Cirbadda Denosumab

Qanacsan

• Cirbadeynta Denosumab (Prolia) ayaa la isticmaalaa
• Cirbadeynta Denosumab (Xgeva) waa la isticmaalay Cirbadeynta Denosumab waxay ku jirtaa nooc daawooyin ah oo loo yaqaan 'RANK ligand inhibitors'. Waxay u shaqeysaa si looga hortago lafaha luminta iyadoo la xakameynayo qaataha jirka qaarkood si loo yareeyo burburka lafaha. Waxay u shaqeysaa in lagu daaweeyo GCTB iyadoo la xakameynayo qaataha qaarkood ee unugyada burooyinka taas oo gaabisa koritaanka burooyinka. Waxay u shaqeysaa in lagu daaweeyo heerarka kaalshiyamka sare iyadoo hoos loo dhigo burburka lafaha maadaama burburka lafaha uu soo daayo kaalshiyam.
• Kahor intaadan helin duritaanka denosumab,
• Cirbadeynta Denosumab waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

Cirbadeynta Denosumab (Prolia) ayaa la isticmaalaa

• in lagu daaweeyo lafo-beelka (xaalad ah in lafuhu noqdaan kuwo khafiif ah oo daciif ah oo si fudud u jaba) haweenka soo maray dayska ('' isbeddelka nolosha; 'dhammaadka caadada) kuwaas oo halistoodu u badan tahay jabka (lafaha jaban) ama aan qaadan karin ama aan ka jawaabin daaweynta kale ee daaweynta ee lafo-beelka.
• in lagu daaweeyo ragga halista u badan ee jabka (lafaha jaban) ama aan qaadan karin ama aan ka jawaabin daaweynta kale ee daaweynta ee lafo-beelka.
• daaweeyo lafo-beelka 'osteoporosis' oo ay sababaan dawooyinka loo yaqaan 'corticosteroid' ee ragga iyo dumarka kuwaas oo qaadan doona daawooyinka 'corticosteroid' ugu yaraan 6 bilood waxayna leeyihiin halista sii kordheysa ee jabka ama kuwa aan qaadan karin ama aan ka jawaabin daaweynta kale ee daaweynta osteoporosis.
• in lagu daweeyo lafaha luminta ragga ee laga daweynayo kansarka qanjirka 'prostate' iyadoo la siinayo daawooyinka qaarkood ee keena lafaha luminta,
• si loo daaweeyo lafaha luminta haweenka qaba kansarka naasaha kuwaas oo qaata daawooyinka qaarkood oo kordhiya halista jabka.

Cirbadeynta Denosumab (Xgeva) waa la isticmaalay Cirbadeynta Denosumab waxay ku jirtaa nooc daawooyin ah oo loo yaqaan 'RANK ligand inhibitors'. Waxay u shaqeysaa si looga hortago lafaha luminta iyadoo la xakameynayo qaataha jirka qaarkood si loo yareeyo burburka lafaha. Waxay u shaqeysaa in lagu daaweeyo GCTB iyadoo la xakameynayo qaataha qaarkood ee unugyada burooyinka taas oo gaabisa koritaanka burooyinka. Waxay u shaqeysaa in lagu daaweeyo heerarka kaalshiyamka sare iyadoo hoos loo dhigo burburka lafaha maadaama burburka lafaha uu soo daayo kaalshiyam.

• si loo yareeyo halista jabka ku dhaca dadka qaba myeloma badan (kansar ka bilaabma unugyada plasma isla markaana sababa lafaha), iyo dadka qaba noocyada kansarka qaarkood oo ka bilaabmay qeyb kale oo jirka ah laakiin ku faafay lafaha.
• dadka qaangaarka ah iyo dhalinyarada qaarkood si loo daaweeyo burooyinka unugyada waaweyn ee lafaha (GCTB, nooc ka mid ah burooyinka lafaha) oo aan lagu daaweyn karin qalliin.
• in lagu daaweeyo heerarka sare ee kaalshiyamka ee uu sababo kansarka dadka aan u jawaabin daawooyinka kale.

Cirbadeynta 'Denosumab' waxay u timaadaa sidii xal (dareere) in si subag ahaan ah loogu mudo (maqaarka hoostiisa) gacanta kore, bawdada kore, ama aagga caloosha. Badanaa waxaa ku duraya dhakhtar ama kalkaaliye caafimaad xafiiska caafimaadka ama rugta caafimaadka. Cirbadeynta Denosumab (Prolia) badiyaa waxaa la siiyaa 6dii biloodba mar. Marka duritaanka denosumab (Xgeva) loo isticmaalo si loo yareeyo halista jabka ka yimaada myeloma badan, ama kansar ku faafay lafaha, badanaa waxaa la siiyaa 4tii toddobaadba mar. Marka cirbadda 'denosumab' (Xgeva) loo isticmaalo in lagu daaweeyo burooyinka unugyada waaweyn ee lafta, ama heerarka sare ee kaalshiyamka ee uu sababo kansarka, badanaa waxaa la siiyaa 7dii maalmoodba mar saddexda qiyaasood ee ugu horreeya (maalinta 1, maalinta 8, iyo maalinta 15) ka dibna hal mar 4tii toddobaadba mar marka laga bilaabo 2 toddobaad ka dib saddexda qiyaasood ee ugu horreeya.

Dhakhtarkaaga ayaa kuu sheegi doona inaad qaadatid kaalshiyamka iyo fitamiin D-ga inta lagugu daweynayo cirbadda denosumab. Qaado kaabisyadan sida saxda ah ee lagu faray.

Marka cirbadda denosumab (Prolia) loo isticmaalo in lagu daaweeyo lafo-beelka ama lafaha luminta, dhakhtarkaaga ama farmashiistaha ayaa ku siin doona warqadda macluumaadka bukaanka soo-saaraha (Tilmaamaha Daaweynta) marka aad bilowdo daaweynta cirbadda denosumab iyo mar kasta oo aad dib u buuxiso daawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor intaadan helin duritaanka denosumab,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay denosumab (Prolia, Xgeva), dawooyin kale oo kasta, cinjirka 'latex', ama mid ka mid ah waxyaabaha ku jira irbadda denosumab. Weydii farmashiistahaaga ama ka hubi Hagaha Daawada liiska waxyaabaha ay ka kooban yihiin.
• waa inaad ogaataa in duritaanka denosumab laga heli karo magacyada caanka ah ee Prolia iyo Xgeva. Waa inaadan helin wax kabadan hal shey oo ay kujirto denosumab isla waqtigaas. Hubso inaad u sheegto dhakhtarkaaga haddii lagugu daaweynayo mid ka mid ah daawooyinkan.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee dhakhtar qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato.Hubso inaad sheegto mid ka mid ah kuwan soo socda: angiogenesis inhibitors sida axitinib (Inlyta), bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), ama sunitinib (Sutent); bisphosphonates sida alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), zoledronic acid (Reclast); daawooyinka kiimikada ee kansarka; daawooyinka xakameynaya habka difaaca jirka sida azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), iyo tacrolimus (Astagraf XL, Envarsus, Prograf) ; steroids sida dexamethasone, methylprednisolone (A-Methapred, Depo-Medrol, Medrol, Solu-Medrol), iyo prednisone (Rayos); ama daawooyinka loo isticmaalo in lagu yareeyo heerarka kaalshiyamkaaga, sida cinacalcet (Sensipar). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• u sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa ku jirtay heer hoose oo kaalshiyam ah oo ku jira dhiiggaaga. Dhakhtarkaaga ayaa laga yaabaa inuu hubiyo heerka kalsiyum ee dhiiggaaga ka hor intaadan bilaabin daaweynta waxaana laga yaabaa inuu kuu sheego inaadan qaadan cirbadeynta 'denosumab' haddii heerku aad u hooseeyo.
• u sheeg dhakhtarkaaga haddii aad qaadanayso daaweyn sifeyn ah ama haddii aad qabto ama aad waligaa dhiig-yaraan ku dhacday (xaalad ah in unugyada dhiigga cas ay keenin oksijiin ku filan dhammaan qaybaha jirka); kansarka; nooc kasta oo infekshan ah, gaar ahaan afkaaga; dhibaatooyinka afka, ilkaha, ciridka, ama ilkaha ilkaha; qalliinka ilkaha ama afka (ilkaha oo laga saaray, qalabka ilkaha); xaalad kasta oo ka joojisa dhiiggaaga inuu si caadi ah u xinjiroobo; xaalad kasta oo hoos u dhigaysa shaqeynta nidaamka difaaca jirka; qalliinka qanjirkaaga qanjirka 'thyroid' ama qanjirka 'parathyroid' (qanjirka yar ee qoorta); qalliin looga saarayo qayb ka mid ah xiidmahaaga yar; dhibaatooyinka calooshaada ama xiidmahaaga oo ku adkeeya jirkaaga inuu nuugo nafaqooyinka; polymyalgia rheumatica (cillad keenta murqaha xanuun iyo daciifnimo); sonkorow, ama parathyroid ama kalyo xanuun.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Waxaad u baahan doontaa in lagaa qaado baaritaanka uurka ee xun kahor intaadan bilaabin daaweynta cirbadda denosumab. Waa inaadan uur yeelan inta aad qaadanaysid duritaanka denosumab. Waa inaad isticmaashaa hab lagu kalsoonaan karo oo ah xakameynta dhalmada si looga hortago uurka inta aad qaadaneyso cirbadeynta denosumab iyo ugu yaraan 5 bilood daaweyntaada ugu dambeysa ka dib. Haddii aad uur yeelato inta aad qaadanaysid duritaanka denosumab, ama 5 bilood gudahood ee daaweyntaada, wac dhakhtarkaaga isla markiiba. Denosumab waxay waxyeeleyn kartaa uurjiifka
• waa inaad ogaataa in cirbadeynta 'denosumab' ay sababi karto osteonecrosis ee daanka (ONJ, xaalad daran oo lafta daanka ah), gaar ahaan haddii aad qalliin ilko ama daaweyn ah inta aad qaadaneyso daawadan. Dhakhtarka ilkaha waa inuu baaraa ilkahaaga oo uu sameeyaa wixii daaweyn ah ee loo baahan yahay, oo ay ka mid yihiin nadiifinta ama hagaajinta ilkaha ilkaha oo jiran, ka hor intaadan bilaabin inaad hesho cirbadeynta denosumab. Hubso inaad cadayato ilkahaaga oo aad si sax ah u nadiifiso afkaaga inta aad qaadanayso cirbadeynta denosumab. La hadal dhakhtarkaaga kahor intaadan qaadan daaweynta ilkaha inta aad qaadanaysid dawadan.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Haddii aad seegto ballan si aad u hesho cirbadda denosumab, waa inaad wacdaa dhakhtarkaaga sida ugu dhakhsaha badan. Qiyaasta la seegay waa in la siiyaa sida ugu dhakhsaha badan ee dib loo ballamayn karo. Marka cirbadda denosumab (Prolia) loo isticmaalo lafo-beelka ama lafaha luminta, ka dib marka aad hesho qiyaasta la seegay, mudistaada xigta waa in la jadwaleeyo 6 bilood laga bilaabo taariikhda duritaankaagii ugu dambeeyay.

Cirbadeynta Denosumab waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• casaan, qalalan, ama cuncun maqaarka ah
• nabarro ama nabarro qoyan oo maqaarka ku yaal
• diirka maqaarka
• dhabar xanuun
• xanuunka gacmahaaga
• bararka gacmaha ama lugaha
• murqaha ama kalagoysyada oo xanuuna
• lallabbo
• shuban
• calool istaag
• calool xanuun
• madax xanuun

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

• murqaha oo adkaada, maroojinta, casiraad, ama dabac
• kabuubyo ama xoqitaan farahaaga, suulashaada, ama agagaarka afkaaga
• cuncun, finan, cuncun, neefsashada ama wax liqidda oo ku adkaata, wejiga oo barar, indhaha, cunaha, carrabka ama bushimaha,
• qandho ama dhaxan
• guduudasho, danqasho, barar ama diirimaad ku dhaca aagga maqaarka
• qandho, qufac, neef qabad
• dheecaan dhegta ama dhag xanuun daran
• u baahdo ama u baahdo degdeg ah inaad kaadi, kaadida oo gubata
• calool xanuun daran
• xanjo xanuun ama barar ah, ilkaha oo debca, kabuubyo ama dareen culus oo daanka ku dhaca, daweynta daanka oo liidata
• dhiigbax ama nabar aan caadi ahayn
• lallabbo, matag, madax xanuun, iyo feejignaan yaraanta ka dib joojinta denosumab iyo ilaa 1 sano ka dib

Cirbadda 'Denosumab' ayaa laga yaabaa inay kordhiso halista ah inaad jabiso lafta (s) bowdada Waxaad dareemi kartaa xanuun miskahaaga, gumaarka, ama bowdada dhowr toddobaad ama bilo kahor intaan lafaha (jibbuhu) jabin, waxaana laga yaabaa inaad hesho mid ama labadaba lafaha bowdadaada ayaa jabay inkasta oo aadan ku dhicin ama aadan la kulmin waxyeello kale. Waa wax aan caadi ahayn lafaha bowdada inay ku jabto dadka caafimaadka qaba, laakiin dadka qaba lafa-beelka lafta way jabin karaan laftaan xitaa haddii aysan helin cirbadeynta denosumab. Cirbadeynta 'Denosumab' sidoo kale waxay sababi kartaa lafo jajaban inay si tartiib ah u bogsadaan oo laga yaabo inay carqaladeeyaan koritaanka lafaha ayna ka hortagaan ilkaha inay si sax ah ugu soo galaan carruurta. Kala hadal dhakhtarkaaga khataraha aad ku leedahay in lagugu mudo irbadda denosumab.

Cirbadeynta Denosumab waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn inta aad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ha ruxin cirbadda denosumab. Ku keydi qaboojiyaha oo ka ilaali iftiinka. Ha barafoobin. Cirbadeynta Denosumab waxaa lagu hayn karaa heerkulka qolka ilaa 14 maalmood.

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaaga ayaa amri doona baaritaano gaar ah si loo hubiyo inay amaan kuu tahay inaad hesho cirbadda denosumab iyo inuu hubiyo jawaabta jirkaaga ee duritaanka denosumab.

Ha u ogolaan qof kale inuu isticmaalo daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Prolia^®
• Xgeva^®