Talimogene Laherparepvec Duritaanka

Qanacsan

• Kahor intaadan helin duritaanka talimogene laherparepvec,
• Talimogene laherparepvec duro waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta taxaddarrada qaaska ah, isla markiiba wac dhakhtarkaaga:

Talimogene laherparepvec irbad ayaa loo isticmaalaa in lagu daaweeyo burooyinka melanoma qaarkood (nooc ka mid ah kansarka maqaarka) burooyinka aan qalliin looga saari karin ama soo laaban kara kadib markii qalliin lagu daweeyey. Talimogene laherparepvec wuxuu ku jiraa nooc daawooyin ah oo loo yaqaan fayraska oncolytic. Waa qaab daciif ah oo la beddelay oo ah nooca Herpes Simplex Virus Nooca I (HSV-1 'virus xanuun qabow') oo ka shaqeeya iyada oo gacan ka geysaneysa dilka unugyada kansarka.

Talaalka Talimogene laherparepvec wuxuu u yimaadaa sidii ganaax (dareere) ah oo uu ku durayo dhakhtar ama kalkaaliye caafimaad xafiiska caafimaadka. Dhakhtarkaagu wuxuu daawada si toos ah ugu duri doonaa burooyinka ku yaal maqaarkaaga, waxyar uun maqaarkaaga, ama qanjidhada qanjidhada. Waxaad heli doontaa daaweyn labaad 3 toddobaad ka dib daaweynta ugu horreysa, ka dibna 2dii toddobaadba mar ka dib. Dhererka daaweynta waxay kuxirantahay sida ugu wanaagsan ee burooyinkaagu uga jawaab celiyaan daaweynta. Waxaa laga yaabaa in dhakhtarkaagu uusan ku durin burooyinka oo dhan booqasho kasta.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo saaraha (Tilmaamaha Daawada) marka aad bilowdo daaweynta talimogene laherparepvec iyo markasta oo aad qaadato cirbadaha. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor intaadan helin duritaanka talimogene laherparepvec,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay talimogene laherparepvec, daawooyin kale, ama mid ka mid ah waxyaabaha ku jira irbadda talimogene laherparepvec. Weydii farmashiistahaaga ama ka hubi Hagaha Daawada liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanaysid wax daawo ah oo daciifiya habkaaga difaaca sida antithymocyte globulin (Atgam, Thymoglobulin), azathioprine (Azasan, Imuran), basiliximab (Simulect), belatacept (Nulojix), belimumab (Benlysta), cortisone, cyclosporine ( Gengraf, Neoral, Sandimmune), dexamethasone, fludrocortisone, methotrexate (Otrexup, Rasuvo, Trexall), methylprednisolone (Depo-medrol, Medrol, Solu-medrol), mycophenolate mofetil (Cellcept), prednisolone (Floprededia, Orap) Rayos), sirolimus (Rapamune), iyo tacrolimus (Astagraf XL, Prograf, Envarsus XR). Daawooyin kale oo badan ayaa sidoo kale daciifin kara nidaamkaaga difaaca, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan. Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan talimogene laherparepvec haddii aad qaadanaysid mid ama in kabadan oo dawooyinkan ah.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: daawooyinka ka hortagga fayraska sida acyclovir (Sitavig, Zovirax), cidofovir, docosanol (Abreva), famciclovir (Famvir), foscarnet (Foscavir), ganciclovir (Cytovene), penciclovir (Denavir), tri Viroptic), valacyclovir (Valtrex), iyo valganciclovir (Valcyte). Daawooyinkani waxay saameyn ku yeelan karaan sida wanaagsan ee talimogene laherparepvec ay adiga kuugu shaqeyso.
• u sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabtid leukemia (kansarka unugyada dhiigga cad), lymphoma (kansarka qayb ka mid ah nidaamka difaaca jirka), fayraska difaaca jirka ee dadka (HIV), helitaanka difaaca jirka oo yaraada (AIDS), ama xaalad kasta oo kale taas oo keenta daciifinta habka difaaca jirka. Dhakhtarkaagu uma baahnaan doono inaadan ku siin tallaalka talimogene laherparepvec.
• u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa ku daaweysey shucaaca aagga burooyinka melanoma, myeloma badan (kansarka unugyada plasma ee dhuuxa lafta), nooc kasta oo cudur isdifaaca jirka ah (xaaladaha nidaamka difaaca jirka uu ku weeraro qaybo caafimaad qaba jirka oo sababa xanuun, barar, iyo dhaawac), ama haddii aad xiriir dhow la leedahay qof uur leh ama difaaca jirkiisu daciif yahay.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Waa inaadan uur yeelan inta lagugu daweynayo irbadda talimogene laherparepvec. Kala hadal dhakhtarkaaga hababka xakameynta dhalmada ee aad isticmaali karto inta lagu jiro daaweyntaada. Haddii aad uur yeelato inta aad qaadanaysid duritaanka talimogene laherparepvec, isla markiiba wac dhakhtarkaaga. Talimogene laherparepvec cirbad ayaa waxyeelayn kara uurjiifka.
• waa inaad ogaataa in tallaalka talimogene laherparepvec uu ku jiro fayras faafin kara oo qaadi kara dadka kale. Waa inaad ka taxaddartaa inaad ku daboosho dhammaan goobaha duritaanka faashado hawo-qaadasho iyo biyo-la'aan ah ugu yaraan 1 toddobaad ka dib daaweyn kasta, ama ka sii dheer haddii goobta duritaanka ay ka soo baxeyso. Haddii faashaddu ay furfurnaato ama ay soo dhacdo, hubso inaad isla markiiba beddesho. Waa inaad isticmaashaan galoofyada cinjirka ah ee cinjirka ama cinjirka 'cinjirka' cinjirka 'latex' ah markaad faashad ku dhejineyso goobaha duritaanka. Waa inaad hubisaa inaad dhigto dhammaan qalabka nadaafadda, galoofyada, iyo faashadda loo isticmaalay goobaha duritaanka bac balaastiig ah oo lagu tuuray qashinka.
• waa inaadan taaban ama xoqin meelaha la isku duray ama faashadda. Tani waxay ku faafin kartaa fayraska daawada talimogene laherparepvec qaybaha kale ee jirkaaga. Dadka hareerahaaga ah waa inay ka taxaddaraan inay xiriir toos ah la yeeshaan goobaha lagugu durayo, faashadda, ama dheecaannada jirka. Wac dhakhtarkaaga isla markiiba haddii adiga, ama qof kasta oo kugu xeerani, uu yeesho astaamo infekshinka herpes ;: xanuun, gubasho, ama finjo fin ah oo ku taal afkaaga, xubnaha taranka, faraha, ama dhegaha; xanuunka indhaha, casaanka, ama jeexitaanka; aragti cakiran; dareenka iftiinka; daciifnimada gacmaha ama lugaha; lulmo xad-dhaaf ah; ama jahwareer maskaxeed.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Talimogene laherparepvec duro waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• daal aan caadi ahayn
• lallabbo
• matagid
• shuban
• calool istaag
• calool xanuun
• madax xanuun
• dawakhaad
• miisaanka oo yaraada
• qalalan, dillaacsan, cuncun, maqaar gubanaya
• murqaha ama kalagoysyada oo xanuuna
• xanuun ku dhaca gacmaha ama lugaha
• bogsiiyay bogagga duritaanka
• xanuun goobaha duritaanka ah

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta taxaddarrada qaaska ah, isla markiiba wac dhakhtarkaaga:

• neefta oo ku qabata ama dhibaatooyin kale oo xagga neefsashada ah
• qufac
• casaan, midab cola leh, ama kaadi xunbo leh
• barar wajiga, gacmaha, cagaha, ama caloosha
• midab luminaya maqaarkaaga, timahaaga, ama indhahaaga
• diirran, casaan, bararsan, ama maqaar xanuun leh agagaarka meesha la isku duro
• qandho, cuna xanuun, dhaxan, ama calaamado kale oo infekshan ah
• nudaha dhintay ama nabaro furan oo ka soo baxa burooyinka la duray

Talimogene laherparepvec cirbad ayaa laga yaabaa inay keento waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn inta aad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Dhammaan ballamaha la dhig dhakhtarkaaga.

Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto tallaalka talimogene laherparepvec.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Xasaasiyad^®

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