Neoplasia endocrine badan (Ragga) I

Noocyo badan oo ah endocrine neoplasia (MEN) nooca I waa cudur hal ama in ka badan oo qanjidhada endocrine ay aad u badan yihiin ama sameeyaan buro. Waxaa loo sii gudbiyaa qoysaska.

Qanjidhada Endocrine ee inta badan ku lug leh waxaa ka mid ah:

• Xammeetida
• Parathyroid
• Pituitary

Ragga I waxaa sababa cillad ku timid hiddo-wadaha oo xambaarsan koodhka borotiinka loo yaqaan 'menin'. Xaaladdu waxay keentaa burooyinka qanjidhada kala duwan inay ka soo muuqdaan isla hal qof, laakiin daruuri maahan inay isku waqti noqdaan.

Cilladaan waxaa laga yaabaa inay dhacdo da 'kasta, waxayna si isku mid ah ugu dhacdaa ragga iyo dumarka. Taariikh qoys oo cilladan ayaa sare u qaadeysa halistaada.

Calaamaduhu way ku kala duwan yihiin qofba qofka kale, waxayna kuxirantahay qanjirka kujira. Waxay ka mid noqon karaan:

• Calool xanuun
• Walaac
• Midab madow, saxaro tarry ah
• Dareenka caloosha ka dib cuntada kadib
• Gubasho, xannuun, ama raaxo-darro gaajo ku jirta caloosha sare ama xabadka hoose oo ay dejiso daawada antacids, caanaha, ama cuntada
• Xiisaha galmada oo yaraaday
• Daal
• Madax xanuun
• Muddooyinka caadada oo yaraada (dumarka)
• Cunto xumo
• Jirka jirka ama timaha wajiga (ragga)
• Isbedelada maskaxda ama jahwareerka
• Murqo xanuun
• Lalabbo iyo matag
• Xasaasiyadda qabowga
• Miisaan lumis aan ula kac ahayn
• Dhibaatooyinka aragga
• Tabar darrida

Bixiyaha xanaanada caafimaadka ayaa sameyn doona baaritaan jireed wuxuuna weydiin doonaa su'aalo ku saabsan taariikhdaada caafimaad iyo astaamahaaga. Tijaabooyinka soo socda waa la samayn karaa:

• Heerka cortisol ee dhiiga
• CT iskaanka caloosha
• Baadhitaanka CT ee madaxa
• Soonka sonkorta
• Tijaabada hidaha
• Tijaabada insulin
• MRI caloosha
• MRI madaxa
• Serum adrenocorticotropic hormone
• Kalsiyum dhiig ah
• Serum follicle kiciya hormoonka
• Serum gastrin
• Serum glucagon
• Serum luteinizing hormoon
• Hormarka serum parathyroid
• Serum prolactin
• Serum tayroodh kiciya
• Ultrasound ee qoorta

Qalliinka looga saarayo qanjirka jirran badanaa waa daaweynta xulashada. Daawada la yiraahdo bromocriptine ayaa loo isticmaali karaa halkii qalliin loogu sameyn lahaa burooyinka pituitary ee sii deynaya hormoonka prolactin.

Qanjirrada 'parathyroid', ee xukuma soo saaridda kaalshiyamka, waa laga saari karaa. Si kastaba ha noqotee, way ku adag tahay jirku inuu xakameeyo heerarka kalsiyum la'aanta qanjidhadaas, sidaas darteed wadarta ka-qaadista parathyroid-ka ah looma sameeyo marka hore kiisaska badankood.

Daawada ayaa la heli karaa si loo yareeyo soosaarka aashitada badan ee caloosha ee ay sababaan burooyinka qaarkood (gastrinomas), iyo in la yareeyo halista boogaha.

Daaweynta bedelka hormoonka waxaa la bixiyaa marka qanjidhada oo dhan laga saaro ama aysan soo saarin hormoonno ku filan.

Burooyinka pituitary iyo parathyroid badanaa waa noncancerous (benign), laakiin qaar ka mid ah burooyinka ganaca ayaa noqon kara kansar (malignant) waxayna ku faafaan beerka. Kuwani waxay yareyn karaan rajada nolosha.

Calaamadaha cudurka ulcer-ka, sonkorta dhiigga oo hooseysa, kaalshiyamka ku badan dhiigga, iyo cillad la'aanta pituitary ayaa caadi ahaan si fiican uga jawaab celiya daaweynta habboon.

Burooyinka ayaa dib u soo laaban kara. Calaamadaha iyo dhibaatooyinka waxay kuxiranyihiin qanjidhada ay kujiraan. Hubinta joogtada ah ee adeeg bixiyahaagu waa muhiim.

Wac daryeel bixiyahaaga haddii aad dareento astaamaha MEN I ama aad leedahay taariikh qoys oo xaaladdan ah.

Baadhitaanka qaraabada dhow ee dadka uu ku dhacay cilladan ayaa lagula talinayaa.

Cudurka 'Wermer syndrome'; RAGA I

• Qanjirada 'Endocrine'

Shabakada Shabakada Shabakada Kansarka oo dhameystiran. Tilmaamaha tababarka caafimaadka ee cudurka kansarka (NCCN guideines): burooyinka neuroendocrine. Nooca 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. La cusbooneysiiyay Maarso 5, 2019. La helay Maarso 8, 2020.

Newey PJ, Thakker RV. Neoplasia endocrine badan. Gudaha: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Buugga Buugga Endocrinology. 14aad. Philadelphia, PA: Elsevier; 2020: cutubka 42.

Nieman LK, Spiegel AM. Cilladaha polyglandular. Gudaha: Goldman L, Schafer AI, eds. Daawada Goldman-Cecil. 26aad. Philadelphia, PA: Elsevier; 2020: cutubka 218.

Thakker RV. Noocyo badan oo endocrine neoplasia 1. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Dadka waaweyn iyo carruurta. 7aad ed. Philadelphia, PA: Elsevier Saunders; 2016: cutubka 148.