Cudurka 'Zollinger-Ellison syndrome'

Cudurka 'Zollinger-Ellison syndrome' waa xaalad jirku soo saaro in badan oo ka mid ah hormoonka gastrin. Inta badan, buro yar (gastrinoma) oo ku taal xammeetida ama xiidmaha yar ayaa ah isha laga helo gastrin dheeri ah oo dhiigga ku jirta.

Cudurka Zollinger-Ellison waxaa sababa burooyin. Koritaankaas waxaa badanaa laga helaa madaxa xammeetida iyo xiidmaha kore ee kore. Burooyinka waxaa loo yaqaan gastrinomas. Heerarka sare ee gastrin-ka ayaa sababa soo saarida aashitada caloosha oo aad u badan.

Gastrinomas waxay u dhacdaa sidii burooyin hal mar ah ama burooyin dhowr ah. Hal iyo badh ama saddex dalool hal gastrinomas waa burooyinka kansarka (malignant). Burooyinkaasi waxay badanaa ku faafaan beerka iyo qanjidhada ku dhow.

Dad badan oo qaba gastrinomas waxay leeyihiin burooyin dhowr ah oo qayb ka ah xaalad loo yaqaan nooca endocrine neoplasia type I (MEN I). Burooyinku waxay ku soo bixi karaan qanjirka 'pituitary gland' (maskaxda) iyo qanjirka 'parathyroid' (qoorta) iyo weliba xammeetida.

Calaamadaha waxaa ka mid noqon kara:

• Calool xanuun
• Shuban
• Matag dhiig (mararka qaarkood)
• Calaamadaha hunguriga daran (GERD)

Calaamadaha waxaa ka mid ah boogaha caloosha iyo xiidmaha yar yar.

Tijaabooyinka waxaa ka mid ah:

• Sawirka CT-ga ee caloosha
• Imtixaanka kaalshiyamka faleebada
• Ultrasound-ka Endoscopic
• Qalliinka sahaminta
• Heerka dhiigga Gastrin
• Skaanka Octreotide
• Imtixaanka kicinta sirta ah

Daawooyinka loo yaqaan 'proton pump inhibitors' (omeprazole, lansoprazole, iyo kuwa kale) ayaa loo isticmaalaa daaweynta dhibaatadan. Daawooyinkani waxay yareeyaan soosaarka aashitada ee caloosha. Tani waxay caawineysaa boogaha caloosha iyo xiidmaha yar yar inay bogsadaan. Daawooyinkani waxay kaloo yareeyaan xanuunka caloosha iyo shubanka.

Qalliin si looga soo saaro hal gastrinoma ayaa la sameyn karaa haddii burooyinka aysan ku faafin xubnaha kale. Qalliin caloosha ah (gastrectomy) si loo xakameeyo wax soo saarka asiidhka ayaa dhif ah in loo baahdo.

Qiyaasta daaweynta waa yar tahay, xitaa marka goor hore la helo oo burada laga saaro. Si kastaba ha noqotee, gastrinomas si tartiib ah ayey u koraan.Dadka qaba xaaladan waxaa laga yaabaa inay noolaadaan sannado badan ka dib marka la ogaado burada. Daawooyinka xakameynaya aashitada waxay si fiican u shaqeeyaan si loo xakameeyo astaamaha.

Dhibaatooyinka waxaa ka mid noqon kara:

• Ku guuldareysiga helitaanka buro inta lagu jiro qalliinka
• Dhiigbaxa mindhicirka ama daloolka (dalool) ka soo baxa boogaha caloosha ama duodenum
• Shuban daran iyo miisaan lumis
• Ku faafidda burada xubnaha kale

Wac daryeel caafimaad bixiyahaaga haddii aad leedahay calool xanuun daran oo aan dhammaanayn, gaar ahaan haddii ay ku dhacdo shuban.

Cudurka Z-E; Gastrinoma

• Qanjirada 'Endocrine'

Jensen RT, Norton JA, Oberg K. burooyinka Neuroendocrine. Gudaha: Feldman M, Friedman LS, Brandt LJ, eds. Cudurka caloosha iyo beerka ee Sleisenger iyo Fordtran. 10aad ed. Philadelphia, PA: Elsevier Saunders; 2016: cutubka 33.

Vella A. Hormoonnada caloosha iyo mindhicirka iyo burooyinka endocrine gut. Gudaha: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Buugga Buugga Endocrinology. 13aad. Philadelphia, PA: Elsevier; 2016: cutubka 38.