Deferasirox

Qanacsan

• Si aad u qaadatid kaniiniyada 'deferasirox' ee ganaax (Exjade), raac talaabooyinkan:
• Ka hor intaadan qaadin daawada loo yaqaan 'deferasirox'
• Deferasirox waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:
• Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa lagu xusay qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga:
• Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

Deferasirox waxay u geysan kartaa dhaawac halis ah ama naf-gooya kelyaha. Halista aad ku yeelan karto dhaawaca kelyaha ayaa ka weyn haddii aad leedahay xaalado caafimaad oo badan, ama aad aad u jiran tahay cudur dhiig ah darteed. U sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabto cudurka kalyaha. Dhakhtarkaaga ayaa laga yaabaa inuu kuu sheego inaadan qaadan daawada loo yaqaan 'defrasirox' Haddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga: kaadida oo yaraata, bararka anqawyada, lugaha, ama cagaha, daal fara badan, neefta oo ku qabata, iyo wareer. Carruurta qaadata dawadan, waxaa jira halista sii kordheysa ee ah inaad ku dhacdo dhibaatooyin kalyaha ah haddii aad ku xanuunsato intaad qaadaneyso 'defrasirox' oo aad ku dhacdo shuban, matag, qandho, ama aad si caadi ah u joojiso cabitaanka cabitaanka. Isla markiiba wac dhakhtarkaaga haddii aad isku aragto mid ka mid ah astaamahan.

Deferasirox waxay sidoo kale u keeni kartaa beerka dhaawac halis ah ama naf-gooya ah. Khatarta aad ku yeelan karto dhaawaca beerka ayaa ka weyn haddii aad ka weyn tahay da'da 55 sano, ama haddii aad leedahay xaalado caafimaad oo kale oo daran. U sheeg dhakhtarkaaga haddii aad qabto ama aad waligaa qabto cudurka beerka. Haddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga: maqaarka ama indhaha oo huruud noqda, calaamadaha hargabka oo kale ah, tamar la'aan, rabitaanka cuntada oo yaraada, xanuunka qaybta sare ee midig ee caloosha, ama nabar ama dhiig bax aan caadi ahayn.

Deferasirox sidoo kale waxay sababi kartaa dhiig bax halis ah ama nafta halis galinaya caloosha ama xiidmaha. Halista aad ugu yeelan karto dhiig bax daran caloosha ama xiidmaha way sii weynaan kartaa haddaad duq tahay, ama aad u jiran tahay xaalad dhiig ah. U sheeg dhakhtarkaaga haddii aad leedahay ama aad waligaa yeelatay heer hoose oo ah platelet (nooc unug unug dhiig ah oo loo baahan yahay si loo xakameeyo dhiig-baxa), ama haddii aad qaadanayso mid ka mid ah daawooyinka soo socda: Xinjirowga lidka ku ah (dhiig khafiifiyeyaasha) sida warfarin (Coumadin) , Jantoven); asbiriin ama dawooyin kale oo ka hortagga bararka jirka (NSAIDs) sida ibuprofen (Advil, Motrin, kuwa kale) iyo naproxen (Aleve, Naprosyn, kuwa kale); daawooyinka qaarkood si loo xoojiyo lafaha oo ay ku jiraan alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), iyo zoledronic acid (Reclast, Zometa); ama steroids sida dexamethasone, methylprednisolone (A-methapred, Depo-medrol, Medrol, Solu-medrol), ama prednisone (Rayos). Haddii aad isku aragto mid ka mid ah astaamaha soo socda, isla markiiba wac dhakhtarkaaga: gubashada calool xanuun, matag midabkiisu casaan yahay ama u eg kafee qaxwaha, dhiig cas cas oo saxarada ku jira, ama saxaro madow ama tarry ah.

Dhammaan ballamaha la dhig dhakhtarkaaga iyo shaybaarka. Dhaqtarkaaga ayaa amri doona baaritaanada sheybaarka kahor iyo inta daaweyntaadu socoto si uu u hubiyo inay amaan kuugu tahay inaad qaadato daawada loo yaqaan 'defrasirox' iyo inuu arko haddii aad horumarinayso waxyeelooyinkan halista ah.

Deferasirox waxaa loo isticmaalaa in lagu daaweeyo dadka waaweyn iyo carruurta 2 sano jirka ah ama ka weyn ee birta aad ugu badan maadama ay heleen dhiig badan oo lagu shubo. Waxaa sidoo kale loo isticmaalaa in lagu daaweeyo dadka waaweyn iyo carruurta 10 sano jirka ah ama ka weyn oo birta aad ugu badan jirkooda sababtoo ah cillad dhiig oo hidde ah oo loo yaqaan 'non-transfusion-dependent thalassaemia (NTDT). Deferasirox waxay ku jirtaa nooc daawooyin ah oo loo yaqaan birta birta. Waxay ku shaqeysaa adoo ku dhejinaya birta jirka si markaa looga soo saari karo saxarada.

Deferasirox waxay u timaadaa sidii kiniin, granules, iyo kiniin ganaax ah (kaniin si ay ugu milmaan dareeraha) oo afka lagu qaato. Waa in lagu qaadaa calool madhan maalintii hal mar, ugu yaraan 30 daqiiqo ka hor inta aan la cunin, Kiniiniyada iyo granules sidoo kale waxaa lagu qaadan karaa cunto fudud sida qamadi dhan oo Ingiriis ah oo leh xabbo iyo caano dufan ah, ama rooti rooti yar oo turkey ah rootiga qamadiga oo dhan. Qaado daawada loo yaqaan 'defrasirox' qiyaastii isla waqtigaas maalin kasta. Si taxaddar leh u raac tilmaamaha ku qoran calaamadaha laguu qoray, oo weydii takhtarkaaga ama farmashiistaha inuu kuu sharxo qayb kasta oo aadan fahmin. Qaado kashifaatsirool si sax ah sida lagu faray. Ha ka qaadin wax ka yar ama ka yar ama u qaado si ka badan inta dhakhtarku kuu qoray.

Waxyaabaha kala duwan ee loo yaqaan 'defrasirox' ayaa jidhku u nuugaa siyaabo kala duwan loomana beddeli karo midba midka kale. Haddii aad u baahan tahay inaad ka beddelatid hal shey oo loo yaqaan 'deferasirox' oo loo beddelo mid kale, dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu saxo qiyaastaada. Waqti kasta oo aad hesho daawadaada, hubi inaad heshay waxsoosaarkii 'defrasirox' oo adiga laguu qoray. Weydii farmasiilahaaga haddii aadan hubin inaad heshay daawada saxda ah.

Ku liq kiniiniyada 'deprasirox' (Jadenu) biyo ama dareere kale. Haddii dhib kaa haysato inaad liqdo kaniiniga, waad burburin kartaa kaniiniga oo waxaad ku qasmi kartaa cunto jilicsan sida yogurt ama tufaax isla markiiba ka hor intaadan qaadan. Si kastaba ha noqotee, ha ku burburin kiniinka 90 mg (Jadenu) adoo adeegsanaya qalab burburin xirfad leh oo leh geesaha geesaha.

Si aad u qaadatid granules (Jadenu), waxaad ku saydhaa bakeeriyada cuntada jilicsan sida yogurt ama tufaax isla markiiba intaadan qaadan.

Si aad u qaadatid kaniiniyada 'deferasirox' ee ganaax (Exjade), raac talaabooyinkan:

1. Had iyo jeer ku milmi kiniinnada ka joojinta dareeraha ka hor intaadan qaadan. Ha calalin ama ha liqin kaniiniyada ganaaxa oo dhan.
2. Haddii aad qaadanayso wax ka yar 1000 mg oo ah 'deferasirox', ku buuxi koob badhkiis (qiyaastii 3.5 oz / 100 mL) biyo, cabitaanka tufaaxa, ama casiirka liinta. Haddii aad qaadanayso wax ka badan 1000 mg oo ah 'deferasirox', ku buuxi koob (qiyaastii 7 oz / 200 mL) biyo, cabitaanka tufaaxa, ama casiirka liinta. Haddii aadan hubin inta jeermis ee aad qaadanayso, weydii dhakhtarkaaga ama farmashiistahaaga.
3. Dhig tirada kiniiniga ah ee dhakhtarkaagu kuu sheegay inaad ku qaadatid koobka.
4. Dareere dareeraha ilaa 3 daqiiqo si aad u wada baabi'iso kiniinnada. Isku darku wuxuu noqon karaa mid qaro leh markaad walaaqaysid.
5. Cab dareeraha isla markiiba.
6. Ku dar qadar yar oo dareere ah koobka madhan oo walaaq. Koobka ku beddel si aad u milisid wax daawo ah oo weli ku jira muraayadda ama walaaqiyaha.
7. Cab dareeraha intiisa kale.

Dhakhtarkaaga ayaa laga yaabaa inuu saxo qiyaastaada 'deferasirox' oo aan ka badnayn hal mar 3dii ilaa 6dii biloodba, taasoo kuxiran natiijooyinka baaritaanka shaybaarkaaga.

Deferasirox waxay birta dheeriga ah ka saareysaa jirkaaga si tartiib tartiib ah waqtiga. Sii wad inaad qaadato 'defrasirox' xitaa haddii aad caafimaad qabtid. Ha u joojin qaadashada dawada loo yaqaan 'defrasirox' adiga oo aan lahadlin dhakhtarkaaga.

Daawadan waxaa loo qori karaa adeegsiyo kale; Weydii dhakhtarkaaga ama farmashiistaha wixii macluumaad dheeraad ah.

Ka hor intaadan qaadin daawada loo yaqaan 'deferasirox'

• u sheeg dhakhtarkaaga iyo farmashiistaha haddii aad xasaasiyad ku leedahay daweynta loo yaqaan 'deferasirox', daawooyin kale oo kasta, ama wax ka mid ah maaddooyinka ku jira kiniiniyada 'defrasirox', granules, ama kaniiniyada hakinta Weydii dhakhtarkaaga ama farmashiistaha liiska waxyaabaha ay ka kooban yihiin.
• u sheeg dhakhtarkaaga iyo farmashiistaha dawooyinka dhakhtarku qoro iyo kuwa aan dhakhtar qorin, fiitamiinnada, nafaqada nafaqada, iyo alaabta dhirta ah ee aad qaadanayso ama aad qorsheyneyso inaad qaadato. Hubso inaad sheegto dawooyinka ku taxan qaybta DIGNIIN MUHIIM AH iyo mid ka mid ah kuwan soo socda: alosetron (Lotronex), khabiir (Cinvanti, Emend), budesonide (Entocort, Pulmicort, Uceris, in Symbicort), buspirone, cholestyramine (Prevalite), colesevelam (Welchol), colestipol (Colestid), conivaptan (Vaprisol), cyclosporine (Gengraf, Neoral, Sandimmune), darifenacin (Enablex), darunavir (Prezista, in Prezcobix), dasatinib (Sprycel), dihydroergotamine (DHE 45, Migran) (Multaq), duloxetine (Cymbalta), eletriptan (Relpax), eplerenone (Inspra), ergotamine (Ergomar, in Cafergot, Migergot), everolimus (Afinitor, Zortress), felodipine, fentanyl (Actiq, Duragesic, Subs) (Arnuity Ellipta, Flovent, oo ku taal Breo Ellipta, Advair), ka hortagga uurka ee hormoonnada (kiniiniyada ka hortagga uurka, balastarro, ama irbado), indinavir (Crixivan), lopinavir (Kaletra), lovastatin (Altoprev), lurasidone (Latuda), maraviroc (Selzentry), midazolam, nisoldipine (Sular), paclitax el (Abraxane, Taxol), phenytoin (Dilantin, Phenytek), phenobarbital, pimozide (Orap), quetiapine (Seroquel), quinidine (Nuedexta), ramelteon (Rozerem), repaglinide (Prandin, Prandimet), rifampin R , Rifamate, Rifater), ritonavir (Norvir, Kaletra, Technivie, Viekira Pak), saquinavir (Invirase), sildenafil (Revatio, Viagra), simvastatin (Flolopid, Zocor, in Vytorin), siroliumus (Rapamus), tacro Astagraf, Envarsus, Prograf), theophylline (Theo-24), ticagrelor (Brilinta), tipranavir (Aptivus), tizanidine (Zanaflex), triazolam (Halcion), tolvaptan (Samsca), iyo vardenafil (Levitra, Staxyn). Dhakhtarkaaga ayaa laga yaabaa inuu u baahdo inuu beddelo qiyaasta daawooyinkaaga ama uu si taxaddar leh kuugu ilaaliyo dhibaatooyinka soo raaca.
• haddii aad qaadanaysid dawooyin ka kooban aluminium oo ay ku jiraan antacids sida Amphojel, Alternagel, Gaviscon, Maalox, ama Mylanta, qaado 2 saacadood ka hor ama ka dib deferasirox.
• u sheeg dhakhtarkaaga waxa ku saabsan alaabooyinka miiska lagaa iibsado ee aad qaadanayso, gaar ahaan melatonin, ama kaabisyada nafaqada leh.
• u sheeg dhakhtarkaaga haddii aad qabtid cilladda 'myelodysplastic syndrome' (dhibaato daran oo la socota dhuuxa lafta oo khatar sare ugu jirta inuu ku dhaco kansar), ama kansar. Dhakhtarkaaga ayaa laga yaabaa inuu kuu sheego inaadan qaadan daawada loo yaqaan 'defrasirox'
• u sheeg dhakhtarkaaga haddii aad uur leedahay, qorsheyso inaad uur yeelato, ama aad naas nuujiso. Haddii aad uur yeelato intaad qaadanaysid daawada loo yaqaan 'defrasirox', wac dhakhtarkaaga.

Ilaa dhakhtarkaagu kuu sheego mooyee, sii wad cuntadaada caadiga ah.

Qaado qiyaasta la seegay maalinta dambe, ugu yaraan 2 saacadood ka dib cuntadaadii ugu dambeysay iyo 30 daqiiqo ka hor intaadan wax cunin. Si kastaba ha noqotee, haddii ay ku dhowdahay waqtiga qiyaasta xigta ama haddii aadan awoodin inaad ku qaadatid calool-fadhiga calool madhan, ka boodi qiyaasta la seegay oo sii wad jadwalkaaga qiyaasta daawada caadiga ah. Ha qaadan laba-qaadasho si aad uhesho mid kaa dhaafay.

Deferasirox waxay sababi kartaa waxyeelo. U sheeg dhakhtarkaaga haddii mid ka mid ah astaamahani ay daran yihiin ama aanad tagin:

• calool xanuun
• lallabbo
• matagid
• shuban

Dhibaatooyinka qaarkood waxay noqon karaan kuwo halis ah. Haddii aad isku aragto mid ka mid ah astaamahan ama kuwa lagu xusay qaybta DIGNIIN MUHIIM AH, isla markiiba wac dhakhtarkaaga:

• maqal la'aanta
• dhibaatooyinka aragga
• finan yaryar, finan yaryar, xoqid ama maqaarka oo bararaya, qandho, qanjidhada oo barara
• neefsashada ama liqidda oo ku adkaata; barar wejiga, cunaha, carrabka, bushimaha, ama indhaha; xabeeb
• nabar ama dhiig bax aan caadi ahayn

Deferasirox waxay sababi kartaa waxyeelo kale. Wac dhakhtarkaaga haddii aad qabtid dhibaatooyin aan caadi ahayn intaad qaadanaysid dawadan.

Haddii aad isku aragto waxyeellooyin daran, adiga ama dhakhtarkaaga ayaa warbixin u diri kara Barnaamijka Ka Warbixinta Dhacdooyinka Xun ee Maamulka Cuntada iyo Dawooyinka (FDA) (http://www.fda.gov/Safety/MedWatch) ama taleefan ( 1-800-332-1088).

Daawadan ku hay weelka ay soo gashay, si adag u xir, iyo meel aysan carruurtu gaarin. Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan (ha ku jirin musqusha).

Waa muhiim inaad ka ilaaliso dhammaan daawooyinka meel aan la arkeynin oo aysan gaari karin carruurta maaddaama weelal badan (sida kuwa toddobaadlaha kiniiniga ka fiirsada iyo kuwa loogu talagalay dhibcaha isha, kareemada, dhejiyeyaasha, iyo kuwa neefta ku siiya) uma adkeysana carruurta, carruurta yaryarna si fudud ayey ku furi karaan. Si aad uga ilaaliso carruurta yaryar sunta, marwalba xiro daboolka badbaadada isla markaana isla markiiba dhig dawada meel aamin ah - mid kor iyo fog kana fog aragooda oo gaadha. http://www.upandaway.org

Daawooyinka aan loo baahnayn waa in lagu tuuraa siyaabo gaar ah si loo hubiyo in xayawaanka, carruurta, iyo dadka kaleba aysan cuni karin. Si kastaba ha noqotee, waa inaadan ku daadinin daawadan musqusha hoosteeda. Taabadalkeed, sida ugufiican ee dawada looga takhalusi karaa waa iyada oo loo maro barnaamijka dib u celinta daawada. La hadal farmashiistahaaga ama la xiriir waaxda qashinka / dib u warshadaynta si aad wax uga ogaato barnaamijyada dib-u-celinta ee bulshadaada. Ka eeg bogga internetka ee 'FDA ee Amni-Qaadashada Daawooyinka (http://goo.gl/c4Rm4p) si aad u hesho macluumaad dheeraad ah haddii aadan marin u helin barnaamijka dib-u-celinta.

Xaalada xad dhaafka ah, wac khadka caawinta ka hortagga sunta 1-800-222-1222. Macluumaadka sidoo kale waxaa laga heli karaa internetka https://www.poisonhelp.org/help. Haddii dhibbanuhu burburay, suuxdin qabtay, neefsashadu dhib ku tahay, ama aan la kici karin, isla markiiba wac adeegyada gurmadka ee 911.

Calaamadaha xad-dhaafka ah waxaa ka mid noqon kara kuwa soo socda:

• hurdi maqaarka ama indhaha
• xanuun qeybta kore ee midig ee caloosha
• nabar ama dhiig bax aan caadi ahayn
• tamar la’aan
• cunto xumo
• astaamaha hargabka oo kale ah
• shuban
• lallabbo
• matagid
• kaadida oo yaraatay
• barar lugaha ama anqawyada

Dhammaan ballamaha la dhig dhakhtarkaaga. Waxaad ubaahantahay in lagugu sameeyo baaritaano maqal iyo indho kahor intaadan bilaabin deferasirox iyo sanadkiiba hal mar inta aad qaadaneysid daawadan.

Ha u ogolaan qof kale inuu qaato daawadaada. Weydii farmashiistahaaga wixii su'aalo ah ee aad ka qabto dib u soo celinta daawada laguu qoray.

Waxaa muhiim kuu ah inaad haysato liis qoran oo ku saabsan dhammaan daawooyinka laguu qoro iyo kuwa aan dhakhtar qorin (warqad dhakhtar la aan ah) ee aad qaadanaysid, iyo sidoo kale wax soo saar kasta sida fiitamiinnada, macdanta, ama nafaqooyinka kale ee nafaqada leh. Waa inaad soo qaadataa liiskan markasta oo aad booqato dhakhtar ama haddii isbitaal la dhigo. Sidoo kale waa macluumaad muhiim ah inaad lasocoto haddii ay jiraan xaalado deg deg ah.

• Soo bixid^®
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