Klinefelter syndrome

Klinefelter syndrome waa xaalad hidde ah oo ku dhacda ragga markay yeeshaan koromosoom X dheeraad ah.

Dadka badankood waxay leeyihiin 46 koromosoom. Koromosoomyada waxaa kujira dhamaan hiddo-wadahaaga iyo DNA-da, dhismooyinka jirka. 2 koromosoomyada galmada (X iyo Y) ayaa go'aamiya inaad wiil ama gabar noqotid. Gabdhaha caadi ahaan waxay leeyihiin 2 X koromosoom. Wiilasha caadi ahaan waxay leeyihiin 1 X iyo 1 Y koromosoom.

Klinefelter syndrome wuxuu keenaa marka wiilku ku dhasho ugu yaraan 1 koromosoom X dheeraad ah. Tan waxaa loo qoray sida XXY.

Cudurka 'Klinefelter syndrome' wuxuu ku dhacaa qiyaastii 1 ka mid ah 500 ilaa 1,000 wiilal wiilal ah. Haweenka uurka yeelaa markay 35 sano gaaraan waxay waxyar u badan tahay inay yeeshaan wiil qaba cilladan marka loo eego dumarka da'da yar.

Dhalmo la'aan waa astaamaha ugu caansan ee cudurka Klinefelter syndrome.

Calaamadaha waxaa ka mid noqon kara mid ka mid ah kuwan soo socda:

• Jaangooyooyin aan caadi ahayn (lugaha dhaadheer, jir gaaban, garabka oo u dhigma cabirka misigta)
• Naaso aan caadi ahayn oo weyn (gynecomastia)
• Madhalaysnimo
• Dhibaatooyinka galmada
• Wax ka yar xaddiga caadiga ah ee xubinta taranka, kilkilaha, iyo timaha wajiga
• Xiniinyaha yar yar ee adag
• Dherer dherer
• Cabirka guska yar
  
  

Cudurka 'Klinefelter syndrome' waxaa laga yaabaa in marka hore la ogaado markii nin u yimaado bixiyaha daryeelka caafimaadka madhalaysnimo darteed. Tijaabooyinka soo socda waa la samayn karaa:

• Karyotyping (wuxuu hubiyaa koromosoomyada)
• Tirada manida

Tijaabooyin dhiig ayaa la qaadi doonaa si loo hubiyo heerarka hoormoonka, oo ay ku jiraan:

• Estradiol, waa nooc ka mid ah estrogen
• Hormone-kiciyaha follicle
• Hormoonka luteinizing
• Hormoonkaas

Daaweynta testosterone ayaa la qori karaa. Tani waxay kaa caawin kartaa:

• Kordhi timaha jirka
• Hagaajinta muuqaalka muruqyada
• Hagaajinta fiirsashada
• Hagaajinta niyadda iyo isku kalsoonaanta
• Kordhi tamarta iyo galmada
• Kordhi xoog

Ragga badankood ee cilladan qaba ma awoodaan inay haween uur qaadaan. Khabiir ku takhasusay madhalaysnimada ayaa ku caawin kara. U tagista dhakhtar loo yaqaan 'endocrinologist' sidoo kale way caawin kartaa.

Ilahaani waxay ku siin karaan macluumaad dheeraad ah cudurka Klinefelter syndrome:

• Isbahaysiga X iyo Y Chromosome Variations - genetic.org
• Maktabada Qaranka ee Daawada, Tixraaca Hoyga ee Genetics - medlineplus.gov/klinefelterssyndrome.html

Ilkaha ballaaran ee dusha khafiifka ah ayaa aad ugu badan cudurka Klinefelter syndrome. Tan waxaa lagu magacaabaa taurodontism. Tan waxaa lagu arki karaa raajada ilkaha.

Klinefelter syndrome sidoo kale waxay kordhisaa halista:

• Ciladda feejignaanta la'aanta (ADHD)
• Xanuunada iswada, sida lupus, rheumatoid arthritis, iyo Sjögren syndrome
• Kansarka naasaha ragga
• Niyad jab
• Naafada waxbarashada, oo ay kujirto dyslexia, oo saameysa aqriska
• Nooc naadir ah oo buro ah oo loo yaqaan 'extragonadal jeermiska unugyada unugyada'
• Cudurka sambabka
• Cudurka Osteoporosis
• Xididdada xididdada

La xiriir adeeg bixiyahaaga haddii wiilkaagu uusan ku soo bixin sifooyin jinsiyeed labaad markuu qaan gaaro. Tan waxaa ka mid ah koritaanka timaha wajiga iyo qoto dheerida codka.

Lataliyaha hidaha iyo hidaha ayaa ku siin kara macluumaad kusaabsan xaaladaan wuxuuna kugula socodsiin karaa kooxaha taageera deegaankaaga.

47 X-X-Y cillad; Xanuunka 'XXY syndrome'; XXY trisomy; 47, XXY / 46, XY; Cudurka Mosaic syndrome; Poly-X Klinefelter syndrome

Allan CA, McLachlan RI. Ciladaha yaraanta Androgen. Gudaha: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Dadka waaweyn iyo carruurta. 7aad ed. Philadelphia, PA: Elsevier Saunders; 2016: cutubka 139.

Matsumoto AM, Anawalt BD, Xanuunada xiniinyaha. Gudaha: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Buugga Buugga Endocrinology. 14aad. Philadelphia, PA: Elsevier; 2020: cutubka 19.

Nussbaum RL, McInnes RR, Willard HF. Kromosomal-ka iyo hiddo-wadaha cudurada: ciladaha autosomyada iyo koromosoomyada galmada. Gudaha: Nussbaum RL, McInnes RR, Willard HF, eds. Thompson & Thompson Genetics ee daawada. 8aad ed. Philadelphia, PA: Elsevier; 2016: cutubka 6.