Tijaabada Antineutrophil Cytoplasmic Antibodies (ANCA)

Qanacsan

• Waa maxay tijaabada antineutrophil cytoplasmic antibodies (ANCA)?
• Maxaa loo adeegsadaa?
• Maxaan ugu baahanahay baaritaanka ANCA?
• Maxaa dhacaya inta lagu jiro baaritaanka ANCA?
• Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?
• Ma jiraan wax khatar ah oo imtaxaanku leeyahay?
• Maxay natiijooyinka ka dhigan yihiin?
• Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka ANCA?
• Tixraacyo

Waa maxay tijaabada antineutrophil cytoplasmic antibodies (ANCA)?

Tijaabadani waxay raadineysaa antineutrophil cytoplasmic antibodies (ANCA) dhiigaaga. Antibodies-ku waa borotiino uu nidaamkaaga difaaca jirka u sameeyo si loola dagaallamo walxaha shisheeye sida fayrasyada iyo bakteeriyada. Laakiin ANCAs waxay si qalad ah u weeraraan unugyada caafimaadka qabta ee loo yaqaanno neutrophils (nooc unugga dhiigga cad). Tani waxay u horseedi kartaa cilad loo yaqaan 'autoimmune vasculitis'. Autasmas vasculitis wuxuu keenaa caabuq iyo barar xididdada dhiigga.

Xididdada dhiigga waxay dhiig ka qaadaan wadnahaaga iyagoo geeya xubnahaaga, unugyadaada, iyo nidaamyada kale, ka dibna mar kale ayey dib u noqdaan. Noocyada xididdada dhiigga waxaa ka mid ah xididdada dhiigga, xididdada dhiigga, iyo xididdada dhiigga. Caabuq ku dhaca xididdada dhiigga wuxuu sababi karaa dhibaatooyin caafimaad oo daran. Dhibaatooyinku way kala duwan yihiin waxayna kuxirantahay xididdada dhiigga iyo nidaamyada jirka ee ay saameeyeen.

Waxaa jira laba nooc oo waaweyn oo ah ANCA. Mid kastaa wuxuu bartilmaameedsanayaa borotiin gaar ah gudaha unugyada dhiigga cad:

• pANCA, oo bartilmaameedsata borotiin loo yaqaan MPO (myeloperoxidase)
• CANCA, oo bartilmaameedsata borotiin loo yaqaan PR3 (proteinase 3)

Tijaabadu waxay muujin kartaa inaad leedahay mid ama labada nooc ee difaaca jirka. Tani waxay ka caawin kartaa bixiyaha xanaanada caafimaadkaaga inuu ogaado oo daaweeyo cilladaada.

Magacyada kale: antibodies ANCA, cANCA pANCA, cytoplasmic neutrophil antibodies, serum, antiytoplasmic autoantibodies

Maxaa loo adeegsadaa?

Tijaabada ANCA badiyaa waxaa loo isticmaalaa in lagu ogaado in aad qabtid nooc ka mid ah difaaca jirka ee 'vasculitis'. Waxaa jira noocyo kala duwan oo cilladaan ah. Dhammaantood waxay sababaan barar iyo barar xididdada dhiigga, laakiin nooc kasta wuxuu saameeyaa xididdada dhiigga iyo qaybaha jirka ee kala duwan. Noocyada vasculitis-ka is-difaaca jirka waxaa ka mid ah:

• Granulomatosis oo leh polyangiitis (GPA), oo markii hore loo yaqaanay cudurka Wegener. Badanaa wuxuu ku dhacaa sambabaha, kilyaha, iyo sanka.
• Cudurka loo yaqaan 'Microscopic polyangiitis' (MPA). Cilladaan waxay saameyn ku yeelan kartaa dhowr xubnood oo jirka ka mid ah, oo ay ka mid yihiin sambabada, kilyaha, habdhiska dareenka, iyo maqaarka.
• Eosinophilic granulomatosis oo leh polyangiitis (EGPA), oo horay loogu magacaabi jiray Churg-Strauss syndrome. Ciladan ayaa sida caadiga ah ku dhacda maqaarka iyo sambabaha. Waxay badanaa keentaa neefta.
• Polyarteritis nodosa (PAN). Cilladan badanaa waxay saameysaa wadnaha, kilyaha, maqaarka, iyo habdhiska neerfaha.

Tijaabada ANCA ayaa sidoo kale loo isticmaali karaa in lagula socdo daaweynta cuduradan.

Maxaan ugu baahanahay baaritaanka ANCA?

Bixiyaha xanaanada caafimaadkaaga ayaa laga yaabaa inuu dalbado baaritaanka ANCA haddii aad leedahay astaamo cudurka vasculitis ee jirka. Calaamadaha waxaa ka mid ah:

• Qandho
• Daal
• Miisaanka oo yaraada
• Muruq iyo / ama xanuun xanuun

Calaamadahaagu sidoo kale waxay saameyn ku yeelan karaan hal ama in ka badan oo xubno gaar ah oo jirkaaga ah. Xubnaha sida caadiga ah loo saameeyo iyo astaamaha ay sababaan waxaa ka mid ah:

• Indhaha
  • Guduudasho
  • Aragga oo xumaaday
  • Aragti lumis
• Dhegaha
  • Dhawaaqa dhegaha (tinnitus)
  • Dhego beelid
• Sinus
  • Xanuunka sanka
  • Sanka oo dareera
  • Sanka ayaa dhiig baxayaa
• Maqaarka
  • Rashes
  • Nabaro ama nabarro, nooc ka mid ah nabarro qoto dheer oo gaabis ah si loo bogsado iyo / ama dib u soo noqoshada
• Sambabada
  • Qufac
  • Neefsashada oo dhib ah
  • Laab xanuun
• Kilyaha
  • Dhiig ku jira kaadida
  • Kaadi xumbo, oo uu sababo borotiinka ku jira kaadida
• Nidaamka neerfaha
  • Kabuubyo iyo ruxruxid qaybaha kala duwan ee jirka

Maxaa dhacaya inta lagu jiro baaritaanka ANCA?

Xirfadlaha daryeelka caafimaadka ayaa tijaabo dhiig ka qaadi doona xididka gacantaada, isagoo isticmaalaya cirbad yar. Kaddib cirbada la geliyo, qadar yar oo dhiig ah ayaa lagu ururin doonaa tuubada baaritaanka ama fijaan. Waxaa laga yaabaa inaad dareento xoog wax yar ah markii irbadda ay soo galayso ama ay ka baxeyso. Tani badanaa waxay qaadataa in ka yar shan daqiiqo.

Ma u baahanahay inaan sameeyo wax walba si aan ugu diyaargaroobo imtixaanka?

Uma baahnid wax diyaargarow gaar ah oo loogu talagalay baaritaanka ANCA.

Ma jiraan wax khatar ah oo imtaxaanku leeyahay?

Khatar aad u yar baa jirta in dhiig lagaa qaado. Waxaa laga yaabaa inaad xanuun yar ama nabar ku yeelato barta irbadda lagu muday, laakiin astaamaha badankood si dhakhso leh ayey u baxaan.

Maxay natiijooyinka ka dhigan yihiin?

Haddii natiijooyinkaagu ahaayeen kuwo taban, waxay ka dhigan tahay in astaamahaagu ay u badan tahay inaysan sabab u ahayn is-beddelka vasculitis.

Haddii natiijooyinkaagu ahaayeen kuwo wanaagsan, waxay noqon kartaa inaad qabtid vasculitis autoimmune. Waxay sidoo kale muujin kartaa haddii la helay cANCAs ama pANCAs. Tani waxay kaa caawin kartaa go'aaminta nooca vaskulitis ee aad leedahay.

Nooc kasta oo unugyada difaaca jirka ee la helay, waxaad u baahan kartaa baaritaan dheeraad ah, oo loo yaqaan biopsy, si loo xaqiijiyo cudurka. Cad ka-qaadis (biopsy) ayaa ah nidaam soo saaraya qayb yar oo unug ama unugyo ah si loo baaro. Bixiyaha xanaanada caafimaadkaaga sidoo kale wuxuu dalban karaa baaritaano dheeri ah si loo cabiro qadarka ANCA ee dhiigaaga.

Haddii hadda lagaa daweynayo vasculitis autoimmune, natiijooyinkaaga ayaa laga yaabaa inay muujiyaan in daaweyntaadu shaqeyneyso iyo in kale.

Haddii aad su'aalo ka qabtid natiijooyinkaaga, la hadal daryeel caafimaad bixiyahaaga.

Wax badan ka baro baaritaanka shaybaarka, kala duwanaanshaha tixraaca, iyo fahamka natiijooyinka.

Ma jiraan wax kale oo aan u baahanahay inaan ka ogaado baaritaanka ANCA?

Haddii natiijooyinkaaga ANCA ay muujiyaan inaad qabtid vasculitis autoimmune, waxaa jira siyaabo lagu daaweeyo loona maareeyo xaaladda. Daaweyntu waxaa ka mid noqon kara daawo, daaweyn si ku meel gaar ah uga saarta ANCAs dhiiggaaga, iyo / ama qalliin.

Tixraacyo

1. Allina Health [Internet]. Minneapolis: Allina Health; Qiyaasta C-ANCA; [daliishaday 2019 Meey 3]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://account.allinahealth.org/library/content/49/150100
2. Allina Health [Internet]. Minneapolis: Allina Health; Qiyaasta P-ANCA; [daliishaday 2019 Meey 3]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://account.allinahealth.org/library/content/49/150470
3. Kliinikada Cleveland [Internet]. Cleveland (OH): Isbitaalka Cleveland; c2019. Boogaha Lugaha iyo Cagta; [daliishaday 2019 Meey 3]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://my.clevelandclinic.org/health/diseases/17169-leg-and-foot-ulcers
4. Tijaabooyinka Shaybaarka ee Internetka [Internetka] Washington DC: Ururka Mareykanka ee Kiimikada Caafimaadka; c2001–2019. Antibodies ANCA / MPO / PR3; [cusboonaysiiyay 2019 Apr 29; daliishaday 2019 Meey 3]; [ilaa 2 shaashad]. Waxaa laga heli karaa: https://labtestsonline.org/tests/ancampopr3-antibodies
5. Tijaabooyinka Shaybaarka ee Internetka [Internetka] Washington DC: Ururka Mareykanka ee Kiimikada Caafimaadka; c2001–2019. Biopsy; [cusboonaysiiyay 2017 Jul 10; daliishaday 2019 Meey 3]; [ilaa 2 shaashad]. Waxaa laga heli karaa: https://labtestsonline.org/glossary/biopsy
6. Tijaabooyinka Shaybaarka ee Internetka [Internetka] Washington DC: Ururka Mareykanka ee Kiimikada Caafimaadka; c2001–2019. Vasculitis; [cusboonaysiiyay 2017 Sep 8; daliishaday 2019 Meey 3]; [ilaa 2 shaashad]. Waxaa laga heli karaa: https://labtestsonline.org/conditions/vasculitis
7. Mansi IA, Opran A, Rosner F. ANCA-Associated Small-Vessel Vasculitis. Am Fam Dhakhtarka [Internet]. 2002 Apr 15 [daliishaday 2019 Meey 3]; 65 (8): 1615-1621. Waxaa laga heli karaa: https://www.aafp.org/afp/2002/0415/p1615.html
8. Sheybaarada Caafimaadka Mayo [Internet]. Aasaaska Mayo ee Caafimaadka Caafimaadka iyo Cilmi-baarista; c1995–2019. Aqoonsiga Imtixaanka: ANCA: Cudurrada 'Cytoplasmic Neutrophil Antibodies', Serum: Clinical and Interpretive; [daliishaday 2019 Meey 3]; [ilaa 4 shaashadood]. Waxaa laga heli karaa: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9441
9. Machadka Wadnaha, Sambabka, iyo Machadka Dhiiga [Internet]. Bethesda (MD): Waaxda Caafimaadka iyo Adeegyada Aadanaha ee Mareykanka; Tijaabooyinka Dhiigga; [daliishaday 2019 Meey 3]; [ilaa 3 shaashad]. Waxaa laga heli karaa: https://www.nhlbi.nih.gov/health-topics/blood-tests
10. Machadka Wadnaha, Sambabka, iyo Machadka Dhiiga [Internet]. Bethesda (MD): Waaxda Caafimaadka iyo Adeegyada Aadanaha ee Mareykanka; Vasculitis; [daliishaday 2019 Meey 3]; [ilaa 2 shaashad]. Waxaa laga heli karaa: https://www.nhlbi.nih.gov/health-topics/vasculitis
11. Radice A, Sinico RA. Antineutrophil Cytoplasmic Antibodies (ANCA). Autoimmunity [Internet]. 2005 Feb [xigasho 2019 May 3]; 38 (1): 93–103. Waxaa laga heli karaa: https://www.ncbi.nlm.nih.gov/pubmed/15804710
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Macluumaadka ku yaal boggan waa in aan loo isticmaalin beddel daryeel caafimaad oo xirfad leh ama talo. La xiriir bixiye daryeel caafimaad haddii aad su'aalo ka qabtid caafimaadkaaga.