TP53 Tijaabada Hidda-socodka

Qanacsan

• Waa maxay baaritaanka hidda-socodka ee TP53?
• Maxaa loo adeegsadaa?
• Maxaan ugu baahanahay baaritaanka hidda-socodka ee TP53?
• Maxaa dhacaya inta lagu jiro baaritaanka hidda-socodka ee TP53?
• Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?
• Ma jiraan wax khatar ah oo imtaxaanku leeyahay?
• Maxay natiijooyinka ka dhigan yihiin?
• Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka TP53?
• Tixraacyo

Waa maxay baaritaanka hidda-socodka ee TP53?

Baadhitaanka hiddo-wadaha ee 'TP53' wuxuu raadiyaa isbeddel, oo loo yaqaan 'mutation', hiddo-wadaha loo yaqaan TP53 (buro borotiin 53). Hidda-wadaha (genes) waa cutubyada aasaasiga ah ee dhaxalka ee laga soo gudbiyay hooyadaa iyo aabahaaga.

TP53 waa hiddo-wade caawiya joojinta koritaanka burooyinka. Waxaa loo yaqaannaa xakameyn buro. Hidda-wadaha xakamaynta burooyinka wuxuu u shaqeeyaa sida biriiga gaariga. Waxay ku dhejineysaa "bareegyada" unugyada, si ayan dhaqso ugu qeybin. Haddii aad isku beddesho TP53, hidda-wadaha ma xakamayn karo koritaanka unugyadaada. Kobaca unugyada ee aan la xakamayn waxay u horseedi karaan kansar.

Isbedelka TP53 waxaa laga dhaxli karaa waalidkaa, ama laga heli karaa noloshaada dambe deegaanka ama qalad ka dhaca jirkaaga inta lagu jiro qeybinta unugyada.

• Isbadal ku dhaca TP53 waxaa loo yaqaan 'Li-Fraumeni syndrome'.
• Li-Fraumeni syndrome waa xaalad dhif ah oo hidde ah oo kordhin karta halista aad u leedahay noocyada kansarrada qaarkood.
• Kansarradan waxaa ka mid ah kansarka naasaha, kansarka lafaha, leukemia, iyo kansarrada unugyada jilicsan, oo sidoo kale loo yaqaan sarcomas.

Qaadashada (sidoo kale loo yaqaan somatic) isbaddelada TP53 aad ayey u badan yihiin. Is-beddelladan waxaa laga helay ku dhowaad kalabar dhammaan kiisaska kansarka, iyo noocyo badan oo kala duwan oo kansar ah.

Magacyada kale: Falanqaynta isbeddelka TP53, TP53 falanqaynta hiddo-wadaha buuxa, TP53 isbedelka somatic

Maxaa loo adeegsadaa?

Tijaabada waxaa loo isticmaalaa in lagu raadiyo isbadal ku dhaca TP53. Ma aha tijaabo joogto ah.Badanaa waxaa la siiyaa dadka iyada oo ku saleysan taariikhda qoyska, astaamaha, ama ogaanshaha hore ee kansarka.

Maxaan ugu baahanahay baaritaanka hidda-socodka ee TP53?

Waxaad u baahan kartaa baaritaanka TP53 haddii:

• Waxaa lagaa helay kansarka lafaha ama jilicsan ka hor da'da 45
• Waxaa lagaa helay, kansarka naasaha kahor caadada, burada maskaxda, leukemia, ama kansarka sanbabada kahor da'da 46
• Waxaad soo aragtay hal ama inbadan oo burooyin ah kahor da'da 46
• Mid ama in kabadan oo kamid ah xubnaha qoyskaaga ayaa lagahelay cudurka Li-Fraumeni syndrome iyo / ama kansar ayuu kudhacay kahor da'da 45 sano

Kuwani waa calaamado laga yaabo inaad leedahay hiddo-wadaha hiddo-wadaha ee hiddo-wadaha TP53.

Haddii lagaa helay kansar oo aadan taariikh qoys u lahayn cudurka, bixiyaha xanaanada caafimaadkaaga ayaa laga yaabaa inuu amro baaritaankaan si loo arko haddii isbeddelka TP53 uu sababi karo kansarkaaga. Ogaanshaha inaad leedahay isbedelku wuxuu ka caawin karaa bixiyahaaga qorsheynta daaweynta iyo saadaalinta natiijada suurtagalka ah ee cudurkaaga.

Maxaa dhacaya inta lagu jiro baaritaanka hidda-socodka ee TP53?

Tijaabada TP53 waxaa badanaa lagu sameeyaa dhiiga ama dhuuxa lafta.

Haddii dhiig lagaa qaadayo, xirfadle daryeel caafimaad ayaa tijaabo dhiig ah ka qaadi doona xididka gacantaada, isagoo isticmaalaya cirbad yar. Kaddib cirbada la geliyo, qadar yar oo dhiig ah ayaa lagu ururin doonaa tuubada baaritaanka ama fijaan. Waxaa laga yaabaa inaad dareento xoog wax yar ah markii irbadda ay soo galayso ama ay ka baxeyso. Tani badanaa waxay qaadataa in ka yar shan daqiiqo.

Haddii lagaa qaadayo baaritaanka dhuuxa lafta, nidaamkaaga waxaa ku jiri kara talaabooyinka soo socda:

• Waxaad u jiifsan doontaa dhinacaaga ama calooshaada, iyadoo ku xiran lafta loo isticmaali doono baaritaanka. Badi baaritaanka dhuuxa lafta waxaa laga qaadaa lafta misigta.
• Jirkaaga waxaa lagu dabooli doonaa maro, sidaa darteed kaliya aagga agagaarka goobta baaritaanka ayaa muujinaya.
• Goobta waxaa lagu nadiifin doonaa daawada jeermiska dila.
• Waxaad lagugu duri doonaa xal suuxdin ah. Way ku dareemi kartaa
• Marka aaggu kabuubyo, bixiyaha xanaanada caafimaadka ayaa tijaabada qaadi doona. Waxaad u baahan doontaa inaad been iska aamustid inta lagu jiro baaritaanka.
• Bixiyaha xanaanada caafimaadka wuxuu isticmaali doonaa qalab gaar ah oo isku laaban lafaha si uu u soo qaado muunad ka mid ah unugyada dhuuxa lafta. Waxaa laga yaabaa inaad xoogaa culeys ah ka dareento goobta inta tijaabada lagaa qaadayo.
• Baaritaanka ka dib, bixiyaha xanaanada caafimaadka ayaa goobta ku dabooli doona faashad.
• Qorsheyso in qof kuu kaxeeyo guriga, maxaa yeelay waxaa lagu siin karaa daawooyin suuxin ah baaritaanka ka hor, taasoo kaa dhigi karta inaad lulmooto.

Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?

Badanaa uma baahnid wax diyaargarow gaar ah oo loogu talagalay baaritaanka dhiig ama dhuuxa lafta.

Ma jiraan wax khatar ah oo imtaxaanku leeyahay?

Khatar aad u yar baa jirta in dhiig lagaa qaado. Waxaa laga yaabaa inaad xanuun yar ama nabar ku yeelato barta irbadda lagu muday, laakiin astaamaha badankood si dhakhso leh ayey u baxaan.

Ka dib baaritaanka dhuuxa lafta, waxaad dareemi kartaa adkaansho ama xanuun meesha la muday. Tani badanaa way baaba'daa maalmo yar gudahood. Bixiyaha xanaanada caafimaadkaaga ayaa kugula talin kara ama kuu qori kara xanuun joojiye inuu ku caawiyo.

Maxay natiijooyinka ka dhigan yihiin?

Haddii lagaa helay cudurka Li-Fraumeni syndrome, waa ma macnaheedu waa inaad kansar qabto, laakiin halistaadu way ka badan tahay dadka badankood. Laakiin haddii aad isbeddel ku samayso, waxaad qaadi kartaa tallaabooyin aad ku yareyn karto halistaada, sida:

• Baadhitaanno badan oo kansar ah. Kansarku waa la daaweyn karaa marka la helo marxaladaha hore.
• Isbedelka qaab nololeedka, sida jimicsi badan iyo cunista cunto caafimaad leh
• Ka-hortagga kiimikada, qaadashada dawooyinka qaarkood, fiitamiinnada, ama walxo kale si loo yareeyo halista ama dib loogu dhigo horumarka kansarka.
• Ka qaadida unugyada "halista ku jira"

Talaabooyinkani way kala duwanaan doonaan iyadoo kuxiran taariikhdaada caafimaad iyo sooyaalka qoyskaaga.

Haddii aad qabto kansar natiijooyinkaaguna muujinayaan isbeddel TP53 ah oo la helay (isbeddel ayaa la helay, laakiin ma lihid taariikh qoys oo kansar ama Li-Fraumeni syndrome), bixiyahaaga ayaa isticmaali kara macluumaadka si uu uga caawiyo saadaalinta sida cudurkaagu u horumarin doono una hagi doono daaweynta.

Wax badan ka baro baaritaanka shaybaarka, kala duwanaanshaha tixraaca, iyo fahamka natiijooyinka.

Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka TP53?

Haddii lagaa helay ama aad ka shakisan tahay inaad qabtid cudurka Li-Fraumeni syndrome, way ku caawin kartaa inaad la hadasho lataliyaha hidda-socodka. Lataliyaha hidaha ayaa ah xirfadle si gaar ah ugu tababaran hidaha iyo baaritaanka hidaha. Haddii aan weli lagu tijaabin, la-taliyaha ayaa kaa caawin kara inaad fahanto halista iyo faa'iidooyinka baaritaanka. Haddii laguu imtixaanay, la-taliyaha ayaa kaa caawin kara inaad fahanto natiijooyinka wuxuuna kuu tilmaami karaa inaad taageerto adeegyada iyo ilaha kale.

Tixraacyo

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Macluumaadka ku yaal boggan waa in aan loo isticmaalin beddel daryeel caafimaad oo xirfad leh ama talo. La xiriir bixiye daryeel caafimaad haddii aad su'aalo ka qabtid caafimaadkaaga.