Cirbadda Tacrolimus

Qanacsan

• Kahor intaadan qaadan cirbadeynta tacrolimus,
• Cirbadda Tacrolimus waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, ama kuwa lagu sheegay qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga:
• Calaamadaha xad dhaafka ah waxaa ka mid noqon kara:

Cirbadda Tacrolimus waa in la siiyaa oo keliya iyadoo uu kormeerayo takhtar khibrad u leh daaweynta dadka lagu tallaalay xubin jirka ah iyo qoritaanka daawooyinka yareeya dhaqdhaqaaqa nidaamka difaaca jirka.

Cirbadda Tacrolimus waxay yareysaa waxqabadka nidaamkaaga difaaca. Tani waxay kordhin kartaa halista aad ku qaadi karto infekshan daran. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga: cuna xanuun; qufac; qandho; daal aad u daran; astaamaha hargabka oo kale; maqaar diiran, casaan ah, ama xanuun leh; ama calaamadaha kale ee cudurka.

Marka nidaamkaaga difaaca uusan si caadi ah u shaqeyneynin, waxaa jiri kara khatar aad u weyn oo ah inaad ku dhacdo kansarka, gaar ahaan lymphoma (nooc ka mid ah kansarka ka bilaabma unugyada habka difaaca jirka). Muddada aad qaadaneyso cirbadeynta tacrolimus ama daawooyin kale oo yareynaya howlaha nidaamka difaaca jirka, iyo heerarkaaga sare ee daawooyinkaan, ayaa inbadan oo halista ah ay sii kordheysaa. Haddii aad isku aragto mid ka mid ah astaamaha soo socda ee lymphoma, wac dhakhtarkaaga isla markiiba: qanjidhada qanjirada ee bararsan ee qoorta, kilkilaha, ama gumaarka; miisaanka oo yaraada; qandho; dhidid habeenkii; daal fara badan ama daciifnimo; qufac; neefsashada oo dhib ku ah; xabad xanuun; ama xanuun, barar, ama buuxisid aagga caloosha.

Takhtarkaaga kala hadal halista qaadashada cirbadda tacrolimus.

Cirbadda Tacrolimus waxaa loo isticmaalaa dawooyin kale si looga hortago diidmada (weerarka xubinta lagu tallaalay nidaamka difaaca jirka qaataha xubinta) ee dadka qaatay kilyaha, beerka, ama wadnaha loo beero. Cirbadda Tacrolimus waa inay isticmaalaan kaliya dadka aan awoodin inay ku qaataan tacrolimus afka. Cirbadda Tacrolimus waxay ku jirtaa nooc ka mid ah daawooyinka loo yaqaan 'immunosupressants'. Waxay ku shaqeysaa iyadoo hoos loo dhigayo howlaha nidaamka difaaca jirka si looga hortago inay weeraraan xubinta la tallaalay.

Cirbadda Tacrolimus waxay u timaaddaa sidii xalka (dareeraha) lagu duray xididka (xididka) dhakhtarka ama kalkaalisada cisbitaalka ama xarunta caafimaadka. Badanaa waxaa loo bixiyaa faleebo socota, bilaaban wax aan kayar 6 saacadood ka dib qalliinka qalliinka iyo in la sii wado ilaa tacrolimus afka laga qaadan karo.

Dhakhtar ama kalkaaliye caafimaad ayaa si dhaw kuu ilaalin doona 30ka daqiiqo ee daaweyntaada ugu horreysa ka dibna si joogto ah ayey kuu ilaalin doontaa si dhakhso leh ayaa lagugu daaweyn karaa haddii aad leedahay xasaasiyad daran.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor intaadan qaadan cirbadeynta tacrolimus,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay tacrolimus, daawooyinka kale, polyoxyl 60 hydrogenated castor oil (HCO-60) ama daawooyinka kale ee ay ku jiraan saliida castor. Weydii dhakhtarkaaga ama farmashiistaha haddii aadan ogeyn haddii daawo aad xasaasiyad ku leedahay ay ku jirto saliid castor ah.
• u sheeg dhakhtarkaaga iyo farmashiistaha dawooyinka dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, iyo nafaqada nafaqada ee aad qaadanaysid ama qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: amphotericin B (Abelcet, Ambisome, Amphotec); antacids; antibiyootikada qaarkood oo ay ku jiraan aminoglycosides sida amikacin, gentamicin, neomycin (Neo-Fradin), streptomycin, iyo tobramycin (Tobi), iyo macrolides sida clarithromycin (Biaxin), erythromycin (EES, E-Mycin, Erythrocin), iyo troleandomycin (TAO) (oo aan laga heli karin Mareykanka); daawooyinka antifungal sida clotrimazole (Lotrimin, Mycelex), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral) iyo voriconazole (Vfend); bromocriptine (Parlodel); Kaalshiyam kaaliyaal diley sida diltiazem (Cardizem), nicardipine (Cardene), nifedipine (Adalat, Procardia), iyo verapamil (Calan, Covera, Isoptin); caspofungin (Cancidas); chloramphenicol; cimetidine (Tagamet); cisapride (Propulsid) (aan laga heli karin Mareykanka); cisplatin (Platinol); danazol (Danocrine); durayo gaar ah ('kaniiniyada biyaha'); ganciclovir (Cytovene); ka hortagga uurka ee hormoonka (kaniiniyada ka hortagga uurka, balastarro, faraantiyo, waxyaabaha la gelinayo, ama irbado); Kahortagayaasha 'protease HIV' sida indinavir (Crixivan), nelfinavir (Viracept), iyo ritonavir (Norvir); lansoprazole (Prevacid); dawooyinka qaarkood ee suuxdinta sida carbamazepine (Tegretol), phenobarbital, iyo phenytoin (Dilantin); methylprednisolone (Medrol); metoclopramide (Reglan); nefazodone; omeprazole (Prilosec); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); iyo sirolimus (Rapamune). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa laga yaabaa inay la falgalaan tacrolimus, markaa u sheeg dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• u sheeg dhakhtarkaaga haddii aad qaadanayso ama aad dhawaan joojisay qaadashada cyclosporine (Gengraf, Neoral, Sandimmune). Haddii aad qaadaneysay cyclosporine, dhakhtarkaaga ayaa laga yaabaa inuusan bilaabi doonin inuu ku siiyo cirbadeynta tacrolimus illaa 24 saacadood ka dib markii aad qaadatay qiyaasta ugu dambeysa ee cyclosporine. Haddii aad joojiso qaadashada cirbadeynta tacrolimus, dhakhtarkaaga ayaa sidoo kale kuu sheegi doona inaad sugto 24 saacadood ka hor intaadan bilaabin qaadashada cyclosporine.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa dhirta ka soo baxda ee aad qaadanaysid, gaar ahaan St. John's wort.
• u sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabtid cudur wadne, kelyo ama beer.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelato inta aad qaadanayso cirbadeynta tacrolimus, wac dhakhtarkaaga.
• haddii aad qalliin ku jirto, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarka ama dhakhtarka ilkaha inaad qaadanayso cirbadeynta tacrolimus.
• waa inaad ogaataa in qaadashada cirbadeynta tacrolimus ay kordhin karto halista ah inaad ku dhacdo kansarka maqaarka. Ka ilaali naftaada kansarka maqaarka adoo iska ilaalinaya soo-gaadhista qorraxda ama iftiinka ultraviolet-ka ee aan loo baahnayn ama daba dheeraaday (sariiraha maqaarka) iyo xirashada dharka ilaaliya, muraayadaha indhaha, iyo shaashadda qorraxda ee leh isirka ilaalinta maqaarka oo sarreeya (SPF)
• waa inaad ogaataa in cirbadeynta tacrolimus ay sababi karto dhiig kar. Dhakhtarkaaga ayaa si taxadar leh ula socon doona cadaadiska dhiiggaaga, waxaana laga yaabaa inuu kuu qoro daawo lagu daaweeyo dhiig karka haddii uu soo baxo.
• waa inaad ogaataa inay jirto halista ah inaad kudhacdo kaadi sonkorow inta aad kujirto daweynta cirbadeynta tacrolimus. Bukaanleyda African American iyo Hispanic ee laga tallaalay kelyaha waxay si gaar ah halista ugu badan ugu jiraan inuu ku dhaco cudurka macaanka inta lagu guda jiro daweynta cirbadaha tacrolimus. U sheeg dhakhtarkaaga haddii adiga ama qof kale oo qoyskaaga ka mid ahi uu qabo ama aad waligiisba sonkorow qabeen. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga: harraad xad dhaaf ah; gaajo xad dhaaf ah; kaadi joogta ah; aragga oo xumaada ama jahwareer.
• ha qaadan wax talaal ah adigoon lahadlin dhaqtarkaaga.

Ka fogow cunista canabka canabka ama cabitaanka casiirka canabka iyadoo aad qaadaneyso cirbadeynta tacrolimus.

Cirbadda Tacrolimus waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• madax xanuun
• gariir aan la koontarooli karin qayb ka mid ah jirka
• shuban
• calool istaag
• lallabbo
• matagid
• laabjeex
• calool xanuun
• cunto xumo
• dhibaato xagga hurdada ama hurdada ah
• dawakhaad
• daciifnimo
• dhabar ama kalagoys xanuun
• gubasho, kabuubyo, xanuun ama ruxitaan gacmaha ama cagaha

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, ama kuwa lagu sheegay qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga:

• finan
• finan
• cuncun
• neefsashada ama wax liqidda oo ku adkaata
• kaadida oo yaraatay
• xanuun ama gubasho xagga kaadida ah
• bararka gacmaha, gacmaha, cagaha, anqawyada ama lugaha hoose
• miisaanka oo kordha
• dhiigbax ama nabar aan caadi ahayn
• qalal
• miyir beelid (miyir beelid muddo ah)

Cirbadda Tacrolimus waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn inta aad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad dhaafka ah waxaa ka mid noqon kara:

• finan
• hurdo la'aan

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa baaritaano gaar ah si loo hubiyo jawaabta jirkaaga ee cirbadeynta tacrolimus.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Barnaamij^®

• FK 506