Ketoconazole

Qanacsan

• Kahor qaadashada ketoconazole,
• Ketoconazole waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Calaamadaha soo socdaa waa kuwo aan caadi ahayn, laakiin haddii aad la kulanto mid ka mid ah ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga ama aad hesho daaweyn caafimaad oo degdeg ah:

Ketoconazole waa in loo isticmaalo kaliya in lagu daaweeyo infekshannada fungal marka daawooyinka kale aan la helin ama aan loo dulqaadan karin.

Ketoconazole wuxuu sababi karaa dhaawac beerka ah, mararka qaarna halis u ah inuu u baahdo beerka beeris ama inuu u dhinto. Dhaawaca beerka waxaa laga yaabaa inuu ku dhaco dadka aan horey u qabin cudurka beerka ama xaalado kale oo kordhiya halista inay ku dhacaan beerka. U sheeg dhakhtarkaaga haddii aad cabto ama aad waligaa cabto qamri aad u tiro badan iyo haddii aad qabto ama aad waligaa qabto cudurka beerka. Ha cabin wax cabitaanno aalkolo ah inta lagu guda jiro daaweyntaada ketoconazole maxaa yeelay cabbista cabbitaannada aalkolada waxay kordhin kartaa halista aad ku yeelan karto dhaawaca beerkaHaddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga: daal aad u daran, cunto xumo, culays miisaanka oo yaraada, lallabbo, matag, maqaarka ama indhaha oo hurdi noqda, kaadida jaallaha ah ee mugdiga ah, saxarada oo cirro leh, xanuunka qaybta midig ee sare caloosha, qandho, ama finan.

Ketoconazole wuxuu sababi karaa dheereynta QT (wadna garaac aan caadi aheyn oo u horseedi kara suuxdin, miyir beelid, suuxdin, ama dhimasho lama filaan ah). Ha u qaadan sibibramram (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), pimozide (Orap), quinidine (Quinidex, Quinaglute), cisapride (Propulsid; mar dambe ma laga heli karo Mareykanka), methadone (Dolophine, Methadose), iyo ranolazine (Ranexa) inta aad qaadaneyso ketoconazole. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, jooji qaadashada ketoconazole isla markaana wac dhakhtarkaaga isla markiiba: dhakhso, garaac, ama wadno garaac aan caadi ahayn; miyir beelid; dawakhaad; madax wareer; ama miyir beelid.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhakhtarkaagu wuxuu amri doonaa baaritaano gaar ah si loo hubiyo jawaabta jirkaaga ee ketoconazole.

Dhakhtarkaaga ama farmashiistahaaga ayaa ku siin doona warqada macluumaadka bukaanka soo saaraha (Tilmaamaha Daawada) markaad bilowdo daaweynta ketoconazole iyo waqti kasta oo aad dib u buuxiso daawadaada. Si taxaddar leh u akhri macluumaadka oo weydii dhakhtarkaaga ama farmashiistaha haddii aad wax su'aalo ah qabtid. Waxa kale oo aad booqan kartaa websaydhka Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ama websaydhka soosaaraha si aad u hesho Hagaha Daawada.

Kala hadal dhakhtarkaaga khataraha qaadashada ketoconazole.

Ketoconazole waxaa loo isticmaalaa in lagu daaweeyo infekshannada fungal marka daawooyinka kale aan la helin ama aan loo dulqaadan karin. Ketoconazole waa in aan loo isticmaalin in lagu daaweeyo qoorgooyaha fangas (infekshan ku dhaca xuubabka ku hareeraysan maskaxda iyo lafdhabarta uu sababay fangaska) ama infekshannada ciddiyaha ku dhaca. Ketoconazole wuxuu ku jiraa fasal ka mid ah antifungals loo yaqaan 'imidazoles'. Waxay ku shaqeysaa iyada oo hoos u dhigeysa koritaanka fangaska ee sababa infekshinka.

Ketoconazole wuxuu u yimaadaa kiniin ahaan afka laga qaato. Waxaa badanaa la qaataa hal mar maalintii Qaado ketoconazole qiyaastii isla waqtigaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado ketoconazole sida saxda ee lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Dhakhtarkaaga ayaa laga yaabaa inuu kordhiyo qiyaastaada haddii xaaladaadu aysan fiicnayn.

Waxaad u baahan kartaa inaad qaadato ketoconazole muddo 6 bilood ah ama ka badan si aad ugu bogsiiso cudurkaaga gebi ahaanba. Sii wad inaad qaadato ketoconazole ilaa dhakhtarkaagu kuu sheego inaad joojiso, xitaa haddii aad ladnaan dareento. Ha u joojin qaadashada ketoconazole adigoon la hadlin dhakhtarkaaga. Haddii aad dhaqso u joojiso qaadashada ketoconazole, infekshankaaga ayaa laga yaabaa inuu soo noqdo muddo gaaban kadib.

Qiyaaso badan oo ketoconazole ah ayaa mararka qaar loo isticmaalaa in lagu daaweeyo Cushing syndrome (xaalad dhacda marka uu jirka ku jiro hormoon badan oo corticosteroid ah) iyo kansarka qanjirka 'prostate' (kansarka qanjirka taranka ragga). Ketoconazole looma muujin inay amaan tahay ama wax ku ool u tahay isticmaalkan. Takhtarkaaga kala hadal isticmaalka ketoconazole ee xaaladdaada.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Kahor qaadashada ketoconazole,

• u sheeg dhakhtarkaaga iyo farmashiistahaaga haddii aad xasaasiyad ku leedahay ketoconazole ama daawooyin kale ama wax ka mid ah maaddooyinka ku jira kiniiniyada ketoconazole. Weydii farmashiistahaaga ama ka hubi Hagaha Daawada liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga haddii aad qaadanaysid alprazolam (Niravam, Xanax); eplerenone (Inspra); ergot alkaloids sida ergotamine (Ergomar, in Cafergot, in Migergot), dihydroergotamine (D.H.E 45, Migranal), iyo methylergonovine (Methergine); felodipine (Plendil); irinotecan (Camptosar); lovastatin (Mevacor); lurasidone (Latuda); midazolam (Aayaad); nisoldipine (Sular); simvastatin (Zocor); tolvaptan (Samsca); iyo triazolam (Halcion). Dhakhtarkaaga ayaa laga yaabaa inuu kuu sheego inaadan qaadan ketoconazole haddii aad qaadanayso mid ama in kabadan oo ka mid ah daawooyinkan ama mid ka mid ah daawooyinka ku qoran qaybta DIGNIIN MUHIIM AH.
• u sheeg dhakhtarkaaga iyo farmashiistaha waxa kale ee daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ee aad qaadaneyso. Hubso inaad sheegto dawooyinka ku qoran qaybta DIGNIIN MUHIIM AH iyo mid ka mid ah kuwan soo socda: aliskiren (Tekturna, Valturna, Amturnide); daawooyinka xinjirowga lidka ku ah ('khafiifiyeyaasha dhiigga') sida dabigatran (Pradaxa), rivaroxaban (Xarelto) iyo warfarin (Coumadin); danaysane (Emend); aripiprazole (Abilify); atorvastatin (Lipitor); bosentan (Tracleer); budesonide (Uceris); buspirone (BuSpar); karbamazepine (Tegretol); kaalsiyamka xanibaada sida amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), nifedipine (Adalat, Procardia), and verapamil (Calan, Covera, Isoptin, Verelan) daawooyinka kansarka sida bortezomib (Velcade); busulfan (Myleran); dasatinib (Sprycel); docetaxel (Taxotere), erlotinib (Tarceva); ixabepilone (Ixempra); lapatinib (Tykerb); nilotinib (Tasigna); paclitaxel (Taxol), trimetrexate (Neutrexin), vincristine (Vincasar), vinblastine, iyo vinorelbine (Navelbine); ciclesonide (Alvesco); cilostazol (Pletal); cinacalcet (Sensipar); colchicine (Colcrys, ee Col-Probenecid); dexamethasone; digoxin (Lanoxin); eletriptan (Relpax); fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis); fesoterodine (Toviaz); fluticasone (Flonase, Flovent); haloperidol (Haldol); Daawooyinka HIV sida darunavir (Prezista), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), maraviroc (Selzentry), nevirapine (Viramune), ritonavir (Norvir), iyo saquinavir (Invirase, Fortovase) difaaca jirka sida cyclosporine (Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), iyo tacrolimus (Prograf); imatinib (Gleevec); dawooyinka cillad la'aanta erectile sida sildenafil (Viagra), tadalafil (Cialis), iyo vardenafil (Levitra); daawooyinka caloosha, calool xanuun, ama boogaha sida cimetidine (Tagamet), famotidine (Pepcid), lansoprazole (Prevacid), nizatidine (Axid), omeprazole (Prilosec), iyo ranitidine (Zantac); dawooyinka lagu daaweeyo cudurka qaaxada sida isoniazid (INH, Nydrazid), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane); methylprednisolone (Medrol); nadolol (Corgard); oxycodone (Oxecta, Oxy Contin, in Percocet, kuwa kale); phenytoin (Dilantin); praziquantel (Biltricide); quetiapine (Seroquel); ramelteon (Rozerem); repaglinide (Prandin, gudaha PrandiMet); risperidone (Risperdal); salmeterol (Serevent, Advair); saxagliptin (Onglyza); solifenacin (Vesicare); difaaca jirka sida cyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), iyo tacrolimus (Prograf); tamsulosin (Flomax, oo ku taal Jalyn); telithromycin (Ketek); iyo tolterodine (Detrol). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca. Daawooyin kale oo badan ayaa sidoo kale la macaamili kara ketoconazole, markaa hubi inaad u sheegto dhakhtarkaaga dhammaan daawooyinka aad qaadanaysid, xitaa kuwa aan ka muuqan liiskan.
• haddii aad qaadanayso antacid ay ku jiraan aluminium, kaalshiyam, ama magnesium (Maalox, Mylanta, Tums, kuwa kale), qaado 1 saac ka hor ama 2 saacadood ka dib qaadashada ketoconazole.
• u sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa soo martay xaaladaha lagu xusay qaybta DIGNIIN MUHIIM AH ama ku filnaansho la'aanta adrenal (xaalad ah in qanjidhada adrenal aysan sameynin hormoonno steroid ku filan)
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelato inta aad qaadanaysid ketoconazole, wac dhakhtarkaaga.
• haddii aad qalliin samaynayso, oo ay ku jiraan qalliinka ilkaha, u sheeg dhakhtarka ama dhakhtarka ilkaha inaad qaadanayso ketoconazole.
• waa inaad ogaataa cabitaanka khamriga (oo ay kujiraan khamriga, biirka, iyo daawooyinka ay kujiraan aalkolada sida sharoobada qufaca) intaad qaadaneyso ketoconazole waxay kordhisaa halista inaad kudhacdo dhaawaca beerka waxayna sababi kartaa astaamo aan fiicneyn sida flushing, rash, lallabo, madax xanuun iyo bararka gacmaha, cagaha, anqawyada, ama lugaha hoose haddii aad khamri cabto intaad qaadanaysid ketoconazole.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Qaado qiyaasta la seegay isla marka aad xasuusatoba. Si kastaba ha noqotee, haddii ay ku dhowdahay waqtiga qiyaasta xigta, ka bood qiyaasta la seegay oo sii wad jadwalka daawadaada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Ketoconazole waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• madax xanuun
• calool xanuun
• shuban
• calool istaag
• laabjeex
• gaaska
• beddelidda awoodda dhadhaminta cuntada
• afka qalalan
• midabka carrabka
• dhibaato xagga hurdada ama hurdada ah
• gariirid
• kabuubyo, gubasho, ama ruxruxasho gacmaha ama cagaha
• murqo xanuun
• timo lumis
• dhaqid
• qarqaryo
• dareenka iftiinka
• sanka oo dhiig ka imanayo
• balaarinta naasaha ee ragga
• hoos u dhaca awooda galmada

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Calaamadaha soo socdaa waa kuwo aan caadi ahayn, laakiin haddii aad la kulanto mid ka mid ah ama kuwa ku taxan qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga ama aad hesho daaweyn caafimaad oo degdeg ah:

• finan
• finan
• cuncun
• barar indhaha, wajiga, dibnaha, carrabka, gacmaha, cagaha, anqawyada, ama lugaha hoose
• xabeeb
• neefsashada ama wax liqidda oo ku adkaata
• daal ama daciifnimo

Ketoconazole wuxuu sababi karaa hoos u dhac ku yimaada tirada shahwada (unugyada taranka ragga) ee la soo saaray, gaar ahaan haddii lagu qaato qadar sare. Kala hadal dhakhtarkaaga halista qaadashada daawadan haddii aad tahay nin oo aad jeceshahay inaad carruur dhasho.

Ketoconazole waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Kahor baaritaanka shaybaarka, u sheeg dhakhtarkaaga iyo shaqaalaha sheybaarka inaad qaadanayso ketoconazole.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga haddii aad qabtid wax su'aalo ah oo ku saabsan dib u soo celinta daawada laguu qoray. Haddii aad wali leedahay calaamadaha cudurka kadib markaad dhameysatid ketoconazole, wac dhakhtarkaaga.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

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