Baadhitaanka Hidaha PTEN

Qanacsan

• Waa maxay baaritaanka hidda-socodka ee PTEN?
• Maxaa loo adeegsadaa?
• Maxaan ugu baahanahay baaritaanka hidda-socodka ee 'PTEN'?
• Maxaa dhacaya inta lagu jiro baaritaanka hidda-socodka ee PTEN?
• Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?
• Ma jiraan wax khatar ah oo imtaxaanku leeyahay?
• Maxay natiijooyinka ka dhigan yihiin?
• Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka hidda-wadaha ee 'PTEN'?
• Tixraacyo

Waa maxay baaritaanka hidda-socodka ee PTEN?

Baadhitaanka hidde-wadaha 'PTEN' wuxuu raadiyaa isbeddel, oo loo yaqaan 'mutation', hiddo-wadaha loo yaqaan PTEN. Hidda-wadaha (genes) waa cutubyada aasaasiga ah ee dhaxalka ee laga soo gudbiyay hooyadaa iyo aabahaaga.

Hidda-wadaha PTEN wuxuu caawiyaa joojinta koritaanka burooyinka. Waxaa loo yaqaannaa xakameyn buro. Hidda-wadaha xakamaynta burooyinka waa sida biriiga gaariga. Waxay ku dhejineysaa "bareegyada" unugyada, si ayan dhaqso ugu qeybin. Haddii aad leedahay hiddo-wadaha hidde-wadaha 'PTEN', wuxuu sababi karaa koritaanka burooyinka aan caadiga ahayn ee loo yaqaan hamartomas. Hamartomas way ka muuqan kartaa jirka oo dhan. Isbeddelku wuxuu sidoo kale u horseedi karaa horumarinta burooyinka kansarka ah.

Isbedelka hidde-wadaha 'PTEN' waxaa laga dhaxli karaa waalidkaa, ama laga heli karaa noloshaada dambe deegaanka ama qalad ka dhaca jirkaaga inta lagu jiro qeybinta unugyada.

Isbadal ku dhaca PTEN wuxuu sababi karaa xanuuno caafimaad oo kala duwan. Qaar ka mid ah kuwan waxay ku bilaaban karaan dhalaanka ama carruurnimada hore. Qaar kale waxay soo muuqdaan iyagoo qaangaar ah. Cilladahaan badanaa waa la isku keenaa waxaana loo yaqaan PTEN hamartoma syndrome (PTHS) waxaana ka mid ah:

• Cowden syndrome, cilad keenta koritaanka hamartomas badan waxayna kordhisaa halista dhowr nooc oo kansar ah, oo ay ku jiraan kansarrada naasaha, ilmo-galeenka, tayroodhka, iyo xiidanka. Dadka qaba Cowden syndrome badanaa waxay leeyihiin madax ka weyn inta caadiga ah (macrocephaly), daahitaanka koritaanka, iyo / ama autismka.
• Bannayan-Riley-Ruvalcaba syndrome sidoo kale wuxuu keenaa hamartomas iyo macrocephaly. Intaas waxaa sii dheer, dadka qaba cilladan cillad-darrada ah waxay yeelan karaan naafonimo xagga waxbarashada iyo / ama autism ah. Ragga qaba cilladaan badanaa waxay leeyihiin calaamado madow oo ku saabsan guska.
• Proteus ama Proteus-like syndrome waxay sababi kartaa kororka lafaha, maqaarka, iyo unugyada kale, iyo sidoo kale hamartomas iyo macrocephaly.

Qaadashada (sidoo kale loo yaqaan somatic) Isbedelada hidaha ee 'PTEN' waa mid ka mid ah isbeddelada guud ee laga helo kansarka dadka. Is-beddelladan waxaa laga helay noocyo badan oo kala duwan oo kansar ah, oo ay ku jiraan kansarka qanjirka 'prostate', kansarka makaanka, iyo noocyo ka mid ah burooyinka maskaxda.

Magacyada kale: Hidda-wadaha PTEN, falanqaynta hidda-wadaha oo buuxa; PTEN isku xigxiga iyo tirtirid / nuqul

Maxaa loo adeegsadaa?

Baaritaanka waxaa loo isticmaalaa in lagu raadsado isbadal hidde ah PTEN. Ma aha tijaabo joogto ah. Badanaa waxaa la siiyaa dadka iyada oo ku saleysan taariikhda qoyska, astaamaha, ama ogaanshaha hore ee kansarka, gaar ahaan kansarka naasaha, tayroodhka, ama ilmo-galeenka.

Maxaan ugu baahanahay baaritaanka hidda-socodka ee 'PTEN'?

Adiga ama ilmahaagu waxaad u baahan kartaan baaritaanka hidda-wadaha ee 'PTEN' haddii aad leedahay taariikh qoys oo ku saabsan is-beddelka hidde-wadaha PTEN iyo / ama mid ama in ka badan oo ka mid ah xaaladaha soo socda ama astaamaha:

• Hamartomas badan, gaar ahaan aagga caloosha
• Macrocephaly (madax ka weyn cabirka caadiga ah)
• Dib udhaca horumarka
• Autism
• Farqiga madow ee guska ragga
• Kansarka naasaha
• Kansarka qanjirka 'thyroid'
• Kansarka makaanka dumarka

Haddii lagaa helay cudurka kansarka oo aadan taariikh u lahayn qoyskaaga cudurka, bixiyaha xanaanada caafimaadkaaga ayaa laga yaabaa inuu amro baaritaankaan si loo arko haddii isbeddelka hidde-wadaha PTEN uu sababi karo kansarkaaga. Ogaanshaha inaad leedahay isbeddellada ayaa ka caawin kara bixiyahaaga inuu saadaaliyo sida cudurkaagu u horumarin doono una hagi doono daaweyntaada.

Maxaa dhacaya inta lagu jiro baaritaanka hidda-socodka ee PTEN?

Baadhitaanka 'PTEN' badiyaa waa dhiig baaris. Inta lagu jiro baaritaanka dhiigga, xirfadle daryeel caafimaad ayaa tijaabo dhiig ka qaadi doona xididka gacantaada, isagoo isticmaalaya cirbad yar. Kaddib cirbada la geliyo, qadar yar oo dhiig ah ayaa lagu ururin doonaa tuubada baaritaanka ama fijaan. Waxaa laga yaabaa inaad dareento xoog wax yar ah markii irbadda ay soo galayso ama ay ka baxeyso. Tani badanaa waxay qaadataa in ka yar shan daqiiqo.

Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?

Badanaa uma baahnid wax diyaargarow gaar ah oo loogu talagalay baaritaanka PTEN.

Ma jiraan wax khatar ah oo imtaxaanku leeyahay?

Khatar aad u yar baa jirta in dhiig lagaa qaado. Waxaa laga yaabaa inaad xanuun yar ama nabar ku yeelato barta irbadda lagu muday, laakiin astaamaha badankood si dhakhso leh ayey u baxaan.

Maxay natiijooyinka ka dhigan yihiin?

Haddii natiijooyinkaagu muujiyaan inaad leedahay astaamaha hidde-wadaha 'PTEN', macnaheedu maahan inaad qabtid kansar, laakiin halistaadu way ka sarreysaa dadka badankood. Laakiin baaritaanka kansarka ee soo noqnoqda ayaa yareyn kara halistaada. Kansarku waa la daaweyn karaa marka la helo marxaladaha hore. Haddii aad isku beddesho, daryeel caafimaad bixiyahaagu wuxuu kugula talin karaa hal ama in kabadan oo kamid ah baaritaanada soosocda

• Colonoscopy, laga bilaabo da'da 35-40
• Raajada naasaha, laga bilaabo da'da 30 ee haweenka
• Imtixaannada naasaha ee billaha ah ee haweenka
• Baadhitaanka makaanka ee haweenka sanadkii
• Baaritaanka qanjirka 'thyroid' sanadkiiba
• Baadhitaanka sanadlaha ah ee maqaarka koritaanka
• Baaritaanka kalyaha sanadkiiba

Baaritaanka qanjirka 'thyroid' iyo baaritaanka maqaarka ayaa sidoo kale lagula taliyaa carruurta leh isbeddellada hidde-wadaha PTEN.

Wax badan ka baro baaritaanka shaybaarka, kala duwanaanshaha tixraaca, iyo fahamka natiijooyinka.

Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka hidda-wadaha ee 'PTEN'?

Haddii lagugu ogaadey isbeddellada hidde-wadaha PTEN ama aad ka fekereyso inaad iska baarto, way ku caawin kartaa inaad la hadasho lataliyaha hidda-socodka. Lataliyaha hidaha ayaa ah xirfadle si gaar ah ugu tababaran hidaha iyo baaritaanka hidaha. Haddii aan weli lagu tijaabin, la-taliyaha ayaa kaa caawin kara inaad fahanto halista iyo faa'iidooyinka baaritaanka. Haddii laguu imtixaanay, la-taliyaha ayaa kaa caawin kara inaad fahanto natiijooyinka wuxuuna kuu tilmaami karaa inaad taageerto adeegyada iyo ilaha kale.

Tixraacyo

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Macluumaadka ku yaal boggan waa in aan loo isticmaalin beddel daryeel caafimaad oo xirfad leh ama talo. La xiriir bixiye daryeel caafimaad haddii aad su'aalo ka qabtid caafimaadkaaga.