Qoyska dysbetalipoproteinemia

Qoyska dysbetalipoproteinemia waa cilad u gudubta qoysaska. Waxay keentaa xaddi badan oo kolestarool iyo triglycerides oo dhiigga ku jira.

Cilad hidde ah ayaa sababa xaaladdan. Ciladdu waxay keentaa soo saarista walxaha waaweyn ee lipoprotein-ka oo ay ku jiraan labada kolestarool iyo nooc dufan ah oo loo yaqaan triglycerides. Cudurku wuxuu xiriir la leeyahay cilladaha hidda-wadaha ee apolipoprotein E.

Hypothyroidism, cayilnaanta, ama sonkorowga ayaa xaalada ka sii dari kara. Waxyaabaha halista u ah qoyska dysbetalipoproteinemia waxaa ka mid ah taariikhda qoyska ee cilladda ama cudurka halbowlayaasha wadnaha.

Calaamadaha laguma arki karo ilaa da'da 20 ama ka weyn.

Kayd huruud ah oo ka mid ah maaddada dufanka leh ee maqaarka loo yaqaan xanthomas ayaa ka soo muuqan kara baalalka indhaha, calaacalaha gacmaha, cagaha cagihiisa, ama muruqyada jilbaha iyo xusullada.

Calaamadaha kale waxaa ka mid noqon kara:

• Laabta xanuun (angina) ama calaamadaha kale ee cudurada halbowlayaasha wadnaha ayaa laga yaabaa inay jiraan da 'yar
• Maroojinta mid ama labada weylo marka la socdo
• Nabarro suulasha oo aan bogsan
• Astaamaha sida istaroogga oo kale ah sida hadalka oo dhib ah, hoos u foorarsiga dhinac wajiga ah, daciifnimo gacan ama lug ah, iyo dheelitirnaan la'aan

Tijaabooyinka laga yaabo in lagu sameeyo si loo ogaado xaaladan waxaa ka mid ah:

• Tijaabada hida-sidaha ee apolipoprotein E (apoE)
• Baaritaanka dhiigga ee guntinta
• Heerka Triglyceride
• Baadhitaan aad u hooseeya oo lipoprotein (VLDL) ah

Ujeedada daaweyntu waa in la xakameeyo xaaladaha sida buurnida, hypothyroidism, iyo sonkorowga.

Sameynta cuntada oo isbeddeleysa si loo yareeyo kalooriyada, dufanka buuxa, iyo kolestaroolka ayaa laga yaabaa inay gacan ka geysato yareynta kolestaroolka dhiigga.

Haddii heerarka kolestaroolka iyo triglyceride ay weli sarreeyaan ka dib markii aad isbeddelayso cuntada, daryeel caafimaad bixiyahaaga ayaa laga yaabaa inuu kaa qaato daawooyin sidoo kale. Daawooyinka si loo yareeyo heerka triglyceride ee dhiigga iyo heerarka kalastarolka waxaa ka mid ah:

• Xakamaynta Bile acid-sequestering.
• Fibrates (gemfibrozil, fenofibrate).
• Nicotinic acid.
• Statins.
• PCSK9 xakameeyayaasha, sida alirocumab (Praluent) iyo evolocumab (Repatha). Kuwani waxay metelaan noocyo cusub oo daroogo ah oo lagu daaweeyo kolestaroolka.

Dadka xaaladan qaba waxay si aad ah ugu sii kordhayaan halista cudurada halbowlayaasha wadnaha iyo xididdada dhiigga ee durugsan.

Daaweynta, dadka badankood waxay awoodaan inay si weyn u yareeyaan heerarkooda kalastarol iyo triglycerides.

Dhibaatooyinka waxaa ka mid noqon kara:

• Wadne qabad
• Faalig
• Cudurka xididdada dhiigga ee durugsan
• Kala-hadal goos goos ah
• Gangrene ee xagjirnimada hoose

Wac adeeg bixiyahaaga haddii lagaa helay cilladan iyo:

• Calaamado cusub ayaa soo kordha.
• Calaamaduhu kuma hagaagaan daaweynta.
• Calaamadaha ayaa ka sii daraya.

Baaritaanka xubnaha qoyska ee dadka xaaladan qaba waxay u horseedi kartaa ogaanshaha iyo daaweynta goor hore.

In goor hore la daweeyo oo la xaddido arrimaha kale ee halista ah sida sigaar cabista ayaa kaa caawin karta kahortagga wadne qabadka hore, istaroog, iyo xididdada dhiigga ee xannibma.

Nooca III hyperlipoproteinemia; Apolipoprotein liita ama cilladaysan E

• Cudurka halbowlayaasha wadnaha

Genest J, Libby P. Dhibaatooyinka Lipoprotein iyo cudurada wadnaha. Gudaha: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Cudurka Wadnaha ee Braunwald: Buugga Buugta Daawada Wadnaha iyo Xididdada. 11aad. Philadelphia, PA: Elsevier; 2019: cutubka 48.

Robinson JG. Cilladaha dheef-shiid kiimikaadka. Gudaha: Goldman L, Schafer AI, eds. Daawada Goldman-Cecil. 26aad. Philadelphia, PA: Elsevier; 2020: cutubka 195.