL oo hooseeya. Si kastaba ha noqotee, qaadashada niacin oo ay weheliso isku-darka antioxidants, oo ay ku jiraan beta-carotene, waxay umuuqataa inay hoos u dhigeyso kororkaan ku yimid HDL. Lama oga in saameyntani ay ku dhacdo dadka aan qabin wadne xanuunka.
Chromium
Qaadashada niacin iyo chromium wadajir waxay yareyn kartaa sonkorta dhiigga. Haddii aad sonkorow qabtid oo aad wada qaadatid waxyaalaha la yiraahdo chromium iyo niacin, ilaali sonkorta dhiiggaaga si aad u hubiso inuusan aad u hooseyn.
Dhir iyo waxyaabo dheeri ah oo waxyeelayn kara beerka
Niacin, gaar ahaan qiyaasta sare waxay sababi kartaa dhaawac beerka ah. Qaadashada niacin oo ay weheliso geedo kale ama kaabisyo wax u dhimi kara beerka ayaa kordhin kara halistaan. Qaar ka mid ah badeecadahan waxaa ka mid ah daawada, caleen borage, chaparral, comfrey, dehydroepiandrosterone (DHEA), jeermiska, kava, saliida pennyroyal, khamiirka cas, iyo kuwa kale.
Dhirta iyo kaabisyada yareyn kara cadaadiska dhiigga
Niacin wuxuu yareyn karaa cadaadiska dhiigga. Qaadashada niacin ee leh geedo kale iyo waxyaabo dheeri ah oo sidoo kale hoos u dhiga cadaadiska dhiigga waxay sababi karaan cadaadiska dhiigga inuu aad hoos ugu dhaco. Dhirta kale iyo kaabayaasha kale ee hoos u dhigi kara cadaadiska dhiigga waxaa ka mid ah andrographis, casein peptides, cadka bisada, coenzyme Q10, L-arginine, lycium, nettle, theanine, iyo kuwa kale.
Dhirta iyo nafaqada oo yareyn kara xinjirowga dhiigga
Niacin wuxuu yareyn karaa xinjirowga dhiigga. Isticmaalka niacin oo ay weheliyaan geedo kale iyo kaabisyo sidoo kale gaabiya xinjirowga dhiigga ayaa kordhin kara halista dhiig-baxa dadka qaarkood. Qaar ka mid ah geedaha kale ee noocan ah waxaa ka mid ah Angelica, clove, danshen, toon, sinjibiil, Panax ginseng, iyo kuwo kale.
Shaah Kombucha
Waxaa jira walaac xoogaa ah in shaaha kombuyuhu uu yareeyo nuugista niacin. Si kastaba ha noqotee, tani waxay u baahan tahay in la barto inbadan.
Selenium
Isku darka niacin iyo daawada loo qoro simvastatin (Zocor) ayaa kor u qaadaya HDL (cufnaanta sare ee lipoprotein) kolestaroolka ("kolestarool wanaagsan") ee dadka qaba cudurada wadnaha iyo heerarka HDL oo hooseeya. Si kastaba ha noqotee, qaadashada niacin oo ay weheliso isku-darka antioxidants, oo ay ku jiraan selenium, waxay umuuqataa inay hoos u dhigeyso kororkaan ku yimid HDL. Lama oga in saameyntani ay ku dhacdo dadka aan qabin wadne xanuunka.
Tryptophan
Qaar ka mid ah tryptophan oo ka socda cuntada ayaa loo rogi karaa niacin jirka ku jirta. Qaadashada niacin iyo tryptophan si wadajir ah waxay kordhin kartaa heerarka iyo dhibaatooyinka soo raaca ee niacin.
Vitamin C
Isku darka niacin iyo daawada loo qoro simvastatin (Zocor) ayaa kor u qaadaya HDL (cufnaanta sare ee lipoprotein) kolestaroolka ("kolestarool wanaagsan") ee dadka qaba cudurada wadnaha iyo heerarka HDL oo hooseeya. Si kastaba ha noqotee, qaadashada niacin oo ay weheliso isku-darka antioxidants, oo ay ku jiraan fitamiin C, waxay umuuqataa inay hoos u dhigeyso kororkaan ku yimid HDL. Lama oga in saameyntani ay ku dhacdo dadka aan qabin wadne xanuunka.
Vitamin E
Isku darka niacin iyo daawada loo qoro simvastatin (Zocor) ayaa kor u qaadaya HDL (cufnaanta sare ee lipoprotein) kolestaroolka ("kolestarool wanaagsan") ee dadka qaba cudurada wadnaha iyo heerarka HDL oo hooseeya. Si kastaba ha noqotee, qaadashada niacin oo ay weheliso isku-darka antioxidants, oo ay ku jiraan fitamiin E, waxay umuuqataa inay hoos u dhigeyso kororkaan ku yimid HDL. Lama oga in saameyntani ay ku dhacdo dadka aan qabin wadne xanuunka.
Zinc
Jirka ayaa sameyn kara niacin. Dadka ay nafaqo darrada hayso oo ay ku yar tahay niacinku, sida dadka aalkolada darada leh, waxay sameeyaan niacin dheeraad ah haddii ay qaataan zinc. Waxaa jiri kara halista sii kordheysa ee waxyeelada la xiriirta niacin sida dhaqidda iyo cuncunka haddii niacin iyo zinc la isu geeyo.
Cabitaano kulul
Niacin wuxuu sababi karaa biyo raacis iyo cuncun. Saameyntan waa la kordhin karaa haddii niacin lagu qaato cabitaan kulul.
Qiyaasaha soo socda ayaa lagu bartay cilmi baarista sayniska:

DADKA WAAWEYN

Afka:
  • Guud: Qaar ka mid ah alaabada dheeraadka ah ee cuntada lagu qoro niacin ku jirta calaamadda ku jirta niacin u dhiganta (NE). 1 mg oo niacin ah waxay lamid tahay 1 mg NE. Marka niacin lagu qoro calaamadda NE, waxaa ku jiri kara noocyo kale oo niacin ah sidoo kale, oo ay ku jiraan niacinamide, inositol nicotinate, iyo tryptophan. Gunooyinka cuntada ee maalinlaha ah ee lagu taliyo (RDAs) ee loogu talagalay niacin ee dadka qaangaarka ah waa 16 mg NE ragga, 14 mg NE haweenka, 18 mg NE haweenka uurka leh, iyo 17 mg NE haweenka nuujinaya.
  • Kalastaroolka sare: Saamaynta niacinku waa mid ku tiirsan qiyaasta daawada. Qiyaasaha niacin ee u hooseeya 50 mg iyo ilaa 12 garaam maalin kasta ayaa la isticmaalay. Si kastaba ha noqotee, kororka ugu weyn ee HDL iyo hoos u dhaca triglycerides wuxuu dhacaa 1200 ilaa 1500 mg / maalin. Saameynta ugu weyn ee Niacin ee LDL waxay dhacdaa 2000 illaa 3000 mg / maalin. Niacin waxaa badanaa loo isticmaalaa daawooyin kale si loo hagaajiyo heerarka kolestaroolka.
  • Kahortaga iyo daweynta fitamiin B3 yaraanta iyo xaaladaha laxiriira sida pellagra: 300-1000 mg maalin kasta qiyaaso kala qaybsan.
  • Daaweynta adkaanta halbowlayaasha: Qiyaasta niacin-ka ayaa sare u kacday 12 garaam maalin kasta. Si kastaba ha noqotee, qiyaas qiyaastii 1 ilaa 4 garaam oo niacin ah maalin kasta, kali ama ay la socdaan statins ama xinjirowga bile acid (daawo yareysa kolestaroolka), ayaa la isticmaali jiray illaa 6.2 sano.
  • Si loo yareeyo dheecaanka ka yimaada sunta daacuunka: 2 garaam maalin kasta ayaa la isticmaalay.
  • Heerarka dufanka aan caadiga ahayn ee daaweynta HIV / AIDS dartiis: Ilaa 2 garaam maalin kasta ayaa la isticmaali jiray.
  • Cudurka dheef-shiid kiimikaadka: 2 garaam oo niacin ah ayaa la qaataa maalin kasta muddo 16 toddobaad ah. Xaaladaha qaarkood, niacin 2 garaam maalin kasta, keligiis ama qiyaastan, ayaa lala socdaa 4 garaam oo ah omega-3 ethyl esters (Lovaza, GlaxoSmithKline Pharmaceuticals).
BY IV:
  • Kahortaga iyo daweynta fitamiin B3 yaraanta iyo xaaladaha laxiriira sida pellagra: 60 mg oo niacin ah ayaa la isticmaalay.
SIDII XABASHI AH:
  • Kahortaga iyo daweynta fitamiin B3 yaraanta iyo xaaladaha laxiriira sida pellagra: 60 mg oo niacin ah ayaa la isticmaalay.
CARRUURTA

Afka:
  • Guud: Gunooyinka cuntada ee maalinlaha ah ee lagu taliyo (RDAs) ee loogu talagalay niacin ee carruurta waa 2 mg NE oo loogu talagalay dhallaanka 0-6 bilood jira, 4 mg NE oo loogu talogalay dhallaanka 7-12 bilood jira, 6 mg NE loogu talagalay carruurta 1-3 sano jir ah, 8 mg NE oo loogu talagalay carruurta 4-8 sano jir ah, 12 mg NE oo loogu talagalay carruurta 9-13 sano jir ah, 16 mg NE oo loogu talagalay wiilasha da'doodu tahay 14-18 sano, iyo 14 mg NE oo loogu talagalay gabdhaha 14-18 sano jir ah.
  • Kahortaga iyo daweynta fitamiin B3 yaraanta iyo xaaladaha laxiriira sida pellagra: 100-300 mg maalintii niacin, oo lagu bixiyo qiyaaso kala qeybsan.
3-Pyridinecarboxylic Acid, Acide Nicotinique, Acide Pyridine-Carboxylique-3, Acid Pyridine-Carboxylique-3, Anti-Blacktongue Factor, Antipellagra Factor, B Complex Vitamin, Complex de Vitamines B, Facteur Anti-Pellagre, Niacina, Niacine, Nicoseine, Acotic Acid, Pellagra Preiting Vitamin B3, Vitamin PP, Vitamina B3, Vitamine B3, Vitamine PP.

Si aad wax badan uga ogaato sida maqaalkan loo qoray, fadlan eeg Daawooyinka Dabiiciga ah ee Xogta Dhamaystiran habka.


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