Cirbadeynta Ocrelizumab

Qanacsan

• Cirbadeynta 'Ocrelizumab' waxaa loo isticmaalaa in lagu daaweeyo dadka qaangaarka ah ee leh noocyo kala duwan oo ah cudurka 'sclerosis' (MS; cudur ku dhaca neerfayaasha oo aan si sax ah u shaqeynin oo dadku la kulmi karaan daciifnimo, kabuubyo, luminta isuduwidda murqaha, iyo dhibaatooyinka aragtida, hadalka, iyo kaadiheysta) oo ay ka mid yihiin:
• Kahor intaadan helin duritaanka ocrelizumab,
• Ocrelizumab waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta HOW, isla markiiba wac dhakhtarkaaga ama u hesho daaweyn caafimaad oo degdeg ah:

Cirbadeynta 'Ocrelizumab' waxaa loo isticmaalaa in lagu daaweeyo dadka qaangaarka ah ee leh noocyo kala duwan oo ah cudurka 'sclerosis' (MS; cudur ku dhaca neerfayaasha oo aan si sax ah u shaqeynin oo dadku la kulmi karaan daciifnimo, kabuubyo, luminta isuduwidda murqaha, iyo dhibaatooyinka aragtida, hadalka, iyo kaadiheysta) oo ay ka mid yihiin:

• qaababka horusocodka aasaasiga ah (astaamaha si tartiib tartiib ah ayey uga sii darayaan waqtiga) ee MS,
• cillad caafimaad oo ku go'doonsan (CIS, astaamaha neerfaha ee dhacda ugu yaraan 24 saacadood),
• foomamka soo noqoshada-dib-u-noqoshada (habka cudurka ee astaamuhu marba marka ka dambeysa u soo baxaan), ama
• foomamka horusocodka labaad (habka cudurka ee soo noqnoqoshada badanaa ku dhaca).

Ocrelizumab oo ku jira fasal dawooyin ah oo loo yaqaan monoclonal antibodies. Waxay ku shaqeysaa iyada oo la joojinayo unugyada qaarkood ee habka difaaca jirka inay waxyeello u geystaan

Cirbadda Ocrelizumab waxay u timaaddaa sidii xalka (dareeraha) lagu duray xididka (xididka) dhakhtar ama kalkaaliye caafimaad. Badanaa waxaa la bixiyaa 2dii toddobaadba mar labadii daaweyn ee ugu horreysa (usbuucii 0aad iyo kii 2aad), ka dibna faleebooyin ayaa la bixiyaa 6dii biloodba mar.

Cirbadda Ocrelizumab waxay sababi kartaa falcelin daran inta lagu jiro faleebada iyo illaa maalin kadib helitaanka faleebada. Waxaa lagu siin karaa daawooyin kale si aad u daaweyso ama kaa caawiso kahortagga falcelinta ocrelizumab. Dhakhtar ama kalkaaliye caafimaad ayaa si dhaw kuu ilaalin doona inta aad qaadanayso faleebada iyo ugu yaraan 1 saacadood ka dib si ay u bixiso daaweyn haddii ay jiraan waxyeellooyin gaar ah oo daawada ah. Dhakhtarkaagu wuxuu si ku-meel-gaar ah ama joogto ah u joojin karaa daaweyntaada ama wuu yareyn karaa qiyaasta, haddii aad la kulanto waxyeelooyin qaarkood. U sheeg dhakhtarkaaga ama kalkaalisada haddii aad la kulanto mid ka mid ah kuwan soo socda inta lagu jiro ama 24 saac gudahood ka dib faleebadaada: finan; cuncun; finan; guduudasho goobta duritaanka; neefsashada ama liqidda oo ku adkaata; qufac; xiiq; finan; dareemid miyir beelid; cun cun cun; afka ama cunaha xanuun; neefta oo ku qabata; barar wejiga, indhaha, afka, cunaha, carrabka, ama dibnaha; biyo raacis qandho; daal; daal; madax xanuun; dawakhaad; lallabbo ama wadne garaacis. Wac dhakhtarkaaga isla markiiba ama hel daryeel caafimaad oo deg deg ah haddii aad isku aragto mid ka mid ah astaamahan ka dib markaad ka tagto xafiiska dhakhtarkaaga ama xarunta caafimaadka.

Ocrelizumab ayaa laga yaabaa inay gacan ka geysato xakamaynta astaamaha cudurka 'sclerosis multiple' laakiin ma daaweynayo.Dhakhtarkaaga ayaa si taxaddar leh kuu fiirin doona si uu u arko sida wanaagsan ee ocrelizumab adiga kuugu shaqeeyo. Waa muhiim inaad u sheegto dhakhtarkaaga sida aad dareemeyso inta lagu jiro daaweyntaada.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo saaraha (Tilmaamaha Daawada) markaad bilowdo daaweynta cirbadeynta ocrelizumab iyo mar kasta oo aad dib u buuxiso daawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa bogga Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soo saaraha si aad u hesho Hagaha Daawada.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor intaadan helin duritaanka ocrelizumab,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay ocrelizumab, daawooyin kale, ama mid ka mid ah waxyaabaha ku jira irbadda ocrelizumab. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto daawooyinka xakameynaya nidaamkaaga difaaca sida kuwa soo socda: corticosteroids oo ay ku jiraan dexamethasone, methylprednisolone (Medrol), iyo prednisone (Rayos); cyclosporine (Gengraf, Neoral, Sandimmune); daclizumab (Zinbryta); fingolimod (Gilenya); mitoxantrone; natalizumab (Tysabri); tacrolimus (Astagraf, Prograf); ama teriflunomide (Aubagio). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• u sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabto cagaarshowga B (HBV; fayras ku dhaca beerka oo sababi kara dhaawac beerka oo daran ama kansarka beerka) Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan helin ocrelizumab.
• u sheeg dhakhtarkaaga haddii aad qabtid nooc cudur ah ka hor intaadan bilaabin daaweyntaada cirbadeynta ocrelizumab.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Isticmaal xakameynta dhalmada oo waxtar leh inta lagu jiro daaweyntaada ocrelizumab iyo 6 bilood ka dib qiyaasta ugu dambeysa. Haddii aad uur yeelato intaad qaadanayso ocrelizumab, wac dhakhtarkaaga. Haddii aad hesho cirbadeynta ocrelizumab inta aad uurka leedahay, hubi inaad kala hadasho dhakhtarka ilmahaaga tan kadib marka ilmahaagu dhasho. Ilmahaaga ayaa laga yaabaa inuu u baahdo inuu dib u dhigo qaadashada tallaalada qaarkood.
• u sheeg dhakhtarkaaga haddii aad qaadatay tallaal dhowaan ama aad u qorsheysan tahay inaad hesho wax tallaal ah. Waxaad u baahan kartaa inaad hesho noocyo tallaal ah ugu yaraan 4 toddobaad kahor iyo kuwa kale ugu yaraan 2 toddobaad ka hor intaadan bilaabin daaweynta cirbadeynta ocrelizumab. Ha haysan wax talaal ah adigoon lahadlin dhaqtarkaaga inta aad daweyneyso.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Haddii aad seegto ballan si aad u hesho ocrelizumab, wac dhakhtarkaaga sida ugu dhakhsaha badan ee suurtogalka ah si aad ballanta kale u ballanto.

Ocrelizumab waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• barar ama xanuun gacmaha, gacmaha, lugaha, ama cagaha
• shuban

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta HOW, isla markiiba wac dhakhtarkaaga ama u hesho daaweyn caafimaad oo degdeg ah:

• qandho, dhaxan, qufac joogto ah, ama calaamado kale oo infekshan ah
• nabar afka ka soo baxa
• shingles (finan yaryar oo ku dhici kara dadka horeyba uga soo dhacay busbuska)
• nabarro ku xeeran xubnaha taranka ama malawadka
• cudurka maqaarka
• daciifnimo dhinac jirka ah; cidhiidhiga gacmaha iyo lugaha; isbedelka aragga; isbeddelada fikirka, xusuusta, iyo jihada; jahwareer; ama shakhsiyadda isbeddelay

Ocrelizumab waxay kordhin kartaa halista kansarrada qaarkood, oo ay ku jiraan kansarka naasaha. Kala hadal dhakhtarkaaga khataraha helitaanka daawadan.

Ocrelizumab waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn inta aad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa tijaabooyinka shaybaarka qaarkood kahor iyo inta daaweyntaadu socoto si loo hubiyo jawaabta jirkaaga ee duritaanka ocrelizumab.

Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto duritaanka ocrelizumab.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Ocrevus^®