Darunavir, Cobicistat, Emtricitabine, iyo Tenofovir

Qanacsan

• Ka hor intaadan qaadan darunavir, cobicistat, emtricitabine, iyo tenofovir,
• Darunavir, cobicistat, emtricitabine, iyo tenofovir waxay sababi karaan waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybaha digniinta muhiimka ah ama taxadarka qaaska ah, wac dhakhtarkaaga isla markiiba ama hel daaweyn caafimaad oo deg deg ah:

Darunavir, cobicistat, emtricitabine, iyo tenofovir waa in aan loo isticmaalin in lagu daaweeyo infekshinka fayraska cagaarshowga B (HBV; infekshinka beerka ee socda). U sheeg dhakhtarkaaga haddii aad qabtid ama aad u malaynaysid inaad leedahay cudurka HBV. Dhakhtarkaaga ayaa laga yaabaa inuu ku tijaabiyo si aad u ogaato inaad qabto HBV ka hor intaadan bilaabin iyo inta aad ku guda jirto daaweyntaada darunavir, cobicistat, emtricitabine, iyo tenofovir. Haddii aad HBV leedahay oo aad qaadatid darunavir, cobicistat, emtricitabine, iyo tenofovir, xaaladaadu si lama filaan ah ayey uga sii dari kartaa markii aad joojiso qaadashada daawadan. Dhakhtarkaaga ayaa ku baari doona kuna amri doona baaritaano shaybaar si joogto ah dhowr bilood ka dib markaad joojiso qaadashada daawadan si loo arko in HBV-gaagu ka sii daray

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa baaritaano gaar ah kahor iyo inta daaweyntaadu socoto si loo hubiyo jawaabta jirkaaga ee darunavir, cobicistat, emtricitabine, iyo tenofovir.

Kala hadal dhakhtarkaaga khataraha qaadashada darunavir, cobicistat, emtricitabine, iyo tenofovir.

Isku darka darunavir, cobicistat, emtricitabine, iyo tenofovir ayaa loo isticmaalaa in lagu daaweeyo infekshinka difaaca jirka ee bini aadamka (HIV) ee dadka waaweyn iyo caruurta culeyskoodu yahay ugu yaraan 88 rodol (40 kg) oo aan lagu daaweynin daawooyinka kale ee HIV ama lagu badalo daaweynta hada ee daawada dad gaar ah oo horeyba u qaatay daawooyinka HIV. Isku darka darunavir, cobicistat, emtricitabine, iyo tenofovir waxay ku jiraan fasal dawooyin ah oo loo yaqaan antiviral. Darunavir, emtricitabine, iyo tenofovir waxay ku shaqeeyaan iyaga oo yareeya xaddiga HIV ee dhiiga ku jira. Cobicistat waxay kaa caawineysaa in darunavir uu jirka ku sii dheeraado si daawadu ay saameyn weyn u yeelato. In kasta oo iskudarka darunavir, cobicistat, emtricitabine, iyo tenofovir aysan daaweyn doonin HIV, daawooyinkaan ayaa yareyn kara fursadaada inaad kuhesho cudurada difaaca jirka (AIDS) iyo cudurada la xiriira HIV sida infekshanada halista ah ama kansarka. Qaadashada daawooyinkan oo ay weheliso ku-dhaqan galmo badbaado leh iyo is-beddello kale oo qaab nololeed ah ayaa yareyn kara halista gudbinta fayraska HIV ee dadka kale.

Isku darka darunavir, cobicistat, emtricitabine, iyo tenofovir waxay u yimaadaan sidii kiniin afka lagu qaato. Badanaa waxaa lagu qaataa cuntada hal mar maalintii. Qaado darunavir, cobicistat, emtricitabine, iyo tenofovir isla waqti isku mid ah maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado darunavir, cobicistat, emtricitabine, iyo tenofovir sida saxda ee laguu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Haddii aad dhib ku qabtid liqidda kiniiniyada, waxaad u kala qaybin kartaa laba qaybood oo leh kiniin-jarjiraha. Qaado kiniiniyada kala jaban isla marka aad gooyso ka dib. Ha u kaydin iyaga mustaqbalka isticmaal.

Isku darka darunavir, cobicistat, emtricitabine, iyo tenofovir waxay gacan ka geysaneysaa xakameynta cudurka HIV laakiin ma daaweyso. Sii wad inaad qaadato darunavir, cobicistat, emtricitabine, iyo tenofovir xitaa haddii aad dareento fiicnaan. Ha u joojin qaadashada darunavir, cobicistat, emtricitabine, iyo tenofovir adigoon dhaqtarkaaga la hadlin.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Ka hor intaadan qaadan darunavir, cobicistat, emtricitabine, iyo tenofovir,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay darunavir, cobicistat, emtricitabine, iyo tenofovir, daawooyin kale oo kasta, dawooyinka sulfa, ama walxaha kale ee ku jira darunavir, cobicistat, emtricitabine, iyo kiniiniyada tenofovir. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanayso mid ka mid ah daawooyinka soo socda: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Tegretol, kuwa kale); cisapride (Propulsid) (aan laga heli karin Mareykanka); colchicine (Colcyrs, Mitigare) ee dadka qaba kelyaha ama cudurka beerka; dronedarone (Multaq); elbasvir iyo grazoprevir (Zepatier); dawooyinka ergot sida dihydroergotamine (DHH 45, Migranal), ergotamine (Ergomar, Cafergot, Migergot), iyo methylergonovine (Methergine); ivabradine (Corlanor); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam afka; naloxegol (Movantik); phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, gudaha Rifamate, Rifater); Johannesört wort; sildenafil (kaliya Revatio, sumadda loo isticmaalo cudurka sanbabada); simvastatin (Simcor, Zocor, oo ku yaal Vytorin); ama triazolam (Halcion). Dhakhtarkaaga ayaa u badan inuu kuu sheego inaadan qaadan darunavir, cobicistat, emtricitabine, iyo tenofovir haddii aad qaadaneysid mid ama kabadan daawooyinkan.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: antibiyootikada aminoglycoside sida 'gentamicin'; daawooyinka antifungal sida isavuconazonium (Cresemba), itraconazole (Onmel, Sporanox), ketoconazole, iyo voriconazole (Vfend); daawooyinka fayraska ka hortagga sida acyclovir (Sitavig, Zovirax), cidofovir, ganciclovir (Cytovene, Valcyte), valacyclovir (Valtrex), iyo valganciclovir (Valcyte); antibiyootigyada sida clarithromycin (Biaxin, PrevPac), erythromycin (E.E.S, Eryc, Ery-Tab), iyo telithromycin (oo aan hadda laga helin Mareykanka, Ketek); apixaban (Eliquis); farshaxanka iyo lumefantrine (Coartem); asbiriin iyo dawooyinka kale ee nonsteroidal anti-bararka (NSAIDs) sida ibuprofen (Advil, Motrin) iyo naproxen (Aleve, Naprosyn); benzodiazepines sida clonazepam (Klonopin), diazepam (Diastat, Valium), estazolam, flurazepam, midazolam oo la siinayo xididada (xididka), iyo zolpidem (Ambien, Zolpmist); beta blockers sida arvedilol (Coreg), metoprolol (Lopressor, Toprol-XL, in Dutoprol), iyo timolol; bosentan (Tracleer); buprenorphine (Belbuca, Buprenex, kuwa kale); buprenorphine iyo naloxone (Bunavail, Suboxone); buspirone; kaalsiyamka xanibaada sida amlodipine (Norvasc), diltiazem (Cardizem, Diltzac, Tiazac, kuwa kale), felodipine, nifedipine (Adalat CC, Afeditab CR, Procardia), iyo verapamil (Calan, Verelan, Tarka); carvedilol (Coreg); daawooyinka kalastarolka ka yareeya (statins) sida atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), iyo rosuvastatin (Crestor); dasatinib (Sprycel); daawooyinka niyadjabka sida amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), iyo trazodone; digoxin (Lanoxin); eslicarbazepine (Aptiom); everolimus (Afinitor, Zortress); fentanyl (Duragesic, Lacag-bixinno); fesoterodine (Toviaz); irinotecan (Camptosar); daawooyinka loogu talagalay garaaca wadnaha oo aan joogto ahayn sida amiodarone (Nexterone, Pacerone), disspyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), iyo quinidine (Nuedexta); daawooyinka xakameynaya nidaamka difaaca jirka sida cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), iyo tacrolimus (Prograf); methadone (Methadose); nilotinib (Tasigna); ka hortagga uurka ('kaniiniyada ka hortagga uurka'); oxcarbazepine (Trileptal); oxycodone (Xtampza, oo ku taal Percodan); perphenazine; quetiapine (Seroquel); fosfodiesterase (PDE5) kahortagayaasha sida avanafil (Stendra), avanafil (Stendra); sildenafil (Viagra), tadalafil (Adcirca, Cialis), iyo vardenafil (Levitra, Staxyn); rifabutin (Mycobutin); rifapentine (Priftin); risperidone (Risperdal); rivaroxaban (Xarelto); salmeterol (Serevent, Advair); simeprevir (Olysio; hadda lagama heli karo Mareykanka); solifenacin (Vesicare); steroids afka laga qaato ama la neefsado sida betamethasone, budesonide (Pulmicort), ciclesonide (Alvesco, Omnaris, Zetonna) dexamethasone, fluticasone (Flonase, Flovent, Advair), methylprednisolone, mometasone (Asmanex, Dulera), iyo triamclone; thioridazine; ticagrelor (Brilinta); tramadol (Conzip, Ultram); vinblastine; vincristine; iyo warfarin (Coumadin, Jantoven). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara darunavir, cobicistat, emtricitabine, iyo tenofovir, marka hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa qabtid xaaladaha lagu xusay qaybta DIGNIINTA MUHIIMKA ah, nooc kasta oo infakshan ah oo aan tagaynin ama yimaadda oo tagaya sida qaaxada (TB; nooc ka mid ah infekshanka sambabaha) ama cytomegalovirus (CMV; infekshin faayras ah oo sababi kara astaamo bukaanjiif leh nidaam difaac daciif ah); sonkorowga; hemophilia (cudur uusan dhiiggu si caadi ah u xinjiroobin); ama cudurka beerka ama kalyaha.
• u sheeg dhakhtarkaaga haddii aad uur leedahay ama aad qorsheyneyso inaad uur yeelato. Haddii aad uur yeelato inta aad qaadanaysid darunavir, cobicistat, emtricitabine, iyo tenofovir, wac dhakhtarkaaga.
• u sheeg dhakhtarkaaga haddii aad naas nuujinayso. Waa inaadan naas nuujin haddii aad qabtid HIV ama haddii aad qaadanaysid darunavir, cobicistat, emtricitabine, iyo tenofovir.
• waa inaad ka warqabtaa in dufanka jirkaagu uu kordhin karo ama u dhaqaaqi karo meelo kala duwan oo jirkaaga ka mid ah, sida dhabarka kore, qoorta ('' buffalo hump ''), naasaha, iyo calooshaada ku wareegsan. Waxaad dareemi kartaa luminta dufanka jirka ee wajiga, lugaha, iyo gacmaha.
• Waa inaad ogaataa inta aad qaadanaysid dawooyinka lagu daaweynayo infekshinka HIV, nidaamkaaga difaaca ayaa laga yaabaa inuu sii xoogeysto oo uu bilaabo inuu la dagaallamo infekshannada kale ee horey ugu jiray jirkaaga. Tani waxay kugu sababi kartaa inaad yeelato calaamadaha infekshannadaas. Haddii aad leedahay calaamado cusub ama ka sii daraya inta lagu jiro daweyntaada darunavir, cobicistat, emtricitabine, iyo tenofovir, hubi inaad u sheegto dhakhtarkaaga.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Qaado qiyaasta la seegay isla marka aad xasuusatoba. Si kastaba ha noqotee, haddii ay ku dhowdahay waqtiga qiyaasta xigta, ka bood qiyaasta la seegay oo sii wad jadwalka daawadaada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Darunavir, cobicistat, emtricitabine, iyo tenofovir waxay sababi karaan waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• shuban
• madax xanuun
• calool xanuun
• gaaska

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybaha digniinta muhiimka ah ama taxadarka qaaska ah, wac dhakhtarkaaga isla markiiba ama hel daaweyn caafimaad oo deg deg ah:

• kaadi kaadi huruud ah ama bunni ah; saxaro midab khafiif ah leh; cunto xumo; lallabbo matagid; midigta sare ee caloosha xanuun; ama maqaarka jaalaha ah ama indhaha
• kaadida oo badatay ama yaraatay
• daciifnimo; muruq xanuun; neefta oo ku qabata ama neefsashada oo deg deg ah; calool xanuun lallabbo iyo matag; gacmaha iyo cagaha qabow ama buluug ah; dawakhaad, madax-wareer; ama garaaca wadnaha oo degdeg ah ama aan caadi ahayn
• cune xanuun; qandho; qarqaryo; qufac; iyo calaamadaha kale ee infekshanka
• firiiric daran ama firiiric leh mid ama inbadan oo ka mid ah kuwan soo socda: qandho, murqo ama kalagoysyo xanuun, indho casaan ama bararsan, finan ama maqaarka oo foorara, nabarro afka ah, ama barar wejiga ama qoorta ah

Darunavir, cobicistat, emtricitabine, iyo tenofovir waxay sababi karaan waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha). Ha ka saarin boorsooyinka qalajiyaha (wakiilka qalajinta).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Ku hayso saadka darunavir, cobicistat, emtricitabine, iyo tenofovir. Ha sugin illaa ay kaa dhammaato daawada si aad ugu buuxiso dawada laguu qoray.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Symtuza^®