Darunavir

Qanacsan

• Kahor qaadashada darunavir,
• Darunavir wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, jooji qaadashada darunavir una wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo degdeg ah:

Darunavir waxaa loo isticmaalaa ritonavir (Norvir) iyo daawooyin kale si loogu daaweeyo infekshanka difaaca jirka ee dadka (HIV) ee dadka waaweyn iyo carruurta 3 sano iyo wixii ka weyn. Darunavir wuxuu ku jiraa nooc daawooyin ah oo loo yaqaan 'protease inhibitors'. Waxay ku shaqeysaa iyadoo la yareeyo qadarka HIV ee dhiiga ku jira. In kasta oo darunavir uusan bogsiinaynin HIV, waxay yareyn kartaa fursaddaada inaad kuhesho cillad difaac la'aanta jirka (AIDS) iyo cudurrada la xiriira HIV sida infekshannada halista ah ama kansarka. Qaadashada daawooyinkan oo ay weheliso ku-dhaqan galmo badbaado leh iyo is-beddello kale oo qaab nololeed ah ayaa yareyn kara halista gudbinta fayraska HIV ee dadka kale.

Darunavir wuxuu u yimaadaa kiniin ahaan iyo hakin afka ah (dareere) si afka looga qaato. Badanaa waxaa lagu qaataa cuntada iyo ritonavir hal mar ama laba jeer maalintii. Qaado darunavir qiyaastii isku wakhti (iskuda) maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado darunavir sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Ha u qaadan darunavir adoon lahayn ritonavir.

Kiniiniyada oo dhan ku liq cabitaan sida biyo ama caano. Ha calalin kiniinka.

Si habsami leh u rux ka joojinta ka hor intaan la istcimaalin dawada si siman. U isticmaal sirinjada daawada lagu qaato ee daawada la socota in aad ka baxdo xaddiga saxda ah ee ka joojinta dhalada. Waxaad si toos ah uga liqi kartaa ganaaxa saliingaha. Ku dhaq saliingaha biyo oo u oggolow inuu si fiican u qalalo ka dib isticmaalka.

Darunavir ayaa xakameeya HIV laakiin ma daaweyso. Sii wad inaad qaadato darunavir xitaa haddii aad dareento fiicnaan. Ha u joojin daawada darunavir adiga oo aan la hadlin dhakhtarkaaga. Haddii aad joojiso qaadashada darunavir ama aad ka booddo qiyaasaha, xaaladdaadu waxay noqon kartaa mid ka sii dhib badan in la daweeyo. Marka sahaydaada darunavir ay bilaabato inay hoos u dhacdo, wax badan ka hel dhakhtarkaaga ama farmashiistahaaga.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada darunavir,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay darunavir, ritonavir, dawooyinka sulfa, daawooyin kale, ama mid ka mid ah waxyaabaha ku jira kiniiniyada darunavir ama ganaax. Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin ama haddii aadan hubin in daawo aad xasaasiyad u leedahay ay tahay dawo sulfa ah.
• u sheeg dhakhtarkaaga haddii aad qaadanayso mid ka mid ah daawooyinka soo socda: alfuzosin (Uroxatral); cisapride (Propulsid) (aan laga heli karin Mareykanka); dronedarone (Multaq); elbasvir / grazoprevir (Zepatier); daawooyinka nooca ergot sida dihydroergotamine (D.H.E 45, Migranal), ergotamine (Ergomar, Cafergot, Migergot), iyo methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Mevacor, oo ku yaal Advicor); lurasidone (Latuda), midazolam (oo afka laga siiyo); pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, gudaha Rifamate, Rifater); sildenafil (kaliya magaca Revatio ee loo isticmaalo cudurka sanbabada); simvastatin (Zocor, oo ku yaal Vytorin); Johannesört wort; ama triazolam (Halcion). Dhakhtarkaaga ayaa laga yaabaa inuu kuu sheego inaadan qaadan darunavir. Sidoo kale, haddii aad qabtid kelyo ama beer xanuun oo aad qaadaneyso colchicine (Colcrys, Mitigare, in Col-Probenecid), dhakhtarkaaga ayaa laga yaabaa inuu kuu sheego inaadan qaadan darunavir.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinada, iyo nafaqada nafaqada aad qaadanaysid ama qorsheyneyso inaad qaadato. Hubso inaad sheegto mid ka mid ah kuwan soo socda: daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida apixaban (Eliquis), rivaroxaban (Xarelto), iyo warfarin (Coumadin, Jantoven); antifungals sida itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), iyo voriconazole (Vfend); artemether / lumefantrine (Coartem); beta beta blockers sida carvedilol (Coreg), metoprolol (Lopressor, Toprol XL, in Dutoprol, in Lopressor HCT), iyo timolol (Betimol, Istalol, in Combigan, in Cosopt, kuwa kale); betamethasone; boceprevir (oo aan hadda laga helin Mareykanka; Victrelis); bosentan (Tracleer); budesonide (Entocort, Pulmicort, Uceris, kuwa kale); buprenorphine (Belbuca, Buprenex, Butrans, gudaha Suboxone, kuwa kale); buprenorphine / naloxone (Bunavail, Suboxone, Zubsolv); buspirone; Kaalshiyam-kanaal xirayaasha sida amlodipine (Norvasc, in Caduet), diltiazem (Cardizem CD, Cartiaz, XT, Diltzac, kuwa kale), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat CC, Afebitab CR, Procardia), iyo verapamil (Calan, Covera, Verelan, oo ku taal Tarka); qaar ka mid ah dawooyinka kemotherabi sida dasatinib (Sprycel), nilotinib (Tasigna), vinblastine, iyo vincristine (Marqibo Kit); daawooyinka kalastarolka ka yareeya (statins) sida atorvastatin (Lipitor, in Caduet), pravastatin (Pravachol), iyo rosuvastatin (Crestor); ciclesonide (Alvesco); clarithromycin (Biaxin, gudaha Prevpac); daawooyinka qaarkood ee niyadjabka sida amitriptyline, desipramine (Norpramin), imipramine, nortriptyline, paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), iyo trazodone; dexamethasone; diazepam (Diastat, Valium); estazolam; fentanyl (Abstral, Duragesic, Subsys); fluticasone (Flonase, Flovent, Advair); dawooyinka qaarkood ee loo yaqaan 'hepatitis C virus' (HCV) sida glecaprevir / pibrentasvir (Mavyret) iyo simeprevir (oo aan hadda laga helin Maraykanka; Olysio); daawooyinka kale ee HIV oo ay ka mid yihiin indinavir (Crixivan), lopinavir / ritonavir (Kaletra), maraviroc (Selzentry), iyo saquinavir (Invirase); ka hortagga uurka ee hormoonka (estrogen) (kaniiniyada ka hortagga uurka, balastarro, faraantiyo, la geliyo, ama irbado); daawooyinka loogu talagalay garaaca wadnaha aan caadiga ahayn oo ay ku jiraan amiodarone (Nexterone, Pacerone), bepridil (oo aan hadda laga heli karin Mareykanka), digoxin (Lanoxin), sibibramram (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), iyo quinidine (Nuedex ); dawooyinka qaarkood ee suuxdinta sida carbamazepine (Carbatrol, Equetro, Tegretol, kuwa kale), clonazepam (Klonopin), phenobarbital, iyo phenytoin (Dilantin, Phenytek); daawooyinka qaarkood ee xakameynaya nidaamka difaaca jirka sida cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), iyo tacrolimus (Astagraf XL, Prograf); methadone (Dolophine, Methadose); methylprednisolone; mometasone (Asmanex); omeprazole (Prilosec); oxycodone (Xtampza); qaar ka mid ah fosfodiesterase inhibitors (PDE-5 inhibitors) oo loo isticmaalo cillad aan caadi ahayn sida avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), iyo vardenafil (Levitra, Staxyn); perphenazine; prednisone (Rayos); quetiapine (Seroquel); rifabutin (Mycobutin); rifapentine (Priftin); risperidone (Risperdal); salmeterol (Serevent, Advair); tadalafil (Adcirca); thioridazine; ticagrelor (Brilinta); tramadol (Conzip); triamcinolone (Nasacort); iyo zolpidem (Ambien, Edluar, Intermezzo). Daawooyin kale oo badan ayaa sidoo kale la macaamili kara darunavir, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan. Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• haddii aad qaadanayso didanosine (Videx), qaado 1 saac ka hor ama 2 saacadood ka dib qaadashada darunavir.
• u sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabto sonkorow ama sonkor dhiig oo sarreeya; hemophilia (cillad dhiig-bax ah oo uusan dhiiggu si habboon u xinjiroobin); cagaarshowga (bararka beerka ee uu sababo fayras), cirrhosis (waa cudur keena unugyada beerka nabar), ama cudur kale oo beerka ah; ama infekshin aan tagin ama yimaado oo tagta sida cytomegalovirus (CMV; infekshinka fayraska oo sababi kara astaamo bukaanjiifka oo leh awood difaac daciif ah), cudurka mycobacterium avium complex (MAC; infekshinka bakteeriyada ee sababi kara astaamo halis ah dadka qaba AIDS), oof-wareen, ama qaaxada (TB; waa nooc ka mid ah infekshanka sambabka).
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelato inta aad qaadanaysid darunavir, wac dhakhtarkaaga. Ha nuujin naaska haddii aad qabtid cudurka HIV ama aad qaadatid darunavir.
• waa inaad ogaataa in darunavir ay yareyn karto waxtarka uur-qaadidda ee hormoonnada (kaniiniyada ka hortagga uurka, dhejisyo, faraantiyo, irbado, ama galmo). Kala hadal dhakhtarkaaga wax ku saabsan xakameynta dhalmada ee aan hoormoonka ahayn sida habka caqabadda (qalab xannibaya shahwada soo galaya ilmo galeenka sida cinjirka galmada ama cinjirka 'diaphragm') si looga hortago uurka inta aad qaadanaysid dawadan. Weydiiso dhakhtarkaaga inuu kaa caawiyo xulashada habka xakameynta dhalmada ee adiga kuu shaqeyn doonta.
• waa inaad ogaataa in dufanka jirkaagu uu kordhin karo ama u dhaqaaqi karo meelo kala duwan oo jirkaaga ah sida naasahaaga, dhabarka kore, qoorta, laabta, iyo aagga caloosha. Lumitaan lugaha, gacmaha, iyo wajiga ayaa waliba dhici kara.
• waa inaad ogaataa inaad la kulmi karto hyperglycemia (kordhinta sonkorta dhiiggaaga) inta aad qaadanaysid dawadan, xitaa haddii aadan horey u qabin cudurka macaanka. Isla markiiba u sheeg dhakhtarkaaga haddii aad isku aragto mid ka mid ah astaamaha soo socda inta aad qaadanaysid darunavir: harraad aad u daran, kaadi badan, gaajo aad u daran, aragga oo xumaada, ama daciifnimo. Aad ayey muhiim u tahay inaad wacdid dhakhtarkaaga isla marka aad isku aragto mid ka mid ah astaamahan, maxaa yeelay sonkorta dhiigga ee sareysa ee aan la daaweyn waxay sababi kartaa xaalad halis ah oo loo yaqaan ketoacidosis. Ketoacidosis wuxuu noqon karaa mid nafta halis geliya haddii aan lagu daaweyn marxaladda hore. Calaamadaha lagu garto ketoacidosis waxaa ka mid ah: af qalalan, lallabbo iyo matag, neefta oo ku qabata, neefta oo urta miraha, iyo miyirka oo yaraada.
• Waa inaad ogaataa inta aad qaadanaysid dawooyinka lagu daaweynayo infekshinka HIV, nidaamkaaga difaaca ayaa laga yaabaa inuu sii xoogeysto oo uu bilaabo inuu la dagaallamo infekshannada kale ee horey ugu jiray jirkaaga. Tani waxay kugu sababi kartaa inaad yeelato calaamadaha infekshannadaas. Haddii aad leedahay calaamado cusub ama ka sii daraya wakhti kasta inta lagu guda jiro daaweyntaada darunavir, hubi inaad u sheegto dhakhtarkaaga.

Kala hadal dhakhtarkaaga cunista canab-gacmeedka iyo cabitaanka casiirka canabka marka aad qaadanaysid dawadan.

Haddii aad qaadatid darunavir hal mar maalintii oo aad seegto qiyaas ka yar 12 saacadood, qaado qiyaasta la seegay isla marka aad xusuusato ka dibna qaado qiyaasta xigta waqtiga loo qorsheeyay. Si kastaba ha noqotee, haddii aad seegto qiyaas ka badan 12 saacadood, ka bood qiyaasta la seegay oo sii wad jadwalkaaga qiyaasta daawada ee caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Haddii aad qaadanayso darunavir laba jeer maalintii oo aad seegto qiyaas ka yar 6 saacadood, qaado qiyaasta la seegay isla marka aad xusuusato ka dibna qaado qiyaasta xigta waqtiga loo qorsheeyay. Si kastaba ha noqotee, haddii aad seegto qiyaas ka badan 6 saacadood, ka bood qiyaasta la seegay oo sii wad jadwalkaaga qiyaasta daawada ee caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Darunavir wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• madax xanuun
• shuban
• matagid
• calool xanuun
• calool istaag

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, jooji qaadashada darunavir una wac dhakhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo degdeg ah:

• finan
• xoqidda ama maqaarka oo bararaya
• nabar afka ka soo baxa
• casaan, bararsan, cuncun, ama indho ilmaynaysa
• muruqyada ama xanuunada wadajirka ah
• qandho
• barar, danqasho, casaan, ama calaamadaha kale ee infekshanka
• lallabbo
• daal xad dhaaf ah
• cunto xumo
• xanuun qeybta kore ee midig ee caloosha
• hurdi maqaarka ama indhaha
• saxaro cirro leh ama madow

Darunavir wuxuu sababi karaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa baaritaano gaar ah si loo hubiyo inay amaan kuu tahay inaad qaadato darunavir iyo inuu hubiyo jawaabta jirkaaga ee darunavir.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Prezista^®
• Prezcobix^® (ay ku jiraan Darunavir, Cobicistat)

• TMC-114