Lumacaftor iyo Ivacaftor

Qanacsan

• Kahor qaadashada lumacaftor iyo ivacaftor,
• Lumacaftor iyo ivacaftor waxay sababi karaan waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac dhakhtarkaaga isla markiiba:
• Calaamadaha xad dhaafka ah waxaa ka mid noqon kara:

Lumacaftor iyo ivacaftor waxaa loo isticmaalaa in lagu daaweeyo noocyada qaarkood ee 'cystic fibrosis' (cudur ku dhasha oo sababa dhibaatooyin xagga neefsashada, dheefshiidka, iyo taranka ah) ee dadka waaweyn iyo carruurta da'doodu tahay 2 sano iyo wixii ka weyn. Lumacaftor wuxuu ku jiraa fasal dawooyin ah oo lagu magacaabo saxeexayaasha habdhiska habdhiska habdhiska habdhiska cystic fibrosis Ivacaftor wuxuu ku jiraa fasal dawooyin ah oo loo yaqaan 'cystic fibrosis transmembrane conductance regulator (CFTR) awood leh.Labada dawooyinba waxay ku shaqeeyaan hagaajinta shaqada borotiinka jirka si loo yareeyo soo dhiska xabka qafiifka ah ee sanbabada iyo hagaajinta calaamadaha kale ee cystic fibrosis.

Isku darka lumacaftor iyo ivacaftor waxay u yimaadaan sidii kiniin ahaan iyo granules oo afka laga qaato. Waxaa badanaa lagu qaataa cunnooyinka dufanka leh laba jeer maalintii, 12 saacadoodna ay isu jiraan. Qaado lumacaftor iyo ivacaftor isla waqtiyada isku mid ah maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado lumacaftor iyo ivacaftor sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Si aad u diyaarisid qaddarka lumacaftor iyo ivacaftor granules, ku qas dhammaan baakadaha granules ku jira 1 qaado yar (5 ml) oo ah cunto jilicsan ama dareere ah (qabow ama heerkulka qolka) sida caano fadhi, tufaax, caano, ama caano. Qaado isku dar ah oo dhan 1 saac gudahood markaad isku dhex qasto qurubyada cuntada ama dareeraha.

Qaado lumacaftor iyo ivacaftor cuntooyinka dufanka leh sida ukunta, avokado, lowska, subagga, subagga looska, jiiska pizza, caano dhan iyo waxyaabaha kale ee caanaha laga sameeyo sida jiiska iyo caano fadhi. Kala hadal dhakhtarkaaga cuntooyinka kale ee dufanka leh si aad ula cuntid lumacaftor iyo ivacaftor.

Lumacaftor iyo ivacaftor waxay xakameeyaan cystic fibrosis laakiin ma daaweynayo. Sii wad inaad qaadatid lumacaftor iyo ivacaftor xitaa haddii aad fiicnaan dareento. Ha u joojin qaadashada lumacaftor iyo ivacaftor adiga oo aan la hadlin dhakhtarkaaga.

Haddii aadan qaadan lumacaftor iyo ivacaftor muddo 7 maalmood ah ama ka badan, dib ha u bilaabin qaadashada mar kale adiga oo aan la hadlin dhakhtarkaaga. Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawadan ama daawooyinka kale ee aad qaadanaysid.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada lumacaftor iyo ivacaftor,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay lumacaftor iyo ivacaftor, daawooyin kale oo kasta, ama wax kasta oo ka mid ah waxyaabaha ku jira lumacaftor iyo kiniiniyada ivacaftor ama granules. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga iyo farmashiistaha dawooyinka dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, iyo nafaqada nafaqada ee aad qaadanaysid ama qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: antifungals qaarkood sida itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), iyo voriconazole (Vfend); antibiyootikada qaarkood sida clarithromycin (Biaxin, in Prevpac), erythromycin (E.E.S, Erythrocin, Eryped, kuwa kale), rifabutin (Mycobutin) iyo rifampin (Rifadin, Rifamate, Rifater, Rimactane); dawooyinka qaarkood ee sonkorowga sida chlorpropamide (Diabinese), glimepiride (Amaryl, in Duetact), glipizide (Glucotrol), glyburide (Diabeta, Glynase, in Glucovance), repaglinide (Prandin), tolazamide iyo tolbutamide; digoxin (Lanoxin); ibuprofen (Advil, Motrin, Vicoprofen); difaaca jirka qaarkood sida cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune) iyo tacrolimus (Astagraf, Prograf); midazolam; montelukast (Singulair); methylprednisolone (Medrol); prednisone (Rayos); qaar ka mid ah proton pump inhibitors (PPIs) sida esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), iyo omeprazole (Prilosec, Zegerid); ranitidine (Zantac); dawooyinka qaarkood ee suuxdinta sida carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, iyo phenytoin (Dilantin, Phenytek); qaar ka mid ah kuwa celiya serotonin reuptake inhibitors (SSRIs) sida citalopram (Celexa), escitalopram (Lexapro), iyo sertraline (Zoloft); triazolam (Halcion); iyo warfarin (Coumadin, Jantoven). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara lumacaftor iyo ivacaftor, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• u sheeg dhakhtarkaaga waxa ka soo baxa dhirta aad qaadanaysid, gaar ahaan johannesört wort. Dhakhtarkaaga ayaa u badan inuu kuu sheego inaadan qaadan johannesört St. John intaad qaadaneysid lumacaftor iyo ivacaftor.
• u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa isku aragtay dhibaatooyin neefsashada ama xaalado ah, xubin lagu beddelayo, ama beerka ama cudurka kelyaha.
• waa inaad ogaataa in lumacaftor iyo ivacaftor ay yareeyn karaan waxtarka ka hortagga uurka ee hormoonada (kaniiniyada xakameynta dhalmada, balastarrada, faraantiyo, irbado, qalab lagu beero, ama aaladda intrauterine). Kala hadal dhakhtarkaaga hababka kale ee ka hortagga uurka ee adiga kuu shaqeyn doona inta aad qaadanayso lumacaftor iyo ivacaftor.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelato inta aad qaadanaysid lumacaftor iyo ivacaftor, wac dhakhtarkaaga.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Haddii aad ku xasuusato qiyaasta la seegay 6 saacadood gudahood laga bilaabo wakhtiga laguu qorsheeyay inaad qaadato, isla markiiba qaado qiyaasta la seegay. Si kastaba ha noqotee, haddii in ka badan 6 saacadood ay ka soo wareegtay xilligii aad sida caadiga ah qaadatid lumacaftor iyo ivacaftor, ka bood qiyaasta la seegay oo sii wad jadwalkaaga daawada ee caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Lumacaftor iyo ivacaftor waxay sababi karaan waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• neefta oo ku qabata
• laab xanuun ama xanuun
• dhibaatooyinka neefsashada
• shuban
• gaaska
• daal fara badan
• finan
• aan caadi ahayn, la seegay, culus ama xanuun caadada ku dhaca, gaar ahaan dumarka qaata ka hortagga uurka ee hormoonka
• sanka oo dareera, hindhiso, qufac, cuna xanuun, ama calaamadaha hargabka oo kale ah
• cune xanuun
• sanka oo xirma ama duuf leh
• madax xanuun

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac dhakhtarkaaga isla markiiba:

• lallabbo
• matagid
• cunto xumo
• xanuun qeybta kore ee midig ee caloosha
• kaadi madow
• jahwareer
• hurdi maqaarka ama indhaha

Lumacaftor iyo ivacaftor waxay sababi karaan cataract (daruuraha muraayada indhaha oo sababi kara dhibaatooyin araga) carruurta iyo dhalinyarada. Carruurta iyo dhallinyarada qaadata lumacaftor iyo ivacaftor waa inay u tagaan dhakhtarka indhaha kahor iyo inta ay daaweynayaan. Kala hadal dhakhtarka ilmahaaga halista ay leedahay in la siiyo lumacaftor iyo ivacaftor ilmahaaga.

Lumacaftor iyo ivacaftor waxay sababi karaan waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad dhaafka ah waxaa ka mid noqon kara:

• madax xanuun
• finan

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhaqtarkaaga ayaa amri doona baaritaanka shaybaarka kahor intaadan bilaabin daaweyntaada si loo ogaado in xaaladaada lagu daaweyn karo lumacaftor iyo ivacaftor maadaama ay tahay in loo isticmaalo kaliya dadka leh jimicsi gaar ah. Dhakhtarkaagu wuxuu amri doonaa baaritaanka indhaha iyo tijaabooyinka shaybaarada qaarkood kahor iyo inta daaweyntaadu socoto si loo hubiyo jawaabta jirkaaga ee lumacaftor iyo ivacaftor. Cadaadiska dhiiggaaga waa in si joogto ah loo hubiyaa inta aad qaadanaysid dawadan.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Orkambi^®