Qoraa: Janice Evans
Taariikhda Abuurista: 26 Julay 2021
Taariikhda Cusboonaysiinta: 15 Noofeembar 2024
Anonim
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Dareemoleyad: Chemoprevention with sulindac/erlotinib may lower duodenal polyp burden in patients with FAP

Qanacsan

Dadka qaata daawooyinka nonsteroidal anti-bararka (NSAIDs) (oo aan ka ahayn asbiriin) sida sulindac waxay yeelan karaan halista ugu sareysa ee wadno qabad ama istaroog marka loo eego dadka aan qaadan daawooyinkan. Dhacdooyinkan waxay dhici karaan digniin la'aan waxayna sababi karaan dhimasho. Khatartani way ka sii badnaan kartaa dadka qaata NSAIDs muddo dheer. Ha u qaadan NSAID sida sulindac haddii aad dhawaan wadno xanuun ku qabatay, ilaa uu takhtarkaagu kugu amro mooyee. U sheeg dhakhtarkaaga haddii adiga ama qof kale oo qoyskaaga ka mid ah uu qabo ama uu waligiis ku dhacay cudur wadne, wadno-qabad, ama istaroog, haddii aad sigaar cabtaan, iyo haddii aad qabateen ama waligiin aad qabateen kolestarool sare, dhiig kar, ama kaadi macaan Hel gargaar caafimaad oo deg-deg ah isla markiiba haddii aad isku aragto mid ka mid ah astaamaha soo socda: laabta oo xanuunta, neefta oo ku qabata, daciifnimo oo ku timaadda qayb ka mid ah jirka ama dhinaceeda, ama hadal dabacsan

Haddii lagaa qaadayo xididdada wadnaha ee xididdada wadnaha (CABG, nooc qalliin wadnaha ah), waa inaadan qaadan sulindac isla qalliinka ka hor ama ka dib.


NSAIDs sida sulindac waxay sababi karaan boogo, dhiig bax, ama godad caloosha ama xiidmaha. Dhibaatooyinkani waxay soo bixi karaan wakhti kasta inta lagu jiro daweynta, waxay dhici karaan iyadoo aan lahayn astaamo digniin ah, waxayna sababi karaan dhimasho. Khatartu way ka sii badnaan kartaa dadka qaata NSAID-yada muddo dheer, da 'weyn, caafimaadkoodu liito, ama caba khamri tiro badan inta aad qaadanaysid sulindac. U sheeg dhakhtarkaaga haddii aad qaadato mid ka mid ah daawooyinka soo socda: daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida warfarin (Coumadin, Jantoven); asbiriin; kale NSAIDs sida diflunisal, ibuprofen (Advil, Motrin) ama naproxen (Aleve, Naprosyn), ama steroids afka laga qaato sida dexamethasone, methylprednisolone (Medrol), iyo prednisone (Rayos); xulashada serotonin reuptake inhibitors (SSRIs) sida citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), iyo sertraline (Zoloft); ama serotonin norepinephrine reuptake inhibitors (SNRIs) sida desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), iyo venlafaxine (Effexor XR). Sidoo kale u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa nabarro ama dhiig ka soo baxeen calooshaada ama xiidmaha, ama xanuunno kale oo dhiig bax ah. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, jooji qaadashada sulindac una wac dhakhtarkaaga: calool xanuun, laab xanuun, matag walax dhiig leh ama u eg qaxwaha, dhiigga saxarada, ama saxarada madow iyo kuwa tarry.


Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaaga ayaa si taxadar leh ula socon doona astaamahaaga wuxuuna ubaahanyahay inuu amro baaritaano qaarkood si loo hubiyo jawaabta jirkaaga ee sulindac Hubso inaad u sheegto dhakhtarkaaga sida aad dareemaysid si dhakhtarkaagu u qori karo xaddiga saxda ah ee daaweynta si loogu daaweeyo xaaladdaada iyada oo ay ugu jirto khatarta ugu hooseysa ee waxyeelooyinka halista ah.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo-saaraha (Tilmaamaha Daawada) markaad bilawdo daaweynta sulindac iyo markasta oo aad dib u buuxiso dawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Sulindac waxaa loo isticmaalaa in lagu yareeyo xanuunka, jilicsanaanta, bararka, iyo qallafsanaanta ay keento osteoarthritis (arthritis ay keento burburka dahaarka kalagoysyada), rheumatoid arthritis (arthritis uu sababo bararka maqaarka laabatooyinka), iyo ankylosing spondylitis (arthritis) taas oo inta badan ku dhacda laf-dhabarka). Sulindac sidoo kale waxaa loo isticmaalaa in lagu daaweeyo xanuunka garabka oo ay keento bursitis (caabuq ku jira dheecaan ka buuxay dareeraha garabka garabka) iyo tendinitis (caabuq ku dhaca unugyada isku xira murqaha iyo lafaha). Waxaa sidoo kale loo isticmaalaa in lagu yareeyo xanuunka loo yaqaan 'gouty arthritis' (weerarada xanuunka daran ee wadajirka ah iyo barar ay sababaan soo saarista walxaha qaarkood ee kalagoysyada). Sulindac wuxuu ku jiraa nooc daawooyin ah oo loo yaqaan NSAIDs. Waxay ku shaqeysaa iyadoo la joojinayo soo saarista jirka ee walax sababa xanuun, qandho, iyo barar.


Sulindac wuxuu u yimaadaa kiniin ahaan afka laga qaato. Badanaa waxaa lagu qaataa cuntada laba jeer maalintii. Qaado sulindac qiyaastii isla waqtiyadaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado sulindac sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Sulindac wuxuu caawiyaa xakamaynta xanuunka arthritis laakiin ma daaweeyo arthritis. Haddii aad u qaadanaysid sulindac in lagu daaweeyo xanuunka arthritis-ka, waxay qaadan kartaa 1 toddobaad ama ka badan ka hor intaadan dareemin faa'iidada buuxda ee sulindac.

Sulindac sidoo kale mararka qaarkood waxaa loo isticmaalaa in lagu yareeyo tirada burooyinka (koritaanka aan caadiga ahayn) ee xiidanka (xiidmaha waaweyn) iyo malawadka bukaanka qaba qoysaska adenomatous polyposis (xaalad boqolaal ama kumanaan burooyin ah ay ku sameysmaan xiidanka iyo kansarka ayaa ku dhici kara). Kala hadal dhakhtarkaaga khataraha aad u leedahay isticmaalka dawadan xaaladaada.

Daawadan ayaa mararka qaarkood loo qoraa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada sulindac,

  • u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay sulindac, aspirin, ama NSAIDs kale sida ibuprofen (Advil, Motrin) iyo naproxen (Aleve, Naprosyn), ama daawooyin kale. Weydii farmashiistahaaga liiska waxyaabaha aan firfircooneyn.
  • u sheeg dhakhtarkaaga iyo farmashiistaha dawooyinka dhakhtarku qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto dawooyinka ku taxan qaybta DIGNIIN MUHIIM AH iyo mid ka mid ah kuwan soo socda: xannibaadayaasha angiotensin-enzyme (ACE) sida benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril ( Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), iyo trandolapril (Mavik, Tarka); angiotensin II antagonists antagonists sida candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor) , telmisartan (Micardis, oo ku taal Twynsta), valsartan (oo ku taal Exforge HCT); cyclosporine (Gengraf, Neoral, Sandimmune); daawooyinka afka laga qaato ee sonkorowga; durayaasha ('kaniiniyada biyaha'); lithium (Lithobid); methotrexate (Otrexup, Rasuvo, Trexall); iyo probenecid (Probalan).
  • u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa dareentay mid ka mid ah xaaladaha lagu xusay qaybta DIGNIINTA MUHIIMKA ah ama neefta, gaar ahaan haddii aad sidoo kale leedahay xirmo badan ama sanka oo duufsan ama polyps sanka (barar ku dhaca dahaadhka sanka); wadnaha oo istaaga; dhagaxyada kelyaha; barar gacmaha, gacmaha, cagaha, anqawyada, ama lugaha hoose; ama cudurka beerka ama kalyaha.
  • u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato; ama naas nuujin Sulindac waxay waxyeelayn kartaa uur-kujirka waxayna dhibaato u keeni kartaa dhalmada haddii la qaato qiyaastii 20 toddobaad ama ka dib muddada uurka. Ha u isticmaalin sulindac qiyaastii ama ka dib 20 toddobaad oo uur ah, ilaa dhakhtarkaagu kuu sheego mooyee. Haddii aad uur yeelato intaad qaadanaysid sulindac, wac dhakhtarkaaga.
  • kala hadal dhakhtarkaaga khataraha iyo faa'iidooyinka u leeyahay qaadashada sulindac haddii aad tahay 75 sano jir ama ka weyn. Ha u qaadan daawadan muddo dheer ama qaadasho ka badan ta dhakhtarku kugula taliyay.
  • haddii aad qalliin tahay, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarka ama dhakhtarka ilkaha inaad qaadanayso sulindac.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Qaado qiyaasta la seegay isla marka aad xasuusatoba. Si kastaba ha noqotee, haddii ay ku dhowdahay waqtiga qiyaasta xigta, ka bood qiyaasta la seegay oo sii wad jadwalka daawadaada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Sulindac wuxuu sababi karaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

  • madax xanuun
  • dawakhaad
  • gariirid
  • shuban
  • calool istaag
  • gaaska
  • dhagaha ka yeeraya

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, ama kuwa lagu sheegay qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga. Ha u qaadan sulindac dambe ilaa aad kala hadasho dhakhtarkaaga:

  • miisaanka oo kordha
  • neefta oo ku qabata ama neefsashada oo ku adkaata
  • barar caloosha, cagaha, anqawyada, ama lugaha hoose
  • qandho
  • qarqaryo
  • qufac
  • dhidid
  • dhaqid
  • murqaha ama kalagoysyada oo xanuuna
  • xabad xanuun
  • finanka
  • finan
  • cuncun
  • finan
  • bararka indhaha, wajiga, dibnaha, carrabka, cunaha, gacmaha, ama gacmaha
  • dhib liqidda
  • xabeeb
  • maqaarka cirro leh
  • garaaca wadnaha
  • daal fara badan
  • dhiigbax ama nabar aan caadi ahayn
  • tamar la’aan
  • calool xanuun
  • cunto xumo
  • xanuun qeybta kore ee midig ee caloosha
  • astaamaha hargabka oo kale ah
  • hurdi maqaarka ama indhaha
  • kaadi daruuro, midab leh, ama dhiig leh
  • dhabar xanuun
  • kaadi adag ama xanuun badan
  • aragga oo xumaada ama dhibaatooyinka kale ee aragga

Sulindac waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

  • miyir beelid
  • miyir beelid
  • dawakhaad
  • aragga oo xumaada
  • calool xanuun
  • kaadida oo yaraatay

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

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