Elexacaftor, Tezacaftor, iyo Ivacaftor

Qanacsan

• Kahor intaadan qaadan isku darka elexacaftor, tezacaftor, iyo ivacaftor,
• Isku darka elexacaftor, tezacaftor, iyo ivacaftor waxay sababi karaan waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

Isku darka elexacaftor, tezacaftor, iyo ivacaftor waxaa loo isticmaalaa in lagu daaweeyo noocyada qaarkood ee 'cystic fibrosis' (cudur ku dhasha oo sababa dhibaatooyin xagga neefsashada, dheefshiidka, iyo taranka ah) ee dadka waaweyn iyo carruurta da'doodu tahay 12 sano iyo wixii ka weyn. Waa in loo isticmaalaa oo keliya dadka leh hidde-gaar ah gaar ahaan. Dhakhtarkaagu wuxuu dalban karaa baaritaanka dhiigga si uu kaaga caawiyo go'aaminta haddii daawadani kugu habboon tahay. Elexacaftor iyo tezacaftor waxay ku jiraan fasal dawooyin ah oo loo yaqaan saxeexayaasha habdhiska habdhaqanka habdhiska cystic fibrosis transmembrane (CFTR) Ivacaftor wuxuu ku jiraa fasal dawooyin ah oo loo yaqaan 'cystic fibrosis transmembrane conductance regulator (CFTR) awood leh. Daawooyinkani waxay ku shaqeeyaan hagaajinta shaqada borotiinka jirka si loo yareeyo soo dhiska xabka qafiifka ah ee sanbabada loona hagaajiyo calaamadaha kale ee 'cystic fibrosis'.

Isku darka elexacaftor, tezacaftor, iyo ivacaftor waxay u yimaadaan sidii kiniinno afka lagu qaato. Qiyaas kasta oo maalinle ah waxay leedahay noocyo kiniin ah oo kala duwan: hal kaniini waa isku darka elexacaftor, tezacaftor, iyo ivacaftor kan kalena waa ivacaftor. Qaado elexacaftor, tezacaftor, iyo ivacaftor (2 kiniin oo oranji ah) subax kasta adigoo wata cunto dufan leh iyo ivacaftor (1 kiniin buluug ah) fiid kasta oo ay ku jiraan cunto dufan leh, 12 saacadoodna u dhexeeya. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. U qaado daawooyinkan sida saxda ah ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Kiniiniyada oo dhan liq; ha kala qaybin, calalin, ama burburin.

Qaado isku darka elexacaftor, tezacaftor, iyo ivacaftor oo leh cuntooyinka dufanka leh sida ukunta, subagga, lowska, subagga looska, jiiska pizza, iyo waxyaabaha caanaha laga sameeyo ee caanaha ka sameysan (sida caano dhan, jiis, iyo caano fadhi). Kala hadal dhakhtarkaaga cuntooyinka kale ee dufanka leh si aad ugu cuntid daawooyinkan.

Isku darka elexacaftor, tezacaftor, iyo ivacaftor wuxuu u shaqeeyaa si loo xakameeyo cystic fibrosis, laakiin ma daaweynayo.Sii wad inaad qaadato daawooyinkan xitaa haddii aad caafimaad qabtid. Ha u joojin qaadashada daawooyinkan adiga oo aan la hadlin dhakhtarkaaga.

Weydii farmashiistahaaga ama dhakhtarkaaga nuqul ka mid ah macluumaadka soo saaraha ee bukaanka.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor intaadan qaadan isku darka elexacaftor, tezacaftor, iyo ivacaftor,

• u sheeg dhakhtarkaaga iyo farmashiistaha haddii aad xasaasiyad ku leedahay elexacaftor, tezacaftor, iyo ivacaftor daawooyin kale oo kasta, ama wax ka mid ah waxyaabaha ku jira elexacaftor, tezacaftor, iyo kiniiniyada ivacaftor Weydii farmashiistahaaga liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, ee aad qaadaneyso ama aad qorsheyneyso inaad qaadato Hubso inaad sheegto mid ka mid ah kuwan soo socda: antibiyootikada qaarkood sida clarithromycin (Biaxin, PrevPac) iyo erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin); antifungals qaarkood sida fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), iyo voriconazole (Vfend); daawooyinka kalastarolka ka yareeya (statins) sida atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), lovastatin (Altoprev), pravastatin (Pravachol), rosuvastatin (Crestor), iyo simvastatin (Zocor, in Vytorin); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); everolimus (Afinitor, Zortress); glimepiride (Amaryl); glipizide (Glucotrol); glyburide (Diabeta); ka hortagga uurka ee hormoonka (kaniiniyada ka hortagga uurka, balastarro, faraantiyo, maqaar saar, ama irbado); dawooyinka qaarkood ee suuxdinta sida carbamazepine (Carbatrol, Epitol, Tegretol, kuwa kale), phenobarbital, iyo phenytoin (Dilantin, Phenytek); nateglinide; dib-u-dejin; rifabutin (Mycobutin); rifampin (Rifadin, Rifamate, Rifater, Rimactane); sirolimus (Rapamune); tacrolimus (Astagraf, Prograf), ama warfarin (Coumadin, Jantoven). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara elexacaftor, tezacaftor, ama ivacaftor, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• u sheeg dhakhtarkaaga waxa ka soo baxa dhirta aad qaadanaysid, gaar ahaan johannesört wort. Dhakhtarkaaga ayaa u badan inuu kuu sheego inaadan qaadan johannesört St. John intaad qaadaneyso isku darka elexacaftor, tezacaftor, iyo ivacaftor.
• u sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabto cudur beerka ama kelyo ah.
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelato inta aad qaadanaysid isku darka elexacaftor, tezacaftor, iyo ivacaftor, wac dhakhtarkaaga.
• waa inaad ogaataa in daawooyinkaasi kaa dhigi karaan kuwo lulmo leh. Gaari ha wadin ama ha ku shaqeynin mishiin ilaa aad ka ogaato sida daawooyinkani kuu saameynayaan.

Ha cunin canab canab ah ama ha cabin casiir canab ah adoo qaadanaya daawooyinkan.

Haddii aad xusuusato subaxdii ama fiidkii qiyaasta la seegay 6 saacadood gudahood ee wakhtiga laguu qorsheeyay inaad qaadato, qaado qiyaasta la seegay isla markaaba cuntada ay ku jirto dufanka oo sii wad jadwalkaaga daawada ee caadiga ah. Si kastaba ha noqotee, haddii in ka badan 6 saacadood ay ka soo wareegtay waqtigii loo qorsheeyay in aad qaadato qiyaastaada subaxa, qaado qiyaasta subaxdii la seegay sida ugu dhakhsaha badan ugana boodi qiyaasta fiidkii, ka dibna sii wad jadwalkaaga qiyaasta daawada ee caadiga ah. Haddii in ka badan 6 saacadood ay ka soo wareegtay xilligii loo qorsheeyay in la qaato qiyaasta fiidkii, ka bood qiyaasta fiidkii ee la seegay oo sii wad jadwalka daawadaada caadiga ah. Ha wada qaadan qaadashada subaxdii iyo fiidkii si aad u dhammaystirto mid ka maqnaa.

Isku darka elexacaftor, tezacaftor, iyo ivacaftor waxay sababi karaan waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• madax xanuun
• sanka oo dareera, hindhiso, iyo cufnaan; qandho; qufac; ama calaamadaha kale ee cudurka
• calool xanuun ama barar
• shuban
• finan
• gaaska
• isha casaan
• cuncun

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan, wac takhtarkaaga isla markiiba ama u hesho daaweyn caafimaad oo deg-deg ah:

• hurdi maqaarka ama indhaha
• cunto xumo
• lallabbo
• matagid
• saxaro cirro leh
• calool xanuun
• kaadi madow

Isku darka elexacaftor, tezacaftor, iyo ivacaftor waxay sababi karaan indho fiiq (daruurta muraayadaha indhaha oo sababi karta dhibaato araga) carruurta iyo dhalinyarada. Carruurta iyo dhalinyarada qaadata elexacaftor, tezacaftor, iyo ivacaftor waa inay u tagaan dhakhtarka indhaha kahor iyo inta ay daaweynayaan. Kala hadal dhakhtarka ilmahaaga khataraha siinta elexacaftor, tezacaftor, iyo ivacaftor ilmahaaga.

Isku darka elexacaftor, tezacaftor, iyo ivacaftor waxay sababi karaan waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa baaritaanka indhaha (ee carruurta iyo dhalinyarada) iyo tijaabooyinka shaybaarka qaarkood sida baaritaanka beerka kahor iyo inta lagu jiro daaweyntaada si loo hubiyo jawaabta jirkaaga ee elexacaftor, tezacaftor, iyo ivacaftor.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

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