Nilotinib

Qanacsan

• Kahor qaadashada nilotinib,
• Nilotinib waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga:

Nilotinib wuxuu sababi karaa dheereynta QT (wadna garaac aan caadi ahayn oo u horseedi kara suuxdin, miyir beelid, suuxdin, ama dhimasho lama filaan ah). U sheeg dhakhtarkaaga haddii adiga ama qof kale oo qoyskaaga ka mid ahi uu leeyahay ama uu waligiis ku dhacay cudurka QT syndrome (xaalad la iska dhaxlo oo qofku ugu dhow yahay inuu ku dheeraado QT) ama aad qabto ama aad waligaa dhiiggaaga ku yar tahay maadada potassium ama magnesium , garaaca wadnaha oo aan joogto ahayn, ama cudur beerka ah. U sheeg dhakhtarkaaga iyo farmashiistaha haddii aad qaadanaysid amiodarone (Nexterone, Pacerone); antifungals sida ketoconazole, itraconazole (Onmel, Sporanox), ama voriconazole (Vfend); chloroquine (Plaquenil); clarithromycin (Biaxin, gudaha Prevpac); sibibramramide (Norpace); erythromycin (EES, Eryc, PCE); dawooyinka qaarkood ee loogu talogalay fayraska difaaca jirka ee dadka (HIV) ama cilladda cillad la'aanta cudurka (AIDS) sida atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), iyo saquinavir (Invirase); haloperidol (Haldol); methadone (Dolophine, Methadose); moxifloxacin (Avelox); nefazodone; pimozide (Orap); procainamide; quinidine (oo ku taal Nuedexta); sotalol (Betapace, Betapace AF, kuwa kale); telithromycin (Ketek); iyo thioridazine. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, jooji qaadashada nilotinib isla markaana wac dhakhtarkaaga isla markiiba: dhakhso, garaac, ama wadno garaac aan caadi ahayn; miyir beelid; miyir beelid; ama qalal.

Ha cunin wax cunto ah ugu yaraan 2 saacadood kahor qaadashada nilotinib iyo 1 saac kadib qaadashada dawadan.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhaqtarkaaga ayaa amri doona baaritaano gaar ah, sida baaritaanada dhiiga iyo electrocardiogram (EKGs, baaritaanada duuba dhaqdhaqaaqa korantada wadnaha) kahor iyo inta lagaa daaweynayo si loo hubiyo inay amaan kuu tahay inaad qaadato nilotinib.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo saaraha (Tilmaamaha Daawada) marka aad bilowdo daaweynta nilotinib iyo mar kasta oo aad dib u buuxiso dawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Kala hadal dhakhtarkaaga khataraha qaadashada nilotinib.

Nilotinib waxaa loo isticmaalaa in lagu daaweeyo noocyo ka mid ah cudurka 'myeloid leukemia chronic' (CML, nooc ka mid ah kansarka unugyada dhiigga cad) kuwaas oo dhowaan lagu ogaaday in ay qabaan xaaladdan dadka waaweyn iyo carruurta 1 sano jir ah iyo wixii ka weyn. Waxaa sidoo kale loo isticmaalaa in lagu daaweeyo noocyo ka mid ah CML oo cudurkooda aan si guul leh loogu daweyn karin imatinib (Gleevec) ama dadka waaweyn ee aan qaadan karin imatinib. Nilotinib sidoo kale waxaa loo isticmaalaa in lagu daaweeyo noocyada kala duwan ee CML ee carruurta jirta 1 sano ama ka weyn oo cudurkooda aan si guul leh loogu daaweyn karin daaweynta kale ee tyrosine kinase inhibitors. Nilotinib wuxuu ku jiraa nooc daawo ah oo loo yaqaan kinase inhibitors. Waxay ku shaqeysaa iyadoo la xakameynayo ficilka borotiinka aan caadiga ahayn ee tilmaamaya unugyada kansarka inay tarmaan. Tani waxay gacan ka geysaneysaa joojinta ama gaabinta faafidda unugyada kansarka.

Nilotinib waxay u timaadaa sidii kaabsul afka laga qaato. Badanaa waxaa la qaataa cunto la'aan laba jeer maalintii. Nilotinib waa in lagu qaadaa calool madhan, ugu yaraan 2 saacadood ka hor ama 1 saac ka dib cunista wax cunto ah. Qaado nilotinib qiyaastii isla waqtiyadii maalin kasta. Isku day inaad isku dhejiso qiyaastaada qiyaas ahaan 12 saacadood. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado nilotinib sida saxda ah ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Kaabsoosha ku wada liq koob biyo ah; ha kala qaybin, calalin, ama burburin. Haddii aadan awoodin inaad wada liqdo kaabsoosha guud ahaan, ku dar waxyaabaha ku jira kaabsulka hal qaado yar oo tufaax ah. Isku walaaq isku dar ah isla markiiba (15 daqiiqo gudahood.) Ha ku kaydin isku darka isticmaalka mustaqbalka.

Dhakhtarkaaga ayaa laga yaabaa inuu yareeyo qiyaastaada nilotinib ama uu joojiyo daaweyntaada iyadoo kuxiran sida ay daawadu kuugu shaqeyso iyo haddii aad la kulanto waxyeellooyin kale. Sii wad inaad qaadato nilotinib xitaa haddii aad caafimaad qabtid. Ha u joojin qaadashada nilotinib adiga oo aan la hadlin dhakhtarkaaga.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada nilotinib,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay nilotinib, daawooyin kale, ama wax kasta oo ka kooban kaabsoosha nilotinib. Weydii farmashiistahaaga ama ka hubi Hagaha Daawada liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinada, iyo nafaqada nafaqada aad qaadanaysid ama qorsheyneyso inaad qaadato. Hubso inaad sheegto dawooyinka ku taxan qaybta DIGNIIN MUHIIM AH iyo mid ka mid ah kuwan soo socda: qaar ka mid ah xannibaadayaasha 'angiotensin-receptor blockers' sida irbesartan (Avapro, in Avalide) iyo losartan (Cozaar, Hyzaar); daawooyinka xinjirowga lidka ku ah ('dhiig khafiifiyeyaasha dhiigga' ') sida warfarin (Coumadin, Jantoven); aripiprazole (Abilify); qaarkood benzodiazepines sida alprazolam (Xanax), diazepam (Valium), midazolam, iyo triazolam (Halcion); buspirone (Buspar); qaar ka mid ah kaalshiyamka kanaaliyayaasha sida amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, kuwa kale), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), iyo verapamil (Calan, Verelan, kuwa kale) ; dawooyinka qaarkood ee hoos u dhiga kolestaroolka (statins) oo ay ku jiraan atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), iyo simvastatin (Zocor); chlorpheniramine (Chlor-Trimeton, qufac kale iyo waxyaabaha qabow); dexamethasone; dihydroergotamine (DHXE 45, Migranal); ergotamine (gudaha Cafergot, Ergomar); fentanyl (Actiq, Duragesic, Lacag); flecainide (Tambocor); dawooyinka qaarkood ee diiqadda sida amitriptyline, desipramine (Norpramin); duloxetine (Cymbalta); imipramine (Tofranil); paroxetine (Brisdelle, Paxil, Pexeva); iyo venlafaxine (Effexor); dawooyinka afka qaarkood ee sonkorowga sida glipizide (Glucotrol) iyo tolbutamide; daawooyinka qaarkood ee xakameynaya nidaamka difaaca jirka sida cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), iyo tacrolimus (Prograf); dawooyinka qaarkood ee suuxdinta sida carbamazepine (Equetro, Tegretol, Teril), phenobarbital, iyo phenytoin (Dilantin, Phenytek); mexiletine; dawooyinka anti-bararka qaarkood ee nonsteroidal (NSAIDs) sida celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), iyo piroxicam (Feldene); ondansetron (Zofran); propafenone (Rythmol); ka hortagayaasha proton-pump sida esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), iyo rabeprazole (AcipHex); quinine (Qualaquin); rifabutin (Mycobutin); rifampin (Rifadin); rifapentine (Priftin); risperidone (Risperdal); sildenafil (Viagra, Revatio); tamoxifen; testosterone (Androderm, Androgel, Striant, kuwa kale); timolol; torsemide; tramadol (Ultram, oo ku taal Ultracet); trazodone; iyo vincristine. Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara nilotinib, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• haddii aad qaadanayso antacids ay ku jiraan magnesium, aluminium (Maalox, Mylanta, Tums, kuwa kale), ama simethicone, qaado antacid 2 saacadood ka hor ama ugu yaraan 2 saacadood ka dib qaadashada nilotinib.
• haddii aad daawo u qaadanaysid calool xanuun, laab xanuun, ama boogo sida cimetidine (Tagamet), famotidine (Pepcid, in Duexis), nizatidine (Axid), ama ranitidine (Zantac), qaado ugu yaraan 10 saacadood kahor ama ugu yaraan 2 saacado kadib markaad qaadato nilotinib.
• u sheeg dhakhtarkaaga waxa ka soo baxa dhirta aad qaadanaysid, gaar ahaan johannesört wort.
• u sheeg dhakhtarkaaga haddii uu istaroog kugu dhacay ama qalliin lagaa saaray caloosha oo dhan (wadar ahaan gastrectomy). Sidoo kale, u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa hoos u dhigtay socodka socodka dhiigga ee lugahaaga, wax dhibaato ah oo wadnaha ah, dhibaatooyin dhiig bax ah, qanjidhada (bararka qanjidhada, qanjirka ka dambeeya ee soo saara walxaha ka caawiya dheef-shiidka), ama xaalad kasta oo waxay kugu adkeyneysaa inaad dheefshiido laaktooska (sonkorta caanaha) ama sonkorta kale.
• u sheeg dhakhtarkaaga haddii aad uur leedahay ama aad qorsheyneyso inaad uur yeelato. Waa inaadan uur yeelan inta aad qaadanayso nilotinib. Waa inaad isticmaashaa xakameynta dhalmada ee wax ku oolka ah si aad uga hortagto uurka inta lagu jiro daaweyntaada nilotinib iyo 14 maalmood ka dib qiyaastaada ugu dambeysa. Kala hadal dhakhtarkaaga hababka xakameynta dhalmada ee aad isticmaali karto inta lagu jiro daaweyntaada. Haddii aad uur yeelato intaad qaadanaysid nilotinib, isla markiiba wac dhakhtarkaaga. Nilotinib waxaa laga yaabaa inuu waxyeelo uurjiifka.
• u sheeg dhakhtarkaaga haddii aad naas nuujinayso. Waa inaadan naas nuujin inta aad qaadaneyso nilotinib iyo 14 maalmood ka dib qiyaastaada ugu dambeysa.
• haddii aad qalliin samaynayso, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarka ama dhakhtarka ilkaha inaad qaadanayso nilotinib.

Ha cunin bambeelmo, ha cabin casiir canab, ama ha qaadan wax dheeri ah oo ay ku jirto soosaarida canab-gacmeedka inta aad qaadanaysid dawadan.

Ka gudub qiyaasta la seegay oo sii wad jadwalkaaga qiyaasta daawada ee caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Nilotinib waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• finan
• cuncun
• lallabbo
• matagid
• shuban
• calool istaag
• laabjeex
• gaaska
• cunto xumo
• madax xanuun
• dawakhaad
• daallan
• dhibaato xagga hurdada ama hurdada ah
• dhidid habeenkii
• murqo xanuun
• dhabarka, lafta, kalagoysyada, addimada, ama muruq xanuun
• timo lumis
• maqaar qalalan ama casaan ah
• kabuubyo, gubasho, ama ruxruxasho gacmaha ama cagaha

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga:

• dhiigbax ama nabar aan caadi ahayn
• dhiig kaadida ku jira
• saxaro dhiig leh ama madow ah
• madax xanuun kedis ah, jahwareer, ama isbeddel ku yimaada aragga
• daal ama daciifnimo aan caadi ahayn
• xabad xanuun ama raaxo la'aan
• dhibaatooyinka socodka ama hadalka
• kabuubyo
• isbeddelka midabka maqaarka lugta
• xanuun ama dareemid qabow lugaha
• calool xanuun lallabbo iyo matag
• qandho, dhaxan, dhuun xanuun, qufac socda iyo ciriiriga, ama calaamadaha kale ee cudurka
• maqaarka cirro leh
• neefta oo ku qabata
• miisaanka oo kordha
• barar gacmaha, anqawyada, cagaha, ama wejiga
• xanuun ama raaxo daro xaga midigta sare ee caloosha
• hurdi maqaarka iyo indhaha
• kaadi madow
• kaadida oo ka yaraata sidii caadiga ahayd

Nilotinib waxay sababi kartaa inay caruurtu si tartiib ah u koraan. Dhakhtarka ilmahaaga ayaa si taxaddar leh u fiirin doona koritaanka ilmahaaga inta cunugaagu qaadanayo nilotinib. Kala hadal dhakhtarka ilmahaaga halista ay leedahay in daawadan la siiyo ilmahaaga.

Nilotinib waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad dhaafka ah waxaa ka mid noqon kara:

• qandho, cuna xanuun, dhaxan, ama calaamado kale oo infekshan ah
• matagid
• lulmid

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Tasigna^®