Cudurka qanjirada 'lymphocytic leukemia' (CLL)

Cudurka 'lymphocytic leukemia' (CLL) waa kansar ka mid ah noocyada unugyada dhiigga cad oo loo yaqaan 'lymphocytes'. Unugyadan waxaa laga helaa dhuuxa lafta iyo qeybaha kale ee jirka. Dhuuxa lafta waa nudaha jilicsan ee ku jira bartamaha lafaha kaas oo ka caawiya sameynta dhamaan unugyada dhiiga.

CLL waxay sababtaa tartiib tartiib ah nooc gaar ah oo unugyada dhiigga cad oo loo yaqaan B lymphocytes, ama unugyada B. Unugyada kansarku waxay ku faafaan dhiigga iyo dhuuxa lafta. CLL waxay sidoo kale saameyn ku yeelan kartaa qanjidhada qanjirada ama xubnaha kale sida beerka iyo beeryarada. CLL aakhirka waxay sababi kartaa dhuuxa lafta inuu waayo shaqadiisa.

Sababta CLL lama yaqaan. Ma jiro xiriirin shucaaca ah. Ma cadda in kiimikooyinka qaarkood ay sababi karaan CLL. Soo-gaadhista Wakaaladda Orange xilligii Dagaalkii Fiyatnaam ayaa lala xiriiriyay wax yar oo ka mid ah halista sii kordheysa ee horumarinta CLL.

CLL waxay badanaa ku dhacdaa dadka waaweyn, gaar ahaan kuwa ka weyn da'da 60. Dadka da'doodu ka yar tahay 45 si dhif ah ayey ugu dhacdaa CLL. CLL waxay caan ku tahay caddaanka marka loo eego qowmiyadaha kale. Waxay ku badan tahay ragga marka loo eego dumarka. Dadka qaarkiis ee qaba xanuunka 'CLL' waxay leeyihiin xubno qoys oo qaba cudurka.

Astaamuhu badanaa waxay u kobcaan si tartiib ah. CLL badanaa ma keento astaamo marka hore. Waxaa laga heli karaa baaritaanka dhiigga ee dadka lagu sameeyo sababo kale awgood.

Calaamadaha CLL waxaa ka mid noqon kara:

• Qanjidhada balaaran, beerka, ama beeryarada
• Dhidid badan, dhidid habeenkii ah
• Daal
• Qandho
• Cudurrada soo noqnoqda (soo noqnoqda), in kasta oo daaweyn la leeyahay
• Rabitaanka cuntada oo luma ama si dhakhso leh u buuxsama (dhereg hore)
• Miisaanka oo yaraada

Bixiyaha xanaanada caafimaadka ayaa sameyn doona baaritaan jireed wuxuuna weydiin doonaa astaamahaaga.

Tijaabooyinka lagu ogaanayo CLL waxaa ka mid noqon kara:

• Tirinta dhiigga oo dhammeystiran (CBC) oo leh unug unugyada dhiigga.
• Qulqulka tijaabada cytometry ee unugyada dhiigga cad.
• Fluorescent in situ hybridization (FISH) waxaa loo isticmaalaa in lagu eego laguna tiriyo hidda-wadaha ama koromosoomyada. Tijaabadani waxay kaa caawin kartaa baaritaanka CLL ama hagista daaweynta.
• Tijaabinta isbeddelada hiddo-wadaha kale ayaa laga yaabaa inay gacan ka geysato saadaalinta sida wanaagsan ee kansarku uga jawaabi doono daaweynta.

Dadka qaba CLL badanaa waxay leeyihiin tirakoob unugga dhiigga oo sarreeya.

Tijaabooyin fiiriya isbeddelada DNA-da ee gudaha unugyada kansarka sidoo kale waa la sameyn karaa. Natiijooyinka ka soo baxa tijaabooyinkan iyo kuwa tijaabinta ah ayaa ka caawiya bixiyahaaga inuu go'aamiyo daaweyntaada.

Haddii aad qabtid CLL marxaladda hore, adeeg bixiyahaaga ayaa si dhow kuula socon doona. Daaweynta guud ahaan lama siinayo marxaladda hore ee CLL, illaa aad:

• Infekshannada soo noqnoqda
• Leukemia oo si dhakhso leh uga sii daraysa
• Unugga dhiigga cas ee hooseeya ama tirinta dhiigga
• Daal, cunno xumo, miisaanka oo yaraada, ama dhidid habeenkii ah
• Qanjidhada oo barara

Daaweynta kiimikada, oo ay ku jiraan dawooyinka la bartilmaameedsaday, ayaa loo isticmaalaa in lagu daaweeyo CLL. Bixiyahaaga ayaa go'aamin doona nooca daawooyinka kugu habboon.

Dhiiga lagu shubo ama platelet-ka lagu shubo ayaa loo baahan karaa hadii tirinta dhiigu yar tahay.

Beerista lafta lafta ama xubinta unugyada asliga ah waxaa loo isticmaali karaa dadka da 'yarta ah ee leh heerka' CLL 'ama kuwa halista sare leh. Beerista xubinta taranka waa daaweynta kaliya ee bixisa daaweyn suurtagal ah CLL, laakiin sidoo kale waxay leedahay khataro. Bixiyahaaga ayaa kaala hadli doona halista iyo faa'iidooyinka adiga.

Adiga iyo daryeel bixiyahaagu waxaad u baahan kartaan inaad maareysaan walaac kale inta aad lekinmia ku daweyneyso, oo ay ku jiraan

• Maareynta xayawaankaaga inta lagu jiro kiimoteraabiga
• Dhibaatooyinka dhiig-baxa
• Af qalalan
• Cunista kalooriyada kugu filan
• Cunista nabdoon inta lagu jiro daaweynta kansarka

Waad yareyn kartaa diiqada jirrada adoo ku biiraya kooxda taageerta kansarka. La wadaagida dadka kale ee leh khibradaha guud iyo dhibaatooyinka ayaa kaa caawin kara inaadan kali dareemin.

Bixiyahaagu wuxuu kaala hadli karaa adiga aragtidaada CLL-kaaga oo ku saleysan marxaladiisa iyo sida ugu wanaagsan ee ay uga jawaab celiso daaweynta.

Dhibaatooyinka CLL iyo daaweynteeda waxaa ka mid noqon kara:

• Autoimmune hemolytic anemia, oo ah xaalad unugyada dhiigga cas ay ku baabi'iyaan nidaamka difaaca jirka
• Dhiigbax ka yimaada tirinta platelet-ka oo hooseeya
• Hypogammaglobulinemia, oo ah xaalad uu ka hooseeyo unugyada difaaca jirka sidii caadiga ahayd, taas oo kordhin karta halista cudurka.
• Idiopathic thrombocytopenic purpura (ITP), cilad dhiig bax
• Infekshannada soo noqnoqda (soo noqnoqda)
• Daalku wuxuu u dhexeeyaa mid fudud ama mid daran
• Kansarrada kale, oo ay ku jiraan lymphoma aad u dagaal badan (Isbeddelka Richter)
• Dhibaatooyinka ay keento kiimoteraabiga

Wac adeeg bixiye haddii aad isku aragto qanjidhada balaaran ama daal aan la sharixin, nabar, dhidid badan, ama miisaan lumis.

CLL; Xanuunka kansarka dhiigga - lymphocytic chronic (CLL); Kansarka dhiigga - lempmia lempmia lymphocytic chronic; Kansarka dhuuxa lafta - lempmia lempmia lymphocytic chronic; Lymphoma - cudurka leukemia-da ee joogtada ah

• Beerista dhuuxa lafta - dheecaan

• Himilada dhuuxa lafta
• Ulaha Auer
• Cudurka kansarka dhiigga ku dhaca ee lymphocytic - aragti cqaadir la'aan
• Antibodies

Awan FT, Byrd JC. Cudurka 'lymphocytic leukemia' oo raaga. Gudaha: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6aad ed. Philadelphia, PA: Elsevier; 2020: cutubka 99.

Websaydhka Machadka Kansarka Qaranka. Daaweynta lempmia lempmia ee joogtada ah (PDQ) - nooca caafimaadka xirfadleyda. www.cancer.gov/types/leukemia/hp/cll-treatment-pdq. La cusbooneysiiyay Janaayo 22, 2020. Waxaa la helay Febraayo 27, 2020.

Shabakada Shabakada Shabakada Kansarka oo dhameystiran. Tilmaamaha tababarka caafimaadka ee NCCN ee ku saabsan cudurka kansarka. Cudurka kansarka dhiigga ku dhaca ee lugaha / lugaha 'lymphocytic lymphoma' oo raaga. Nooca 4.2020. www.nccn.org/professionals/physician_gls/pdf/cll.pdf. La cusbooneysiiyay Diseembar 20, 2019. Waxaa la helay Febraayo 27, 2020.