Mifepristone (Korlym)

Qanacsan

• Kahor qaadashada mifepristone,
• Mifepristone wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

Dumarka bukaanka ah:

Ha qaadan mifepristone haddii aad uur leedahay ama qorsheyso inaad uur yeelato. Mifepristone wuxuu sababi karaa luminta uurka. Waa inaad iska qaaddaa baaritaanka uurka kahor intaadan bilaabin daaweynta mifepristone iyo kahor intaadan bilaabin daaweynta markale haddii aad joojiso qaadashadeeda in kabadan 14 maalmood. Haddii aad uur qaadi karto, waxaad u baahan doontaa inaad iska ilaaliso inaad uur yeelato muddada daaweyntaada ee 'mifepristone'. Waa inaad isticmaashaa qaababka xakameynta dhalmada ee la aqbali karo inta lagu jiro daweyntaada iyo ugu yaraan 1 bil kadib daaweyntaada la dhammeeyo. Dhakhtarkaaga ayaa kuu sheegi doona noocyada ka hortagga uurka ee la aqbali karo. Haddii aad u maleyneyso inaad uur leedahay, waxaad seegaysaa caadada, ama aad galmo sameysid adigoon isticmaalin xakamaynta dhalmada inta aad qaadaneyso mifepristone ama 1 bil gudahood daaweyntaada, wac dhaqtarkaaga isla markiiba.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu dalban karaa baaritaano gaar ah si loo hubiyo jawaabta jirkaaga ee mifepristone.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo saaraha (Hagaha Daawada) marka aad bilawdo daaweynta mifepristone iyo mar kasta oo aad dib u buuxiso dawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Kala hadal dhakhtarkaaga halista (yada) qaadashada mifepristone.

Mifepristone (Korlym) waxaa loo isticmaalaa in lagu daaweeyo hyperglycemia (sonkorta dhiiga oo sareysa) dadka qaba nooc nooc oo ah Cushing's syndrome kaas oo jirku sameeyo cortisol aad u badan (hormoon) iyo kuwa ku fashilmay qalliinka ama aan qalliin lagu daaweyn karin xaaladan. Mifepristone wuxuu ku jiraa nooc daawo ah oo loo yaqaan 'cortisol receptor blockers'. Waxay ku shaqeysaa iyadoo la xannibayo waxqabadka cortisol.

Mifepristone sidoo kale waxaa loo heli karaa iyada oo ah wax soo saar kale (Mifeprex) oo kaligiis la isticmaalo ama lagu daro daawo kale si loo soo afjaro uurka hore. Noocani wuxuu kaliya bixiyaa macluumaad ku saabsan mifepristone (Korlym) oo loo isticmaalo in lagu xakameeyo hyperglycemia ee dadka qaba nooc ka mid ah noocyada 'Cushing's syndrome'. Haddii aad u isticmaaleyso mifepristone inaad joojiso uurka, akhri monograph xaq u leh mifepristone (Mifeprex), oo laga qoray wax soo saarkan.

Mifepristone wuxuu u yimaadaa kiniin ahaan afka laga qaato. Badanaa waxaa la qaataa maalintii hal mar oo cunto ah. Qaado mifepristone qiyaastii isla waqtigaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado mifepristone sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Kiniiniyada oo dhan liq; ha kala qaybin, calalin, ama burburin. U sheeg dhakhtarkaaga ama farmashiistaha haddii aadan awoodin inaad kiniinnada wada liqdo.

Dhakhtarkaagu wuxuu kugu bilaabi doonaa qadar yar oo ah 'mifepristone' wuxuuna si tartiib tartiib ah u kordhin doonaa qiyaastaada, ugu badnaan badiyaa hal jeer 2 ilaa 4 toddobaad kasta. Haddii aad joojiso qaadashada mifepristone, wac dhakhtarkaaga. Dhakhtarkaaga ayaa laga yaabaa inuu kugu bilaabo mar kale qiyaasta ugu hooseysa ee mifepristone oo si tartiib tartiib ah u kordhiya qiyaastaada.

Mifepristone ayaa xakameyn kara xaaladaada laakiin ma daaweynayo. Waxay qaadan kartaa 6 toddobaad ama ka badan ka hor intaadan dareemin faa'iidada buuxda ee mifepristone. Sii wad qaadashada daawada 'mifepristone' xitaa haddii aad caafimaad qabtid.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada mifepristone,

• u sheeg dhakhtarkaaga haddii aad xasaasiyad ku leedahay mifepristone, dawooyinka kale, ama wax ka mid ah maaddooyinka ku jira kiniiniyada 'mifepristone'. Weydii farmashiistahaaga ama ka hubi macluumaadka bukaanka soo saaraha liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanayso mid ka mid ah daawooyinka soo socda ama aad qaadatay labadii toddobaad ee ugu dambeeyay: , fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, kuwa kale), prednisolone (Prelone, kuwa kale), prednisone (Deltasone, Meticorten, Sterapred, kuwa kale), iyo triamcinolone (Aristocort, Azmacort) daawooyinka xakameynaya nidaamka difaaca jirka sida cyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), iyo tacrolimus (Prograf); dihydroergotamine (DHXE 45, Migranal); ergotamine (Ergomar, gudaha Cafergot, gudaha Migergot); fentanyl (Duragesic); lovastatin (Mevacor); pimozide (Orap); quinidine (Quinidex); iyo simvastatin (Zocor). Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan mifepristone haddii aad qaadanayso mid ama in kabadan oo daawooyinkan ah.
• u sheeg dhakhtarkaaga iyo farmashiistaha dawooyinka kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadato ama aad qaadatay labadii toddobaad ee la soo dhaafay. Hubso inaad sheegto mid ka mid ah kuwan soo socda: daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida warfarin (Coumadin); antifungals sida itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), ama voriconazole (Vfend); asbiriin iyo dawooyinka kale ee nonsteroidal anti-bararka (NSAIDs) sida ibuprofen (Advil, Motrin) iyo naproxen (Aleve, Naprosyn); bupropion (Wellbutrin); ciprofloxacin (Cipro); clarithromycin (Biaxin); conivaptan (Vaprisol); diltiazem (Cardizem); erythromycin (E.E.S, E-Mycin, Erythrocin); fluvastatin (Lescol); ka hortagga uurka ee hormoonnada sida kiniinka ka hortagga uurka, maqaar-galaha, dhejiska, giraanyada, ama irbado; daawooyinka cagaarshowga C sida boceprevir (Victrelis) iyo telaprevir (Incivek); daawooyinka HIV ama AIDS sida amprenavir (Agenerase), atazanavir (Reyataz), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir iyo ritonavir (Kaletra), nelfinavir (Viracept), ritonav, iyo saquinavir (Fortovase, Invirase); daawooyinka qalalaasaha sida carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin); dawooyinka qaaxada sida rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifamate, Rifater) iyo rifapentine (Priftin); nefazodone (Serzone); dib-u-dhiska (Prandin); telithromycin (Ketek); iyo verapamil (Calan, Isoptin, kuwa kale). Daawooyin kale oo badan ayaa sidoo kale la macaamili kara mifepristone, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan. Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• u sheeg dhakhtarkaaga waxa ka soo baxa dhirta aad qaadanaysid, gaar ahaan St. John's Wort.
• u sheeg dhakhtarkaaga haddii aad waligaa ku tallaashay xubin xubin jir ah ama haddii aad qabto ama aad waligaa qabto cudurka qanjirka 'thyroid'. Haddii aad tahay qof dumar ah oo aan qalliin lagaa saarin ilmagaleenkaaga, u sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa yeelatay dhiig bax siilka ah oo aan la garanayn, endometrial hyperplasia (xuubka xubinta ilma galeenka oo aad u weyn), ama kansarka endometrial (kansarka ku dhaca dahaarka ilmagaleenkaaga) Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan mifepristone.
• u sheeg dhakhtarkaaga haddii aad qabtid ama aad waligaa wadnaha istaagtay, waqti dheer oo QT ah (dhibaato wadnaha oo dhif ah oo sababi karta garaaca wadnaha oo aan joogto ahayn, miyir beelid, ama geeri lama filaan ah), macdanta dhiigga ee dhiigga ku yar, adrenal insufficiency (xaalad ku jirta qanjidhada adrenal) Ha soo saarin ku filan hormoonnada qaarkood ee loogu baahan yahay howlaha jirka ee muhiimka ah), cillad dhiig-bax ah, ama beerka, kilyaha, ama cudur wadne.
• u sheeg dhakhtarkaaga haddii aad naas nuujinayso.

Ha cunin canab canab ah ama ha cabin casiir canab ah inta aad qaadanaysid dawadan.

Qaado qiyaasta la seegay isla marka aad xasuusatoba. Si kastaba ha noqotee, haddii ay ku dhowdahay waqtiga qiyaasta xigta, ka bood qiyaasta la seegay oo sii wad jadwalka daawadaada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Mifepristone wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• madax xanuun
• matagid
• afka qalalan
• shuban
• calool istaag
• kalagoys ama muruq xanuun
• barar gacmaha, cagaha, anqawyada, ama lugaha hoose
• finan
• cuncun

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

• lallabbo
• cunto xumo
• dawakhaad ama madax-wareer
• daal ama daciifnimo aan caadi ahayn
• gariir ama xanaaq
• xishood
• dhidid
• murqaha oo daciifa, xanuun, ama casiraad
• degdeg ah, aan caadi ahayn, ama garaaca wadne garaac
• dhiigbax siilka ah ama dhibic aan la filayn
• neefta oo ku qabata

Mifepristone wuxuu sababi karaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Kahor baaritaanka shaybaarka, u sheeg dhakhtarkaaga iyo shaqaalaha sheybaarka inaad qaadanayso mifepristone.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Korlym^®