Telaprevir

Qanacsan

• Kahor qaadashada telaprevir,
• Telaprevir waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama mid ka mid ah kuwa ku taxan qaybta DIGNIIN MUHIIM AH, wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:
• Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

Telaprevir hadda lagama heli karo Mareykanka wixii ka dambeeya Oktoobar 16, 2014. Haddii aad hadda qaadaneyso telaprevir, waa inaad wacdaa dhakhtarkaaga si aad ugala hadasho u beddelashada daaweyn kale.

Telaprevir waxay sababi kartaa falcelin maqaarka oo halis ah ama nafta halis gelisa. Wac dhakhtarkaaga isla markiiba ama raadso daaweyn caafimaad oo degdeg ah haddii aad isku aragto mid ka mid ah astaamaha soo socda: finan, nabarro, ama nabar maqaarka ku yaal; cuncun; qandho; barar wejiga; nabarro ku dhaca afka; ama casaan, barar, cuncun, ama indho ilmo. Dhakhtarkaagu wuxuu kuu sheegi karaa inaad joojiso qaadashada daawada telaprevir (iyo malaha dawooyinka kale) haddii maqaarkaagu isbeddelo; Ha u joojin qaadashada daawadaada ilaa dhakhtarkaagu kuu sheego mooyee. Haddii dhakhtarkaagu kuu sheego inaad joojiso qaadashada daawada loo yaqaan 'telaprevir' isbeddellada maqaarka awgeed, waa inaadan mar dambe qaadan.

Telaprevir waxaa loo isticmaalaa laba daawo oo kale (ribavirin [Copegus, Rebetol] iyo peginterferon alfa [Pegasys]) si loogu daaweeyo cagaarshowga C ee joogtada ah (infekshin joogto ah oo beerka waxyeelleeya) oo loogu talagalay dadka aan weli laga daweyn xaaladan ama cidda Xaaladda si guul leh looma daaweyn karin ribavirin iyo peginterferon alfa oo keliya. Telaprevir wuxuu ku jiraa nooc daawo ah oo loo yaqaan 'protease inhibitors'. Waxay ku shaqeysaa iyadoo la yareeyo xaddiga fayraska cagaarshowga C (HCV) ee jirka ku jira. Telaprevir lagama yaabo inay ka hortagto inuu ku faafo cagaarshowga C dadka kale.

Telaprevir wuxuu u yimaadaa kiniin ahaan afka laga qaato. Badanaa waxaa la qaataa laba jeer maalintii (10 ilaa 14 saacadood kasta). Waa inaad cuntaa cunto ama cunto fudud oo ka kooban ilaa 20 garaam oo dufan ah 30 daqiiqo gudahood ka hor intaadan qaadan daawada loo yaqaan 'telaprevir'. Tusaalooyinka cunnooyinka (noocyada caadiga ah, ee aan ahayn dufanka yar ama waxyaabaha aan dufanka lahayn) ee lagu qaadan karo telaprevir waxaa ka mid ah: bagel leh jiis kareem ah, 1/2 koob oo nuts ah, 3 qaado oo subagga looska ah, 1 koob oo jalaato ah, 2 wiqiyadood oo Mareykan ah ama cheddar jiis, 2 wiqiyadood oo ah baradhada baradhada, ama 1/2 koob oo isku darka raadraaca. Weydiiso dhakhtarkaaga tusaalooyinka kale ee cuntooyinka ay ku jiraan 20 garaam oo dufan ah oo aad cuni karto markii aad qaadato telaprevir. Ha u qaadan telaprevir cunto la'aan. Qaado telaprevir qiyaastii isla waqtiyadaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado telaprevir sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Kiniiniyada oo dhan liq; ha kala jabin, burburin, ama calalin. Haddii aadan wada liqi karin kaniiniyada, u sheeg dhakhtarkaaga.

Sii wad inaad qaadato telaprevir xitaa haddii aad ladnaan dareento. Telaprevir waa in lagu qaataa isku darka peginterferon alfa iyo ribavirin, badiyaa waa 12 toddobaad. Peginterferon alfa iyo ribavirin badanaa waa la sii wadaa ka dib marka la dhameeyo daaweynta telaprevir. Ha u joojin qaadashada telaprevir, peginterferon alfa, ama ribavirin, ilaa dhakhtarkaagu kuu sheego mooyee.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo saaraha (Hagaha Daawada) markaad bilawdo daaweynta telaprevir iyo mar kasta oo aad dib u buuxiso dawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada telaprevir,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay telaprevir, ribavirin (Copegus, Rebetol), peginterferon alfa (Pegasys), dawooyin kale oo kasta, ama wax ka mid ah maaddooyinka ku jira kiniinnada telaprevir. Weydii farmashiistahaaga ama ka hubi Hagaha Daawada liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanayso mid ka mid ah daawooyinka soo socda ama dhirta ka soo baxda: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); cisapride (Propulsid) (hadda lagama heli karo Mareykanka); dawooyinka ergot sida dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), ergonovine, iyo methylergonovine (Methergine); lovastatin (Altoprev, Mevacor, in Advicor); midazolam oo afka laga qaato; phenobarbital, phenytoin (Dilantin, Phenytek); pimozide (Orap); rifampin (Rifadin, Rimactane, gudaha Rifamate, Rifater); sildenafil (kaliya magaca Revatio ee loo isticmaalo cudurka sanbabada); simvastatin (Zocor, gudaha Simcor, Vytorin); Johannesört wort; triazolam (Halcion); iyo tadalafil (kaliya magaca Adcirca ee loo isticmaalo cudurka sanbabada). Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan telaprevir haddii aad qaadanaysid mid ama kabadan daawooyinkan.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinada, iyo nafaqada nafaqada aad qaadanaysid ama qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: alprazolam (Niravam, Xanax); daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida warfarin (Coumadin, Jantoven); daawooyinka antifungal sida itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ama voriconazole (Vfend); bosentan (Tracleer); budesonide (Pulmicort, Rhinocort, in Symbicort); Kaalshiyamka kaaliyayaasha sida amlodipine (Norvasc, in Amturnide, Tekamlo), diltiazem (Cardizem, Cartia XT, Dilacor, Diltzac, Dilt-CD, Tiazac, Taztia XT, kuwa kale), felodipine (Plendil), nicardipine (Cardene), nifedipine (Afeditab CR, Adalat, Procardia), nisoldipine (Sular), iyo verapamil (Calan, Covera, Verelan, in Tarka); daawooyinka qaarkood ee yareeya kolestaroolka sida atorvastatin (Lipitor, in Caduet, in Liptruzet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), iyo rosuvastatin (Crestor); clarithromycin (Biaxin, gudaha Prevpac); colchicine (Colcrys, ee Col-probenecid); digoxin (Lanoxin); efavirenz (Sustiva, oo ku taal Atripla); erythromycin (E.E.S., E-Mycin, kuwa kale); escitalopram (Lexapro); fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Subsys); fluticasone (gudaha Advair, Flonase, Flovent); daaweynta beddelka hormoonka (HRT); difaaca jirka sida cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), ama tacrolimus (Prograf); daawooyinka erectile dysfunction (ED) sida sildenafil (Viagra), tadalafil (Cialis), ama vardenafil (Levitra, Staxyn); daawooyinka loogu talagalay garaaca wadnaha aan caadiga ahayn sida amiodarone (Cordarone, Pacerone), flecainide, lidocaine (Lidoderm, Lidopen, Xylocaine), propafenone (Rhythmol), ama quinidine; methadone (Dolophine, Methadose); irbadda midazolam; ka hortagga uurka ('kaniiniyada ka hortagga uurka'); dawooyinka afka laga qaato sida dexamethasone, methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol), iyo prednisone (Rayos); repaglinide (Prandin, gudaha Prandimet); rifabutin (Mycobutin); ritonavir (Norvir, oo ku yaal Kaletra) oo loo isticmaalay iskudhafka kahortagayaasha kale ee HIV sida atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), iyo lopinavir (Kaletra); salmeterol (Serevent, Advair); telithromycin (Ketek); tenofovir (Viread, Atripla, Stribild, Truvada); trazodone (Oleptro); iyo zolpidem (Ambien, Edluar, Intermezzo, Zolpmist). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara telaprevir, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• u sheeg dhakhtarkaaga haddii lagu beeray xubin xubin. Sidoo kale u sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa dhiig-yaraan ku dhacday (kuma filna unugyada dhiigga cas ee dhiigga ku jira si ay oksijiinka ugu gudbiyaan jirka intiisa kale), gout (weerarada xanuunka wadajirka ah ee ay sababaan heerarka sare ee uric acid ee dhiigga ku jirta), fayraska difaaca jirka ee dadka (HIV), dhibaatooyinka nidaamkaaga difaaca, cagaarshowga B (HBV) ama cudurka beerka ee aan aheyn hepatitis C ..
• haddii aad qalliin ku jirto, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarkaaga ama dhakhtarkaaga ilkaha inaad qaadanayso telaprevir.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad uur yeelan karto. Haddii aad tahay lab, u sheeg dhakhtarkaaga haddii lammaanahaagu uur leeyahay, qorsheynayo inuu uur qaado, ama suuragal tahay inuu uur qaado. Telaprevir waa in lagu qaataa ribavirin, kaas oo dhaawici kara uurjiifka. Waa inaad isticmaashaa laba qaab oo xakameynta dhalmada ah si looga hortago uur qaadista adiga ama lammaanahaaga inta lagu guda jiro daaweynta daawooyinkan iyo 6 bilood daaweyntaada ka dib. Kala hadal dhakhtarkaaga hababka ay tahay inaad isticmaasho; kahortaga uurka (kaniiniyada xakameynta dhalmada, balastarro, implants, ring, ama irbado) sifiican ugama shaqeyn karaan dumarka qaata daawooyinkaan iyo ilaa 2 usbuuc daaweynta kadib. Adiga ama lammaanahaaga waa in lagaa baaraa uurka bil kasta inta lagu jiro daaweyntaada iyo 6 bilood daaweyntaada ka dib. Haddii adiga ama lammaanahaagu aad uur yeelataan inta aad qaadanaysaan daawooyinkan, isla markiiba wac dhakhtarkaaga.
• u sheeg dhakhtarkaaga haddii aad naas nuujinayso.

Gaar ahaan ka taxaddar inaad cabto dareere kugu filan intaad ku daweyneyso dawadan.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Haddii aad ku xasuusato qiyaasta la seegay 6 saacadood gudahood ee wakhtiga jadwalkaaga ahaa inaad qaadatid, ku qaado qiyaasta la seegay cunto fudud ama cunto (ay ku jiraan qiyaastii 20 garaam oo dufan ah) isla markiiba. Si kastaba ha noqotee, haddii ay ka badan tahay 6 saacadood markii aad qaadan lahayd qiyaasta, ka bood qiyaasta la seegay oo ku sii wad jadwalkaaga qaadashada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Telaprevir waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• lallabbo
• matagid
• shuban
• beddelo awoodda dhadhaminta
• cuncun
• babaasiirta
• raaxo la'aan, gubasho, ama cuncun agagaarka futada

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama mid ka mid ah kuwa ku taxan qaybta DIGNIIN MUHIIM AH, wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

• maqaarka cirro leh
• dawakhaad
• neefta oo ku qabata
• daallan
• daciifnimo
• harraad u kordhay
• kaadi midab madow
• afka qalalan
• xaddiga kaadida ama qadarka
• ay kugu adkaato cunista ama matag daran ama shuban.

Telaprevir waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

• lallabbo
• shuban
• matagid
• madax xanuun
• cunto xumo
• isbedelka dhadhanka

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa tijaabooyinka shaybaarka qaarkood si loo hubiyo jawaabta jirkaaga ee telaprevir.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Ku dar^®