Cirbadda Vincristine

Qanacsan

• Kahor helitaanka vincristine,
• Vincristine waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, una wac dhakhtarkaaga isla markiiba ama aad u hesho daaweyn caafimaad oo deg-deg ah:
• Calaamadaha xad dhaafka ah waxaa ka mid noqon kara:

Vincristine waa in lagu qaataa xididka kaliya. Si kastaba ha noqotee, waxay ku daadan kartaa unugyada ku hareeraysan oo keenaya xanaaq ama dhaawac daran. Dhaqtarkaaga ama kalkaaliyahaaga ayaa kormeeri doona goobtaada maamulka falcelintan. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga: xanuun, cuncun, casaan, barar, finno, ama nabarro ku yaal meeshii lagu muday daawada.

Vincristine waa in la siiyaa oo keliya iyadoo uu kormeerayo dhakhtar khibrad u leh isticmaalka daawooyinka kiimikada lagu daweeyo.

Vincristine waxaa loo isticmaalaa dawooyinka kale ee daaweynta kiimikada ee lagu daaweeyo noocyo ka mid ah leukemia (kansarka unugyada dhiigga cad), oo ay ku jiraan myeloid leukemia daran (AML, ANLL) iyo lymphoblastic leukemia daran (ALL), Hodgkin's lymphoma (cudurka Hodgkin), iyo non -Hodgkin's lymphoma (noocyada kansarka ee ka bilaabma nooc ka mid ah unugyada dhiigga cad oo caadi ahaan la dagaallama infekshinka). Vincristine waxaa sidoo kale loo isticmaalaa dawooyinka kale ee kiimoteraabiga lagu daaweeyo burooyinka Wilms (nooc ka mid ah kansarka kalyaha ee ku dhaca carruurta), neuroblastoma (kansar ka bilaabma unugyada neerfaha oo badanaa ku dhaca carruurta), iyo rhabdomyosarcoma (kansar ku dhaca murqaha carruurta). Vincristine wuxuu ku jiraa nooc daawooyin ah oo loo yaqaan 'vinca alkaloids'. Waxay ku shaqeysaa adigoo gaabinaya ama joojinaya koritaanka unugyada kansarka ee jirkaaga.

Vincristine waxay u timaadaa xalka (dareeraha) lagu duray xididka (xididka) dhakhtar ama kalkaaliso caafimaad. Waxaa badanaa la siiyaa toddobaadkii hal mar. Dhererka daaweyntu waxay kuxirantahay noocyada daawooyinka aad qaadanaysid, sida ugufiican ee jidhkaagu uga jawaabo iyaga, iyo nooca kansarka kugu dhaca.

Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu daahiyo daaweyntaada ama uu beddelo qiyaastaada haddii aad la kulanto waxyeelo gaar ah. Waxaa muhiim kuu ah inaad u sheegto dhakhtarkaaga sida aad dareemeyso inta lagu jiro daweyntaada cirbadeynta vincristine.

Dhakhtarkaagu wuxuu kuu sheegi karaa inaad qaadato saxaro jilciya ama calool jilciso si looga hortago calool istaagga inta lagu jiro daweynta lagugu durayo vincristine.

Vincristine sidoo kale mararka qaar waxaa loo isticmaalaa in lagu daaweeyo noocyo ka mid ah burooyinka maskaxda, noocyada kansarka sanbabada, myeloma badan (nooc ka mid ah kansarka ku dhaca dhuuxa lafta), lempmia lempmia lymphocytic chronic (CLL; nooc ka mid ah kansarka unugyada dhiiga cad), Kaposi's sarcoma (waa nooc ka mid ah kansarka keena unugyada aan caadiga ahayn inay ku koraan qeybaha kala duwan ee jirka) oo la xiriira cilladda cillad la'aanta jirka (AIDS), Ewings sarcoma (nooc ka mid ah kansarka ku dhaca lafaha ama murqaha), iyo burooyinka uur-ku-jirta xilliga uurka (nooc buro ah) ku sameysma gudaha ilmo galeenka dumarka inta ay uurka leedahay). Vincristine sidoo kale mararka qaar waxaa loo isticmaalaa in lagu daaweeyo thrombotic thrombocytopenic purpura (TPP; cillad dhiig oo keenta xinjirowga dhiigga ee ku sameysma xididdada dhiigga ee yaryar ee jirka). Kala hadal dhakhtarkaaga khataraha aad u leedahay isticmaalka dawadan xaaladaada.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor helitaanka vincristine,

• u sheeg dhakhtarkaaga iyo farmashiistaha haddii aad xasaasiyad ku leedahay vincristine, daawooyin kale, ama wax kasta oo ka mid ah waxyaabaha ku jira cirbadda vincristine. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinada iyo nafaqada nafaqada ee aad qaadaneyso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwa soo socda: karbamazepine (Tegretol); antifungals qaarkood sida itraconazole (Sporanox), ketoconazole (Nizoral), voriconazole (Vfend), iyo posaconazole (Noxafil); clarithromycin (Biaxin, gudaha Prevpac); darifenacin (Enablex); dexamethasone (Decadron); fesoterodine (Toviaz); Kahortagayaasha 'protease inhibitors' ee ay ka mid yihiin atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), iyo saquinavir (Invirase); nefazodone; oxybutynin (Ditropan, Ditropan XL, Oxytrol); phenobarbital; phenytoin (Dilantin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); rifapentine (Priftin); solifenacin (Vesicare); telithromycin (Ketek); trospium (Sanctura); ama tolterodine (Detrol, Detrol LA). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• u sheeg dhakhtarkaaga waxa ka soo baxa dhirta aad qaadanaysid, gaar ahaan johannesört wort.
• u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa qabtid cillad saameyn ku yeelata neerfahaaga. Waxaa laga yaabaa in dhakhtarkaagu uusan rabin inaad hesho cirbadda vincristine.
• u sheeg dhakhtarkaaga haddii aad qaadanayso ama aad waligaa qaadatay shucaac (raajo), haddii aad qabto infekshan, ama haddii aad qabto ama aad waligaa qabto cudur sambabada ama beerka ah
• waa inaad ogaataa in vincristine ay faragalin karto caadada caadada ee caadiga ah (muddada) dumarka waxayna si ku meel gaar ah ama joogto ah u joojin kartaa soo saarida manida ragga. U sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Waa inaadan uur yeelan ama naasnuujin inta aad qaadanayso cirbadda vincristine. Haddii aad uur yeelato inta aad qaadanaysid cirbadda vincristine, wac dhakhtarkaaga. Vincristine waxay waxyeeleyn kartaa uurjiifka.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Vincristine waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• lallabbo
• matagid
• nabarro ku dhaca afka iyo cunaha
• luminta rabitaanka cuntada ama culeyska jirka
• calool xanuun
• shuban
• madax xanuun
• timo lumis

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, una wac dhakhtarkaaga isla markiiba ama aad u hesho daaweyn caafimaad oo deg-deg ah:

• finan
• finan
• cuncun
• neefsashada ama wax liqidda oo ku adkaata
• calool istaag
• kaadida oo badatay ama yaraatay
• barar wajiga, gacmaha, gacmaha, cagaha, anqawyada, ama lugaha hoose
• dhiigbax ama nabar aan caadi ahayn
• daal ama daciifnimo aan caadi ahayn
• xanuun, kabuubyo, gubasho, ama xoqitaan gacmaha ama cagaha
• socodka oo ku adkaada ama socodka oo aan degganeyn
• murqaha ama kalagoysyada oo xanuuna
• isbeddellada lama filaanka ah ee aragga, oo ay ku jiraan luminta aragga
• maqal la'aanta
• dawakhaad
• luminta awoodda dhaqaajinta muruqyada iyo inaad dareento qayb ka mid ah jirka
• xabeeb ama luminta awoodda hadalka si sare
• qalal
• daanka xanuun
• qandho, cuna xanuun, dhaxan, ama calaamado kale oo infekshan ah

Vincristine waxay kordhin kartaa halista aad kuleedahay kansarro kale. Kala hadal dhakhtarkaaga halista qaadashada cirbadda vincristine.

Vincristine waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn inta aad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad dhaafka ah waxaa ka mid noqon kara:

• qalal
• calool xanuun daran
• calool xanuun
• dhiigbax ama nabar aan caadi ahayn

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa tijaabooyinka shaybaarka qaarkood si loo hubiyo jawaabta jirkaaga ee vincristine.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Oncovin^®¶
• Vincasar^® PFS
• Vincrex^®¶

• Saliida Leurocristine
• LCR
• VCR

^¶ Shaygaan sumadda leh kuma sii jiro suuqa. Beddelka guud ayaa la heli karaa.