Saquinavir

Qanacsan

• Kahor qaadashada saquinavir,
• Saquinavir wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:
• Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

Saquinavir waxaa loo isticmaalaa oo lagu daray ritonavir (Norvir) iyo daawooyin kale si loogu daaweeyo infekshanka difaaca jirka ee aadanaha (HIV). Saquinavir wuxuu ku jiraa nooc daawo ah oo loo yaqaan 'protease inhibitors'. Waxay ku shaqeysaa iyadoo la yareeyo qadarka HIV ee dhiiga ku jira. In kasta oo saquinavir uusan daaweynin HIV, waxay yareyn kartaa fursaddaada inaad kuhesho cillad difaac la'aanta jirka (AIDS) iyo cudurrada la xiriira HIV sida infekshannada halista ah ama kansarka. Qaadashada daawooyinkan oo ay weheliso ku-dhaqan galmo badbaado leh iyo isbeddello kale oo hab-nololeed ah ayaa yareyn kara halista u gudbinta fayraska HIV dadka kale.

Saquinavir wuxuu u yimaadaa sida kaabsul iyo kiniin afka laga qaato. Waxaa badanaa la qaataa isla waqtigaas sida ritonavir (Norvir) laba jeer maalintii 2 saacadood gudahood cuntada kadib. Way fududaan kartaa in la xasuusto in la qaato saquinavir haddii aad cuntada ku qaadato. Qaado saquinavir qiyaastii isla waqtiyadii maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado saquinavir sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Kiniiniyada oo dhan liq; ha calalin, ama ha burburin.

Haddii aadan awoodin inaad wada liqdo kaabsulka oo dhan, waxaad ku qaadan kartaa saquinavir adigoo furaya kaabsulka kuna qasaaya waxyaabaha ku jira sharoobada sonkorta, sorbitol, ama macaanka. Si aad isugu diyaariso qiyaas kasta, ku dar 3 qaado (15 ml) oo ah sharoobada sonkorta, sorbitol, ama macaanka weel madhan. Fur kapinavir kaabsal oo ku dar waxa ku jira weelka. Walaaq walaaq 30 ilaa 60 ilbidhiqsi. Haddii aad isticmaashay sharoobada qabow, sorbitol, ama macaanka, sug in isku darku yimaado heerkulka qolka ka hor intaadan wax cunin. Hubso inaad cunto isku dar dhan si aad u hesho qiyaasta buuxda.

Sii wad inaad qaadato saquinavir xitaa haddii aad dareento fiicnaan. Ha u joojin qaadashada saquinavir adigoon la hadlin dhakhtarkaaga. Haddii aad seegto qiyaasaha, aad qaadato wax ka yar intii laguu qoray ama aad joojiso qaadashada saquinavir, xaaladdaadu way sii adkaan kartaa in la daweeyo.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo-saaraha (Tilmaamaha Daawada) markaad bilowdo daaweynta saquinavir iyo markasta oo aad dib u buuxiso dawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Saquinavir waxaa mararka qaarkood loo isticmaalaa ritonavir (Norvir) iyo daawooyin kale si looga caawiyo kahortaga infekshinka shaqaalaha daryeelka caafimaadka ama dadka kale ee uu ku dhacay HIV. Kala hadal dhakhtarkaaga khataraha aad u leedahay qaadashada dawadan xaaladaada.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada saquinavir,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay saquinavir, daawooyin kale oo kasta, laaktoos, ama wax kasta oo ka mid ah maaddooyinka kale ee ku jira saquinavir capsules ama kiniinno Dhakhtarkaagu wuxuu kuu sheegi karaa inaadan qaadan saquinavir. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanayso mid ka mid ah daawooyinka soo socda: alfuzosin (Uroxatral); atazanavir (Reyataz, oo ku taal Evotaz); clarithromycin (Biaxin, gudaha Prevpac); clozapine (Clozaril, Fazaclo, Versacloz); dasatinib (Sprycel); dawooyinka ergot sida dihydroergotamine (D.H.E. 45, Migranal), ergoloid mesylates (Hydergine), ergonovine (Ergotrate), ergotamine (Ergomar, in Cafergot, in Migergot, others), iyo methylergonovine (Methergine); erythromycin (E.E.S., E-mycin, Erythrocin, kuwa kale); halofantrine; haloperidol (Haldol); dawooyinka qaarkood ee garaaca wadnaha oo aan joogto ahayn sida amiodarone (Nexterone, Pacerone), rebupyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), lidocaine (Xylocaine), propafenone (Rhythmol), iyo quinidine (Nuedexta); lovastatin (Altoprev); lurasidone (Latuda); daawooyinka cudurada maskaxda iyo lallabbo sida chlorpromazine, iyo thioridazine; midazolam afka; pentamidine (Nebupent, Pentam); pimozide (Orap); quinine (Qualaquin); rifampin (Rifadin, Rimactane, gudaha Rifamate, Rifater); sildenafil (kaliya magaca Revatio ee loo isticmaalo cudurka sanbabada); simvastatin (Zocor, Flolopid, oo ku taal Vytorin); sunatinib (Sutent); tacrolimus (Astagraf XL, Envarsus XR, Prograf); trazodone; triazolam (Halcion); ama ziprasidone (Geodon). Sidoo kale u sheeg dhakhtarkaaga ama farmashiistaha haddii aad qaadanaysid daawada rilpivirine (Edurant, Juluca, Odefsey, Complera) ama haddii aad joojisay qaadashadeeda labadii toddobaad ee la soo dhaafay. Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan saquinavir haddii aad qaadanaysid mid ama in kabadan oo daawooyinkan ah.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinada, iyo nafaqada nafaqada aad qaadanaysid ama qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida warfarin (Coumadin, Jantoven); antifungals sida itraconazole (Onmel, Sporanox) iyo ketoconazole benzodiazepines sida alprazolam (Xanax), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), iyo flurazepam; beta beta blockers sida atenolol (Tenormin, Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol, in Loressor HCT), nadolol (Corgard, in Corzide), iyo propranolol (Hemangeol, Inderal, Innopran); bosentan (Tracleer); Kaalshiyamka kaaliyayaasha sida amlodipine (Norvasc, in Caduet, Lotrel, kuwa kale), diltiazem (Cardizem, Cartia, Tiazac, kuwa kale), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), nimodipine (Nym ), nisoldipine (Sular), iyo verapamil (Calan, Verelan, Tarka); dawooyinka qaarkood ee yareeya kolestaroolka (statins) sida atorvastatin (Lipitor, in Caduet); cobicistat (Tybost, gudaha Evotaz, Genvoya, Prezcobix, iyo Stribild); corticosteroids sida betamethasone, budesonide (Entocort, Pulmicort, Uceris, in Symbicort), ciclesonide (Alvesco, Zetonna, Omnaris), dexamethasone, fluticasone (Arnuity Ellipta, Flonase, Flovent, Advair, kuwo kale), methylpnis, kuwa kale ), prednisone (Rayos), iyo triamcinolone (Kenalog); colchicine (Colcrys, Mitigare); digoxin (Lanoxin); fentanyl (Abstral, Actiq, Duragesic, kuwa kale); difaaca jirka qaarkood sida cyclosporine (Gengraf, Neoral, Sandimmune), iyo sirolimus (Rapamune); dawooyinka lagu daaweeyo HIV ama AIDS oo ay ku jiraan indinavir (Crixivan), lopinavir oo leh ritonavir (Kaletra), maraviroc (Selzentry), nelfinavir (Viracept), ama tipranavir oo leh ritonavir (Aptivus); dawooyinka qaarkood ee garaaca wadnaha aan caadiga ahayn sida ibutilide (Corvert), iyo sotalol (Betapace, Sorine, Sotylize); daawooyinka lagu daaweeyo qalalka sida carbamazepine (Carbatrol, Epitol, Tegretol, kuwa kale), phenytoin (Dilantin, Phenytek), iyo phenobarbital; methadone (Dolophine, Methadose); nefazodone; omeprazole (Prilosec, gudaha Yosprela, Zegerid); qaar ka mid ah xannibaadayaasha fosfodiesterase (PDE5) sida sildenafil (Viagra), tadalafil (Adcirca, Cialis), iyo vardenafil (Levitra, Staxyn); quetiapine (Seroquel); quinupristin iyo dalfopristin (Synercid); rifabutin (Mycobutin); salmeterol (Serevent, Advair); iyo dawooyinka murugada leh ee tricyclic qaarkood oo ay ku jiraan amitriptyline, clomipramine (Anafranil), imipramine (Surmontil, Tofranil), iyo maprotiline. Daawooyinka kale waxay la macaamili karaan saquinavir, markaa hubi inaad u sheegto dhakhtarkaaga iyo farmashiistaha dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan. Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• u sheeg dhakhtarkaaga waxa ka soo baxa dhirta aad qaadanayso ama aad qorshaynayso inaad qaadato, gaar ahaan St. John's wort, iyo kaabsulka kaabaska ah.
• u sheeg dhakhtarkaaga haddii aad cabto ama aad waligaa cabto qamri aad u tiro badan, iyo haddii adiga ama qof kale oo qoyskaaga ka mid ah uu qabo ama aad waligiis sonkorow qabeen. Sidoo kale u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa wadno garaac aan caadi ahayn, kolestarool sare ama triglycerides (dufanka dhiigga ku jira); hemophilia (cilad dhiig leh); xaaladaha jirku uusan awoodin inuu soo saaro lactase ku filan ama uusan u dulqaadan karin laaktooska, ama wadnaha ama cudurka kelyaha.
• u sheeg dhakhtarkaaga haddii aad uur leedahay ama aad qorsheyneyso inaad uur yeelato. Haddii aad uur yeelato inta aad qaadanaysid saquinavir, wac dhakhtarkaaga. Waa inaadan naas nuujin haddii aad qabtid cudurka HIV ama aad qaadaneyso saquinavir.
• waa inaad ogaataa in saquinavir ay yareyn karto waxtarka uur-qaadidda ee hormoonnada (kaniiniyada xakameynta dhalmada, dhejiska, giraanyada, ama cirbadaha). Kala hadal dhakhtarkaaga isticmaalka nooc kale oo ah ka hortagga uurka.
• haddii aad qalliin tahay, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarka ama dhakhtarka ilkaha inaad qaadanayso saquinavir.
• waa inaad ka warqabtaa in dufanka jirkaagu uu kordhin karo ama u dhaqaaqi karo meelo kala duwan oo jirkaaga ka mid ah, sida dhabarka kore, qoorta ('' buffalo hump ''), naasaha, iyo calooshaada ku wareegsan. Waxaad dareemi kartaa luminta dufanka jirka ee wajiga, lugaha, iyo gacmaha.
• waa inaad ogaataa inaad la kulmi karto hyperglycemia (kordhinta sonkorta dhiiggaaga) inta aad qaadanaysid dawadan, xitaa haddii aadan horey u qabin cudurka macaanka. Isla markiiba u sheeg dhakhtarkaaga haddii aad isku aragto mid ka mid ah astaamaha soo socda inta aad qaadanaysid saquinavir: harraad aad u daran, kaadi badan, gaajo aad u daran, aragga oo xumaada, ama daciifnimo. Aad ayey muhiim u tahay inaad wacdid dhakhtarkaaga isla marka aad isku aragto mid ka mid ah astaamahan, maxaa yeelay sonkorta dhiigga ee sareysa ee aan la daaweyn waxay sababi kartaa xaalad halis ah oo loo yaqaan ketoacidosis. Ketoacidosis wuxuu noqon karaa mid nafta halis geliya haddii aan lagu daaweyn marxaladda hore. Calaamadaha lagu garto ketoacidosis waxaa ka mid ah afka oo qalala, lallabbo iyo matag, neefta oo ku qabata, neefta oo urta miraha, iyo miyirka oo yaraada.
• Waa inaad ogaataa inta aad qaadanaysid dawooyinka lagu daaweynayo infekshinka HIV, nidaamkaaga difaaca ayaa laga yaabaa inuu sii xoogeysto oo uu bilaabo inuu la dagaallamo infekshannada kale ee horay ugu jiray jirkaaga ama u sababi kara xaalado kale inay dhacaan. Tani waxay kugu sababi kartaa inaad yeelato calaamadaha cuduradaas ama xaaladahaas. Haddii aad leedahay calaamado cusub ama ka sii daraya ka dib markii aad ku bilaabatay daaweynta saquinavir, hubi inaad u sheegto dhakhtarkaaga.

Kala hadal dhakhtarkaaga wax ku saabsan cunitaanka canab-gacmeedka iyo cabitaanka casiir canab ah adoo qaadanaya dawadan.

Qaado qiyaasta la seegay isla marka aad xasuusatoba. Si kastaba ha noqotee, haddii ay ku dhowdahay waqtiga qiyaasta xigta, ka bood qiyaasta la seegay oo sii wad jadwalka daawadaada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Saquinavir wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• shuban
• calool xanuun
• lallabbo
• matagid
• calool istaag
• daallan
• dhabar xanuun
• bushimaha qalalan ama maqaarka
• qandho

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

• finan, cuncun, barar indhaha, wejiga, afka, cunaha, ama dibnaha, neefsashada ama liqidda oo dhib ku ah
• maqaarka oo bararaya ama fiiqan
• hurdi maqaarka ama indhaha, cunno xumo, hargab sida astaamaha, daal fara badan, kaadi midab madow ah, saxaro midab khafiif ah leh, calool xanuun qeybta kore ee midig
• dawakhaad, madax-wareer, gaabis, aan caadi ahayn, ama garaaca wadnaha oo suuxaan

Saquinavir wuxuu sababi karaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

• hungur xanuun

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa tijaabooyinka shaybaarka qaarkood kahor iyo inta daaweyntaadu socoto si loo hubiyo jawaabta jirkaaga ee saquinavir. Dhakhtarkaagu wuxuu kaloo amri karaa electrocardiogram-ka (ECG; baaritaanka cabiraya dhaqdhaqaaqa korantada ee wadnaha) kahor iyo inta lagaa daaweynayo.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Invirase^®