Mifepristone (Mifeprex)

Qanacsan

• Kahor qaadashada mifepristone,
• Mifepristone wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

Dhiigbax siilka ah oo halis ah ama nafta halis galinaya ayaa dhici kara marka uurka lagu dhameeyo dhicis ama soo ridid ​​caafimaad ama qalliin. Lama oga haddii qaadashada mifepristone ay kordhinayso halista ah inaad la kulanto dhiig bax aad u culus. U sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa dhibaato dhiig-qab, dhiig-yaraan (ka yar tahay tirada caadiga ah ee unugyada dhiigga cas), ama haddii aad qaadanayso dawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida aspirin, apixaban (Eliquis), dabigatran (Pradaxa) , dalteparin (Fragmin), edoxaban (Savaysa). enoxaparin (Lovenox), Fondaparinux (Arixtra), heparin, rivaroxaban (Xarelto), ama warfarin (Coumadin, Jantoven). Hadday sidaas tahay, dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan mifepristone. Haddii aad isku aragtid dhiig bax aad u culus oo siilka ah, sida inaad ku qoyso laba suuf oo fayadhowr buuxa oo buuxa ah saacad kasta laba saacadood oo isdaba-joog ah, wac dhakhtarkaaga isla markiiba ama raadso daryeel caafimaad oo degdeg ah.

Infekshano halis ah ama nafta halis geliya ayaa dhici kara marka uurka lagu soo gabagabeeyo dhicis ama soo ridid ​​caafimaad ama qalliin. Tiro yar oo bukaanno ah ayaa u dhintey cudurro ay soo qaadeen kadib markii ay isticmaaleen mifepristone iyo misoprostol si ay u soo afjaraan uurkooda. Lama oga haddii mifepristone iyo / ama misoprostol ay keeneen infekshanadan ama dhimashadan. Haddii aad isku aragto infekshan daran, waxaa laga yaabaa inaadan lahayn astaamo badan calaamadahaaguna aysan noqon karin kuwo aad u daran. Waa inaad isla markiiba wacdaa dhakhtarkaaga ama aad u hesho daaweyn caafimaad oo deg deg ah haddii aad isku aragto mid ka mid ah astaamaha soo socda: qandho ka weyn 100.4 ° F (38 ° C) oo soconaya in ka badan 4 saacadood, xanuun daran ama danqasho ka jirta aagga hoose ee dhexda, dhaxan, wadna garaac dhakhso leh, ama miyir beelid.

Sidoo kale waa inaad isla markiiba wacdaa dhakhtarkaaga ama aad u hesho daaweyn caafimaad oo deg deg ah haddii aad leedahay calaamadaha guud ee jirada sida daciifnimo, lallabbo, matag, shuban, ama aad dareento jirro wax ka badan 24 saacadood ka dib qaadashada mifepristone xitaa haddii aanad lahayn qandho ama xanuun aagga dhexdaada ka hooseeya.

Khataraha dhibaatooyinka daran awgood, mifepristone waxaa lagu heli karaa oo keliya barnaamijka xaddidan. Barnaamij hoos loogu magac daray Barnaamijka Qiimaynta Khatarta Mifeprex iyo Xeeladaha Yaraynta (REMS) ayaa loo sameeyay dhammaan bukaanada dumarka ah ee loo qoro mifepristone. Dhakhtarkaagu wuxuu ku siin doonaa warqada macluumaadka bukaanka soo-saaraha (Tilmaamaha Daawada) si aad u aqriso ka hor intaadan bilaabin daaweynta mifepristone. Waxa kale oo aad u baahan doontaa inaad saxeexdo heshiiska bukaanka ka hor qaadashada mifepristone. U sheeg dhakhtarkaaga haddii aad su'aalo ka qabtid daaweynta mifepristone ama haddii aadan raaci karin tilmaamaha ku jira heshiiska bukaanka. Mifepristone waxaa kaliya laga heli karaa rugaha caafimaadka, xafiisyada caafimaadka, iyo isbitaalada lagumana bixiyo farmasiyada tafaariiqda.

La hadal dhakhtarkaaga oo go'aan ka gaadh cidda aad u yeedhayso iyo waxa la sameeyo haddii ay dhacdo xaalad degdeg ah ka dib qaadashada mifepristone. U sheeg dhakhtarkaaga haddii aadan u malayn inaad awood u yeelan doonto inaad raacdo qorshahan ama aad si dhakhso leh u hesho daaweyn degdeg ah inta lagu jiro xaaladaha degdegga ah inta lagu jiro labada toddobaad ee ugu horreeya ka dib qaadashada mifepristone. Wac hagahaaga daawada haddii aad booqato qolka gargaarka degdegga ah ama aad u doonato daryeel caafimaad oo deg-deg ah si dhakhaatiirta ku daweynayaa ay u fahmaan inaad ku socoto ilmo iska soo ridid.

Dhammaan ballamaha la dhig dhakhtarkaaga. Ballamadan ayaa lagama maarmaan u ah in la hubiyo in uurkaagu dhammaaday oo aanad la soo dersin dhibaatooyin daran oo ah uurka ka soo rididda caafimaad.

Takhtarkaaga kala hadal halista qaadashada mifepristone.

Mifepristone waxaa loo isticmaalaa misoprostol (Cytotec) si loo joojiyo uurka hore. Uurka hore wuxuu ka dhigan yahay inay ahayd 70 maalmood ama ka yar tan iyo markii caadadaadii ugu dambeysay ay bilaabatay. Mifepristone wuxuu ku jiraa fasal dawooyin ah oo loo yaqaanno steroids ka hortagga cuncunka. Waxay ku shaqeysaa iyadoo la xannibayo waxqabadka progesterone, walax jirkaagu sameeyo si looga caawiyo sii wadida uurka.

Mifepristone waxaa sidoo kale loo heli karaa shey kale (Korlym), kaas oo loo isticmaalo in lagu xakameeyo hyperglycemia (sonkorta dhiiga oo saraysa) dadka qaba nooc gaar ah oo ah Cushing's Syndrome oo jidhku aad uga sameeyo hormoonka cortisol. Noocani wuxuu kaliya bixinayaa macluumaad ku saabsan mifepristone (Mifeprex), kaas oo keligiis la isticmaalo ama lagu daro daawo kale si loo soo afjaro uurka hore. Haddii aad u isticmaaleyso mifepristone si aad u xakameyso hyperglycemia-ka uu sababo cudurka 'Cushing's syndrome', akhri hal-ku-dheggan cinwaankiisu yahay mifepristone (Korlym) ee laga qoray wax soo saarkan.

Mifepristone wuxuu u yimaadaa kiniin ahaan afka laga qaato. Waxaad qaadan doontaa hal kaniini oo ah 'mifepristone' hal mar maalinta ugu horreysa. 24 ilaa 48 saacadood gudahood ka dib qaadashada mifepristone, waxaad codsan doontaa afar kaniini oo wadar ahaan ah daawo kale oo loo yaqaan misoprostol buccally (inta u dhaxeysa ciridka iyo dhabanka) adoo ku ridaya laba kaniini bohol kasta oo daan ah muddo 30 daqiiqo ah, ka dibna liqaaya inta hartay biyo ama mid kale dareere ah. Hubso inaad joogto meesha ku habboon markaad qaadanayso misoprostol sababta oo ah dhiigbaxa siilka, casiraad, lallabbo, iyo shuban badanaa wuxuu bilaabmaa 2 ilaa 24 saacadood kadib qaadashada laakiin wuxuu ku bilaaban karaa 2 saacadood gudahood.Dhiigbaxa siilka ama dhibcaha xubinta taranka badanaa waxay socdaan 9 ilaa 16 maalmood laakiin waxay socon karaan 30 maalmood ama ka badan. Waa inaad dib ugu noqotaa dhakhtarkaaga si baaritaan ama ultrasound 7 ilaa 14 maalmood kadib qaadashada mifepristone si loo xaqiijiyo in uurku dhammaaday iyo in la hubiyo xaddiga dhiigbaxa. Qaado mifepristone sida saxda ee lagu faray.

Mifepristone sidoo kale mararka qaarkood waxaa loo isticmaalaa in lagu soo afjaro uurka markii in ka badan 70 maalmood laga soo gudbay tan iyo haweeneydii caadadeedii ugu dambeysay; sida ka hortagga degdegga ah ee galmada ka dib galmada aan la ilaalin ('kiniiniga subaxa ka dambeeya'); si loo daaweeyo burooyinka maskaxda, endometriosis (koritaanka unugyada ilmo galeenka ee ka baxsan ilmo galeenka), ama fibroids (burooyinka aan caadiga ahayn ee ku dhaca ilmo galeenka); ama fooshu kiciso (si looga caawiyo bilowga hawsha dhalashada ee haween uur leh). Kala hadal dhakhtarkaaga khataraha suurtagalka ah ee isticmaalka daroogada ee xaaladdaada.

Kahor qaadashada mifepristone,

• u sheeg dhakhtarkaaga haddii aad xasaasiyad ku leedahay mifepristone (finan, finan, cuncun, barar wejiga, indhaha, afka, cunaha, gacmaha; neefsashada ama wax liqidda oo dhib ah); misoprostol (Cytotec, oo ku yaal Arthrotec); prostaglandins kale sida alprostadil (Caverject, Edex, Muse, kuwa kale), karboprost tromethamine (Hemabate), dinoprostone (Cervidil, Prepidil, Prostin E2), epoprostenol (Flolan, Veletri), latanoprost (Xalatan), treprostinil (Orenitram, Rem ); Daawooyinka kale, ama walxaha kujira kiniiniyada 'mifepristone'. Weydii farmashiistahaaga ama ka hubi Hagaha Daawada liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanaysid corticosteroids sida beclomethasone (Beconase, QNASL, QVAR), betamethasone (Celestone), budesonide (Entocort, Pulmicort, Uceris), cortisone, dexamethasone, fludrocortisone, flunisolide (Aerosparas, HFA) , Veramyst, kuwa kale), hydrocortisone (Cortef, Solu-Cortef, U-Cort, kuwa kale), methylprednisolone (Medrol, Depo-Medrol), prednisolone (Omnipred, Prelone, kuwa kale), prednisone (Rayos), iyo triamcinolone (Kenalog, kuwa kale) ). Dhakhtarkaaga ayaa u badan inuu kuu sheego inaadan qaadan mifepristone.
• u sheeg dhakhtarkaaga dawooyinka kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, iyo nafaqada nafaqada ee aad qaadanaysid. Hubso inaad sheegto dawooyinka ku taxan qaybta DIGNIIN MUHIIM AH iyo mid ka mid ah kuwan soo socda: benzodiazepines sida alprazolam (Xanax), diazepam (Diastat, Valium), midazolam, ama triazolam (Halcion); buspirone; kaalsiyamka xanibaada sida amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, kuwa kale), felodipine, nifedipine (Adalat, Afeditab CR, Procardia), nisoldipine (Sular), ama verapamil (Calan, Verelan, in Tarka); carbamazepine (Equetro, Tegretol, Teril, kuwa kale); chlorpheniramine (antihistamine ee qufaca iyo waxyaabaha qabow); daawooyinka kalastarolka ka yareeya (statins) sida atorvastatin (Lipitor, in Caduet), lovastatin (Altoprev, in Advicor), ama simvastatin (Simcor, Zocor, in Vytorin); clarithromycin (Biaxin, gudaha Prevpac); cyclosporine (Gengraf, Neoral, Sandimmune); erythromycin (E.E.S., Erythrocin, kuwa kale); haloperidol; furosemide; Kahortagayaasha 'protease HIV' sida indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra, kuwa kale), ama saquinavir (Invirase); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); methadone (Dolophine, Methadose); nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); propranolol (Hemangeol, Gudaha, Innopran); quinidine (oo ku taal Nuedexta); rifampin (Rifadin, Rimactane, gudaha Rifamate, Rifater); rifabutin (Mycobutin); tacrolimus (Astagraf, Prograf, Protopic, kuwa kale); tamoxifen (Soltamox); trazodone; ama vincristine (Marqibo Kit). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• u sheeg dhakhtarkaaga waxa ka soo baxa dhirta aad qaadanaysid, gaar ahaan johannesört wort.
• u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa yeelatay uur ku dhaca ilmo galeenka ('uurka tubal' ama uur ka baxsan ilmo-galeenka), adrenal failure (dhibaatooyinka qanjidhada adrenal), ama porphyria (cudur dhiig oo la iska dhaxlo oo sababi kara maqaarka ama dhibaatooyinka nidaamka neerfaha ). Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan mifepristone. Sidoo kale, u sheeg dhakhtarkaaga haddii lagaa geliyay aaladda ilmo-galeenka (IUD). Waa in laga saaraa ka hor intaadan qaadin mifepristone.
• waa inaad ogaataa inay macquul tahay in mifepristone uusan joojin doonin uurkaaga. Dhakhtarkaagu wuxuu hubin doonaa inuu uurkaagu dhammaaday markaad ku soo noqotid ballantaada dabagalka ah ka dib markaad qaadato mifepristone. Haddii aad weli uur leedahay ka dib qaadashada daawada 'mifepristone', waxaa jirta fursad ah in ilmahaagu ku dhasho cilladaha dhalashada. Haddii uurkaagu aanu dhammaanteed dhammaanin, dhakhtarkaagu wuxuu kaala hadli doonaa xulashooyinka kale ee la tixgelinayo. Waxaad dooran kartaa inaad sugto, aad qaadato qadar kale oo ah misoprostol ama qalliin lagu joojiyo uurka. Haddii aad qaadato qiyaasta ku-celiska ah ee loo yaqaan 'misoprostol', waa inaad booqasho dabagal ah la yeelataa dhakhtarkaaga 7 maalmood ka dib qiyaastaas si aad u hubiso in uurkaagu dhammaaday.

• u sheeg dhakhtarkaaga haddii aad naas nuujinayso.

• haddii aad qalliin ku jirto, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarka ama dhakhtarka ilkaha inaad qaadatay mifepristone.
• waa inaad ogaataa ka dib markaad uurka ku dhameyso mifepristone, inaad mar labaad uur qaadi karto isla markaaba, xitaa ka hor intaan caadadu kugu soo noqon. Haddii aadan rabin inaad uur yeelatid mar labaad, waa inaad bilowdaa isticmaalka ka hortagga uurka isla marka uurkaani dhammaado ama ka hor intaadan bilaabin galmo mar kale.

Ha ku qaadin mifepristone casiir canab ah. Kala hadal dhakhtarkaaga wixii ku saabsan cabitaanka casiirka canabka kadib qaadashada dawadan.

Kaliya waxaad ku qaadan doontaa mifepristone xafiiska dhakhtarkaaga ama rugta caafimaadka, sidaa darteed uma baahnid inaad ka walwasho inaad illowdo inaad qaadasho ku qaadato guriga.

Mifepristone wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• dhiig siilka ama dhibic ka soo baxa
• casiraad
• xanuunka miskaha
• gubashada siilka, cuncunka, ama dheecaanka
• madax xanuun

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamaha lagu xusay qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga.

Mifepristone wuxuu sababi karaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Dhakhtarkaagu wuxuu dawada ku keydin doonaa xafiiskiisa ama ayada.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

• dawakhaad
• miyir beelid
• aragga oo xumaada
• lallabbo
• daallan
• daciifnimo
• neefta oo ku qabata
• garaaca wadnaha

Waa inaad ka heshaa mifepristone kaliya takhtar la aqoonsan yahay oo aad u isticmaashaa daawadan kaliya inta aad ku jirtid daryeelka dhakhtarka. Waa inaadan ka iibsan mifepristone ilo kale, sida internetka, maxaa yeelay waxaad dhaafi doontaa ilaalin muhiim ah oo lagu ilaaliyo caafimaadkaaga.

Ha u ogolaan qof kale inuu qaato daawadaada.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Mifeprex^®

• RU-486