Atazanavir

Qanacsan

• Kahor qaadashada atazanavir,
• Atazanavir waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga ama aad u hesho daaweyn degdeg ah
• Haddii aad isku aragto finan daran oo leh mid ka mid ah astaamaha soo socda, jooji qaadashada atazanavir isla markaana wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo degdeg ah:
• Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

Atazanavir waxaa loo isticmaalaa dawooyin kale, sida ritonavir (Norvir), si loogu daaweeyo infekshinka difaaca jirka ee HIV (HIV) ee dadka waaweyn iyo carruurta ugu yaraan 3 bilood jira oo miisaankoodu yahay ugu yaraan 22 lb (10 kg). Atazanavir waxay ku jirtaa nooc dawooyin ah oo loo yaqaan 'protease inhibitors'. Waxay ku shaqeysaa iyadoo la yareeyo qadarka HIV ee dhiiga ku jira. In kasta oo atazanavir uusan daaweynin HIV, waxay yareyn kartaa fursaddaada inaad kuhesho cudurada difaaca jirka (AIDS) iyo cudurada la xiriira HIV sida infekshanada halista ah ama kansarka. Qaadashada daawooyinkan oo ay weheliso ku-dhaqan galmo badbaado leh iyo is-beddello kale oo qaab nololeed ah ayaa yareyn kara halista gudbinta fayraska HIV ee dadka kale.

Atazanavir waxay u timaadaa sidii kaabsul iyo sidii budo afka laga qaato. Kaabsoolka iyo budada waxaa badanaa la qaataa maalintii hal mar iyadoo la cunayo ama la cunayo. Qaado atazanavir qiyaastii waqti isku mid ah maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado atazanavir sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Waxaad u qaadan doontaa daawooyin kale HIV-ga inta aad qaadanayso atazanavir. Dhakhtarkaaga ayaa kuu sheegi doona in daawooyinkan la qaato isla waqtigaas iyo atazanavir, ama dhowr saacadood kahor ama ka dib marka aad qaadato atazanavir. Si taxaddar leh u raac jadwalkaan, oo weydii takhtarkaaga ama farmashiistaha haddii aad su'aalo ka qabtid waqtiyada ay tahay inaad daawooyinkaaga qaadato.

Budada Atazanavir waa in lagu qaataa ritonavir (Norvir). Ha u qaadan budada atazanavir adoon lahayn ritonavir (Norvir).

Kaabsoosha wada liq; ha kala jabin, calalin, hana furin. Haddii aadan awoodin inaad liqdo kaabsoosha, u sheeg dhakhtarkaaga ama farmashiistahaaga.

Budada Atazanavir waxaa lagu dari karaa cuntooyinka ay ka mid yihiin tufaax ama caano fadhi, ama cabitaanno sida biyo, caano, ama caanaha carruurta. Si fiican isku qas, oo qaado dhammaan isku darka isla markiiba si aad u qaadato qaddarka buuxa. Haddii lagu qaso biyo, cun cunno fudud isla marka aad qaadatid isku darka budada. Dhallaanka (da'doodu ka weyn tahay 3 bilood) ee aan awoodin inay wax ka cabbaan koob, budada waxaa lagu qasi karaa caanaha carruurta oo waxaa lagu siin karaa sirinji afka looga qaato; Ha siinin isku darka dhallaanka dhalada ilmaha. Haddii isku darka isla markiiba la qaadan waa in lagu kaydiyaa heerkulka qolka laguna qaadaa 1 saac gudahood. Si taxaddar leh u akhri tilmaamaha soo-saaraha ee sharaxaya sida loo isku daro loona qaato qiyaasta atazanavir. Hubso inaad weydiiso farmashiistahaaga ama dhakhtarkaaga haddii aad wax su'aalo ah ka qabtid sida la isugu daro ama loo qaato dawadan.

Kala hadal dhakhtarka waxa la sameeyo haddii ilmahaagu matago, candhuufto, ama uu qaato qayb ka mid ah qiyaasta atazanavir.

Atazanavir waxay caawisaa xakamaynta cudurka HIV, laakiin ma daaweyso. Sii wad inaad qaadato atazanavir xitaa haddii aad dareento fiicnaan. Ha u joojin qaadashada atazanavir adigoon la hadlin dhakhtarkaaga. Marka saadkaaga atazanavir uu bilaabo inuu hooseeyo, wax badan ka hel dhakhtarkaaga ama farmashiistahaaga. Haddii aad joojiso qaadashada atazanavir ama aad ka booddo qiyaasaha, xaaladdaadu way sii adkaan kartaa in la daweeyo.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka. Si taxaddar leh u akhri macluumaadkan oo weydii takhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid.

Atazanavir sidoo kale mararka qaarkood waxaa loo isticmaalaa in looga hortago infekshinka shaqaalaha daryeelka caafimaadka ama dadka kale ee si kama 'ah ugu dhacay HIV. Kala hadal dhakhtarkaaga khataraha aad u leedahay isticmaalka dawadan xaaladaada.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada atazanavir,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay atazanavir, dawooyin kale, ama wax kasta oo ka kooban kaabsulka ama budada atazanavir. Dhakhtarkaagu wuxuu kuu sheegi karaa inaadan qaadan atazanavir. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanayso mid ka mid ah daawooyinka soo socda ama dhirta ka soo baxda: alfuzosin (Uroxatral); cisapride (Propulsid; lagama heli karo Mareykanka); elbasvir iyo grazoprevir (Zepatier); ergot alkaloids sida dihydroergotamine (D.H.E. 45, Migranal), ergonovine, ergotamine (Ergomar, in Cafergot, in Migergot), ama methylergonovine (Methergine); glecaprevir iyo pibrentasvir (Mavyret); indinavir (Crixivan); irinotecan (Camptosar); lovastatin (Altoprev); lurasidone (Latuda); midazolam afka; nevirapine (Viramune), pimozide (Orap); rifampin (Rimactane, Rifadin, oo ku yaal Rifater, gudaha Rifamate); sildenafil (kaliya magaca Revatio ee loo isticmaalo cudurka sanbabada); simvastatin (Zocor, oo ku yaal Vytorin); Johannesört wort; iyo triazolam (Halcion). Dhakhtarkaagu wuxuu kuu sheegi doonaa inaadan qaadan atazanavir haddii aad qaadanayso mid ama in kabadan oo daawooyinkan ah.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinada, wax soo saarka dhirta, iyo nafaqada nafaqada ee aad qaadaneyso ama aad qorsheyneyso inaad qaadato.Hubso inaad sheegto mid ka mid ah kuwan soo socda: daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida warfarin (Coumadin, Jantoven); dawooyinka lidka diiqadda ('wiishka niyadda)' sida amitriptyline, desipramine (Norpramin), doxepin (Silenor, Zonalon), imipramine (Tofranil, Surmontil), protriptyline (Vivactil), trazodone, iyo trimipramine (Surmontil); antifungals qaarkood sida itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), iyo voriconazole (Vfend); bepridil (Vascor) (oo aan laga heli karin Mareykanka); beta beta sida labetalol (Trandate), nadolol (Corgard, Corzide), iyo propranolol (Hemangeol, Inderal, Innopran XL, in Inderide); boceprevir (oo aan hadda laga helin Mareykanka; Victrelis); bosentan (Tracleer); buprenorphine (Buprenex, Butrans, oo ku yaal Bunavail, Suboxone, Zubsolv); Kaalshiyam kaaliyaal dilaaleyaal ah sida diltiazem (Cardizem, Cartia, Tiazac, kuwa kale), felodipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia), iyo verapamil (Calan, Verelan, Tarka, kuwa kale); dawooyinka qaarkood ee yareeya kolestaroolka (statins) sida atorvastatin (Lipitor, in Caduet), iyo rosuvastatin (Crestor); clarithromycin (Biaxin, gudaha Prevpac); colchicine (Colcrys, Mitigare); digoxin (Lanoxin); fluticasone (Flonase, Flovent, Advair); daawooyinka loogu talagalay garaaca wadnaha aan joogtada ahayn sida amiodarone (Cordarone, Nexterone, Pacerone), lidocaine (Octocaine, Xylocaine), iyo quinidine (Nuedexta); daawooyinka xakameynaya nidaamka difaaca jirka sida cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), iyo tacrolimus (Astagraf, Prograf); daawooyinka kale ee HIV ama AIDS oo ay ka mid yihiin efavirenz (Sustiva, Atripla), ritonavir (Norvir, Kaletra, in Viekira Pak), saquinavir (Invirase), iyo tenofovir (Viread, Atripla, Stribild, Truvada, kuwo kale); midazolam irbad ahaan; paclitaxel (Abraxane, Taxol); qaar ka mid ah fosfodiesterase inhibitors (PDE-5 inhibitors) oo loo isticmaalo cillad aan caadi ahayn sida sildenafil (Viagra), tadalafil (Cialis), iyo vardenafil (Levitra, Staxyn); repaglinide (Prandin, gudaha Prandimet); quetiapine (Seroquel); rifabutin (Mycobutin); salmeterol (Serevent, Advair); sofosbuvir, velpatasvir, iyo voxilaprevir (Sovaldi, Epclusa, Vosevi); iyo tadalafil (Adcirca, Cialis). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara atazanavir, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• haddii aad qaadanaysid dawada antacids, didanosine capsules-daaha (Videx EC), ama dawooyin kale oo buffay sida aspirin buufis ah (Bufferin), qaado atazanavir 2 saac kahor ama 1 saac kadib markaad daawada qaadato. Weydii dhakhtarkaaga ama farmashiistahaaga haddii aadan hubin in mid ka mid ah daawooyinka aad qaadanaysid lagu buufiyey.
• u sheeg dhakhtarkaaga haddii aad daawo u qaadanaysid calool xanuun, laab xanuun, ama boogaha sida cimetidine, esomeprazole (Nexium, in Vimovo), famotidine (Pepcid, in Duexis), lansoprazole (Prevacid, in Prevpac), nizatidine (Axid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), rabeprazole (AcipHex), ama ranitidine (Zantac). Dhakhtarkaagu wuxuu kuu sheegi karaa inaadan qaadan daawada ama aad qaadato qadar ka yar oo daawada ah. Haddii aad sii wadayso qaadashada daawada, dhakhtarkaaga ayaa kuu sheegi doona inta jeer ee ay tahay inaad u oggolaato inta u dhexeysa qaadashada daawada iyo qaadashada atazanavir.
• u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa wadno garaac aan caadi ahayn, sonkorow ama sonkor dhiig oo sarreeya, hemophilia (xaalad aanu dhiiggu si caadi ah u xinjiroobin) ama cudur kale oo dhiig-bax ah, cagaarshow (fayras beerka ku dhaca oo fayras ah) ama cudurada kale ee beerka, kilyaha ama cudurada wadnaha.
• u sheeg dhakhtarkaaga haddii aad uur leedahay ama aad qorsheyneyso inaad uur yeelato. Haddii aad uur yeelato intaad qaadaneysid atazanavir, wac dhakhtarkaaga. Waa inaadan naas nuujin haddii aad qabtid HIV oo aad qaadatid atazanavir.
• waa inaad ogaataa in atazanavir ay yareyn karto waxtarka uur-qaadidda ee hormoonnada (kaniiniyada xakameynta dhalmada, dhejiska, faraantiyo, maqaar-galaha, iyo cirbadaha). Kala hadal dhakhtarkaaga hababka ka hortagga uurka ee kuu shaqeyn doona inta aad qaadanayso atazanavir.
• haddii aad qalliin samaynayso, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarka ama dhakhtarka ilkaha inaad qaadanayso atazanavir.
• waa inaad ogaataa inaad la kulmi karto hyperglycemia (kordhinta sonkorta dhiiggaaga) inta aad qaadanaysid dawadan, xitaa haddii aadan horey u qabin cudurka macaanka. Isla markiiba u sheeg dhakhtarkaaga haddii aad isku aragto mid ka mid ah astaamaha soo socda inta aad qaadanayso atazanavir: harraad aad u daran, kaadi badan, gaajo aad u daran, aragga oo xumaada, ama daciifnimo. Aad ayey muhiim u tahay inaad wacdid dhakhtarkaaga isla marka aad isku aragto mid ka mid ah astaamahan, maxaa yeelay sonkorta dhiigga ee sareysa ee aan la daaweyn waxay sababi kartaa xaalad halis ah oo loo yaqaan ketoacidosis. Ketoacidosis wuxuu noqon karaa mid nafta halis geliya haddii aan lagu daaweyn marxaladda hore. Calaamadaha lagu garto ketoacidosis waxaa ka mid ah: af qalalan, lallabbo iyo matag, neefta oo ku qabata, neefta oo urta miraha, iyo miyirka oo yaraada.
• waa inaad ogaataa inta aad qaadaneyso atazanavir in dufanka jirkaagu uu kordhi karo ama u dhaqaaqi karo meelo kala duwan oo jirkaaga ah sida dhabarka qoortaada iyo garbaha sare (’buffalo hump’), caloosha, iyo naasaha. Waxaa laga yaabaa inaad dufan ka weydo gacmaha, lugaha, wajiga, iyo badhida. La hadal dhakhtarkaaga haddii aad ku aragto mid ka mid ah isbeddelladan dufanka jidhkaaga.
• haddii aad leedahay phenylketonuria (PKU, xaalad la iska dhaxlo oo ah in cunno gaar ah la raaco si looga hortago dib-u-dhac maskaxeed), waa inaad ogaataa in budada afka ee atazanavir lagu macaaneeyo aspartame oo sameysa phenylalanine.
• Waa inaad ogaataa inta aad qaadanaysid dawooyinka lagu daaweynayo infekshinka HIV, nidaamkaaga difaaca ayaa laga yaabaa inuu sii xoogeysto oo uu bilaabo inuu la dagaallamo infekshannada kale ee horey ugu jiray jirkaaga. Tani waxay kugu sababi kartaa inaad yeelato calaamadaha infekshannadaas. Haddii aad leedahay calaamado cusub ama ka sii daraya wakhti kasta inta lagu jiro daaweyntaada atazanavir, hubi inaad u sheegto dhakhtarkaaga.

Kala hadal dhakhtarkaaga wax ku saabsan cunitaanka canab-gacmeedka ama cabitaanka casiir canab ah adoo qaadanaya dawadan.

Qaado qiyaasta la seegay isla marka aad xasuusatoba. Si kastaba ha noqotee, haddii ay ku dhowdahay waqtiga qiyaasta xigta, ka bood qiyaasta la seegay oo sii wad jadwalka daawadaada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Atazanavir waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• lallabbo
• matagid
• calool xanuun
• shuban
• madax xanuun
• niyad jab
• qandho
• dhibaato xagga hurdada ama hurdada ah
• murqo xanuun
• finan yaryar
• kabuubyo, gubasho, xanuun, ama gariirid gacmaha ama cagaha

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga ama aad u hesho daaweyn degdeg ah

• garaaca wadnaha oo aan joogto ahayn
• dawakhaad
• dareemid suuxdin ama madax-wareer
• aragtida isbeddelay
• hurdi maqaarka ama indhaha (gaar ahaan dhallaanka hadda dhashay)
• xanuunka dhabarkaaga ama dhinacaaga
• xanuun ama gubasho leh kaadi
• dhiig kaadida ku jira
• matagid
• cunto xumo
• barar gacmaha, cagaha, lugaha, ama anqawyada
• kaadida oo yaraatay
• kaadi midab madow
• saxaro midab khafiif ah leh
• kacsiga oo soconaya in ka badan 4 saacadood

Haddii aad isku aragto finan daran oo leh mid ka mid ah astaamaha soo socda, jooji qaadashada atazanavir isla markaana wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo degdeg ah:

• dareen xanuun guud ama astaamaha 'sida hargabka oo kale ah'
• qandho
• muruqyada ama xanuunada wadajirka ah
• indho casaan ama bararsan
• nabarro ama maqaarka ka soo baxa
• nabar afka ka soo baxa
• barar wejigaaga ama qoorta ah
• xanuun, diirimaad, ama buro guduudan maqaarkaaga hoostiisa

Atazanavir waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ama baakadda ay soo gashay, si adag u xir, oo ka fog carruurta iyo xayawaanka rabaayadda ah. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

• hurdi maqaarka ama indhaha

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa tijaabooyinka shaybaarka qaarkood kahor iyo inta daaweyntaadu socoto si loo hubiyo jawaabta jirkaaga ee atazanavir.

Gacanta ku hay saadka atazanavir. Ha sugin illaa ay kaa dhammaato daawada si aad ugu buuxiso dawada laguu qoray.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Reyataz^®

• Evotaz^® (oo ay ku jiraan Atazanavir, Cobicistat)

• ATZ