Insulin Glargine (asalka rDNA) Cirbadda

Qanacsan

• Kahor isticmaalka insulin glargine,
• Dawadani waxay sababi kartaa isbeddel ku dhaca sonkorta dhiiggaaga. Waa inaad ogaataa astaamaha sonkorta dhiiga oo hooseysa iyo kuwa sare iyo waxa la sameeyo haddii aad leedahay astaamahan.
• Insulin glargine waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto astaamahan, wac dhakhtarkaaga isla markiiba ama u hel daaweyn degdeg ah:
• Qiyaasta xad-dhaafka ah ee 'insulin glargine' ayaa dhici karta haddii aad isticmaasho in badan oo ka mid ah 'insulin glargine' ama haddii aad isticmaasho qaddarka saxda ah ee 'insulin glargine' laakiin aad wax ka yar ka caadiga u dhigato ama aad jimicsi ka samayso sidii caadiga ahayd. Qiyaasta xad-dhaafka ah ee 'insulin glargine' waxay sababi kartaa hypoglycemia. Haddii aad leedahay astaamaha hypoglycemia, raac tilmaamaha dhakhtarkaaga ee wixii aad sameyn lahayd haddii aad ku dhacdo hypoglycemia. Calaamadaha kale ee xad dhaafka ah:

Insulin glargine waxaa loo isticmaalaa in lagu daaweeyo nooca 1aad ee sonkorowga (xaalad jirku uusan soo saarin insulin oo markaa ma xakamayn karo qadarka sonkorta dhiiga ku jirta). Waxaa sidoo kale loo isticmaalaa in lagu daaweeyo dadka qaba nooca sonkorowga 2 (xaalad jirku uusan u isticmaalin insulin si caadi ah, sidaa darteedna, ma xakamayn karo qadarka sonkorta dhiiga ku jirta) ee u baahan insulin si loo xakameeyo macaankooda. Dadka qaba nooca 1aad ee sonkorowga, glargine-ta insulin waa in loo isticmaalaa nooc kale oo ah insulin (insulin shaqeyn-gaaban). Dadka qaba sonkorowga nooca 2-aad, glargine-ka insulin ayaa sidoo kale loo isticmaali karaa nooc kale oo insulin ah ama daawooyinka afka laga qaato ee sonkorowga. Insulin glargine waa hawl-qaadasho muddo dheer ah, oo ah nooca dadka lagu sameeyo ee insulin-ta aadanaha. Insulin glargine waxay ku shaqeysaa iyadoo la badalayo insulin-ta caadiga ah ee jirku soo saaro waxayna caawineysaa in sokorta dhiiga looga wareejiyo unugyada kale ee jirka halkaasoo loogu isticmaalo tamar. Waxay kaloo joojisaa beerka inuu soo saaro sonkor badan.

Waqti ka dib, dadka qaba sonkorowga iyo sonkorta dhiigga oo sareeya waxay la kulmi karaan dhibaatooyin halis ah ama naf-gooya, oo ay ku jiraan cudurrada wadnaha, istaroogga, dhibaatooyinka kelyaha, dhaawaca dareemaha, iyo dhibaatooyinka indhaha. Isticmaalka daawooyinka (yada), sameynta isbeddelada hab-nololeedka (tusaale, cuntada, jimicsiga, joojinta sigaar cabbista), iyo in si joogto ah loo hubiyo sonkorta dhiiggaaga ayaa gacan ka geysan karta maareynta sonkorowgaaga iyo hagaajinta caafimaadkaaga. Daaweyntani waxay sidoo kale yareyn kartaa fursadahaaga wadno qabad, istaroog, ama dhibaatooyin kale oo la xiriira sonkorowga sida kalyo-baxa, dhaawaca dareemaha (kabuubyo, lugaha qabow ama cagaha; hoos u dhaca awoodda galmada ee ragga iyo dumarka), dhibaatooyinka indhaha, oo ay ku jiraan isbeddelada ama aragga oo kaa luma, ama cirrid xannuun ah. Dhakhtarkaaga iyo bixiyeyaasha kale ee daryeelka caafimaad ayaa kaala hadli doona sida ugu wanaagsan ee loo maareeyo sonkorowgaaga.

Insulin glargine waxay u timaaddaa sidii xal (dareere) in si subag ah loogu mudo (maqaarka hoostiisa). Waxaa la isku duraa hal mar maalintii. Waa inaad isticmaashaa dhalada insulin-ta isla waqtigaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. U isticmaal glargine insulin sida loogu talagalay. Ha u isticmaalin wax ka yar ama ka yar ama u isticmaal si ka badan inta dhakhtarku kuu qoray.

Weligaa ha u isticmaalin glargine-ta insulin-ta markaad leedahay calaamadaha hypoglycemia (sonkorta dhiiga oo hooseysa) ama haddii aad hubisay sonkorta dhiiggaaga oo aad aragtay inay hooseyso.

Insulin glargine waxay xakameysaa cudurka macaanka laakiin ma daaweyso. Sii wad inaad isticmaasho glargine-ka insulin xitaa haddii aad fiicnaan dareento. Ha u joojin isticmaalka insulin glargine adigoon la hadlin dhakhtarkaaga. Ha u beddelin nooc kale ama nooc insulin ah ama ha u beddelin qiyaasta nooc kasta oo ah insulin aad isticmaaleyso adigoon dhaqtarkaaga la hadlin. Had iyo jeer hubi calaamadda insulin si aad u hubiso inaad ka heshay nooca saxda ah ee insulin farmasiga.

Insulin glargine waxay ku timaaddaa dhalooyinka iyo qiyaasta daawada oo ay ku jiraan xabbado daawo ah. Hubso inaad ogtahay nooca weel ay glargine-kaaga ay soo galaan iyo waxayaabaha kale ee ay ka midka yihiin irbadaha, siliingaha, ama qalimaanta, waxaad u baahan doontaa inaad isku durto dawadaada.

Haddii glargine-kaaga insulin uu soo galo weello, waxaad u baahan doontaa inaad isticmaasho siriinjyo si aad isugu durto qiyaastaada. Weydiiso dhakhtarkaaga ama farmashiistaha inuu ku tuso sida aad isugu durto insulin glargine adoo isticmaalaya siliinge. Weydii dhakhtarkaaga ama farmashiistaha haddii aad qabtid su'aalo ku saabsan nooca saliingaha ay tahay inaad isticmaasho.

Haddii glargine-kaaga insulin uu ku yimaado qalimaan, hubi inaad aqriso oo aad fahanto tilmaamaha soo saaraha. Weydiiso dhakhtarkaaga ama farmashiistaha inuu ku tuso sida loo isticmaalo qalinka. Raac tilmaamaha si taxaddar leh, mar walbana samee tijaabada amniga kahor isticmaalka.

Marna dib ha u isticmaalin irbado ama sirinjeeryo weligaa ha la wadaagin irbadaha, irbadaha, ama qalimaanta. Haddii aad isticmaaleyso qalin insulin, marwalba cirbadda ka qaad isla marka aad durto qiyaastaada. Ku tuur cirbadaha iyo cirbadaha weel u adkaysata daloolka. Weydii dhakhtarkaaga ama farmashiistaha sida loo tuuro weelka daloolka u adkaysta.

Ha ku milmin glargine-ka insulin hana ku darin glarginta insulin nooc kale oo insulin ah.

Waxaad ku duri kartaa glargine-kaaga insulin qeybta kore ee gacanta, bowdada, ama caloosha. Marna ha isku dusin glargine insulin xidid ama muruq. Ku beddel (wareeji) barta la isku duro ee aagga la doortay qiyaas kasta; iskuday inaad ka fogaato isku duritaanka isla goobta marar badan hal mar 1 ilaa 2 asbuuc kasta.

Had iyo jeer fiiri glargine-kaaga insulin intaadan isku durin. Waa inuu noqdaa mid cad oo aan midab lahayn. Ha u isticmaalin dhalada insulin-taada haddii ay midab leedahay, daruur leedahay, ama ay ku jiraan qurubyo adag, ama haddii taariikhda dhicitaanka dhalada ay dhaaftay.

Ha ku isticmaalin glargine-ka insulin-ta bamka insulin-ta dibadda.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor isticmaalka insulin glargine,

• u sheeg dhakhtarkaaga iyo farmasiilahaaga haddii aad xasaasiyad ku leedahay insulin (Humulin, Novolin, kuwa kale), mid ka mid ah waxyaabaha ka kooban glargine-ka insulin, ama daawooyin kale. Weydii farmashiistahaaga ama ka hubi macluumaadka bukaanka soo saaraha liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga iyo farmashiistaha dawooyinka dhakhtarku qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta aad qaadanayso. Hubso inaad sheegto mid ka mid ah kuwan soo socda: albuterol (Accuneb, Proair, Proventil, kuwa kale); daawooyinka dhakhtar qoro iyo kuwa aan dhakhtar qorin ee khamriga ku jira; angiotensin-converting enzyme inhibitors (ACE inhibitors) sida benazepril (Lotensin, in Lotrel), captopril, enalapril (Epaned, Vasotec, Vaseretic), fosinopril, lisinopril (Prinzide, Zestoretic), moexipril, perindopril, in quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), iyo trandolapril (Mavik, in Tarka); angiotensin receptor blockers (ARBs) sida azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), telmisartan (Micardis, Micardis HCT, Twynsta), valsartan (Diovan, Diovan HCT, Exforge); daawooyinka dhimirka aan caadiga ahayn sida clozapine (Clozaril, Fazaclo, Versacloz) iyo olanzapine (Zyprexa, in Symbyax); beta-blockers sida atenolol (Tenormin, Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, Corzide), iyo propranolol (Hemangeol, Inderal LA, Innopran XL); dawooyinka qaarkood ee yareeya kolestaroolka sida fenofibrate (Antara, Lipofen, Triglide), gemfibrozil (Lopid), iyo niacin (Niacor, Niaspan); clonidine (Catapres, Catapres-TTS, Kapvay, in Clorpres, kuwa kale); danazol; sibibramramide (Norpace); durayaasha ('kaniiniyada biyaha'); estrogens; fluoxetine (Prozac, Sarafem, Selfemra, oo ku taal Symbyax); glucagon; guanethidine (oo aan laga heli karin Mareykanka); Kahortagayaasha 'protease inhibitors' oo ay ka mid yihiin atazanavir (Reyataz), indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, Kaletra, Viekira Pak), iyo saquinavir (Invirase); daaweynta beddelka hoormoonka (kaniiniyada ka hortagga uurka, balastarro, faraantiyo, irbado, ama implant); isoniazid (Laniazid, Rifamate, Rifater); lithium (Lithobid); daawooyinka neefta iyo hargabka; daawooyinka cudurada maskaxda iyo lallabbada; monoamine oxidase (MAO) inhibitors ay ka mid yihiin isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), iyo tranylcypromine (Parnate); octreotide (Sandostatin); p-pillerka (kaniiniyada xakameynta dhalmada); daawooyinka afka laga qaato ee sonkorowga sida pioglitazone (Actos, in Actoplus Met, in Oseni, kuwo kale) iyo rosiglitazone (Avandia); steroids-ka afka laga qaato sida dexamethasone, methylprednisolone (Medrol), iyo prednisone (Rayos); pentamidine (NebuPent, Pentam); pentoxifylline (Pentoxil); pramlintide (Symlin); propoxyphene (aan laga heli karin Mareykanka); keydka; salicylate xanuun joojiyeyaasha sida asbiriin, choline magnesium trisalicylate, choline salicylate, diflunisal, magnesium salicylate (Doan’s, kuwa kale), iyo salsalate; somatropin (Genotropin, Humatrope, Nutropin, Serostim, kuwa kale); antibiyootikada sulfa; terbutaline; iyo dawooyinka tayroodhka. Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• u sheeg dhakhtarkaaga haddii aad leedahay ama waligaa aad dareentay dhaawac dareemayaasha oo ay sababeen sonkorowgaaga, wadnaha oo istaaga, heerarka dhiigga ee ka hooseeya kaalshiyamka; ama xaalado kale oo caafimaad, oo ay ku jiraan wadnaha, beerka ama cudurka kelyaha.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelatid intaad isticmaaleysid insulin glargine, wac dhakhtarkaaga.
• haddii aad qalliin samaynayso, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarka ama dhakhtarka ilkaha inaad isticmaasho glargine insulin.
• khamrigu wuxuu sababi karaa isbadal ku dhaca sonkorta dhiiga. Weydii dhakhtarkaaga wax ku saabsan isticmaalka aaminka ah ee cabitaanka khamriga ah inta aad isticmaaleysid glargine insulin.
• Weydii dhakhtarkaaga waxa la sameeyo haddii aad xanuunsato, ama aad dareento walwal aan caadi ahayn, ama aad beddesho cuntadaada, jimicsigaaga, ama jadwalkaaga waxqabad. Isbeddeladani waxay saameyn ku yeelan karaan sonkorta dhiiggaaga iyo xaddiga insulin-ta aad u baahan doonto.
• Weydii dhakhtarkaaga inta jeer ee ay tahay inaad iska hubiso sonkorta dhiiggaaga. Ogsoonow in hypoglycemia ay saameyn ku yeelan karto awoodaada inaad qabato howlo sida wadista oo weydii dhakhtarkaaga haddii aad u baahan tahay inaad hubiso sonkorta dhiiggaaga ka hor intaadan wadin ama aadan mishiinka wadin.

Hubso inaad raacdo dhammaan jimicsiga iyo talooyinka cuntada ee dhakhtarkaagu ama nafaqeeyahaagu kuu qoro. Waa muhiim in la cuno cunto caafimaad leh iyo in la cuno qiyaas isku mid ah oo noocyo cunto ah isku mid ah maalin kasta. Ka-boodidda ama dib-u-dhigista cuntada ama beddelidda qadarka ama nooca cuntada aad cunayso waxay dhibaato ku keeni kartaa xakamaynta sonkorta dhiiggaaga.

Kahor intaadan bilaabin isticmaalka insulin glargine, weydii dhakhtarkaaga waxa la sameeyo haddii aad ilowdo inaad isticmaasho qadar ama haddii aad si shil ah u isticmaasho qadar dheeraad ah. Qor tilmaamahan si aad mar dambe ugu tixraaci karto iyaga.

Dawadani waxay sababi kartaa isbeddel ku dhaca sonkorta dhiiggaaga. Waa inaad ogaataa astaamaha sonkorta dhiiga oo hooseysa iyo kuwa sare iyo waxa la sameeyo haddii aad leedahay astaamahan.

Insulin glargine waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• casaan, barar, xanuun, ama cuncun meesha la muday
• isbeddellada dareenka maqaarkaaga, maqaarka oo sii adkaada (dufanka oo kordha), ama niyad jab yar oo maqaarka ah (dufanka oo burbura)
• qandho, qufac, cuna xanuun, ama calaamadaha kale ee infekshanka

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto astaamahan, wac dhakhtarkaaga isla markiiba ama u hel daaweyn degdeg ah:

• finan, finan, ama cuncun jirka oo dhan
• taahid
• neefsashada ama wax liqidda oo ku adkaata
• garaaca wadnaha
• dhidid
• bararka indhaha, wejiga, dibnaha, carrabka, ama cunaha
• xabeeb
• daciifnimo
• murqo xanuun
• garaaca wadnaha oo aan caadi ahayn
• miisaanka oo kordha
• bararka anqawyada ama cagaha
• neefta oo ku qabata
• aragtida isbeddelay

Insulin glargine waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad isticmaaleyso daawadan.

Daawadan ku hay weelka ay ka soo gashay iyo meelaha ay carruurtu gaarto. Ku keydi fijaannada glargine-ka insulin aan furin iyo qalimaanta qaboojiyaha. Marnaba ha u oggolaan in glargine-ka insulin uu barafoobo; Ha u isticmaalin dhalada insulin-ta ee barafoobay ee dhalaashay. Daawada insulin-ta qaboojiyaha ah ee aan la furin ayaa lagu keydin karaa ilaa taariikhda lagu muujiyay astaanta shirkadda.

Haddii qaboojiye aan la heli karin (tusaale ahaan, marka la joogo fasaxa), ku kaydi fijaannada ama qalimaanta heerkulka qolka oo ka fog qorraxda tooska ah iyo kuleylka daran. Weelasha aan la qaboojin ama qalimaanta waxaa lagu isticmaali karaa 28 maalmood gudahood; waqtigaas kadib waa in la tuuraa. Weelasha furan ayaa lagu kaydin karaa 28 maalmood heerkulka qolka ama qaboojiyaha. Qalimmada furan waa in lagu kaydiyaa heerkulka qolka waana la isticmaali karaa ilaa 28 maalmood ka dib isticmaalka koowaad. Tuur insuliin kasta oo soo gaadhay kuleyl daran ama qabow.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Qiyaasta xad-dhaafka ah ee 'insulin glargine' ayaa dhici karta haddii aad isticmaasho in badan oo ka mid ah 'insulin glargine' ama haddii aad isticmaasho qaddarka saxda ah ee 'insulin glargine' laakiin aad wax ka yar ka caadiga u dhigato ama aad jimicsi ka samayso sidii caadiga ahayd. Qiyaasta xad-dhaafka ah ee 'insulin glargine' waxay sababi kartaa hypoglycemia. Haddii aad leedahay astaamaha hypoglycemia, raac tilmaamaha dhakhtarkaaga ee wixii aad sameyn lahayd haddii aad ku dhacdo hypoglycemia. Calaamadaha kale ee xad dhaafka ah:

• miyir beelid
• qalal

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Sonkorta dhiiggaaga iyo glycosylated hemoglobin (HbA1c) waa in si joogto ah loo hubiyaa si loo ogaado jawaabtaada insulin glargine. Dhakhtarkaaga ayaa sidoo kale kuu sheegi doona sida loo hubiyo jawaabtaada daawadan adoo ku cabbiraya heerarka sonkorta dhiiggaaga guriga. Si taxaddar leh u raac tilmaamahaas.

Waa inaad marwalba xidhataa jijin aqoonsiga kaadi macaanka si loo hubiyo inaad hesho daaweyn sax ah markay tahay xaalad degdeg ah.

Ha u ogolaan qof kale inuu isticmaalo daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Basaglar^®
• Lantus^®
• Toujeo^®
• Soliqua^® (sida shey isku dhafan oo ay kujiraan Insulin Glargine iyo Lixisenatide),