Tijaabada hidaha ee BCR ABL

Qanacsan

• Waa maxay baaritaanka hidda-socodka ee BCR-ABL?
• Maxaa loo adeegsadaa?
• Maxaan ugu baahanahay baaritaanka hidda-socodka BCR-ABL?
• Maxaa dhacaya inta lagu jiro baaritaanka hidda-socodka ee BCR-ABL?
• Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?
• Ma jiraan wax khatar ah oo imtaxaanku leeyahay?
• Maxay natiijooyinka ka dhigan yihiin?
• Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka hidda-socodka BCR-ABL?
• Tixraacyo

Waa maxay baaritaanka hidda-socodka ee BCR-ABL?

Baadhitaanka hidde-wadaha BCR-ABL wuxuu raadiyaa isbeddel hidde ah (isbeddel) koromosoom gaar ah.

Chromosomes waa qeybaha unugyadaada oo ay kujiraan hiddo-wadahaaga. Hiddo-wadayaashu waa qaybo ka mid ah hidde-sideyaasha DNA ee laga soo gudbiyay hooyadaa iyo aabbahaa Waxay sitaan macluumaad go'aamiya astaamahaaga gaarka ah, sida dhererka iyo midabka indhaha.

Dadku caadi ahaan waxay leeyihiin 46 koromosoom, oo loo qaybiyay 23 lammaane, qol kasta. Labada koromosoom midkood wuxuu ka yimaadaa hooyadaa, labada kalena waxay ka yimaadaan aabbahaa.

BCR-ABL waa isbadal ku yimaada isku dhafka laba hidde, oo loo yaqaan BCR iyo ABL. Waxaa mararka qaarkood loo yaqaan hidda-wadaha isugeynta.

• Hidda-wadaha BCR wuxuu caadi ahaan ku jiraa koromosoom lambar 22.
• Hidda-wadaha ABL wuxuu caadi ahaan ku jiraa koromosoomka lambar 9.
• Isbedelka BCR-ABL wuxuu dhacaa markii qaybo ka mid ah hiddo-wadayaasha BCR iyo ABL ay jabaan oo beddelaan meelaha.
• Isbeddelku wuxuu ka soo muuqanayaa koromosoomka 22, halkaasoo qayb ka mid ah koromosoomka 9 ay isku dhegan tahay.
• Koromosoomka isbeddelay ee 22 waxaa loo yaqaan 'Philadelphia chromosome' sababtoo ah waa magaaladii ugu horreysay ee cilmi-baarayaashu ka heleen.
• Hidda-wadaha BCR-ABL ma aha nooca isku-beddelashada ee laga dhaxlo waalidkaa. Waa nooc ka mid ah isbeddellada somatic, oo macnaheedu yahay inaadan ku dhalan. Waxaad kuhelaysaa noloshaada dambe.

Hidda-wadaha BCR-ABL wuxuu soo bandhigayaa bukaanno qaba noocyo leukemia ah qaarkood, kansar ku dhaca dhuuxa lafta iyo unugyada dhiigga cad. BCR-ABL waxaa laga helaa ku dhowaad dhammaan bukaanada qaba nooca kansarka dhiigga ee loo yaqaan 'myeloid leukemia chronic' (CML). Magac kale oo loo yaqaan 'CML' waa mid daba dheeraada myelogenous leukemia. Labada magacba waxaa loola jeedaa isku cudur.

Hiddo-wadaha BCR-ABL ayaa sidoo kale laga helaa bukaanjiifka qaarkood oo qaba nooc ka mid ah cudurka halista ah ee loo yaqaan 'lymphoblastic leukemia' (DHAMMAAN) oo marar dhif ah bukaannada qaba cudurka 'myelogenous leukemia' ee daran.

Daawooyinka kansarka qaarkood ayaa si gaar ah waxtar ugu leh daaweynta bukaanka kansarka dhiigga qaba hiddasidaha hidde-wadaha BCR-ABL. Daawooyinkani sidoo kale waxay leeyihiin waxyeellooyin ka yar daaweynta kale ee kansarka. Isla daawooyinka waxtar uma leh daaweynta noocyada kala duwan ee leukemia ama kansarrada kale.

Magacyada kale: BCR-ABL1, isugeynta BCR-ABL1, koromosoomka 'Philadelphia'

Maxaa loo adeegsadaa?

Imtixaanka BCR-ABL waxaa badanaa loo isticmaalaa in lagu ogaado ama looga saaro cudurka 'myeloid leukemia chronic' (CML) ama nooc gaar ah oo ka mid ah cudurka leukemia lymphoblastic daran (ALL) oo loo yaqaan 'Ph-positive ALL'. Ph-positive macnaheedu waa koromosoomka Philadelphia ayaa la helay. Tijaabada looma isticmaalo in lagu baaro noocyada kale ee leukemia.

Baaritaanka waxaa sidoo kale loo isticmaali karaa:

• Eeg haddii daaweynta kansarku waxtar leedahay.
• Eeg haddii bukaanku u yeeshay iska caabin daaweynta qaarkood. Taasi waxay ka dhigan tahay in daaweyn wax ku ool u ahaan jirtay aysan sii shaqeyneynin.

Maxaan ugu baahanahay baaritaanka hidda-socodka BCR-ABL?

Waxaa laga yaabaa inaad u baahato baaritaanka BCR-ABL haddii aad leedahay astaamaha cudurka 'myeloid leukemia chronic' (CML) ama 'Ph-positive lymphoblastic leukemia (ALL). Kuwaas waxaa ka mid ah:

• Daal
• Qandho
• Miisaanka oo yaraada
• Dhididka habeenkii (dhidid badan markaad seexanayso)
• Wadajir ama laf xanuun

Dadka qaar ee qaba CML ama Ph-positive DHAMMAAN wax calaamado ah, ama astaamo aad u fudud, gaar ahaan heerarka hore ee cudurka. Markaa bixiyaha xanaanada caafimaadkaaga ayaa laga yaabaa inuu amro baaritaankaan hadii tirinta dhiiga oo dhameystiran ama baaritaan kale oo dhiig ah ay muujiso natiijooyin aan caadi aheyn. Sidoo kale waa inaad u sheegtaa bixiyahaaga haddii aad leedahay wax calaamado ah oo adiga ku khuseeya. CML iyo Ph-positive DHAMMAAN way fududahay in la daweeyo marka hore la helo.

Waxa kale oo laga yaabaa inaad u baahato baadhitaankan haddii hadda lagaa daaweynayo CML ama Ph-positive ALL. Baaritaanku wuxuu ka caawin karaa bixiyahaaga inuu arko haddii daaweyntaadu shaqeynayso.

Maxaa dhacaya inta lagu jiro baaritaanka hidda-socodka ee BCR-ABL?

Baadhitaanka BCR-ABL badanaa waa baadhitaan dhiig ama nidaam loo yaqaan himilada dhuuxa lafta iyo baadhitaanka.

Haddii dhiig lagaa qaadayo, xirfadle daryeel caafimaad ayaa tijaabo dhiig ah ka qaadi doona xididka gacantaada, isagoo isticmaalaya cirbad yar. Kaddib cirbada la geliyo, qadar yar oo dhiig ah ayaa lagu ururin doonaa tuubada baaritaanka ama fijaan. Waxaa laga yaabaa inaad dareento xoog wax yar ah markii irbadda ay soo galayso ama ay ka baxeyso. Tani badanaa waxay qaadataa in ka yar shan daqiiqo.

Haddii aad helayso hamiga dhuuxa lafta iyo dheecaanka, nidaamkaaga waxaa ku jiri kara talaabooyinka soo socda:

• Waxaad u jiifsan doontaa dhinacaaga ama calooshaada, iyadoo ku xiran lafta loo isticmaali doono baaritaanka. Badi baaritaanka dhuuxa lafta waxaa laga qaadaa lafta misigta.
• Jirkaaga waxaa lagu dabooli doonaa maro, sidaa darteed kaliya aagga agagaarka goobta baaritaanka ayaa muujinaya.
• Goobta waxaa lagu nadiifin doonaa daawada jeermiska dila.
• Waxaad lagugu duri doonaa xal suuxdin ah. Way ku dareemi kartaa
• Marka aaggu kabuubyo, bixiyaha xanaanada caafimaadka ayaa tijaabada qaadi doona. Waxaad u baahan doontaa inaad been iska aamustid inta lagu jiro baaritaanka.
  • Himilada dhuuxa lafta, oo badanaa la sameeyo marka hore, daryeel caafimaad bixiyaha ayaa irbad ka galin doona lafta oo soo saari doona dheecaanka dhuuxa lafta iyo unugyada. Waxaa laga yaabaa inaad dareento xanuun fiiqan laakiin kooban markii irbadda lagaa gelinayo.
  • Cad ka-qaadista laf-dhabarka dhuuxa lafta, bixiyaha daryeelka caafimaad wuxuu u isticmaali doonaa qalab gaar ah oo qalloocinaya lafta si uu u soo qaado shaybaarka unugyada dhuuxa lafta. Waxaa laga yaabaa inaad xoogaa culeys ah ka dareento goobta inta tijaabada lagaa qaadayo.
• Waxay qaadataa qiyaastii 10 daqiiqo in la sameeyo labada baaritaanba.
• Baaritaanka ka dib, bixiyaha xanaanada caafimaadka ayaa goobta ku dabooli doona faashad.
• Qorsheyso in qof kuu kaxeeyo guriga, maxaa yeelay waxaa lagu siin karaa daawooyin suuxin ah baaritaanka ka hor, taasoo kaa dhigi karta inaad lulmooto.

Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?

Badanaa uma baahnid wax diyaargarow gaar ah oo loogu talagalay baaritaanka dhiig ama dhuuxa lafta.

Ma jiraan wax khatar ah oo imtaxaanku leeyahay?

Khatar aad u yar baa jirta in dhiig lagaa qaado. Waxaa laga yaabaa inaad xanuun yar ama nabar ku yeelato barta irbadda lagu muday, laakiin astaamaha badankood si dhakhso leh ayey u baxaan.

Ka dib baaritaanka dhuuxa lafta, waxaad dareemi kartaa adkaansho ama xanuun meesha la muday. Tani badanaa way baaba'daa maalmo yar gudahood. Bixiyaha xanaanada caafimaadkaaga ayaa kugula talin kara ama kuu qori kara xanuun joojiye inuu ku caawiyo.

Maxay natiijooyinka ka dhigan yihiin?

Haddii natiijooyinkaagu muujiyaan inaad leedahay hiddo-wadaha BCR-ABL, iyo sidoo kale qaddar aan caadi ahayn oo ah unugyada dhiigga cad, waxaa laga yaabaa in lagaa helo cudurka 'myeloid leukemia chronic' (CML) ama 'Ph-positive', 'lymphoblastic leukemia (ALL).

Haddii hadda lagaa daaweynayo CML ama Ph-positive ALL, natiijooyinkaaga ayaa laga yaabaa inay muujiyaan:

• Qaddarka BCR-ABL ee dhiigaaga ama dhuuxa lafta ayaa sii kordhaya. Tani waxay macnaheedu noqon kartaa in daaweyntaadu aysan shaqeynaynin iyo / ama aad adkaysi u yeelatay daaweyn cayiman.
• Qaddarka BCR-ABL ee dhiigaaga ama dhuuxa lafta ayaa sii yaraanaya. Tani waxay macnaheedu noqon kartaa in daaweyntaadu shaqeyneyso.
• Qaddarka BCR-ABL ee ku jira dhiiggaaga ama dhuuxa lafta ma uusan kordhin mana yarayn. Tan macnaheedu waxay noqon kartaa in cudurkaagu deggan yahay.

Haddii aad su'aalo ka qabtid natiijooyinkaaga, la hadal daryeel caafimaad bixiyahaaga.

Wax badan ka baro baaritaanka shaybaarka, kala duwanaanshaha tixraaca, iyo fahamka natiijooyinka.

Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka hidda-socodka BCR-ABL?

Daaweynta loogu talagalay myeloid leukemia daba-dheer (CML) iyo Ph-positive, lempmia lempmia lempmia daran (ALL) ayaa lagu guuleystay bukaanada qaba noocyadan leukaemia. Waa muhiim inaad aragto bixiyaha xanaanada caafimaadkaaga si joogto ah si loo hubiyo in daaweyntaada ay ushaqeyso. Haddii aad adkaysi u yeelato daaweynta, daryeel bixiyahaagu wuxuu kugula talin karaa noocyada kale ee daaweynta kansarka.

Tixraacyo

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Macluumaadka ku yaal boggan waa in aan loo isticmaalin beddel daryeel caafimaad oo xirfad leh ama talo. La xiriir bixiye daryeel caafimaad haddii aad su'aalo ka qabtid caafimaadkaaga.